RU2006139073A - Способы лечения боли, обусловленной раком кости, путем введения антагониста фактора роста нервов - Google Patents
Способы лечения боли, обусловленной раком кости, путем введения антагониста фактора роста нервов Download PDFInfo
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- RU2006139073A RU2006139073A RU2006139073/14A RU2006139073A RU2006139073A RU 2006139073 A RU2006139073 A RU 2006139073A RU 2006139073/14 A RU2006139073/14 A RU 2006139073/14A RU 2006139073 A RU2006139073 A RU 2006139073A RU 2006139073 A RU2006139073 A RU 2006139073A
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- Prior art keywords
- ngf
- bone
- cancer
- antagonist
- antibody
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- 206010005949 Bone cancer Diseases 0.000 title claims abstract 13
- 208000018084 Bone neoplasm Diseases 0.000 title claims abstract 13
- 208000002193 Pain Diseases 0.000 title claims abstract 13
- 239000005557 antagonist Substances 0.000 title claims abstract 10
- 239000003102 growth factor Substances 0.000 title 1
- 102000015336 Nerve Growth Factor Human genes 0.000 claims abstract 12
- 108010025020 Nerve Growth Factor Proteins 0.000 claims abstract 12
- 210000000988 bone and bone Anatomy 0.000 claims abstract 8
- 229940122467 Nerve growth factor antagonist Drugs 0.000 claims 10
- 230000003042 antagnostic effect Effects 0.000 claims 6
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000046917 human NGF Human genes 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010050017 Lung cancer metastatic Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000004084 narcotic analgesic agent Substances 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 229940053128 nerve growth factor Drugs 0.000 abstract 3
- 206010058019 Cancer Pain Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (20)
1. Способ лечения боли, обусловленной раком кости у субъекта, который включает введение данному субъекту эффективного количества антагониста фактора роста нервов (NGF).
2. Способ по п.1, в котором боль, обусловленная раком кости, является следствием рака, возникающего в кости.
3. Способ по п.2, в котором боль, обусловленная раком кости, является следствием остеосаркомы.
4. Способ по п.1, в котором боль, обусловленная раком кости, является следствием рака, метастазирующего в кость.
5. Способ по п.4, в котором боль, обусловленная раком кости, является следствием рака предстательной железы, метастазирующего в кость.
6. Способ по п.4, в котором боль, обусловленная раком кости, является следствием рака молочной железы, метастазирующего в кость.
7. Способ по п.4, в котором боль, обусловленная раком кости, является следствием рака легкого, метастазирующего в кость.
8. Способ по п.4, в котором боль, обусловленная раком кости, является следствием саркомы, метастазирующей в кость.
9. Способ по п.4, в котором боль, обусловленная раком кости, является следствием рака почки, метастазирующего в кость.
10. Способ по п.1, в котором антагонист NGF является антагонистическим антителом против NGF.
11. Способ по п.10, в котором антагонистическое антитело против NGF является моноклональным антителом.
12. Способ по п.10, в котором антагонистическое антитело против NGF является гуманизированным антителом.
13. Способ по п.10, в котором антагонистическое антитело против NGF является антителом человека.
14. Способ по п.10, в котором антагонистическое антитело против NGF связывает NGF человека.
15. Способ по п.14, в котором антагонистическое антитело против NGF дополнительно связывает NGF грызунов.
16. Способ по п.14, в котором антагонистическое антитело против NGF связывает NGF человека с КD около 0,1 нМ или менее чем примерно 0,1 нМ.
17. Способ по п.10, в котором вариабельная область тяжелой цепи антагонистического антитела против NGF включает аминокислотную последовательность, представленную SEQ ID NO:1.
18. Способ по п.10, в котором вариабельная область легкой цепи антагонистического антитела против NGF включает аминокислотную последовательность, представленную SEQ ID NO:2.
19. Способ по п.1, в котором антагонист NGF вводят без наркотического анальгетика.
20. Набор для лечения боли, обусловленной раком кости, который включает антагонист NGF и инструкции по использованию антагониста NGF для лечения боли, обусловленной раком кости.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56078104P | 2004-04-07 | 2004-04-07 | |
| US60/560,781 | 2004-04-07 | ||
| US62065404P | 2004-10-19 | 2004-10-19 | |
| US60/620,654 | 2004-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006139073A true RU2006139073A (ru) | 2008-05-20 |
| RU2389509C2 RU2389509C2 (ru) | 2010-05-20 |
Family
ID=35394727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006139073/14A RU2389509C2 (ru) | 2004-04-07 | 2005-04-07 | Способы лечения боли, обусловленной раком кости, путем введения антагониста фактора роста нервов |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US7425329B2 (ru) |
| EP (3) | EP3372614B1 (ru) |
| JP (3) | JP5301152B2 (ru) |
| KR (3) | KR20060135060A (ru) |
| AT (1) | ATE456580T1 (ru) |
| AU (2) | AU2005243247B2 (ru) |
| BR (1) | BRPI0508390B8 (ru) |
| CA (1) | CA2562024C (ru) |
| DE (1) | DE602005019144D1 (ru) |
| DK (2) | DK2206728T3 (ru) |
| ES (2) | ES2338344T3 (ru) |
| HU (1) | HUE037549T2 (ru) |
| IL (3) | IL178226A (ru) |
| MX (1) | MXPA06011463A (ru) |
| NO (2) | NO343065B1 (ru) |
| NZ (1) | NZ549990A (ru) |
| PL (2) | PL2206728T3 (ru) |
| PT (2) | PT2206728T (ru) |
| RU (1) | RU2389509C2 (ru) |
| SG (1) | SG152226A1 (ru) |
| SI (2) | SI2206728T1 (ru) |
| TW (1) | TWI367101B (ru) |
| WO (1) | WO2005111077A2 (ru) |
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