RU2006137060A - Человеческие антитела к рецептору эпидермального фактора роста - Google Patents
Человеческие антитела к рецептору эпидермального фактора роста Download PDFInfo
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- RU2006137060A RU2006137060A RU2006137060/13A RU2006137060A RU2006137060A RU 2006137060 A RU2006137060 A RU 2006137060A RU 2006137060/13 A RU2006137060/13 A RU 2006137060/13A RU 2006137060 A RU2006137060 A RU 2006137060A RU 2006137060 A RU2006137060 A RU 2006137060A
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- 102000001301 EGF receptor Human genes 0.000 title 1
- 108060006698 EGF receptor Proteins 0.000 title 1
- 238000000034 method Methods 0.000 claims 21
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 18
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 6
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 6
- 229940034982 antineoplastic agent Drugs 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 229940122558 EGFR antagonist Drugs 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 102000004584 Somatomedin Receptors Human genes 0.000 claims 2
- 108010017622 Somatomedin Receptors Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 201000010174 renal carcinoma Diseases 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
- -1 target Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (41)
1. Изолированное человеческое антитело или фрагмент антитела, содержащее один или более участок, определяющий комплементарность, выбранный из группы, включающей SEQ ID NO:2 на CDRH1; SEQ ID NO:4 на CDRH2; SEQ ID NO:6 на CDRH3; SEQ ID NO:10 на CDRL1; SEQ ID NO:12 на CDRL2; и SEQ ID NO:14 на CDRL3.
2. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:2 на CDRH1; SEQ ED NO:4 на CDRH2; и SEQ ID NO:6 на CDRH3.
3. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:8.
4. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:10 на CDRL1; SEQ ID NO:12 на CDRL2; и SEQ ID NO:14 на CDRL3.
5. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:16.
6. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:2 на CDRH1; SEQ ID NO:4 на CDRH2; SEQ ID NO:6 на CDRH3; SEQ ID NO:10 на CDRL1; SEQ ID NO:12 на CDRL2; и SEQ ID NO:14 на CDRL3.
7. Антитело или фрагмент антитела по п.1, содержащее SEQ ID NO:8 и SEQ ID NO:16.
8. Антитело или фрагмент антитела по пп.1-7, селективно связывающееся с EGFR.
9. Антитело или фрагмент антитела по пп.1-7, ингибирующее связывание EGFR с лигандом EGFR.
10. Антитело или фрагмент антитела по пп.1-7, нейтрализующее EGFR.
11. Антитело или фрагмент антитела по пп.1-7, выбираемое из группы, состоящей из моноцепочного антитела, Fab, моноцепочного Fv, ди-тела и три-тела.
12. Конъюгат антитела или фрагмента антитела по пп.1-7.
13. Конъюгат по п.12, содержащий анти-неопластический агент, мишень или маркер.
14. Изолированный полинуклеотид, кодирующий антитело или фрагмент антитела и содержащий одну или более нуклеотидную последовательность, выбранную из группы, состоящей из SEQ ID NO:1 на CDRH1; SEQ ID NO:3 на CDRH2; SEQ ID NO:5 на CDRH3; SEQ ID NO:9 на CDRL1; SEQ ID NO:11 на CDRL2; и SEQ ID NO:13 на CDRL3.
15. Изолированный полинуклеотид по п.14, содержащий SEQ ID NO:7.
16. Изолированный полинуклеотид по п.14, содержащий SEQ ID NO:15.
17. Вектор экспрессии, содержащий полинуклеотид по пп.14-16.
18. Рекомбинантная хост-клетка, содержащая вектор экспрессии по п.17.
19. Рекомбинантная хост-клетка по п.18, производящая полипептид, содержащий SEQ ED NO:8, и полипептид, содержащий SEQ ID NO:16.
20. Рекомбинантная хост-клетка по п.18, производящая полипептид, содержащий SEQ ED NO:8 и SEQ ID NO:16.
21. Способ ингибирования роста опухоли у млекопитающих, включающий введение терапевтически эффективного количества антитела по пп.1-11.
22. Способ по п.21, в котором опухоль производит EGFR.
23. Способ по п.21, в котором опухоль перепроизводит EGFR.
24. Способ по п.21, в котором опухоль является первичной раковой опухолью.
25. Способ по п.21, в котором опухоль является метастатической раковой опухолью.
26. Способ по п.21, в котором опухоль является невосприимчивой раковой опухолью.
27. Способ по п.21, в котором опухоль является васкуляризированной раковой опухолью.
28. Способ по п.21, в котором опухоль является выбранной из группы, состоящей из колоректальной раковой опухоли, раковой опухоли головы или шеи, панкреатической раковой опухоли, раковой опухоли легких, раковой опухоли груди, почечной карциномы и глиобластомы.
29. Способ по п.21, в котором антитело или фрагмент антитела вводится в комбинации с анти-неопластическим агентом.
30. Способ по п.29, в котором анти-неопластический агент является химиотерапевтическим агентом.
31. Способ по п.29, в котором анти-неопластический агент является иринотеканом (СРТ-11).
32. Способ по п.29, в котором анти-неопластический агент, является радиацией.
33. Способ по п.21, в котором антитело или фрагмент антитела вводят с EGFR-антагонистом.
34. Способ по п.33, в котором EGFR антагонист является внутриклеточным EGFR антагонистом.
35. Способ по п.21, дополнительно включающий введение терапевтически эффективного количества антагониста рецептора васкулярного эндотелиального фактора (vascular endothelial factor receptor, VEGFR).
36. Способ по п.21, включающий введение терапевтически эффективного количества антагониста рецептора инсулиноподобного фактора роста (insulin like growth factor receptor, IGFR).
37. Способ лечения гиперпролиферативных расстройств, включающий введение терапевтически эффективного количества антитела по пп.1-11.
38. Способ по п.37, в котором гиперпролиферативным расстройством является псориаз.
39. Способ по п.38, в котором антитело или фрагмент антитела вводят в сочетании с местным или общим агентом для псориаза.
40. Способ по п.38, в котором антитело или фрагмент антитела вводят в сочетании с кортикостероидом.
41. Способ по п.38, в котором антитело или фрагмент антитела вводят в сочетании с ретиноидом.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55455504P | 2004-03-19 | 2004-03-19 | |
| US60/554,555 | 2004-03-19 | ||
| US62426404P | 2004-11-02 | 2004-11-02 | |
| US60/624,264 | 2004-11-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006137060A true RU2006137060A (ru) | 2008-04-27 |
| RU2402569C2 RU2402569C2 (ru) | 2010-10-27 |
Family
ID=34964896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006137060/13A RU2402569C2 (ru) | 2004-03-19 | 2005-03-21 | Человеческие антитела к рецептору эпидермального фактора роста |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7598350B2 (ru) |
| EP (2) | EP2332990A1 (ru) |
| JP (1) | JP4734319B2 (ru) |
| CN (1) | CN103007279B (ru) |
| AU (1) | AU2005224267B2 (ru) |
| CA (1) | CA2560305C (ru) |
| CY (2) | CY1113037T1 (ru) |
| DK (1) | DK1735348T3 (ru) |
| ES (1) | ES2387809T3 (ru) |
| HU (1) | HUS000495I2 (ru) |
| LT (1) | LTC1735348I2 (ru) |
| LU (1) | LU93093I2 (ru) |
| MX (1) | MXPA06010715A (ru) |
| NL (1) | NL300819I2 (ru) |
| PL (1) | PL1735348T3 (ru) |
| PT (1) | PT1735348E (ru) |
| RU (1) | RU2402569C2 (ru) |
| WO (1) | WO2005090407A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2498819C2 (ru) * | 2008-08-05 | 2013-11-20 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и профилактики злокачественных опухолей |
| US8828398B2 (en) | 2010-02-04 | 2014-09-09 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| US8911740B2 (en) | 2010-02-04 | 2014-12-16 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| US8937160B2 (en) | 2010-02-04 | 2015-01-20 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| US9115200B2 (en) | 2010-02-04 | 2015-08-25 | Toray Industries, Inc. | Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1 |
| US9175074B2 (en) | 2011-08-04 | 2015-11-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US9181348B2 (en) | 2011-08-04 | 2015-11-10 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US9181334B2 (en) | 2011-08-04 | 2015-11-10 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US9180187B2 (en) | 2010-02-04 | 2015-11-10 | Toray Industries, Inc. | Medicament for treating and/or preventing cancer |
| US9180188B2 (en) | 2011-08-04 | 2015-11-10 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US9260513B2 (en) | 2012-02-21 | 2016-02-16 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| US9266958B2 (en) | 2012-02-21 | 2016-02-23 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| US9273128B2 (en) | 2011-08-04 | 2016-03-01 | Toray Industries, Inc | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US9273130B2 (en) | 2012-02-21 | 2016-03-01 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| US9409993B2 (en) | 2011-08-04 | 2016-08-09 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of pancreatic cancer |
| US9416193B2 (en) | 2012-03-30 | 2016-08-16 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of liver cancer |
| US9428581B2 (en) | 2012-03-30 | 2016-08-30 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of gallbladder cancer |
| US9573993B2 (en) | 2012-02-21 | 2017-02-21 | Toray Industries, Inc. | Pharmaceutical composition for treatment of cancer comprising an anti-CAPRIN-1 peptide antibody |
| US9753038B2 (en) | 2012-07-19 | 2017-09-05 | Toray Industries, Inc. | Method for detecting cancer via measurement of caprin-1 expression level |
| US9772332B2 (en) | 2012-07-19 | 2017-09-26 | Toray Industries, Inc. | Method for detecting CAPRIN-1 in a biological sample |
| US9796775B2 (en) | 2011-08-04 | 2017-10-24 | Toray Industries, Inc. | Method for detecting pancreatic cancer |
| US9862774B2 (en) | 2013-08-09 | 2018-01-09 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| US11137401B2 (en) | 2008-08-05 | 2021-10-05 | Toray Industries, Inc. | Method for detecting cancer using CAPRIN-1 as a marker |
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|---|---|---|---|---|
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| KR20020000223A (ko) * | 1999-05-14 | 2002-01-05 | 존 비. 랜디스 | 표피성장인자 수용체 길항제를 사용한 인간 난치성 종양의치료 방법 |
| WO2002011677A2 (en) * | 2000-08-09 | 2002-02-14 | Imclone Systems Incorporated | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2560305A1 (en) | 2005-09-29 |
| HUS1600030I1 (hu) | 2016-07-28 |
| PT1735348E (pt) | 2012-07-24 |
| AU2005224267A1 (en) | 2005-09-29 |
| EP1735348B1 (en) | 2012-06-20 |
| JP2008500815A (ja) | 2008-01-17 |
| WO2005090407A8 (en) | 2005-12-01 |
| LTC1735348I2 (lt) | 2017-11-10 |
| AU2005224267B2 (en) | 2011-07-21 |
| EP1735348A1 (en) | 2006-12-27 |
| CA2560305C (en) | 2016-07-05 |
| HUS000495I2 (hu) | 2021-03-29 |
| CY2016016I1 (el) | 2016-12-14 |
| MXPA06010715A (es) | 2007-05-23 |
| NL300819I2 (ru) | 2016-07-21 |
| DK1735348T3 (da) | 2012-07-16 |
| CN103007279A (zh) | 2013-04-03 |
| JP4734319B2 (ja) | 2011-07-27 |
| US7598350B2 (en) | 2009-10-06 |
| CY2016016I2 (el) | 2016-12-14 |
| RU2402569C2 (ru) | 2010-10-27 |
| ES2387809T3 (es) | 2012-10-02 |
| WO2005090407A1 (en) | 2005-09-29 |
| PL1735348T3 (pl) | 2012-11-30 |
| LU93093I2 (fr) | 2016-08-01 |
| CN103007279B (zh) | 2017-01-11 |
| US20070264253A1 (en) | 2007-11-15 |
| EP2332990A1 (en) | 2011-06-15 |
| CY1113037T1 (el) | 2016-04-13 |
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