RU2005103399A - Поли-гамма-глутамат сверхвысокого молекулярного веса и способ его применения - Google Patents
Поли-гамма-глутамат сверхвысокого молекулярного веса и способ его применения Download PDFInfo
- Publication number
- RU2005103399A RU2005103399A RU2005103399/04A RU2005103399A RU2005103399A RU 2005103399 A RU2005103399 A RU 2005103399A RU 2005103399/04 A RU2005103399/04 A RU 2005103399/04A RU 2005103399 A RU2005103399 A RU 2005103399A RU 2005103399 A RU2005103399 A RU 2005103399A
- Authority
- RU
- Russia
- Prior art keywords
- phg
- molecular weight
- mineral
- high molecular
- mineral substance
- Prior art date
Links
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 5
- 239000011707 mineral Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 238000010521 absorption reaction Methods 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 235000000853 Bacillus subtilis subsp chungkookjang Nutrition 0.000 claims 1
- 244000192971 Bacillus subtilis subsp chungkookjang Species 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000006096 absorbing agent Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Polyamides (AREA)
- Fodder In General (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- General Preparation And Processing Of Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (14)
1. Сверхвысокомолекулярный поли-γ-глутамат (ПГГ), имеющий средний молекулярный вес более 5000 кДа.
2. ПГГ по п.1, имеющий средний молекулярный вес в пределах от 5000 до 15 000 кДа.
3. ПГГ по п.1 или 2, продуцируемый Bacillus subtilis var. chungkookjang (КТСС 0697ВР).
4. Гидрогель, полученный из ПГГ по любому из пп.1-3.
5. Косметическое средство, содержащее ПГГ по любому из пп.1-3.
6. Пищевой продукт, содержащий ПГГ по любому из пп.1-3.
7. Корм, содержащий ПГГ по любому из пп.1-3.
8. Водопоглощающее средство, содержащее гидрогель по п.4.
9. Способствующая всасыванию минерального вещества композиция, содержащая ПГГ по любому из пп.1-3 и минеральное вещество.
10. Способствующая всасыванию минерального вещества композиция по п.9, обладающая свойством замедленного высвобождения.
11. Способствующая всасыванию минерального вещества композиция по п.9, в которой минеральное вещество представляет собой Са, Fe, Mg, Zn, Cu или Se.
12. Способствующая всасыванию минерального вещества композиция по п.9, в которой ПГГ заменен сополимером сверхвысокомолекулярного ПГГ со средним молекулярным весом более 5000 кДа и полиаминокислоты, несущей положительный заряд.
13. Способствующая всасыванию минерального вещества композиция по п.12, в которой полиаминокислота представляет собой полилизин или полиаргинин.
14. Применение ПГГ по любому из пп.1-3 в качестве средства, усиливающего всасывание минерального вещества.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020040083A KR100399091B1 (en) | 2002-07-10 | 2002-07-10 | Macromolecular weight poly(gamma-glutamic acid) and its use |
| KR10-2002-0040083 | 2002-07-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005103399A true RU2005103399A (ru) | 2005-07-20 |
| RU2281958C2 RU2281958C2 (ru) | 2006-08-20 |
Family
ID=36584211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005103399/04A RU2281958C2 (ru) | 2002-07-10 | 2003-07-10 | Поли-гамма-глутамат сверхвысокого молекулярного веса и его применение |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060127447A1 (ru) |
| EP (1) | EP1519979A4 (ru) |
| JP (2) | JP2005532462A (ru) |
| KR (1) | KR100399091B1 (ru) |
| CN (1) | CN1324143C (ru) |
| AU (1) | AU2003252420A1 (ru) |
| CA (1) | CA2490976A1 (ru) |
| RU (1) | RU2281958C2 (ru) |
| WO (1) | WO2004007593A1 (ru) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4015988B2 (ja) * | 2003-12-19 | 2007-11-28 | トン ハイ バイオテクノロジー コーポレイション | 三次元架橋した、安定した生分解性の高吸水性γポリグルタミン酸ヒドロゲル、及びその調製方法 |
| US7364879B2 (en) | 2003-12-19 | 2008-04-29 | Tung Hai Biotechnology Corporation | Stable biodegradable, high water absorbable polyglutamic acid hydrogel by 3-dimensional cross-linking and its preparation method |
| JP4845359B2 (ja) * | 2004-09-16 | 2011-12-28 | 弘 竹田 | 口腔ケア用組成物 |
| ES2607780T3 (es) * | 2005-01-12 | 2017-04-04 | Tung Hai Biotechnology Corporation | Hidrogeles de gamma-poliglutamato para su uso como superhumectantes en productos de cosmética y cuidado personal |
| KR100517114B1 (ko) * | 2005-02-25 | 2005-09-27 | 주식회사 바이오리더스 | 폴리감마글루탐산을 함유하는 면역보강제 조성물 |
| KR100670166B1 (ko) | 2005-09-26 | 2007-01-16 | (주)오리엔탈 바이오텍 | 폴리감마글루탐산을 생산하는 신규 바실러스 서브틸리스ｃｈ-10 균주와 이를 이용한 폴리감마글루탐산의 제조방법 |
| KR100717169B1 (ko) | 2005-09-26 | 2007-05-10 | (주)오리엔탈 바이오텍 | 폴리감마글루탐산을 생산하는 신규한 바실러스속 ｙｎ-1균주와 이를 이용한 폴리감마글루탐산의 제조방법 |
| KR100582120B1 (ko) * | 2005-10-20 | 2006-05-22 | 주식회사 바이오리더스 | 폴리감마글루탐산을 유효성분으로 함유하는 히알루로니다제저해제 |
| KR100656560B1 (ko) | 2005-12-29 | 2006-12-11 | 주식회사 바이오리더스 | 폴리감마글루탐산을 함유하는 항응고제 및 혈전예방용조성물 |
| CA2652432A1 (en) * | 2006-05-23 | 2007-11-29 | Toyo Boseki Kabushiki Kaisha | .gamma.-l-pga producing microorganism, method of producing .gamma.-l-pga using the microorganism, crosslinked substance produced using the microorganism, and external dermal agentproduced using the microorganism |
| EP2187897B1 (en) * | 2007-09-13 | 2012-11-07 | Bioleaders Corporation | Composition for preventing virus infection comprising poly-gamma-glutamic acid |
| US8486467B1 (en) * | 2007-09-20 | 2013-07-16 | Albert G. Prescott | Dermal filler and method of using same |
| WO2009157595A1 (en) * | 2008-06-24 | 2009-12-30 | Bioleaders Corporation | Method for preparing poly-gamma-glutamic acid hydrogel |
| KR101006976B1 (ko) | 2008-06-24 | 2011-01-12 | 국민대학교산학협력단 | 폴리감마글루탐산 하이드로젤의 제조방법 |
| KR101067335B1 (ko) | 2008-07-04 | 2011-09-23 | 엠에스바이오텍 주식회사 | 바실러스 서브틸리스 ｓｅ-4 및 이의 발효대사물을 함유하는 칼슘 보충용 조성물 |
| CN102481360B (zh) | 2009-06-25 | 2015-06-17 | 生物领先公司 | 包含聚γ谷氨酸-壳聚糖纳米颗粒的佐剂组合物 |
| JP2011241188A (ja) * | 2010-05-19 | 2011-12-01 | Pias Arise Kk | 表皮角化正常化剤、及び、該表皮角化正常化剤を含む皮膚外用剤、表皮正常化用外用剤、化粧料、表皮正常化用化粧料、医薬部外品、又は表皮正常化用医薬部外品 |
| CN102093582A (zh) * | 2011-01-04 | 2011-06-15 | 上海大学 | 一种辐射交联水凝胶的制备方法 |
| KR102091588B1 (ko) * | 2013-05-27 | 2020-03-24 | 주식회사 바이오리더스 | 폴리감마글루탐산을 함유하는 점액 분산 또는 수화용 조성물 |
| JP6474251B2 (ja) * | 2014-12-25 | 2019-02-27 | 株式会社リブドゥコーポレーション | 吸水性樹脂およびその製造方法 |
| JP2016121187A (ja) * | 2016-03-31 | 2016-07-07 | 株式会社はつらつ | 増粘性組成物および皮膚外用剤 |
| JP6371810B2 (ja) * | 2016-08-25 | 2018-08-08 | 花王株式会社 | ポリ−ガンマ−グルタミン酸の生産方法 |
| CN110913836B (zh) | 2017-05-27 | 2023-08-15 | 埃科维亚可再生能源有限公司 | 聚（氨基酸）流变改性剂组合物以及使用方法 |
| CN108611308B (zh) * | 2018-05-02 | 2021-06-01 | 湖北大学 | 一种高产聚γ-谷氨酸的地衣芽胞杆菌的制备方法及应用 |
| KR102021097B1 (ko) * | 2018-06-04 | 2019-09-11 | 주식회사 잇츠한불 | γ-PGA 생산능이 향상된 신규한 바실러스 서브틸리스 HB-31 균주 및 γ-PGA 생산용 배지 |
| KR101968118B1 (ko) * | 2018-06-04 | 2019-05-07 | 주식회사 잇츠한불 | 신규한 바실러스 서브틸리스 HB-31 균주를 이용한 γ-PGA의 생산방법 |
| CN111253592B (zh) * | 2020-02-06 | 2022-06-07 | 南京工业大学 | 一种光交联的γ-聚谷氨酸水凝胶及其制备方法和应用 |
| CN111567777A (zh) * | 2020-04-30 | 2020-08-25 | 广州正明生物科技有限公司 | 一种益生菌卤水及其在槟榔加工中的应用 |
| CN111904894B (zh) * | 2020-08-18 | 2023-07-28 | 华熙生物科技股份有限公司 | 超高分子量γ-PGA或其盐在化妆品中的应用及化妆品组合物 |
| CN116083278B (zh) * | 2022-09-19 | 2025-12-12 | 中国科学院成都生物研究所 | 一株超高分子量γ-聚谷氨酸合成菌株及其应用 |
| JP2024052354A (ja) | 2022-09-30 | 2024-04-11 | 国立大学法人神戸大学 | 超高分子ガンマ－ポリグルタミン酸、該ポリグルタミン酸を産生するバチルス属細菌変異株及び該バチルス属細菌変異株のスクリーニング方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5885813A (ja) * | 1981-11-17 | 1983-05-23 | Toyo Jozo Co Ltd | 吸収性良好な製剤 |
| US5447732A (en) * | 1992-11-25 | 1995-09-05 | Ajinomoto Co., Inc. | High-absorption mineral-containing composition and foods |
| US5449720A (en) * | 1993-05-24 | 1995-09-12 | Biotech Australia Pty Limited | Amplification of the VB12 uptake system using polymers |
| JP3669390B2 (ja) * | 1995-02-09 | 2005-07-06 | 味の素株式会社 | バチルス属細菌由来のトランスグルタミナーゼ |
| JPH08308590A (ja) * | 1995-05-18 | 1996-11-26 | Fukuoka Pref Gov | ポリ−γ−グルタミン酸の製造方法 |
| JP3712530B2 (ja) * | 1998-05-28 | 2005-11-02 | キッコーマン株式会社 | 新種クリプトコッカス・ノダエンシス、それを用いる耐塩性耐熱性グルタミナーゼの製造法並びにグルタミン酸含量の多い蛋白加水分解物の製造法 |
| KR100327561B1 (ko) * | 1999-12-29 | 2002-03-15 | 윤덕용 | 고점도 발효액으로부터 폴리글루탐산의 제조방법 |
| KR20010078440A (ko) * | 2001-01-11 | 2001-08-21 | 김형순,성문희 | 고분자량의 폴리-감마-글루탐산을 생산하는 내염성 균주바실러스 서브틸리스 청국장 |
| CN1346891A (zh) * | 2001-09-29 | 2002-05-01 | 南京工业大学 | γ－聚谷氨酸及其盐的制备方法 |
-
2002
- 2002-07-10 KR KR1020020040083A patent/KR100399091B1/ko not_active Expired - Lifetime
-
2003
- 2003-07-10 CN CNB038157691A patent/CN1324143C/zh not_active Expired - Lifetime
- 2003-07-10 CA CA002490976A patent/CA2490976A1/en not_active Abandoned
- 2003-07-10 JP JP2004521259A patent/JP2005532462A/ja active Pending
- 2003-07-10 EP EP03764235A patent/EP1519979A4/en not_active Withdrawn
- 2003-07-10 AU AU2003252420A patent/AU2003252420A1/en not_active Abandoned
- 2003-07-10 RU RU2005103399/04A patent/RU2281958C2/ru not_active IP Right Cessation
- 2003-07-10 US US10/520,557 patent/US20060127447A1/en not_active Abandoned
- 2003-07-10 WO PCT/KR2003/001369 patent/WO2004007593A1/en not_active Ceased
-
2008
- 2008-02-04 JP JP2008024118A patent/JP2008202043A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2490976A1 (en) | 2004-01-22 |
| KR100399091B1 (en) | 2003-09-22 |
| CN1665862A (zh) | 2005-09-07 |
| EP1519979A4 (en) | 2005-08-17 |
| JP2005532462A (ja) | 2005-10-27 |
| CN1324143C (zh) | 2007-07-04 |
| EP1519979A1 (en) | 2005-04-06 |
| WO2004007593A1 (en) | 2004-01-22 |
| JP2008202043A (ja) | 2008-09-04 |
| US20060127447A1 (en) | 2006-06-15 |
| AU2003252420A1 (en) | 2004-02-02 |
| RU2281958C2 (ru) | 2006-08-20 |
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