RU2005102105A - Способы и лекарственные формы для контролируемой доставки палиперидона - Google Patents
Способы и лекарственные формы для контролируемой доставки палиперидона Download PDFInfo
- Publication number
- RU2005102105A RU2005102105A RU2005102105/15A RU2005102105A RU2005102105A RU 2005102105 A RU2005102105 A RU 2005102105A RU 2005102105/15 A RU2005102105/15 A RU 2005102105/15A RU 2005102105 A RU2005102105 A RU 2005102105A RU 2005102105 A RU2005102105 A RU 2005102105A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- paliperidone
- acceptable salt
- pharmaceutically acceptable
- layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (21)
1. Лекарственная форма для лечения субъекта, содержащая фармацевтически эффективное количество палиперидона, рисперидона или их фармацевтически приемлемой соли, при этом указанная лекарственная форма сохраняет возрастающую скорость высвобождения указанных палиперидона, рисперидона или их фармацевтически приемлемой соли на протяжении длительного периода времени.
2. Лекарственная форма по п.1, которая сохраняет возрастающую скорость высвобождения в течение от приблизительно 10 до приблизительно 24 ч после введения.
3. Лекарственная форма по п.1, которая сохраняет возрастающую скорость высвобождения в течение от приблизительно 16 до приблизительно 22 ч после введения.
4. Лекарственная форма по п.1, которая сохраняет возрастающую скорость высвобождения в течение от приблизительно 18 до приблизительно 21 ч после введения.
5. Лекарственная форма по п.1, где Cmax достигается приблизительно через 14 ч после введения.
6. Лекарственная форма по п.1, где Cmax достигается в интервале от приблизительно 16 до приблизительно 22 ч после введения.
7. Лекарственная форма по п.1, где Cmax достигается в интервале от приблизительно 18 до приблизительно 21 ч после введения.
8. Лекарственная форма по п.1, где T90 достигается в интервале от приблизительно 18 до приблизительно 22 ч после введения.
9. Лекарственная форма по п.1, которая подходит для введения один раз в день.
10. Лекарственная форма по п.1, где снижение побочных эффектов ассоциировано с высокой концентрацией антипсихотических агентов в плазме крови.
11. Лекарственная форма по п.10, где указанные побочные эффекты выбраны из группы, состоящей из тревоги, сонливости, головокружения, запора и экстрапирамидных симптомов.
12. Лекарственная форма, содержащая два или более слоев, в число которых входят первый и второй слои, указанный первый слой содержит палиперидон, рисперидон или их фармацевтически приемлемую соль, указанный второй слой содержит полимер; наружную оболочку, окружающую указанные два или более слоя; и отверстие в указанной наружной оболочке.
13. Лекарственная форма по п.12, где указанный первый слой содержит осмотический агент.
14. Лекарственная форма по п.13, где указанный осмотический агент представляет собой хлорид натрия.
15. Лекарственная форма по п.13, где указанный осмотический агент присутствует в количестве, по меньшей мере, 20 мас.% указанного первого слоя.
16. Лекарственная форма по пункту 12, где указанный второй слой дополнительно содержит палиперидон или его фармацевтически приемлемую соль, причем соотношение количества палиперидона или его фармацевтически приемлемой соли в указанном первом слое к количеству палиперидона или его фармацевтически приемлемой соли в указанном втором слое составляет менее 1,0.
17. Лекарственная форма по п.16, где соотношение количества палиперидона или его фармацевтически приемлемой соли в указанном первом слое к количеству палиперидона или его фармацевтически приемлемой соли в указанном втором слое составляет менее 0,44.
18. Лекарственная форма по п.17, где соотношение количества палиперидона или его фармацевтически приемлемой соли в указанном первом слое к количеству палиперидона или его фармацевтически приемлемой соли в указанном втором лекарственном слое составляет менее 0,33.
19. Лекарственная форма по п.12, дополнительно содержащая подслой, который находится в пределах указанной наружной оболочки и окружает указанный первый слой и указанный второй слой.
20. Лекарственная форма по п.12, где указанный подслой содержит гидроксиалкилцеллюлозный полимер, имеющий молекулярную массу от приблизительно 8500 до приблизительно 4000000.
21. Лекарственное средство для лечения субъекта, содержащее: лекарственное средство, изготовленное с содержанием фармацевтически эффективной дозы палиперидона, рисперидона или их фармацевтически приемлемой соли для введения указанному субъекту; которое сохраняет минимальную фармакодинамическую концентрацию указанных палиперидона, рисперидона или их фармацевтически приемлемой соли, одновременно сохраняя количество, которое не превышает предельно допустимую концентрацию указанных палиперидона, рисперидона или их фармацевтически приемлемой соли.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39959002P | 2002-07-29 | 2002-07-29 | |
| US60/399,590 | 2002-07-29 | ||
| US40600502P | 2002-08-26 | 2002-08-26 | |
| US60/406,005 | 2002-08-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005102105A true RU2005102105A (ru) | 2005-08-10 |
| RU2321391C2 RU2321391C2 (ru) | 2008-04-10 |
Family
ID=31191280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005102105/15A RU2321391C2 (ru) | 2002-07-29 | 2003-07-28 | Способы и лекарственные формы для контролируемой доставки палиперидона |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040092534A1 (ru) |
| EP (1) | EP1539115B1 (ru) |
| JP (1) | JP4500679B2 (ru) |
| KR (1) | KR100699516B1 (ru) |
| CN (1) | CN1684670A (ru) |
| AR (1) | AR040721A1 (ru) |
| AT (1) | ATE373472T1 (ru) |
| AU (1) | AU2003256844A1 (ru) |
| BR (1) | BR0313139A (ru) |
| CA (1) | CA2494234C (ru) |
| CO (1) | CO5580742A2 (ru) |
| CY (1) | CY1107096T1 (ru) |
| DE (1) | DE60316454T2 (ru) |
| DK (1) | DK1539115T3 (ru) |
| ES (1) | ES2293039T3 (ru) |
| HR (1) | HRP20050077B1 (ru) |
| IL (1) | IL166489A (ru) |
| MX (1) | MXPA05001191A (ru) |
| MY (1) | MY137049A (ru) |
| NO (1) | NO324821B1 (ru) |
| NZ (1) | NZ570198A (ru) |
| PE (1) | PE20040132A1 (ru) |
| PL (1) | PL210119B1 (ru) |
| PT (1) | PT1539115E (ru) |
| RU (1) | RU2321391C2 (ru) |
| TW (1) | TWI363637B (ru) |
| WO (1) | WO2004010981A1 (ru) |
| ZA (1) | ZA200501641B (ru) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| EP1802286B1 (en) * | 2004-08-04 | 2008-07-23 | ALZA Corporation | Sustained drug release composition demonstrating an ascending zero order release pattern, methods of manufacturing such a composition |
| WO2006085856A1 (en) * | 2005-02-04 | 2006-08-17 | Alza Corporation | Methods and dosage forms for reducing side effects of benzisozazole derivatives |
| US20060189635A1 (en) * | 2005-02-04 | 2006-08-24 | Michelle Kramer | Enhanced efficacy benzisoxazole derivative dosage forms and methods |
| US20070031496A1 (en) * | 2005-08-04 | 2007-02-08 | Edgren David E | Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties |
| US20070166381A1 (en) * | 2006-01-06 | 2007-07-19 | Iran Reyes | Osmotic dosage form with controlled release and fast release aspects |
| EP1993559B1 (en) | 2006-02-03 | 2016-06-22 | OPKO Renal, LLC | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US20070232624A1 (en) | 2006-04-03 | 2007-10-04 | Palumbo Joseph M | Use of paliperidone for the treatment of sleep disturbances and/or excessive daytime sleepiness in psychiatric patients |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| US8524749B2 (en) * | 2007-02-09 | 2013-09-03 | Alza Corporation | Controlled release compositions of tizanidine |
| JP2010525080A (ja) * | 2007-04-25 | 2010-07-22 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
| HRP20231142T3 (hr) | 2007-04-25 | 2024-01-05 | Eirgen Pharma Ltd. | Kontrolirano oslobađanje 25-hidroksivitamina d |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| PL2079446T3 (pl) * | 2007-08-21 | 2012-04-30 | Teva Pharma | Preparat paliperidonu o przedłużonym uwalnianiu |
| US20090087489A1 (en) | 2007-09-25 | 2009-04-02 | Bella Gerber | Imatinib compositions |
| SI2234617T2 (sl) | 2007-12-19 | 2025-05-30 | Janssen Pharmaceutica Nv | Režim odmerjanja v zvezi z dolgodelujočimi paliperidonijevimi estri za injiciranje |
| US20090247553A1 (en) * | 2008-03-27 | 2009-10-01 | Actavis Group Ptc Ehf | Highly Pure Paliperidone or a Pharmaceutically Acceptable Salt Thereof Substantially Free of Keto Impurity |
| WO2010009900A1 (en) * | 2008-07-25 | 2010-01-28 | Krka, D.D. Novo Mesto | Paliperidone composition comprising solid matrix particles |
| EP2161019A1 (en) | 2008-09-05 | 2010-03-10 | KRKA, D.D., Novo Mesto | Prolonged release multiparticulate pharmaceutical composition comprising paliperidone |
| US20110177137A1 (en) | 2008-09-15 | 2011-07-21 | Intas Pharmaceuticals Limited | Novel dosage form of paliperidone and process for preparing the same |
| JP2012504146A (ja) * | 2008-09-30 | 2012-02-16 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． | リスペリドン送達用埋め込み可能型装置およびその使用方法 |
| WO2011018246A2 (en) | 2009-08-13 | 2011-02-17 | Synthon B.V. | Controlled release paliperidone composition |
| US20110052687A1 (en) * | 2009-08-26 | 2011-03-03 | Glenmark Generics Ltd | Extended release pharmaceutical composition of paliperidone |
| CA2777856A1 (en) * | 2009-10-16 | 2011-04-21 | Ranbaxy Laboratories Limited | Extended release pharmaceutical compositions of paliperidone and processes of preparation thereof |
| US9271939B2 (en) | 2010-03-15 | 2016-03-01 | Inventia Healthcare Private Limited | Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| CN103209704B (zh) | 2010-04-22 | 2017-10-27 | 细胞内治疗公司 | 有机化合物 |
| WO2012014052A2 (en) | 2010-07-30 | 2012-02-02 | Micro Labs Limited | Novel coated extended release pharmaceutical compositions containing paliperidone |
| CN102058517A (zh) * | 2010-12-31 | 2011-05-18 | 泰州万全医药科技有限公司 | 一种帕潘立酮缓释剂及其制备方法 |
| US20130034605A1 (en) | 2011-08-01 | 2013-02-07 | Micro Labs Limited | Extended release pharmaceutical compositions containing paliperidone |
| CN102274164B (zh) * | 2011-08-22 | 2014-07-02 | 长春健欣生物医药科技开发有限公司 | 帕潘立酮及帕潘立酮衍生物的注射用缓释凝胶剂 |
| AU2013245702A1 (en) | 2012-04-14 | 2014-11-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| WO2014145192A1 (en) | 2013-03-15 | 2014-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN103271889B (zh) * | 2013-05-23 | 2015-10-28 | 沈阳药科大学 | 帕利哌酮新型递增释放渗透泵制剂及其制备方法 |
| CN103385857A (zh) * | 2013-06-29 | 2013-11-13 | 北京万全德众医药生物技术有限公司 | 帕利哌酮的药物组合物 |
| WO2015001488A1 (en) | 2013-07-01 | 2015-01-08 | Ranbaxy Laboratories Limited | Extended-release tablets of paliperidone and processes of preparation thereof |
| WO2015085004A1 (en) | 2013-12-03 | 2015-06-11 | Intra-Cellular Therapies, Inc. | Novel methods |
| CA2944755A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| KR20170012210A (ko) | 2014-04-04 | 2017-02-02 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2015191554A1 (en) | 2014-06-09 | 2015-12-17 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
| US20160000654A1 (en) * | 2014-07-07 | 2016-01-07 | Cadila Healthcare Limited | Method for determining formulation orientation of asymmetric multi-layered osmotic tablets |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN104257622B (zh) * | 2014-10-01 | 2020-02-07 | 浙江华海药业股份有限公司 | 一种帕利哌酮控释片及其制备方法 |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| GR1008842B (el) | 2015-08-06 | 2016-09-05 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο σκευασμα περιεχον εναν ατυπο αντιψυχωσιμο παραγοντα και μεθοδος για την παρασκευη αυτου |
| CN105147629B (zh) * | 2015-09-24 | 2017-08-25 | 吉林大学 | 一种异丁利酮片剂及制备方法 |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| DK3407889T3 (da) | 2016-03-25 | 2021-08-09 | Intra Cellular Therapies Inc | Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet |
| CN108883120A (zh) | 2016-03-28 | 2018-11-23 | 欧普科爱尔兰环球控股有限公司 | 维生素d治疗方法 |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| US20190105277A1 (en) | 2016-04-05 | 2019-04-11 | Pharmathen S.A. | Pharmaceutical composition comprising an atypical antipsychotic agent and method for the preparation thereof |
| US11331316B2 (en) | 2016-10-12 | 2022-05-17 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| US20190321367A1 (en) * | 2016-11-23 | 2019-10-24 | Children's Hospital Medical Center | Paliperidone for treatment of drug refractory irritability and autism spectrum disorder |
| CN106727392A (zh) * | 2016-12-15 | 2017-05-31 | 上海奕利制药有限公司 | 一种帕利哌酮缓释片剂及其制备方法 |
| WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2018175969A1 (en) | 2017-03-24 | 2018-09-27 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| CA3071137A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | Prodrugs of substituted heterocycle fused gamma-carbolines |
| CN111093665A (zh) | 2017-07-26 | 2020-05-01 | 细胞内治疗公司 | 有机化合物 |
| WO2019183341A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN112088004A (zh) | 2018-03-23 | 2020-12-15 | 细胞内治疗公司 | 有机化合物 |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| AU2019331490B2 (en) | 2018-08-31 | 2025-04-24 | Intra-Cellular Therapies, Inc. | Novel methods |
| JP7546546B2 (ja) | 2018-08-31 | 2024-09-06 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| EP4134101A1 (en) | 2019-07-07 | 2023-02-15 | Intra-Cellular Therapies, Inc. | Deuterated lumateperone for the treatment of the bipolar ii disorder |
| KR102285510B1 (ko) | 2019-10-29 | 2021-08-04 | 강동국 | 양액 농도조절용 캡슐 및 그 용도 |
| WO2022231930A1 (en) | 2021-04-26 | 2022-11-03 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| CN113616610B (zh) * | 2021-07-30 | 2023-05-12 | 石药集团欧意药业有限公司 | 一种帕利哌酮缓释片及其制备方法 |
| US20230364009A1 (en) * | 2022-05-12 | 2023-11-16 | Celanese Eva Performance Polymers Llc | Implantable Medical Device for the Delivery of an Antipsychotic |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| EP4642458A1 (en) | 2022-12-30 | 2025-11-05 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656092A (en) * | 1985-10-15 | 1987-04-07 | R. P. Scherer Corporation | Target shooting capsules |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
| PT1033128E (pt) * | 1993-09-28 | 2008-08-08 | Scherer Gmbh R P | Fabrico de cápsulas de gelatina mole |
| HU219487B (hu) * | 1993-11-19 | 2001-04-28 | Janssen Pharmaceutica Nv. | Riszperidont tartalmazó mikrorészecskék, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények és előállításuk |
| TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| WO1998006380A2 (en) * | 1996-08-16 | 1998-02-19 | Alza Corporation | Dosage form for providing ascending dose of drug |
| US6919373B1 (en) * | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| JP2002516848A (ja) * | 1998-06-03 | 2002-06-11 | アルザ・コーポレーション | 長時間の薬物療法を与える方法および装置 |
| US6706282B1 (en) * | 1998-11-02 | 2004-03-16 | Evangeline Cruz | Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones |
| JP4711510B2 (ja) * | 1998-11-02 | 2011-06-29 | アルザ・コーポレーション | 抗鬱剤の制御送達 |
| CN1161101C (zh) * | 1998-12-17 | 2004-08-11 | 阿尔扎有限公司 | 用多层包衣将填充液体的明胶胶囊转变成控制释放的系统 |
| BR0009437A (pt) * | 1999-03-31 | 2002-01-15 | Janssen Pharmaceutica Nv | Amido pré-gelatinizado em uma formulação de liberação controlada |
| US6599532B2 (en) * | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
| US6491949B2 (en) * | 2000-01-14 | 2002-12-10 | Osmotica Corp. | Osmotic device within an osmotic device |
| US6375981B1 (en) * | 2000-06-01 | 2002-04-23 | A. E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| US6530962B1 (en) * | 2001-08-31 | 2003-03-11 | R.P. Scherer Technologies, Inc. | Emulsion of water soluble dyes in a lipophilic carrier |
-
2003
- 2003-07-28 JP JP2004524886A patent/JP4500679B2/ja not_active Expired - Lifetime
- 2003-07-28 CA CA002494234A patent/CA2494234C/en not_active Expired - Lifetime
- 2003-07-28 CN CNA03822948XA patent/CN1684670A/zh active Pending
- 2003-07-28 KR KR1020057001460A patent/KR100699516B1/ko not_active Expired - Lifetime
- 2003-07-28 BR BR0313139-4A patent/BR0313139A/pt not_active Application Discontinuation
- 2003-07-28 WO PCT/US2003/023433 patent/WO2004010981A1/en not_active Ceased
- 2003-07-28 RU RU2005102105/15A patent/RU2321391C2/ru not_active Application Discontinuation
- 2003-07-28 DK DK03771910T patent/DK1539115T3/da active
- 2003-07-28 AU AU2003256844A patent/AU2003256844A1/en not_active Abandoned
- 2003-07-28 DE DE60316454T patent/DE60316454T2/de not_active Expired - Lifetime
- 2003-07-28 EP EP03771910A patent/EP1539115B1/en not_active Revoked
- 2003-07-28 PT PT03771910T patent/PT1539115E/pt unknown
- 2003-07-28 ES ES03771910T patent/ES2293039T3/es not_active Expired - Lifetime
- 2003-07-28 US US10/629,211 patent/US20040092534A1/en not_active Abandoned
- 2003-07-28 AT AT03771910T patent/ATE373472T1/de active
- 2003-07-28 HR HRP20050077AA patent/HRP20050077B1/hr not_active IP Right Cessation
- 2003-07-28 MX MXPA05001191A patent/MXPA05001191A/es active IP Right Grant
- 2003-07-28 NZ NZ570198A patent/NZ570198A/en not_active IP Right Cessation
- 2003-07-28 PL PL376258A patent/PL210119B1/pl unknown
- 2003-07-29 TW TW092120703A patent/TWI363637B/zh not_active IP Right Cessation
- 2003-07-29 MY MYPI20032846A patent/MY137049A/en unknown
- 2003-07-29 AR AR20030102717A patent/AR040721A1/es unknown
- 2003-07-30 PE PE2003000749A patent/PE20040132A1/es not_active Application Discontinuation
-
2005
- 2005-01-25 IL IL166489A patent/IL166489A/en active IP Right Grant
- 2005-02-22 NO NO20050956A patent/NO324821B1/no not_active IP Right Cessation
- 2005-02-24 ZA ZA2005/01641A patent/ZA200501641B/en unknown
- 2005-02-28 CO CO05018509A patent/CO5580742A2/es not_active Application Discontinuation
-
2007
- 2007-12-18 CY CY20071101601T patent/CY1107096T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005102105A (ru) | Способы и лекарственные формы для контролируемой доставки палиперидона | |
| KR100196674B1 (ko) | 디페닐부틸-피페라진카르복사미드를 이용한 물질 남용 장애의 치료방법 및 그를 함유하는 약제학적 조성물 | |
| JP3712420B2 (ja) | ５―ｈｔアゴニストの処方物 | |
| AU702106C (en) | Use of carbazole compounds for the treatment of congestive heart failure | |
| CA2661759A1 (en) | Buprenophine-wafer for drug substitution therapy | |
| HU202108B (en) | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol | |
| AU2017200626A1 (en) | Sublingual and buccal film compositions | |
| JP2000508341A (ja) | 片頭痛の治療法及び薬効の強化組成物 | |
| US20100168147A1 (en) | Medicinal Compositions Comprising Buprenorphine And Naloxone | |
| CN1856339A (zh) | 肺动脉高血压症治疗的伊洛前列素联合疗法 | |
| EP0514023B1 (en) | Use of glycine/NMDA receptor ligands for the manufacture of a medicament for the treatment of drug dependence and withdrawal | |
| US20080247961A1 (en) | Nasally administrable compositions of zolpidem and methods of use | |
| Naclerio | The effect of antihistamines on the immediate allergic response: a comparative review | |
| JP2002538102A (ja) | 光学的に純粋なｒ（＋）オンダンセトロンを使用する無呼吸および無呼吸障害の治療方法 | |
| Berzsenyi et al. | Fluoxetine activity on muricidal aggression induced in rats by p‐chlorophenylalanine | |
| Bablenis et al. | Clozapine: A novel antipsychotic agent | |
| CN100418526C (zh) | 依贝沙坦在制备用来预防或治疗肺动脉高压的药物中的应用 | |
| WO2010151258A1 (en) | Methods of treating psychological conditions | |
| US20090291939A1 (en) | Treating Alcohol And Or Substance Abuse By Antagonizing Alpha 2 Adrenergic Receptors With Weak Dopamine Blocking | |
| ES2899885T3 (es) | Nueva composición farmacéutica de liberación diferencial que contiene tres principios activos | |
| EP1267849B1 (en) | Restricting reinstatement of drug use | |
| JP2002012558A (ja) | 肥満の治療又は体重の減少を容易にし又は促進するための医薬組成物 | |
| JP2957618B2 (ja) | アミオダロンと、ニトロ誘導体、特にイソソルビト二硝酸と、必要に応じてさらにβ―遮断薬とを含む心臓保護効果のある医薬組成物 | |
| WO2007062837A2 (en) | Use of a 5-ht4 agonist for the treatment of irritable bowel syndrome characterized by mixed or alternating bowel habits | |
| JPH0788300B2 (ja) | エピニンあるいはその製薬的に許容しうる塩を含む医薬組成物ならびに用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070201 |
|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20070413 |