CO5580742A2 - Metodos y formas de dosificacion para la administracion con- trolada de paliperidona - Google Patents
Metodos y formas de dosificacion para la administracion con- trolada de paliperidonaInfo
- Publication number
- CO5580742A2 CO5580742A2 CO05018509A CO05018509A CO5580742A2 CO 5580742 A2 CO5580742 A2 CO 5580742A2 CO 05018509 A CO05018509 A CO 05018509A CO 05018509 A CO05018509 A CO 05018509A CO 5580742 A2 CO5580742 A2 CO 5580742A2
- Authority
- CO
- Colombia
- Prior art keywords
- approximately
- dosage form
- hours
- administration
- further characterized
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 abstract 11
- 230000001174 ascending effect Effects 0.000 abstract 3
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 abstract 2
- 229960001057 paliperidone Drugs 0.000 abstract 2
- 229960001534 risperidone Drugs 0.000 abstract 2
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Una forma de dosificación para tratar a un sujeto que comprende: una cantidad farmacéuticamente eficaz de paliperidona, risperidona o una sal farmacéuticamente aceptable de la misma, en donde dicha forma de dosificación mantiene un índice de liberación ascendente de paliperidona, risperidona o una sal farmacéuticamente aceptable de la misma a lo largo de un periodo de tiempo prolongado.2.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque el índice de liberación ascendente se mantiene por aproximadamente 10 a aproximadamente 24 horas después de la administración.3.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque el índice de liberación ascendente se mantiene por aproximadamente 16 a aproximadamente 22 horas después de la administración. 4.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque el índice de liberación ascendente se mantiene por aproximadamente 18 a aproximadamente 21 horas después de la administración.5.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque la Cmax se alcanza a aproximadamente 14 horas después la administración.6.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque la Cmax se alcanza a aproximadamente 16 horas a aproximadamente 22 horas después de la administración.7.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque la Cmax se alcanza a aproximadamente 18 horas a aproximadamente 21 horas después de la administración.8.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque la Cmax se alcanza a aproximadamente 18 horas a aproximadamente 22 horas después de la administración.9.- La forma de dosificación de conformidad con la reivindicación 1, caracterizada además porque la forma de dosificación es adecuada para administrarse una vez al día.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39959002P | 2002-07-29 | 2002-07-29 | |
| US40600502P | 2002-08-26 | 2002-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5580742A2 true CO5580742A2 (es) | 2005-11-30 |
Family
ID=31191280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05018509A CO5580742A2 (es) | 2002-07-29 | 2005-02-28 | Metodos y formas de dosificacion para la administracion con- trolada de paliperidona |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040092534A1 (es) |
| EP (1) | EP1539115B1 (es) |
| JP (1) | JP4500679B2 (es) |
| KR (1) | KR100699516B1 (es) |
| CN (1) | CN1684670A (es) |
| AR (1) | AR040721A1 (es) |
| AT (1) | ATE373472T1 (es) |
| AU (1) | AU2003256844A1 (es) |
| BR (1) | BR0313139A (es) |
| CA (1) | CA2494234C (es) |
| CO (1) | CO5580742A2 (es) |
| CY (1) | CY1107096T1 (es) |
| DE (1) | DE60316454T2 (es) |
| DK (1) | DK1539115T3 (es) |
| ES (1) | ES2293039T3 (es) |
| HR (1) | HRP20050077B1 (es) |
| IL (1) | IL166489A (es) |
| MX (1) | MXPA05001191A (es) |
| MY (1) | MY137049A (es) |
| NO (1) | NO324821B1 (es) |
| NZ (1) | NZ570198A (es) |
| PE (1) | PE20040132A1 (es) |
| PL (1) | PL210119B1 (es) |
| PT (1) | PT1539115E (es) |
| RU (1) | RU2321391C2 (es) |
| TW (1) | TWI363637B (es) |
| WO (1) | WO2004010981A1 (es) |
| ZA (1) | ZA200501641B (es) |
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| EP1993559B1 (en) | 2006-02-03 | 2016-06-22 | OPKO Renal, LLC | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US20070232624A1 (en) | 2006-04-03 | 2007-10-04 | Palumbo Joseph M | Use of paliperidone for the treatment of sleep disturbances and/or excessive daytime sleepiness in psychiatric patients |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
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| US6706282B1 (en) * | 1998-11-02 | 2004-03-16 | Evangeline Cruz | Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones |
| JP4711510B2 (ja) * | 1998-11-02 | 2011-06-29 | アルザ・コーポレーション | 抗鬱剤の制御送達 |
| CN1161101C (zh) * | 1998-12-17 | 2004-08-11 | 阿尔扎有限公司 | 用多层包衣将填充液体的明胶胶囊转变成控制释放的系统 |
| BR0009437A (pt) * | 1999-03-31 | 2002-01-15 | Janssen Pharmaceutica Nv | Amido pré-gelatinizado em uma formulação de liberação controlada |
| US6599532B2 (en) * | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
| US6491949B2 (en) * | 2000-01-14 | 2002-12-10 | Osmotica Corp. | Osmotic device within an osmotic device |
| US6375981B1 (en) * | 2000-06-01 | 2002-04-23 | A. E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| US6530962B1 (en) * | 2001-08-31 | 2003-03-11 | R.P. Scherer Technologies, Inc. | Emulsion of water soluble dyes in a lipophilic carrier |
-
2003
- 2003-07-28 JP JP2004524886A patent/JP4500679B2/ja not_active Expired - Lifetime
- 2003-07-28 CA CA002494234A patent/CA2494234C/en not_active Expired - Lifetime
- 2003-07-28 CN CNA03822948XA patent/CN1684670A/zh active Pending
- 2003-07-28 KR KR1020057001460A patent/KR100699516B1/ko not_active Expired - Lifetime
- 2003-07-28 BR BR0313139-4A patent/BR0313139A/pt not_active Application Discontinuation
- 2003-07-28 WO PCT/US2003/023433 patent/WO2004010981A1/en not_active Ceased
- 2003-07-28 RU RU2005102105/15A patent/RU2321391C2/ru not_active Application Discontinuation
- 2003-07-28 DK DK03771910T patent/DK1539115T3/da active
- 2003-07-28 AU AU2003256844A patent/AU2003256844A1/en not_active Abandoned
- 2003-07-28 DE DE60316454T patent/DE60316454T2/de not_active Expired - Lifetime
- 2003-07-28 EP EP03771910A patent/EP1539115B1/en not_active Revoked
- 2003-07-28 PT PT03771910T patent/PT1539115E/pt unknown
- 2003-07-28 ES ES03771910T patent/ES2293039T3/es not_active Expired - Lifetime
- 2003-07-28 US US10/629,211 patent/US20040092534A1/en not_active Abandoned
- 2003-07-28 AT AT03771910T patent/ATE373472T1/de active
- 2003-07-28 HR HRP20050077AA patent/HRP20050077B1/hr not_active IP Right Cessation
- 2003-07-28 MX MXPA05001191A patent/MXPA05001191A/es active IP Right Grant
- 2003-07-28 NZ NZ570198A patent/NZ570198A/en not_active IP Right Cessation
- 2003-07-28 PL PL376258A patent/PL210119B1/pl unknown
- 2003-07-29 TW TW092120703A patent/TWI363637B/zh not_active IP Right Cessation
- 2003-07-29 MY MYPI20032846A patent/MY137049A/en unknown
- 2003-07-29 AR AR20030102717A patent/AR040721A1/es unknown
- 2003-07-30 PE PE2003000749A patent/PE20040132A1/es not_active Application Discontinuation
-
2005
- 2005-01-25 IL IL166489A patent/IL166489A/en active IP Right Grant
- 2005-02-22 NO NO20050956A patent/NO324821B1/no not_active IP Right Cessation
- 2005-02-24 ZA ZA2005/01641A patent/ZA200501641B/en unknown
- 2005-02-28 CO CO05018509A patent/CO5580742A2/es not_active Application Discontinuation
-
2007
- 2007-12-18 CY CY20071101601T patent/CY1107096T1/el unknown
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