RU2002113746A - Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII - Google Patents
Производные изоксазола в качестве ингибиторов фосфодиэстеразы VIIInfo
- Publication number
- RU2002113746A RU2002113746A RU2002113746/15A RU2002113746A RU2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746/15 A RU2002113746/15 A RU 2002113746/15A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A
- Authority
- RU
- Russia
- Prior art keywords
- solvates
- formula
- acceptable salts
- physiologically acceptable
- disorders
- Prior art date
Links
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 title claims 3
- 150000002545 isoxazoles Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Claims (3)
1. Соединения формулы I
в которой R1, R2, R3, R4 каждый независимо друг от друга представляет собой Hal, ОА1, SA1, А, Н, СООА1, CN или CONA1A2,
R5 представляет собой СООА1, CN или CONA1A2,
А1, А2 каждый независимо друг от друга представляет собой Н, А, алкенил, циклоалкил или алкиленциклоалкил,
А представляет собой алкил, имеющий от 1 до 10 атомов С, Hal представляет собой F, Cl, Br или I,
а также их физиологически приемлемые соли и/или сольваты в качестве ингибиторов фосфодиэстеразы VII.
2. Фармацевтический препарат, отличающийся тем, что содержит по меньшей мере один ингибитор фосфодиэстеразы VII формулы I по п.1 и/или одну из его физиологически приемлемых солей и/или один из его сольватов.
3. Применение соединений формулы I по п.1 и/или их физиологически приемлемых солей или сольватов для получения фармацевтического препарата для контролирования аллергических расстройств, астмы, хронического бронхита, атонического дерматита, псориаза и других кожных нарушений, воспалительных расстройств, автоиммунных заболеваний, таких как, например, ревматоидный артрит, рассеянного склероза, болезни Крона, сахарного диабета или язвенного колита, остеопороза, реакции отторжения трансплантатов, кахексии, роста опухолей или метастаз опухолей, сепсиса, нарушений памяти, атеросклероза и СПИДа.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953024A DE19953024A1 (de) | 1999-11-04 | 1999-11-04 | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
| DE19953024.6 | 1999-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002113746A true RU2002113746A (ru) | 2004-01-10 |
Family
ID=7927860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002113746/15A RU2002113746A (ru) | 1999-11-04 | 2000-10-18 | Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6531498B1 (ru) |
| EP (1) | EP1225896B1 (ru) |
| JP (1) | JP2003513042A (ru) |
| KR (1) | KR20020047329A (ru) |
| CN (1) | CN1384744A (ru) |
| AR (1) | AR026350A1 (ru) |
| AT (1) | ATE300945T1 (ru) |
| AU (1) | AU781607B2 (ru) |
| BR (1) | BR0015333A (ru) |
| CA (1) | CA2389647C (ru) |
| CZ (1) | CZ20021441A3 (ru) |
| DE (2) | DE19953024A1 (ru) |
| ES (1) | ES2243313T3 (ru) |
| HU (1) | HUP0203187A3 (ru) |
| MX (1) | MXPA02004441A (ru) |
| NO (1) | NO20022123D0 (ru) |
| PL (1) | PL355021A1 (ru) |
| RU (1) | RU2002113746A (ru) |
| SK (1) | SK5942002A3 (ru) |
| WO (1) | WO2001032175A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262098B1 (en) * | 1998-08-07 | 2001-07-17 | Chiron Corporation | Estrogen receptor modulators |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| KR100666052B1 (ko) * | 2004-02-12 | 2007-01-09 | 조극래 | 원적외선이용한 건조장치 |
| MX301558B (es) * | 2005-07-29 | 2012-07-20 | Ciba Sc Holding Ag | Estabilizacion de productos para el cuidado del cuerpo y el hogar contra la degradacion por radiacion uv usando derivados de merocianina. |
| MX2009010450A (es) * | 2007-03-27 | 2009-11-23 | Omeros Corp | El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento. |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| CA2817071C (en) | 2010-11-08 | 2018-04-24 | Omeros Corporation | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| CN104725329B (zh) * | 2015-01-13 | 2017-01-18 | 陕西科技大学 | 一种具有抗肿瘤活性的异恶唑羧酸类化合物及其合成方法 |
| KR102640696B1 (ko) | 2017-07-12 | 2024-02-27 | 다트 뉴로사이언스, 엘엘씨 | Pde7 억제제로서 치환된 벤즈옥사졸 및 벤조푸란 화합물 |
| EP4572766A1 (en) | 2022-08-18 | 2025-06-25 | Mitodicure GmbH | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399577A (en) * | 1991-05-01 | 1995-03-21 | Taiho Pharmaceutical Co., Ltd. | Isoxazole derivatives and salts thereof |
| PL314605A1 (en) | 1993-11-26 | 1996-09-16 | Pfizer | Isoxazolin compounds as anti-inflammatory agents |
| US5686434A (en) | 1993-11-26 | 1997-11-11 | Pfizer Inc. | 3-aryl-2-isoxazolines as antiinflammatory agents |
-
1999
- 1999-11-04 DE DE19953024A patent/DE19953024A1/de not_active Withdrawn
-
2000
- 2000-10-18 ES ES00971393T patent/ES2243313T3/es not_active Expired - Lifetime
- 2000-10-18 HU HU0203187A patent/HUP0203187A3/hu unknown
- 2000-10-18 WO PCT/EP2000/010239 patent/WO2001032175A1/de not_active Ceased
- 2000-10-18 CA CA2389647A patent/CA2389647C/en not_active Expired - Fee Related
- 2000-10-18 EP EP00971393A patent/EP1225896B1/de not_active Expired - Lifetime
- 2000-10-18 RU RU2002113746/15A patent/RU2002113746A/ru unknown
- 2000-10-18 JP JP2001534380A patent/JP2003513042A/ja active Pending
- 2000-10-18 US US10/129,270 patent/US6531498B1/en not_active Expired - Fee Related
- 2000-10-18 CN CN00814943A patent/CN1384744A/zh active Pending
- 2000-10-18 KR KR1020027005728A patent/KR20020047329A/ko not_active Withdrawn
- 2000-10-18 CZ CZ20021441A patent/CZ20021441A3/cs unknown
- 2000-10-18 SK SK594-2002A patent/SK5942002A3/sk not_active Application Discontinuation
- 2000-10-18 PL PL00355021A patent/PL355021A1/xx unknown
- 2000-10-18 BR BR0015333-8A patent/BR0015333A/pt not_active Application Discontinuation
- 2000-10-18 AT AT00971393T patent/ATE300945T1/de not_active IP Right Cessation
- 2000-10-18 AU AU10262/01A patent/AU781607B2/en not_active Ceased
- 2000-10-18 DE DE50010885T patent/DE50010885D1/de not_active Expired - Lifetime
- 2000-11-03 AR ARP000105799A patent/AR026350A1/es unknown
-
2002
- 2002-05-03 NO NO20022123A patent/NO20022123D0/no not_active Application Discontinuation
- 2002-05-03 MX MXPA02004441A patent/MXPA02004441A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE300945T1 (de) | 2005-08-15 |
| ES2243313T3 (es) | 2005-12-01 |
| CA2389647A1 (en) | 2001-05-10 |
| EP1225896B1 (de) | 2005-08-03 |
| HUP0203187A3 (en) | 2004-12-28 |
| JP2003513042A (ja) | 2003-04-08 |
| NO20022123L (no) | 2002-05-03 |
| PL355021A1 (en) | 2004-03-22 |
| HUP0203187A2 (hu) | 2003-01-28 |
| SK5942002A3 (en) | 2002-09-10 |
| CN1384744A (zh) | 2002-12-11 |
| AR026350A1 (es) | 2003-02-05 |
| BR0015333A (pt) | 2002-07-09 |
| NO20022123D0 (no) | 2002-05-03 |
| AU1026201A (en) | 2001-05-14 |
| WO2001032175A1 (de) | 2001-05-10 |
| EP1225896A1 (de) | 2002-07-31 |
| DE50010885D1 (de) | 2005-09-08 |
| KR20020047329A (ko) | 2002-06-21 |
| AU781607B2 (en) | 2005-06-02 |
| CZ20021441A3 (cs) | 2002-07-17 |
| US6531498B1 (en) | 2003-03-11 |
| DE19953024A1 (de) | 2001-05-10 |
| MXPA02004441A (es) | 2004-09-10 |
| CA2389647C (en) | 2010-08-10 |
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