RO81504B - Procedeu pentru prepararea unor 1-fenil-iminoidazolidine substituite - Google Patents
Procedeu pentru prepararea unor 1-fenil-iminoidazolidine substituiteInfo
- Publication number
- RO81504B RO81504B RO103172A RO10317279A RO81504B RO 81504 B RO81504 B RO 81504B RO 103172 A RO103172 A RO 103172A RO 10317279 A RO10317279 A RO 10317279A RO 81504 B RO81504 B RO 81504B
- Authority
- RO
- Romania
- Prior art keywords
- dihydroxyphenyl
- bromo
- imidazolidines
- phenylimino
- dimethoxyphenyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 2-bromo-4,5-dihydroxyphenyl Chemical group 0.000 abstract 10
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor 1-fenilimino-imidazolidine substituite cu formula generala I: (vezi form. in desc.) în care R1 reprezinta un radical 2-brom-4,5-dihidroxifenil, 3-clor-4-hidroxifenil, 4-brom-2,5-dihidroxifenil,3,5-dihidroxifenil, 5-clor-2,4-dihidroxifenil, 3,4,5-trihidroxifenil, cît si a sarurilor lor de aditie cu acizi, caracterizat prin aceea ca se trateaza compusi avînd formula generala II: (vezi form. in desc.) în care R2 reprezinta un radical 2-brom-4,5-dimetoxifenil, 3-clor-4-metoxifenil, 4-brom -2,5-dimetoxifenil, 3,5-dimetoxifenil, 5-toxifenil, 3,5-dimetoxifenil, 3-metoxi -4-metilfenil sau 3,4,5-trimetoxifenil, cu acid bromhidric 48% la temperatura de reflux.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782806775 DE2806775A1 (de) | 1978-02-17 | 1978-02-17 | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81504A RO81504A (ro) | 1983-04-29 |
| RO81504B true RO81504B (ro) | 1983-04-30 |
Family
ID=6032231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO103172A RO81504B (ro) | 1978-02-17 | 1979-02-13 | Procedeu pentru prepararea unor 1-fenil-iminoidazolidine substituite |
| RO7996602A RO76799A (ro) | 1978-02-17 | 1979-02-17 | PROCEDEU PнNTRU PREPARAREA UNOR FENOLIMINOIMIDAZOLIDINE SUBSTITUITE |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7996602A RO76799A (ro) | 1978-02-17 | 1979-02-17 | PROCEDEU PнNTRU PREPARAREA UNOR FENOLIMINOIMIDAZOLIDINE SUBSTITUITE |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US4250186A (ro) |
| JP (1) | JPS54122273A (ro) |
| AT (1) | AT370093B (ro) |
| AU (1) | AU519356B2 (ro) |
| BE (1) | BE874252A (ro) |
| CA (1) | CA1115717A (ro) |
| CH (1) | CH640230A5 (ro) |
| CS (2) | CS207773B2 (ro) |
| DD (1) | DD142048A5 (ro) |
| DE (1) | DE2806775A1 (ro) |
| DK (1) | DK69479A (ro) |
| ES (2) | ES477784A1 (ro) |
| FI (1) | FI69301C (ro) |
| FR (1) | FR2417502A1 (ro) |
| GB (1) | GB2014575B (ro) |
| GR (2) | GR67626B (ro) |
| HU (1) | HU180430B (ro) |
| IE (1) | IE48073B1 (ro) |
| IL (1) | IL56678A (ro) |
| IT (1) | IT1113469B (ro) |
| LU (1) | LU80924A1 (ro) |
| NL (1) | NL7901241A (ro) |
| NO (1) | NO151239C (ro) |
| NZ (1) | NZ189684A (ro) |
| PH (1) | PH16188A (ro) |
| PL (2) | PL115759B1 (ro) |
| PT (1) | PT69239A (ro) |
| RO (2) | RO81504B (ro) |
| SE (1) | SE7901405L (ro) |
| SU (2) | SU812175A3 (ro) |
| YU (1) | YU36779A (ro) |
| ZA (1) | ZA79709B (ro) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
| EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
| GB2137191A (en) * | 1983-02-28 | 1984-10-03 | Sumitomo Chemical Co | Fungicidal N-phenylimidates |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| JP2003166617A (ja) | 2001-11-28 | 2003-06-13 | Honda Motor Co Ltd | トルクコンバータ付き内燃機関 |
| JP2007308392A (ja) * | 2006-05-16 | 2007-11-29 | Bayer Cropscience Ag | 殺虫性ベンズアミジン類 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2938038A (en) * | 1960-05-24 | X-dihydroxyphenylamino | ||
| US2899426A (en) * | 1959-08-11 | Synthesis of l | ||
| FR1211341A (fr) * | 1955-12-19 | 1960-03-15 | A Wander Dr | Procédé pour la préparation de 2-amino-imidazolines |
| US3595961A (en) * | 1965-10-01 | 1971-07-27 | Boehringer Sohn Ingelheim | Hypotensive compositions containing 2-(2' - halo-anilino) - 1,3 -diazacyclopentenes-(2) and methods of using the same |
| DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
| AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
| DE2446758C3 (de) * | 1974-10-01 | 1979-01-04 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie |
| DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
-
1978
- 1978-02-17 DE DE19782806775 patent/DE2806775A1/de not_active Withdrawn
-
1979
- 1979-02-09 SU SU792721602A patent/SU812175A3/ru active
- 1979-02-12 AT AT0101579A patent/AT370093B/de not_active IP Right Cessation
- 1979-02-12 GR GR58340A patent/GR67626B/el unknown
- 1979-02-13 RO RO103172A patent/RO81504B/ro unknown
- 1979-02-14 CH CH142879A patent/CH640230A5/de not_active IP Right Cessation
- 1979-02-15 PT PT7969239A patent/PT69239A/pt unknown
- 1979-02-15 DD DD79211044A patent/DD142048A5/de unknown
- 1979-02-15 YU YU00367/79A patent/YU36779A/xx unknown
- 1979-02-15 LU LU80924A patent/LU80924A1/de unknown
- 1979-02-15 IT IT48010/79A patent/IT1113469B/it active
- 1979-02-15 IL IL56678A patent/IL56678A/xx unknown
- 1979-02-15 FI FI790510A patent/FI69301C/fi not_active IP Right Cessation
- 1979-02-15 HU HU79BO1764A patent/HU180430B/hu unknown
- 1979-02-16 AU AU44325/79A patent/AU519356B2/en not_active Ceased
- 1979-02-16 ZA ZA79709A patent/ZA79709B/xx unknown
- 1979-02-16 IE IE311/79A patent/IE48073B1/en unknown
- 1979-02-16 FR FR7904052A patent/FR2417502A1/fr active Granted
- 1979-02-16 SE SE7901405A patent/SE7901405L/xx not_active Application Discontinuation
- 1979-02-16 BE BE0/193531A patent/BE874252A/xx not_active IP Right Cessation
- 1979-02-16 DK DK69479A patent/DK69479A/da not_active Application Discontinuation
- 1979-02-16 JP JP1715679A patent/JPS54122273A/ja active Pending
- 1979-02-16 NO NO790523A patent/NO151239C/no unknown
- 1979-02-16 US US06/012,650 patent/US4250186A/en not_active Expired - Lifetime
- 1979-02-16 ES ES477784A patent/ES477784A1/es not_active Expired
- 1979-02-16 CA CA321,805A patent/CA1115717A/en not_active Expired
- 1979-02-16 NZ NZ189684A patent/NZ189684A/xx unknown
- 1979-02-16 PL PL1979213475A patent/PL115759B1/pl unknown
- 1979-02-16 GB GB7905506A patent/GB2014575B/en not_active Expired
- 1979-02-16 PL PL1979221508A patent/PL116527B1/pl unknown
- 1979-02-16 NL NL7901241A patent/NL7901241A/xx not_active Application Discontinuation
- 1979-02-17 RO RO7996602A patent/RO76799A/ro unknown
- 1979-02-19 CS CS791092A patent/CS207773B2/cs unknown
- 1979-02-19 CS CS798500A patent/CS207774B2/cs unknown
- 1979-06-18 GR GR59371A patent/GR69232B/el unknown
- 1979-10-16 ES ES485043A patent/ES485043A1/es not_active Expired
-
1980
- 1980-01-30 SU SU802874805A patent/SU828964A3/ru active
- 1980-08-20 US US06/179,839 patent/US4293564A/en not_active Expired - Lifetime
- 1980-09-08 PH PH24546A patent/PH16188A/en unknown
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