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PT99188A - Processo de preparacao de acetilenos di-substituidos com um grupo fenilo e um grupo cromanilo, tiocromanilo ou 1,2,3,4-tetra-hidroquinolinilo 2-substituidos e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de acetilenos di-substituidos com um grupo fenilo e um grupo cromanilo, tiocromanilo ou 1,2,3,4-tetra-hidroquinolinilo 2-substituidos e de composicoes farmaceuticas que os contem Download PDF

Info

Publication number
PT99188A
PT99188A PT99188A PT9918891A PT99188A PT 99188 A PT99188 A PT 99188A PT 99188 A PT99188 A PT 99188A PT 9918891 A PT9918891 A PT 9918891A PT 99188 A PT99188 A PT 99188A
Authority
PT
Portugal
Prior art keywords
compound
formula
process according
hydrogen
lower alkyl
Prior art date
Application number
PT99188A
Other languages
English (en)
Portuguese (pt)
Inventor
Roshantha A S Chandraratna
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of PT99188A publication Critical patent/PT99188A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT99188A 1990-10-09 1991-10-09 Processo de preparacao de acetilenos di-substituidos com um grupo fenilo e um grupo cromanilo, tiocromanilo ou 1,2,3,4-tetra-hidroquinolinilo 2-substituidos e de composicoes farmaceuticas que os contem PT99188A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59488290A 1990-10-09 1990-10-09

Publications (1)

Publication Number Publication Date
PT99188A true PT99188A (pt) 1992-09-30

Family

ID=24380813

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99188A PT99188A (pt) 1990-10-09 1991-10-09 Processo de preparacao de acetilenos di-substituidos com um grupo fenilo e um grupo cromanilo, tiocromanilo ou 1,2,3,4-tetra-hidroquinolinilo 2-substituidos e de composicoes farmaceuticas que os contem

Country Status (12)

Country Link
EP (1) EP0553156A4 (fr)
JP (1) JPH06501948A (fr)
AU (1) AU652189B2 (fr)
CA (1) CA2092178A1 (fr)
FI (1) FI931625A7 (fr)
HU (1) HUT63405A (fr)
IE (1) IE913569A1 (fr)
IL (1) IL99617A0 (fr)
PL (1) PL168679B1 (fr)
PT (1) PT99188A (fr)
WO (1) WO1992006084A1 (fr)
ZA (1) ZA918026B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101160A1 (fr) * 1991-02-13 1992-08-14 Roshantha A. Chandraratna Chromane et thiochromanes avec substituants phenylethynyliques en position 7, possedant une activite biologique de type retinoide
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
JP3995716B2 (ja) 1996-03-18 2007-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合環含有カルボン酸誘導体
US6740676B2 (en) * 2002-03-19 2004-05-25 Allergan, Inc. 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity
MX2012000768A (es) 2009-07-16 2012-02-13 Stiefel Laboratories Derivados de tazaroteno.
CN107176945B (zh) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810804A (en) * 1987-03-26 1989-03-07 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity
US4980369A (en) * 1989-09-19 1990-12-25 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity
CA2101160A1 (fr) * 1991-02-13 1992-08-14 Roshantha A. Chandraratna Chromane et thiochromanes avec substituants phenylethynyliques en position 7, possedant une activite biologique de type retinoide

Also Published As

Publication number Publication date
WO1992006084A1 (fr) 1992-04-16
FI931625L (fi) 1993-06-07
HUT63405A (en) 1993-08-30
JPH06501948A (ja) 1994-03-03
AU8721091A (en) 1992-04-28
ZA918026B (en) 1992-06-24
IL99617A0 (en) 1992-08-18
FI931625A0 (fi) 1993-04-08
IE913569A1 (en) 1992-04-22
PL168679B1 (en) 1996-03-29
HU9301030D0 (en) 1993-07-28
EP0553156A4 (en) 1993-11-18
FI931625A7 (fi) 1993-06-07
AU652189B2 (en) 1994-08-18
EP0553156A1 (fr) 1993-08-04
CA2092178A1 (fr) 1992-04-10

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PT99189A (pt) Processo de preparacao de acetilenos di-substutuidos com um grupo heteroaromatico e um grupo cromanilo,tiocromanilo ou 1,2,3,4-tetra-hidroquinolinilo 2-substitiuidos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920427

FC3A Refusal

Effective date: 19990106