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ZA918026B - Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity - Google Patents

Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Info

Publication number
ZA918026B
ZA918026B ZA918026A ZA918026A ZA918026B ZA 918026 B ZA918026 B ZA 918026B ZA 918026 A ZA918026 A ZA 918026A ZA 918026 A ZA918026 A ZA 918026A ZA 918026 B ZA918026 B ZA 918026B
Authority
ZA
South Africa
Prior art keywords
group
thiochromanyl
retinoid
activity
tetrahydroquinolinyl
Prior art date
Application number
ZA918026A
Other languages
English (en)
Inventor
Roshantha A S Chandraratna
A S Chandraratna Roshantha
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of ZA918026B publication Critical patent/ZA918026B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA918026A 1990-10-09 1991-10-08 Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity ZA918026B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59488290A 1990-10-09 1990-10-09

Publications (1)

Publication Number Publication Date
ZA918026B true ZA918026B (en) 1992-06-24

Family

ID=24380813

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918026A ZA918026B (en) 1990-10-09 1991-10-08 Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Country Status (12)

Country Link
EP (1) EP0553156A4 (xx)
JP (1) JPH06501948A (xx)
AU (1) AU652189B2 (xx)
CA (1) CA2092178A1 (xx)
FI (1) FI931625A7 (xx)
HU (1) HUT63405A (xx)
IE (1) IE913569A1 (xx)
IL (1) IL99617A0 (xx)
PL (1) PL168679B1 (xx)
PT (1) PT99188A (xx)
WO (1) WO1992006084A1 (xx)
ZA (1) ZA918026B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101160A1 (en) * 1991-02-13 1992-08-14 Roshantha A. Chandraratna Chroman and thiochromans with phenylethynyl substituents at the 7-position having retinoid-like biological activity
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
JP3995716B2 (ja) 1996-03-18 2007-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合環含有カルボン酸誘導体
US6740676B2 (en) * 2002-03-19 2004-05-25 Allergan, Inc. 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity
MX2012000768A (es) 2009-07-16 2012-02-13 Stiefel Laboratories Derivados de tazaroteno.
CN107176945B (zh) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810804A (en) * 1987-03-26 1989-03-07 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity
US4980369A (en) * 1989-09-19 1990-12-25 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity
CA2101160A1 (en) * 1991-02-13 1992-08-14 Roshantha A. Chandraratna Chroman and thiochromans with phenylethynyl substituents at the 7-position having retinoid-like biological activity

Also Published As

Publication number Publication date
WO1992006084A1 (en) 1992-04-16
FI931625L (fi) 1993-06-07
HUT63405A (en) 1993-08-30
PT99188A (pt) 1992-09-30
JPH06501948A (ja) 1994-03-03
AU8721091A (en) 1992-04-28
IL99617A0 (en) 1992-08-18
FI931625A0 (fi) 1993-04-08
IE913569A1 (en) 1992-04-22
PL168679B1 (en) 1996-03-29
HU9301030D0 (en) 1993-07-28
EP0553156A4 (en) 1993-11-18
FI931625A7 (fi) 1993-06-07
AU652189B2 (en) 1994-08-18
EP0553156A1 (en) 1993-08-04
CA2092178A1 (en) 1992-04-10

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