PT97905A - Processo para a preparacao de composicoes farmaceuticas contendo derivados da cistina - Google Patents

Processo para a preparacao de composicoes farmaceuticas contendo derivados da cistina

Info

Publication number: PT97905A
Authority: PT; Portugal
Prior art keywords: cistine; derivatives; pharmaceutical compositions; compositions containing; preparing pharmaceutical
Prior art date: 1990-06-08

Application number

PT97905A

Other languages

English (en)

Other versions

PT97905B (pt

Inventor

Carl-Magnus Alexande Andersson

Sten Hakan Axel Bergstrand

Anders Rudolf Hallberg

Bengt Olof Sarnstrand

Per Anders Sigvard Tunek

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-08

Filing date

1991-06-07

Publication date

1992-03-31

1990-06-08 Priority claimed from SE9002067A external-priority patent/SE9002067D0/xx

1990-06-28 Priority claimed from SE9002275A external-priority patent/SE9002275D0/xx

1991-06-07 Application filed by Astra Ab filed Critical Astra Ab

1992-03-31 Publication of PT97905A publication Critical patent/PT97905A/pt

1998-10-30 Publication of PT97905B publication Critical patent/PT97905B/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Virology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Otolaryngology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT97905A 1990-06-08 1991-06-07 Processo para a preparacao de composicoes farmaceuticas contendo derivados da cistina PT97905B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9002067A SE9002067D0 (sv)	1990-06-08	1990-06-08	The pharmacological use of certain cystine derivatives
SE9002275A SE9002275D0 (sv)	1990-06-28	1990-06-28	Novel 3,3'-dithiobis(propionic acids)

Publications (2)

Publication Number	Publication Date
PT97905A true PT97905A (pt)	1992-03-31
PT97905B PT97905B (pt)	1998-10-30

Family

ID=26660796

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97905A PT97905B (pt)	1990-06-08	1991-06-07	Processo para a preparacao de composicoes farmaceuticas contendo derivados da cistina

Country Status (20)

Country	Link
US (2)	US5441976A (pt)
EP (1)	EP0532595B1 (pt)
JP (1)	JP3204320B2 (pt)
KR (1)	KR100236253B1 (pt)
AT (1)	ATE144705T1 (pt)
AU (1)	AU652946B2 (pt)
CA (1)	CA2083274C (pt)
DE (1)	DE69122961T2 (pt)
DK (1)	DK0532595T3 (pt)
HK (1)	HK62597A (pt)
HU (1)	HU215920B (pt)
IE (1)	IE80754B1 (pt)
IL (1)	IL98310A (pt)
LV (2)	LV10186B (pt)
NO (1)	NO924723L (pt)
NZ (1)	NZ247658A (pt)
PT (1)	PT97905B (pt)
RU (1)	RU2119793C1 (pt)
SG (1)	SG49736A1 (pt)
WO (1)	WO1991018594A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9018994D0 (en) *	1990-08-31	1990-10-17	Secr Defence	Toxic agent protective compounds
US5889050A (en) *	1991-06-21	1999-03-30	Astra Aktiebolag	3,3'-dithiobis (propionic acids) and esters thereof
SE9103572D0 (sv) *	1991-11-29	1991-11-29	Astra Ab	Organic salts of n,n'-diacetyl cystine
JP2947044B2 (ja) *	1993-01-27	1999-09-13	味の素株式会社	免疫不全症候群治療の補助療法剤
DE4329857C2 (de) *	1993-09-03	1995-08-24	Deutsches Krebsforsch	Verbindung zur Stärkung des Immunsystems und von Immunreaktionen
SE9500897D0 (sv) *	1995-03-14	1995-03-14	Astra Ab	The pharmacological use of certain cystine derivatives
SE9501067D0 (sv) *	1995-03-24	1995-03-24	Astra Ab	New peptides
SE9602262D0 (sv) *	1996-06-06	1996-06-06	Astra Ab	New use of derivatives of cystine
US6197749B1 (en)	1997-10-29	2001-03-06	Ajinomoto Co., Inc.	Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
US20030203006A1 (en) *	1997-10-29	2003-10-30	Ajinomoto Co. Inc.	Immunomodulator
CN100408560C (zh)	1998-10-09	2008-08-06	味之素株式会社	半胱氨酸衍生物
EP1004302A3 (en) *	1998-10-29	2003-06-04	Ajinomoto Co., Inc.	Immunomodulator
SE9900438D0 (sv) *	1999-02-10	1999-02-10	Astra Ab	The pharmacological use of certian cystine derivatives
JP3988014B2 (ja) *	2000-02-02	2007-10-10	味の素株式会社	ウイルス感染症予防剤
DK1337240T4 (en)	2000-11-30	2015-01-05	Vectura Ltd	A process for the preparation of particles for use in a pharmaceutical composition
SE518784C2 (sv) *	2000-12-27	2002-11-19	Nactilus Ab	"N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
US8530509B2 (en)	2003-06-20	2013-09-10	Siga Technologies, Inc.	Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
DE102004043055B4 (de)	2004-09-06	2009-04-02	Siemens Ag	Führungsvorrichtung zur Führung eines bewegbaren Maschinenelementes einer Maschine
JP2010505844A (ja) *	2006-10-03	2010-02-25	ガレオン・フアーマシユーチカルズ・インコーポレーテツド	Ｓ−ニトロソチオール化合物および関連誘導体
CA2866037C (en) *	2007-04-23	2017-05-16	Siga Technologies, Inc.	Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7829709B1 (en)	2007-08-10	2010-11-09	Marquette University	Cysteine prodrugs to treat schizophrenia and drug addiction
WO2009100431A1 (en) *	2008-02-07	2009-08-13	Marquette University	Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings
KR20160147960A (ko)	2014-04-25	2016-12-23	아지노모토 가부시키가이샤	면역자극제
US20230373913A1 (en) *	2017-11-09	2023-11-23	Nacuity Pharmaceuticals, Inc.	Methods of Making Deuterium-Enriched N-Acetylcysteine Amide (D-NACA) and (2R,2R)-3,3-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR8205M (pt) *	1968-12-20	1970-09-14
US3878305A (en) *	1972-05-25	1975-04-15	Procter & Gamble	Fortification of foodstuffs with n-acyl derivatives of sulphur-containing l-amino acids
US3952115A (en) *	1975-04-02	1976-04-20	The Procter & Gamble Company	Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters
GB2097256B (en) *	1981-04-02	1985-05-30	Morelle Jean V	Compositions containing n-butyryl alphaaminoacids
FR2503151A1 (fr) *	1981-04-02	1982-10-08	Morelle Jean	Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux
DE3343141A1 (de) *	1983-11-29	1985-06-05	Hermann P.T. 7400 Tübingen Ammon	Verwendung von cystein-derivaten oder deren salzen, zur steigerung der insulinsekretion der langerhans'schen inseln der bauchspeicheldruese
US4708965A (en) *	1985-09-16	1987-11-24	Morgan Lee R	Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
US4724239A (en) *	1985-09-16	1988-02-09	Morgan Lee R	Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US4827016A (en) *	1985-09-16	1989-05-02	Morgan Lee R	Method and compounds for reducing dermal inflammations
IT1249650B (it) *	1991-05-29	1995-03-09	Poli Ind Chimica Spa	N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico

1991
- 1991-05-30 IL IL9831091A patent/IL98310A/en not_active IP Right Cessation
- 1991-06-03 AU AU80941/91A patent/AU652946B2/en not_active Ceased
- 1991-06-03 DK DK91910813.4T patent/DK0532595T3/da active
- 1991-06-03 RU RU92016463A patent/RU2119793C1/ru not_active IP Right Cessation
- 1991-06-03 SG SG1996004501A patent/SG49736A1/en unknown
- 1991-06-03 HU HU9203871A patent/HU215920B/hu not_active IP Right Cessation
- 1991-06-03 DE DE69122961T patent/DE69122961T2/de not_active Expired - Fee Related
- 1991-06-03 JP JP51096391A patent/JP3204320B2/ja not_active Expired - Fee Related
- 1991-06-03 WO PCT/SE1991/000388 patent/WO1991018594A1/en not_active Ceased
- 1991-06-03 EP EP91910813A patent/EP0532595B1/en not_active Expired - Lifetime
- 1991-06-03 KR KR1019920703125A patent/KR100236253B1/ko not_active Expired - Fee Related
- 1991-06-03 CA CA002083274A patent/CA2083274C/en not_active Expired - Fee Related
- 1991-06-03 AT AT91910813T patent/ATE144705T1/de not_active IP Right Cessation
- 1991-06-07 IE IE194591A patent/IE80754B1/en not_active IP Right Cessation
- 1991-06-07 PT PT97905A patent/PT97905B/pt not_active IP Right Cessation
1992
- 1992-12-04 US US07/949,648 patent/US5441976A/en not_active Expired - Lifetime
- 1992-12-07 NO NO92924723A patent/NO924723L/no unknown
1993
- 1993-05-20 NZ NZ247658A patent/NZ247658A/en unknown
- 1993-08-06 LV LVP-93-1017A patent/LV10186B/en unknown
1995
- 1995-06-01 US US08/457,004 patent/US5780508A/en not_active Expired - Fee Related
1997
- 1997-05-08 HK HK62597A patent/HK62597A/en not_active IP Right Cessation
- 1997-10-30 LV LVP-97-219A patent/LV11985B/en unknown

Also Published As

Publication number	Publication date
HUT70055A (en)	1995-09-28
EP0532595A1 (en)	1993-03-24
EP0532595B1 (en)	1996-10-30
JPH05507705A (ja)	1993-11-04
DK0532595T3 (da)	1997-04-07
SG49736A1 (en)	1998-06-15
LV11985B (en)	1998-06-20
NO924723D0 (no)	1992-12-07
AU8094191A (en)	1991-12-31
IL98310A (en)	1996-08-04
ATE144705T1 (de)	1996-11-15
CA2083274A1 (en)	1991-12-09
IE80754B1 (en)	1999-01-13
HU9203871D0 (en)	1993-03-29
LV10186B (en)	1995-08-20
KR100236253B1 (ko)	1999-12-15
LV11985A (lv)	1998-03-20
DE69122961D1 (de)	1996-12-05
US5441976A (en)	1995-08-15
RU2119793C1 (ru)	1998-10-10
NZ247658A (en)	2000-07-28
US5780508A (en)	1998-07-14
CA2083274C (en)	2002-05-28
IE911945A1 (en)	1991-12-18
WO1991018594A1 (en)	1991-12-12
PT97905B (pt)	1998-10-30
JP3204320B2 (ja)	2001-09-04
AU652946B2 (en)	1994-09-15
HU215920B (hu)	1999-03-29
LV10186A (lv)	1994-10-20
NO924723L (no)	1992-12-07
DE69122961T2 (de)	1997-03-13
HK62597A (en)	1997-05-16
IL98310A0 (en)	1992-06-21

Publication	Publication Date	Title
PT97905A (pt)	1992-03-31	Processo para a preparacao de composicoes farmaceuticas contendo derivados da cistina
DE69620877D1 (de)	2002-05-29	Arzneimittelformulierungen für il-12
ES2076935T3 (es)	1995-11-16	Compuesto de pirazolopiridina y procedimientos para su preparacion.
SE8602723L (sv)	1986-12-23	Tiazoler, deras framstellning och farmaceutiska kompositioner innehallande dem
MX9100990A (es)	1992-05-04	Compuesto monohidrato de furoato de mometasona,al procedimiento para su preparacion y a las composiciones farmaceuticas
FI932909A7 (fi)	1993-12-25	Tiatsolin haarautuneita alkyyliaminojohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
MX9202544A (es)	1992-11-01	Compuestos de diaminoftalimidas substituidas y analogas, procedimiento para su preparacion y preparados farmaceuticos que los contienen.
MX9304793A (es)	1994-05-31	Glicanas de actividad inmunoestimulante.
PT789590E (pt)	2002-12-31	Imunopotenciacao induzida por quitosano
NO921382D0 (no)	1992-04-08	Amidinofenylalaninderivater, samt fremstilling, anvendelse og preparater inneholdende forbindelsene
MX9204318A (es)	1994-07-29	Complejos de derivados de pleuromutilina para su preparacion y composiciones farmaceuticas que los contienen.
GR1001597B (el)	1994-06-30	Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
DK561089A (da)	1990-05-11	Anvendelse af lactamimider til fremstilling af laegemidler
GR1000467B (el)	1992-07-30	Μεθοδος παρασκευης τρικυκλικων παραγωγων 3-οξο-προπανονιτριλιου.
OA09794A (fr)	1994-04-15	Dérivés de pyridone amino acide azetidinyl substitués, leur préparation et leur application en tant que médicaments.
PT989994E (pt)	2005-08-31	Derivados de estreptograminas, a sua preparacao e as composicoes que os contem
SE8503447L (sv)	1986-01-13	Farmaceutiska och kosmetiska kompositioner, innehallande dihydroxi-1,8-fenyl-10-antron-9 som verksam bestandsdel, samt sett att framstella den verksamma foreningen
ES2087178T3 (es)	1996-07-16	Disulfato de ws7622a, procedimiento para su preparacion y su uso.
DK0579765T3 (da)	2000-10-09	Fremgangsmåde og præparat til behandling af herpes-relaterede sygdomme
ATE145647T1 (de)	1996-12-15	Gem-diphosphonsäure-nitrosocarbamoylderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zubereitungen
SE9203296D0 (sv)	1992-11-05	The use of inositoltrisphate for the preparing of medicaments
MX9101806A (es)	1993-04-01	Composicion para preparaciones farmaceuticas que contienen un derivado de vitamina d3 procedimiento para preparar la misma
NO924145D0 (no)	1992-10-27	Sammensetning for faste, farmasoeytiske preparater inneholdende vitamin d3-derivat, og fremgangsmaate for fremstilling derav
IT1254938B (it)	1995-10-11	Derivati otticamente attivi della n-imminoalchil-n'-((2-idrossi- 2-fenil-2-cicloesil)-etil)-piperazina

Legal Events

Date	Code	Title	Description
1992-03-31	BB1A	Laying open of patent application	Effective date: 19911118
1998-10-30	FG3A	Patent granted, date of granting	Effective date: 19980723
2005-03-31	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050124

Date

Code

Title

Description

1992-03-31

BB1A

Laying open of patent application

Effective date: 19911118

1998-10-30

FG3A

Patent granted, date of granting

Effective date: 19980723

2005-03-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20050124