PT80117B - Processo para a preparacao de 2-oxindole-1-carboxamidas 3-substituidas uteis como agentes analgesicos e anti-inflamatorios - Google Patents

Processo para a preparacao de 2-oxindole-1-carboxamidas 3-substituidas uteis como agentes analgesicos e anti-inflamatorios

Info

Publication number: PT80117B
Authority: PT; Portugal
Prior art keywords: oxindole; carboxamides; analgesic; alkyl; preparation
Prior art date: 1984-03-19

Application number

PT80117A

Other languages

English (en)

Other versions

PT80117A (en

Inventor

Saul Bernard Kadin

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-19

Filing date

1985-03-15

Publication date

1987-10-20

1985-03-15 Application filed by Pfizer filed Critical Pfizer

1985-04-01 Publication of PT80117A publication Critical patent/PT80117A/pt

1987-10-20 Publication of PT80117B publication Critical patent/PT80117B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT80117A 1984-03-19 1985-03-15 Processo para a preparacao de 2-oxindole-1-carboxamidas 3-substituidas uteis como agentes analgesicos e anti-inflamatorios PT80117B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59065984A	1984-03-19	1984-03-19
US06/684,634 US4556672A (en)	1984-03-19	1984-12-21	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Publications (2)

Publication Number	Publication Date
PT80117A PT80117A (en)	1985-04-01
PT80117B true PT80117B (pt)	1987-10-20

Family

ID=27080909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT80117A PT80117B (pt)	1984-03-19	1985-03-15	Processo para a preparacao de 2-oxindole-1-carboxamidas 3-substituidas uteis como agentes analgesicos e anti-inflamatorios

Country Status (36)

Country	Link
US (1)	US4556672A (pt)
EP (1)	EP0156603B1 (pt)
JP (1)	JPH04235165A (pt)
KR (1)	KR860001873B1 (pt)
AT (1)	ATE45731T1 (pt)
AU (1)	AU549927B2 (pt)
BG (1)	BG60347B2 (pt)
CA (2)	CA1251441A (pt)
CS (1)	CS249539B2 (pt)
CY (1)	CY1668A (pt)
DE (1)	DE3572481D1 (pt)
DK (1)	DK162090C (pt)
EG (1)	EG17795A (pt)
ES (1)	ES8603408A1 (pt)
FI (2)	FI82042C (pt)
GR (1)	GR850668B (pt)
HK (1)	HK78392A (pt)
HU (1)	HU196178B (pt)
IE (1)	IE57743B1 (pt)
IL (3)	IL74631A (pt)
LV (1)	LV5618A3 (pt)
MA (1)	MA20380A1 (pt)
MY (1)	MY101987A (pt)
NL (1)	NL940025I2 (pt)
NO (1)	NO165799C (pt)
NZ (2)	NZ211486A (pt)
OA (1)	OA07966A (pt)
PH (2)	PH21323A (pt)
PL (1)	PL145951B1 (pt)
PT (1)	PT80117B (pt)
RO (1)	RO90952B (pt)
SI (1)	SI8510440A8 (pt)
SU (1)	SU1445556A3 (pt)
UA (1)	UA6343A1 (pt)
YU (1)	YU43870B (pt)
ZW (1)	ZW4785A1 (pt)

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DE3681358D1 (de) *	1985-07-09	1991-10-17	Pfizer	Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8623819D0 (en) *	1986-10-03	1986-11-05	Glaxo Group Ltd	Heterocyclic compounds
US5036099A (en) *	1987-02-02	1991-07-30	Pfizer Inc.	Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
US4885370A (en) *	1987-03-11	1989-12-05	Pfizer Inc.	Synthetic method for indol-2(3H)-ones
US4761485A (en) *	1987-03-11	1988-08-02	Pfizer Inc.	Synthetic method for indol-2(3H)-ones
GB8720693D0 (en) *	1987-09-03	1987-10-07	Glaxo Group Ltd	Chemical compounds
DE3803775A1 (de) *	1988-02-09	1989-08-17	Boehringer Mannheim Gmbh	Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4853409A (en) *	1988-04-13	1989-08-01	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
EP0365194B1 (en) *	1988-10-18	1995-08-02	Pfizer Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
MX18021A (es) *	1988-10-18	1993-11-01	Pfizer	Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias
HU215112B (hu) *	1989-01-10	1998-12-28	Pfizer Inc.	Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
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US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) *	1991-04-08	1994-06-01	Mack Chem Pharm	Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5166401A (en) *	1991-06-25	1992-11-24	Pfizer Inc	Intermediates for 5-fluoro-6-chlorooxindole
US5210212A (en) *	1991-06-25	1993-05-11	Pfizer Inc	Process for 5-fluoro-6-chlorooxindole
TW438798B (en) *	1992-10-07	2001-06-07	Pfizer	3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5288743A (en) *	1992-11-20	1994-02-22	Abbott Laboratories	Indole carboxylate derivatives which inhibit leukotriene biosynthesis
NZ261449A (en) *	1993-01-22	1996-08-27	Pfizer	Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1- carboxamide and pharmaceutical compositions thereof
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5270331A (en) *	1993-01-26	1993-12-14	Pfizer, Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
DK0683777T3 (da) *	1993-02-09	1997-04-28	Pfizer	Oxindol-1-N-(alkoxycarbonyl)carboxamider og -1-(N-carboxamido)carboxamider som antiinflammatoriske midler
ES2076106B1 (es) *	1993-08-26	1996-06-16	Pfizer	Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5449788A (en) *	1994-01-28	1995-09-12	Catalytica, Inc.	Process for preparing 2-oxindole-1-carboxamides
EP0679396A1 (en) *	1994-03-02	1995-11-02	Pfizer Inc.	Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
US6469181B1 (en)	1995-01-30	2002-10-22	Catalytica, Inc.	Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US6043232A (en) *	1997-07-23	2000-03-28	Nitromed, Inc.	Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US6051588A (en) *	1995-04-19	2000-04-18	Nitromed Inc	Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
AU7503496A (en) *	1995-12-19	1997-07-14	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
HUP9600855A3 (en) *	1996-04-03	1998-04-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing tenidap
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BR9916327A (pt)	1998-12-17	2001-09-18	Hoffmann La Roche	Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
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WO2001030151A1 (en) *	1999-10-26	2001-05-03	The University Of Texas Southwestern Medical Center	Methods of treating hair loss comprising administering indoline compound
US6313310B1 (en)	1999-12-15	2001-11-06	Hoffmann-La Roche Inc.	4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
IT1318673B1 (it) *	2000-08-08	2003-08-27	Nicox Sa	Farmaci per le disfunzioni sessuali.
IT1318674B1 (it) *	2000-08-08	2003-08-27	Nicox Sa	Faramaci per l'incontinenza.
US20030129186A1 (en)	2001-07-25	2003-07-10	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CN101287411B (zh)	2005-04-28	2013-03-06	普罗秋斯生物医学公司	药物信息系统及其用途
CN101594878A (zh)	2006-09-18	2009-12-02	雷普特药品公司	通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
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1984
- 1984-12-21 US US06/684,634 patent/US4556672A/en not_active Expired - Lifetime
1985
- 1985-03-15 DE DE8585301808T patent/DE3572481D1/de not_active Expired
- 1985-03-15 IE IE684/85A patent/IE57743B1/en not_active IP Right Cessation
- 1985-03-15 GR GR850668A patent/GR850668B/el unknown
- 1985-03-15 PT PT80117A patent/PT80117B/pt unknown
- 1985-03-15 EP EP85301808A patent/EP0156603B1/en not_active Expired
- 1985-03-15 AT AT85301808T patent/ATE45731T1/de not_active IP Right Cessation
- 1985-03-15 CA CA000476605A patent/CA1251441A/en not_active Expired
- 1985-03-17 EG EG174/85A patent/EG17795A/xx active
- 1985-03-18 BG BG069278A patent/BG60347B2/bg unknown
- 1985-03-18 PL PL1985252434A patent/PL145951B1/pl unknown
- 1985-03-18 AU AU40059/85A patent/AU549927B2/en not_active Expired
- 1985-03-18 ZW ZW47/85A patent/ZW4785A1/xx unknown
- 1985-03-18 NO NO851054A patent/NO165799C/no not_active IP Right Cessation
- 1985-03-18 DK DK121385A patent/DK162090C/da not_active IP Right Cessation
- 1985-03-18 IL IL74631A patent/IL74631A/xx not_active IP Right Cessation
- 1985-03-18 NZ NZ211486A patent/NZ211486A/xx unknown
- 1985-03-18 NZ NZ224134A patent/NZ224134A/xx unknown
- 1985-03-18 KR KR1019850001746A patent/KR860001873B1/ko not_active Expired
- 1985-03-18 UA UA3869754A patent/UA6343A1/uk unknown
- 1985-03-18 FI FI851069A patent/FI82042C/fi not_active IP Right Cessation
- 1985-03-18 HU HU85992A patent/HU196178B/hu unknown
- 1985-03-18 IL IL85130A patent/IL85130A/xx not_active IP Right Cessation
- 1985-03-18 MA MA20604A patent/MA20380A1/fr unknown
- 1985-03-18 ES ES541372A patent/ES8603408A1/es not_active Expired
- 1985-03-18 SU SU853869754A patent/SU1445556A3/ru active
- 1985-03-18 PH PH32001A patent/PH21323A/en unknown
- 1985-03-19 YU YU440/85A patent/YU43870B/xx unknown
- 1985-03-19 RO RO118055A patent/RO90952B/ro unknown
- 1985-03-19 SI SI8510440A patent/SI8510440A8/sl unknown
- 1985-03-19 CS CS851920A patent/CS249539B2/cs unknown
- 1985-03-19 OA OA58541A patent/OA07966A/xx unknown
1986
- 1986-02-21 PH PH33439A patent/PH21470A/en unknown
1987
- 1987-08-17 MY MYPI87001358A patent/MY101987A/en unknown
1988
- 1988-01-19 IL IL85130A patent/IL85130A0/xx unknown
- 1988-07-07 CA CA000571475A patent/CA1288422C/en not_active Expired - Lifetime
1989
- 1989-09-26 FI FI894540A patent/FI82449C/fi not_active IP Right Cessation
1991
- 1991-06-04 JP JP3132826A patent/JPH04235165A/ja active Granted
1992
- 1992-10-15 HK HK783/92A patent/HK78392A/en not_active IP Right Cessation
1993
- 1993-05-14 CY CY1668A patent/CY1668A/xx unknown
- 1993-11-11 LV LV931200A patent/LV5618A3/xx unknown
1994
- 1994-12-15 NL NL940025C patent/NL940025I2/nl unknown

Also Published As

Publication number	Publication date
DK121385D0 (da)	1985-03-18
ES541372A0 (es)	1985-12-16
EP0156603A2 (en)	1985-10-02
US4556672A (en)	1985-12-03
ES8603408A1 (es)	1985-12-16
FI894540L (fi)	1989-09-26
NO165799B (no)	1991-01-02
MA20380A1 (fr)	1985-10-01
IL85130A0 (en)	1988-06-30
OA07966A (fr)	1987-01-31
PL145951B1 (en)	1988-12-31
PH21470A (en)	1987-10-28
BG60347B2 (bg)	1994-09-30
NO851054L (no)	1985-09-20
NZ224134A (en)	1988-10-28
RO90952A (ro)	1987-02-27
IL74631A0 (en)	1985-06-30
YU43870B (en)	1989-12-31
GR850668B (pt)	1985-07-16
MY101987A (en)	1992-02-29
PL252434A1 (en)	1985-12-03
NL940025I1 (nl)	1995-02-01
DE3572481D1 (en)	1989-09-28
IE57743B1 (en)	1993-03-24
HK78392A (en)	1992-10-23
JPH04235165A (ja)	1992-08-24
JPH0561269B2 (pt)	1993-09-06
PH21323A (en)	1987-09-28
NO165799C (no)	1991-04-10
FI851069L (fi)	1985-09-20
DK121385A (da)	1985-09-20
KR850006173A (ko)	1985-10-02
NL940025I2 (nl)	2000-01-03
EG17795A (en)	1990-08-30
CA1251441A (en)	1989-03-21
HUT37398A (en)	1985-12-28
UA6343A1 (uk)	1994-12-29
RO90952B (ro)	1987-03-01
DK162090C (da)	1992-02-24
FI82042B (fi)	1990-09-28
FI851069A0 (fi)	1985-03-18
AU549927B2 (en)	1986-02-20
HU196178B (en)	1988-10-28
CA1288422C (en)	1991-09-03
DK162090B (da)	1991-09-16
IL85130A (en)	1988-07-31
PT80117A (en)	1985-04-01
IE850684L (en)	1985-09-19
AU4005985A (en)	1985-09-26
YU44085A (en)	1988-02-29
ZW4785A1 (en)	1985-06-19
SU1445556A3 (ru)	1988-12-15
FI82449C (fi)	1991-03-11
FI82449B (fi)	1990-11-30
SI8510440A8 (sl)	1996-06-30
EP0156603A3 (en)	1986-02-12
FI894540A0 (fi)	1989-09-26
CS249539B2 (en)	1987-03-12
FI82042C (fi)	1991-01-10
ATE45731T1 (de)	1989-09-15
LV5618A3 (lv)	1994-05-10
CY1668A (en)	1993-05-14
IL74631A (en)	1988-07-31
KR860001873B1 (ko)	1986-10-24
NZ211486A (en)	1988-10-28
EP0156603B1 (en)	1989-08-23

Publication	Publication Date	Title
PT80117B (pt)	1987-10-20	Processo para a preparacao de 2-oxindole-1-carboxamidas 3-substituidas uteis como agentes analgesicos e anti-inflamatorios
DE3587148D1 (de)	1993-04-08	Indolsaeureverbindungen und ihre anwendung als antiallergische heilmittel.
ES534859A0 (es)	1986-02-01	Procedimiento para la obtencion de derivados de 1-(4'-alquilsulfonilfenil)-2-amino-1,3-propandiol n-substituidos
IT1209644B (it)	1989-08-30	Composti farmacologicamente attivi.
IT1205640B (it)	1989-03-23	Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
FI905922A0 (fi)	1990-11-30	Antagonister foer a-adrenerga receptorer.