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PT3581650T - Mutante de polipéptido de fator ix, as suas utilizações e um método para a sua produção - Google Patents

Mutante de polipéptido de fator ix, as suas utilizações e um método para a sua produção

Info

Publication number
PT3581650T
PT3581650T PT191745173T PT19174517T PT3581650T PT 3581650 T PT3581650 T PT 3581650T PT 191745173 T PT191745173 T PT 191745173T PT 19174517 T PT19174517 T PT 19174517T PT 3581650 T PT3581650 T PT 3581650T
Authority
PT
Portugal
Prior art keywords
factor
production
polypeptide mutant
mutant
polypeptide
Prior art date
Application number
PT191745173T
Other languages
English (en)
Original Assignee
Uniqure Biopharma B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41397565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3581650(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ITBO2008A000564A external-priority patent/IT1394177B1/it
Priority claimed from ITBO2009A000275A external-priority patent/IT1395980B1/it
Application filed by Uniqure Biopharma B V filed Critical Uniqure Biopharma B V
Publication of PT3581650T publication Critical patent/PT3581650T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT191745173T 2008-09-15 2009-09-15 Mutante de polipéptido de fator ix, as suas utilizações e um método para a sua produção PT3581650T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO2008A000564A IT1394177B1 (it) 2008-09-15 2008-09-15 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
ITBO2009A000275A IT1395980B1 (it) 2009-05-06 2009-05-06 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione

Publications (1)

Publication Number Publication Date
PT3581650T true PT3581650T (pt) 2023-03-08

Family

ID=41397565

Family Applications (1)

Application Number Title Priority Date Filing Date
PT191745173T PT3581650T (pt) 2008-09-15 2009-09-15 Mutante de polipéptido de fator ix, as suas utilizações e um método para a sua produção

Country Status (19)

Country Link
US (13) USRE50288E1 (pt)
EP (5) EP2337849B1 (pt)
CA (1) CA2737094C (pt)
CY (2) CY1125885T1 (pt)
DK (2) DK3581650T3 (pt)
ES (3) ES2985035T3 (pt)
FI (5) FI3581650T3 (pt)
FR (4) FR23C1028I1 (pt)
HK (1) HK1244507A1 (pt)
HR (2) HRP20230259T1 (pt)
HU (6) HUE067487T2 (pt)
LT (5) LT3581650T (pt)
NO (2) NO2023029I1 (pt)
PL (3) PL2337849T3 (pt)
PT (1) PT3581650T (pt)
SI (1) SI3581650T1 (pt)
SM (2) SMT202300084T1 (pt)
TR (1) TR201813067T4 (pt)
WO (1) WO2010029178A1 (pt)

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TWI595004B (zh) 2010-11-03 2017-08-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
BR112015001628A2 (pt) 2012-07-25 2017-11-07 Catalyst Biosciences Inc polipeptídeos de fator x modificados e uso dos mesmos
ES2959747T3 (es) 2013-02-15 2024-02-28 Bioverativ Therapeutics Inc Gen del factor VIII optimizado
WO2016004113A1 (en) 2014-06-30 2016-01-07 Biogen Ma Inc. Optimized factor ix gene
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
IL256517B2 (en) 2015-06-23 2024-06-01 Childrens Hospital Philadelphia Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues
EP3411478B1 (en) 2016-02-01 2022-06-08 Bioverativ Therapeutics Inc. Optimized factor viii genes
MX2019000962A (es) 2016-07-26 2019-08-01 Biomarin Pharm Inc Novedosas proteinas de la capside del virus adenoasociado.
CN116355883A (zh) * 2016-10-14 2023-06-30 四川至善唯新生物科技有限公司 一种高活性凝血因子ix突变体、重组蛋白与融合蛋白的制备与应用
AR112057A1 (es) 2017-05-22 2019-09-18 Baxalta Inc Vectores virales que codifican variantes de fix recombinantes con mayor expresión para la terapia génica de hemofilia b
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WO2019217513A2 (en) 2018-05-09 2019-11-14 Biomarin Pharmaceutical Inc. Methods of treating phenylketonuria
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
JP2021523198A (ja) 2018-05-14 2021-09-02 ビオマリン プハルマセウトイカル インコーポレイテッド 幼若対象におけるａａｖベクターの安定的発現
GB201813528D0 (en) 2018-08-20 2018-10-03 Ucl Business Plc Factor IX encoding nucleotides
SG11202101560QA (en) * 2018-08-20 2021-03-30 Ucl Business Ltd Factor ix encoding nucleotides
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
UY38389A (es) * 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
CN113260701A (zh) 2018-10-18 2021-08-13 英特利亚治疗股份有限公司 用于表达因子ix的组合物和方法
US12403164B2 (en) 2019-09-30 2025-09-02 Bioverativ Therapeutics Inc. Lentiviral vector formulations
WO2021154414A2 (en) 2020-01-29 2021-08-05 Catalyst Biosciences, Inc. Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides
JP2023537565A (ja) 2020-06-24 2023-09-04 バイオベラティブ セラピューティクス インコーポレイテッド タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法
US20240293516A1 (en) * 2021-07-01 2024-09-05 CSL Behring Lengnau AG Factor ix subcutaneous administration with enhanced safety
WO2025022005A1 (en) * 2023-07-26 2025-01-30 Le Quellec Sandra Intranasal administration of factor ix polypeptides

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Also Published As

Publication number Publication date
HUS2300024I1 (hu) 2023-08-28
EP4219547A2 (en) 2023-08-02
WO2010029178A1 (en) 2010-03-18
DK3581650T3 (da) 2023-03-13
US20180258413A1 (en) 2018-09-13
FIC20240036I1 (fi) 2024-10-29
FIC20230026I1 (fi) 2023-07-25
US20110244550A1 (en) 2011-10-06
EP2337849B1 (en) 2018-06-13
DK2337849T3 (en) 2018-10-01
EP3581650A2 (en) 2019-12-18
EP4032979B1 (en) 2024-05-01
HUE067487T2 (hu) 2024-10-28
FR24C1040I1 (fr) 2024-12-06
HK1244507A1 (en) 2018-08-10
FR25C1004I1 (fr) 2025-02-28
EP3581650A3 (en) 2020-03-25
TR201813067T4 (tr) 2018-09-21
ES2687038T3 (es) 2018-10-23
ES2985035T3 (es) 2024-11-04
CA2737094F (en) 2010-03-18
US20250179462A1 (en) 2025-06-05
LTPA2024530I1 (pt) 2024-11-25
EP4219547A3 (en) 2023-10-18
US20160122740A1 (en) 2016-05-05
LTPA2023521I1 (pt) 2023-08-25
EP4032979A1 (en) 2022-07-27
PL3581650T3 (pl) 2023-05-22
CA2737094C (en) 2018-02-20
HRP20230259T1 (hr) 2023-04-28
USRE50288E1 (en) 2025-02-04
US20220090042A1 (en) 2022-03-24
FIC20240037I1 (fi) 2024-10-30
US9982248B2 (en) 2018-05-29
EP4032979C0 (en) 2024-05-01
LTPA2025503I1 (pt) 2025-02-10
US20200231958A1 (en) 2020-07-23
US20200190498A1 (en) 2020-06-18
ES2940323T3 (es) 2023-05-05
FR23C1028I1 (fr) 2023-10-06
PL2337849T3 (pl) 2018-11-30
HRP20181442T1 (hr) 2018-12-14
US9249405B2 (en) 2016-02-02
US20200199564A1 (en) 2020-06-25
US20210214704A1 (en) 2021-07-15
EP2337849A1 (en) 2011-06-29
SI3581650T1 (sl) 2023-06-30
HUS2500006I1 (hu) 2025-02-28
CY1125885T1 (el) 2024-02-16
US20170355973A1 (en) 2017-12-14
FIC20250007I1 (fi) 2025-01-22
EP3581650B1 (en) 2022-12-28
LTPA2024529I1 (pt) 2024-12-10
EP3252157A1 (en) 2017-12-06
LT3581650T (lt) 2023-05-10
HUS2400036I1 (hu) 2024-11-28
HUE061345T2 (hu) 2023-06-28
FI3581650T3 (fi) 2023-03-23
NO2023029I1 (no) 2023-07-31
HUS2400037I1 (hu) 2024-11-28
CA2737094A1 (en) 2010-03-18
US10465180B2 (en) 2019-11-05
PL4032979T3 (pl) 2024-09-30
US20220002702A1 (en) 2022-01-06
SMT202300084T1 (it) 2023-05-12
CY2023016I1 (el) 2024-02-16
SMT201800468T1 (it) 2018-11-09
CY2023016I2 (el) 2024-02-16
US20210238573A1 (en) 2021-08-05
NO2025007I1 (no) 2025-01-21
FR24C1041I1 (fr) 2024-12-06

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