DK3581650T3 - Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf - Google Patents
Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf Download PDFInfo
- Publication number
- DK3581650T3 DK3581650T3 DK19174517.3T DK19174517T DK3581650T3 DK 3581650 T3 DK3581650 T3 DK 3581650T3 DK 19174517 T DK19174517 T DK 19174517T DK 3581650 T3 DK3581650 T3 DK 3581650T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor
- procedure
- manufacture
- polypeptide mutant
- mutant
- Prior art date
Links
- 229960004222 factor ix Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO2008A000564A IT1394177B1 (it) | 2008-09-15 | 2008-09-15 | Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione |
| ITBO2009A000275A IT1395980B1 (it) | 2009-05-06 | 2009-05-06 | Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione |
| EP17175191.0A EP3252157A1 (en) | 2008-09-15 | 2009-09-15 | Factor ix polypeptide mutant, its uses and a method for its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3581650T3 true DK3581650T3 (da) | 2023-03-13 |
Family
ID=41397565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19174517.3T DK3581650T3 (da) | 2008-09-15 | 2009-09-15 | Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf |
| DK09748260.8T DK2337849T3 (da) | 2008-09-15 | 2009-09-15 | Faktor ix-polypeptidmutant, anvendelser deraf og fremgangsmåde til fremstiling deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09748260.8T DK2337849T3 (da) | 2008-09-15 | 2009-09-15 | Faktor ix-polypeptidmutant, anvendelser deraf og fremgangsmåde til fremstiling deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (13) | US9249405B2 (da) |
| EP (5) | EP3581650B1 (da) |
| CA (1) | CA2737094C (da) |
| CY (2) | CY1125885T1 (da) |
| DK (2) | DK3581650T3 (da) |
| ES (3) | ES2985035T3 (da) |
| FI (5) | FI3581650T3 (da) |
| FR (4) | FR23C1028I1 (da) |
| HK (1) | HK1244507A1 (da) |
| HR (2) | HRP20181442T1 (da) |
| HU (6) | HUE067487T2 (da) |
| LT (5) | LT3581650T (da) |
| NO (2) | NO2023029I1 (da) |
| PL (3) | PL2337849T3 (da) |
| PT (1) | PT3581650T (da) |
| SI (1) | SI3581650T1 (da) |
| SM (2) | SMT202300084T1 (da) |
| TR (1) | TR201813067T4 (da) |
| WO (1) | WO2010029178A1 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE067487T2 (hu) | 2008-09-15 | 2024-10-28 | Uniqure Biopharma B V | IX-es faktor polipeptid mutánsa, alkalmazásai és eljárás az elõállítására |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| AU2013293573B2 (en) | 2012-07-25 | 2016-10-27 | Catalyst Biosciences, Inc. | Modified Factor X polypeptides and uses thereof |
| LT2956477T (lt) | 2013-02-15 | 2021-02-10 | Bioverativ Therapeutics Inc. | Optimizuotas faktoriaus viii genas |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| PT3313991T (pt) | 2015-06-23 | 2024-09-27 | Childrens Hospital Philadelphia | Fator ix modificado e composições, métodos e utilizações para transferência de genes para células, órgãos e tecidos |
| PL3411478T3 (pl) | 2016-02-01 | 2022-10-03 | Bioverativ Therapeutics Inc. | Geny zoptymalizowanego czynnika VIII |
| IL263801B2 (en) | 2016-07-26 | 2024-01-01 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| CN106497949A (zh) * | 2016-10-14 | 2017-03-15 | 上海交通大学医学院附属瑞金医院 | 一种高活性凝血因子ix突变体、重组蛋白与融合蛋白的制备与应用 |
| KR102386890B1 (ko) | 2017-05-22 | 2022-04-15 | 다케다 야쿠힌 고교 가부시키가이샤 | B형 혈우병 유전자 요법을 위한 증가된 발현을 가지는 재조합 fix 변이체를 암호화하는 바이러스 벡터 |
| JP7764129B2 (ja) | 2017-07-10 | 2025-11-05 | ユニキュアー アイピー ビー.ブイ. | ヒトにおけるaav遺伝子療法のための手段及び方法 |
| US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
| WO2019217513A2 (en) | 2018-05-09 | 2019-11-14 | Biomarin Pharmaceutical Inc. | Methods of treating phenylketonuria |
| EP3794112A1 (en) | 2018-05-14 | 2021-03-24 | BioMarin Pharmaceutical Inc. | Stable expression of aav vectors in juvenile subjects |
| TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| SG11202101560QA (en) * | 2018-08-20 | 2021-03-30 | Ucl Business Ltd | Factor ix encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| UY38389A (es) * | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| BR112021007301A2 (pt) | 2018-10-18 | 2021-07-27 | Intellia Therapeutics, Inc. | composições e métodos para expressar fator ix |
| CN115279896A (zh) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | 慢病毒载体配制品 |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| MX2023000156A (es) | 2020-06-24 | 2023-02-16 | Bioverativ Therapeutics Inc | Metodos para la eliminacion de factor viii libre de preparaciones de vectores lentivirales modificados para expresar dicha proteina. |
| EP4362971A1 (en) * | 2021-07-01 | 2024-05-08 | CSL Behring Lengnau AG | Factor ix subcutaneous administration with enhanced safety |
| WO2025022005A1 (en) * | 2023-07-26 | 2025-01-30 | Le Quellec Sandra | Intranasal administration of factor ix polypeptides |
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| HUE067487T2 (hu) | 2008-09-15 | 2024-10-28 | Uniqure Biopharma B V | IX-es faktor polipeptid mutánsa, alkalmazásai és eljárás az elõállítására |
| ES2524974T3 (es) | 2009-06-25 | 2014-12-16 | The University Of North Carolina At Chapel Hill | Moléculas del Factor VII quimérico |
| CA2769258A1 (en) | 2009-07-31 | 2011-02-03 | Bayer Healthcare Llc | Modified factor ix polypeptides and uses thereof |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| US10398787B2 (en) | 2012-10-26 | 2019-09-03 | Vrije Universiteit Brussel | Vectors for liver-directed gene therapy of hemophilia and methods and use thereof |
| EP2881463A1 (en) | 2013-12-09 | 2015-06-10 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| JP6879486B2 (ja) | 2015-03-17 | 2021-06-02 | フリーイェ・ユニヴェルシテイト・ブリュッセルVrije Universieit Brussel | Fviiiおよびfix用の最適化された肝臓特異的発現系 |
| US10058624B2 (en) | 2015-04-16 | 2018-08-28 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
| PT3313991T (pt) | 2015-06-23 | 2024-09-27 | Childrens Hospital Philadelphia | Fator ix modificado e composições, métodos e utilizações para transferência de genes para células, órgãos e tecidos |
| MX2018001497A (es) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Proteinas de fusion de factor ix y metodos para producirlas y usarlas. |
| AU2017248659B2 (en) | 2016-04-15 | 2022-08-11 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating hemophilia A |
| WO2017180861A1 (en) | 2016-04-15 | 2017-10-19 | The Trustees Of The University Of Pennsulvania | Gene therapy for treating hemophilia b |
| JP7764129B2 (ja) | 2017-07-10 | 2025-11-05 | ユニキュアー アイピー ビー.ブイ. | ヒトにおけるaav遺伝子療法のための手段及び方法 |
| US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
-
2009
- 2009-09-15 HU HUE21200005A patent/HUE067487T2/hu unknown
- 2009-09-15 US US13/063,898 patent/US9249405B2/en not_active Ceased
- 2009-09-15 SI SI200932179T patent/SI3581650T1/sl unknown
- 2009-09-15 EP EP19174517.3A patent/EP3581650B1/en active Active
- 2009-09-15 DK DK19174517.3T patent/DK3581650T3/da active
- 2009-09-15 HR HRP20181442TT patent/HRP20181442T1/hr unknown
- 2009-09-15 EP EP17175191.0A patent/EP3252157A1/en not_active Ceased
- 2009-09-15 EP EP22214327.3A patent/EP4219547A3/en active Pending
- 2009-09-15 HR HRP20230259TT patent/HRP20230259T1/hr unknown
- 2009-09-15 SM SM20230084T patent/SMT202300084T1/it unknown
- 2009-09-15 PT PT191745173T patent/PT3581650T/pt unknown
- 2009-09-15 PL PL09748260T patent/PL2337849T3/pl unknown
- 2009-09-15 US US18/153,894 patent/USRE50288E1/en active Active
- 2009-09-15 HU HUE19174517A patent/HUE061345T2/hu unknown
- 2009-09-15 ES ES21200005T patent/ES2985035T3/es active Active
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