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DK3581650T3 - Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf - Google Patents

Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK3581650T3
DK3581650T3 DK19174517.3T DK19174517T DK3581650T3 DK 3581650 T3 DK3581650 T3 DK 3581650T3 DK 19174517 T DK19174517 T DK 19174517T DK 3581650 T3 DK3581650 T3 DK 3581650T3
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DK
Denmark
Prior art keywords
factor
procedure
manufacture
polypeptide mutant
mutant
Prior art date
Application number
DK19174517.3T
Other languages
English (en)
Inventor
Paolo Simioni
Original Assignee
Uniqure Biopharma B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41397565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3581650(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ITBO2008A000564A external-priority patent/IT1394177B1/it
Priority claimed from ITBO2009A000275A external-priority patent/IT1395980B1/it
Application filed by Uniqure Biopharma B V filed Critical Uniqure Biopharma B V
Application granted granted Critical
Publication of DK3581650T3 publication Critical patent/DK3581650T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/644Coagulation factor IXa (3.4.21.22)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21022Coagulation factor IXa (3.4.21.22)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK19174517.3T 2008-09-15 2009-09-15 Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf DK3581650T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITBO2008A000564A IT1394177B1 (it) 2008-09-15 2008-09-15 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
ITBO2009A000275A IT1395980B1 (it) 2009-05-06 2009-05-06 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
EP17175191.0A EP3252157A1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production

Publications (1)

Publication Number Publication Date
DK3581650T3 true DK3581650T3 (da) 2023-03-13

Family

ID=41397565

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19174517.3T DK3581650T3 (da) 2008-09-15 2009-09-15 Faktor ix polypeptidmutant, anvendelse deraf og en fremgangsmåde til fremstilling deraf
DK09748260.8T DK2337849T3 (da) 2008-09-15 2009-09-15 Faktor ix-polypeptidmutant, anvendelser deraf og fremgangsmåde til fremstiling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09748260.8T DK2337849T3 (da) 2008-09-15 2009-09-15 Faktor ix-polypeptidmutant, anvendelser deraf og fremgangsmåde til fremstiling deraf

Country Status (19)

Country Link
US (13) US9249405B2 (da)
EP (5) EP3581650B1 (da)
CA (1) CA2737094C (da)
CY (2) CY1125885T1 (da)
DK (2) DK3581650T3 (da)
ES (3) ES2985035T3 (da)
FI (5) FI3581650T3 (da)
FR (4) FR23C1028I1 (da)
HK (1) HK1244507A1 (da)
HR (2) HRP20181442T1 (da)
HU (6) HUE067487T2 (da)
LT (5) LT3581650T (da)
NO (2) NO2023029I1 (da)
PL (3) PL2337849T3 (da)
PT (1) PT3581650T (da)
SI (1) SI3581650T1 (da)
SM (2) SMT202300084T1 (da)
TR (1) TR201813067T4 (da)
WO (1) WO2010029178A1 (da)

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Also Published As

Publication number Publication date
HUE061345T2 (hu) 2023-06-28
FI3581650T3 (fi) 2023-03-23
HUS2400036I1 (hu) 2024-11-28
US20220002702A1 (en) 2022-01-06
TR201813067T4 (tr) 2018-09-21
EP3581650B1 (en) 2022-12-28
FR23C1028I1 (fr) 2023-10-06
HUS2500006I1 (hu) 2025-02-28
HK1244507A1 (en) 2018-08-10
US20220090042A1 (en) 2022-03-24
EP3581650A2 (en) 2019-12-18
ES2985035T3 (es) 2024-11-04
PT3581650T (pt) 2023-03-08
HUS2400037I1 (hu) 2024-11-28
PL2337849T3 (pl) 2018-11-30
FR24C1040I1 (fr) 2024-12-06
LTPA2024530I1 (da) 2024-11-25
SMT202300084T1 (it) 2023-05-12
LTPA2025503I1 (da) 2025-02-10
EP4219547A3 (en) 2023-10-18
EP4032979B1 (en) 2024-05-01
US20200231958A1 (en) 2020-07-23
US20210214704A1 (en) 2021-07-15
HUE067487T2 (hu) 2024-10-28
EP3581650A3 (en) 2020-03-25
FR24C1041I1 (fr) 2024-12-06
US20180258413A1 (en) 2018-09-13
HRP20181442T1 (hr) 2018-12-14
CY2023016I1 (el) 2024-02-16
CA2737094C (en) 2018-02-20
CA2737094A1 (en) 2010-03-18
EP3252157A1 (en) 2017-12-06
EP2337849A1 (en) 2011-06-29
SI3581650T1 (sl) 2023-06-30
EP2337849B1 (en) 2018-06-13
EP4219547A2 (en) 2023-08-02
US10465180B2 (en) 2019-11-05
HRP20230259T1 (hr) 2023-04-28
PL3581650T3 (pl) 2023-05-22
ES2687038T3 (es) 2018-10-23
EP4032979C0 (en) 2024-05-01
CY1125885T1 (el) 2024-02-16
EP4032979A1 (en) 2022-07-27
CY2023016I2 (el) 2024-02-16
US20110244550A1 (en) 2011-10-06
NO2023029I1 (no) 2023-07-31
FIC20230026I1 (fi) 2023-07-25
FIC20250007I1 (fi) 2025-01-22
US9982248B2 (en) 2018-05-29
US20200199564A1 (en) 2020-06-25
US9249405B2 (en) 2016-02-02
HUS2300024I1 (hu) 2023-08-28
US20200190498A1 (en) 2020-06-18
LT3581650T (lt) 2023-05-10
PL4032979T3 (pl) 2024-09-30
LTPA2023521I1 (da) 2023-08-25
SMT201800468T1 (it) 2018-11-09
USRE50288E1 (en) 2025-02-04
CA2737094F (en) 2010-03-18
US20210238573A1 (en) 2021-08-05
DK2337849T3 (da) 2018-10-01
US20250179462A1 (en) 2025-06-05
NO2025007I1 (no) 2025-01-21
FIC20240036I1 (fi) 2024-10-29
LTPA2024529I1 (da) 2024-12-10
FIC20240037I1 (fi) 2024-10-30
US20160122740A1 (en) 2016-05-05
US20170355973A1 (en) 2017-12-14
WO2010029178A1 (en) 2010-03-18
FR25C1004I1 (fr) 2025-02-28
ES2940323T3 (es) 2023-05-05

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