PT3160978T - Profármacos de gemcitabina - Google Patents

Profármacos de gemcitabina

Info

Publication number: PT3160978T
Authority: PT; Portugal
Prior art keywords: gemcitabine prodrugs; gemcitabine; prodrugs
Prior art date: 2014-06-25

Application number

PT157334970T

Other languages

English (en)

Original Assignee

NuCana plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-06-25

Filing date

2015-06-25

Publication date

2020-08-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53499027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3160978(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-06-25 Priority claimed from GBGB1411253.6A external-priority patent/GB201411253D0/en

2015-06-25 Application filed by NuCana plc filed Critical NuCana plc

2020-08-24 Publication of PT3160978T publication Critical patent/PT3160978T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Nutrition Science (AREA)
Physiology (AREA)

PT157334970T 2014-06-25 2015-06-25 Profármacos de gemcitabina PT3160978T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN2050MU2014		2014-06-25
GBGB1411253.6A GB201411253D0 (en)	2014-06-25	2014-06-25	Prodrug

Publications (1)

Publication Number	Publication Date
PT3160978T true PT3160978T (pt)	2020-08-24

Family

ID=53499027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT157334970T PT3160978T (pt)	2014-06-25	2015-06-25	Profármacos de gemcitabina

Country Status (29)

Country	Link
US (2)	US10662213B2 (pt)
EP (2)	EP3757112B1 (pt)
JP (2)	JP6982957B2 (pt)
KR (2)	KR102407935B1 (pt)
CN (2)	CN106459129B (pt)
AU (2)	AU2015278899B2 (pt)
CA (1)	CA2945938C (pt)
CL (1)	CL2016003260A1 (pt)
CY (1)	CY1123389T1 (pt)
DK (1)	DK3160978T3 (pt)
EA (1)	EA034890B1 (pt)
ES (2)	ES2948660T3 (pt)
HR (2)	HRP20230584T1 (pt)
HU (2)	HUE053240T2 (pt)
IL (2)	IL248642B (pt)
LT (1)	LT3160978T (pt)
ME (1)	ME03817B (pt)
MX (2)	MX391758B (pt)
MY (1)	MY183198A (pt)
NZ (2)	NZ725205A (pt)
PH (1)	PH12016502553B1 (pt)
PL (1)	PL3160978T3 (pt)
PT (1)	PT3160978T (pt)
RS (1)	RS60968B1 (pt)
SG (2)	SG11201608808TA (pt)
SI (1)	SI3160978T1 (pt)
SM (1)	SMT202000564T1 (pt)
TW (2)	TWI695718B (pt)
WO (1)	WO2015198058A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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JP2016506371A (ja)	2012-11-16	2016-03-03	ユニバーシティカレッジカーディフコンサルタンツリミテッド	ヌクレオシドプロドラッグを調製する方法
SI3160978T1 (sl)	2014-06-25	2020-11-30	NuCana plc	Gemcitabin predzdravila
BR112016025787B1 (pt)	2014-06-25	2022-12-13	NuCana plc	Formulação farmacêutica compreendendo gencitabina-[fenil- (benzóxi-l-alaninil)]-fosfato, seu uso no tratamento de câncer, método de preparação e kit compreendendo a mesma
GB201417644D0 (en)	2014-10-06	2014-11-19	Nucana Biomed Ltd	Method of separating phosphate diastereoisomers
CN106543252A (zh) *	2015-09-16	2017-03-29	博瑞生物医药（苏州）股份有限公司	核苷氨基磷酸酯类前药的制备方法及其中间体
CN106543220A (zh)	2015-09-16	2017-03-29	博瑞生物医药（苏州）股份有限公司	氨基磷酸酯化合物及其制备方法和晶体
CN112156102B (zh) *	2015-09-16	2023-10-03	济南高合医疗科技有限公司	一种nuc-1031单一异构体的晶型及其制备方法
AU2015411525B2 (en)	2015-10-05	2021-08-12	NuCana plc	Combination therapy
JP6889180B2 (ja)	2015-12-11	2021-06-18	ニューカナパブリックリミテッドカンパニー	ホスフェート誘導体及びゲムシタビンプロドラッグｎｕｃ−１０３１のジアステレオ選択性合成
GB201522771D0 (en)	2015-12-23	2016-02-03	Nucana Biomed Ltd	Crystalline form of a phosphate derivative
GB201609600D0 (en) *	2016-06-01	2016-07-13	Nucuna Biomed Ltd	Cancer treatments
WO2018019188A1 (zh) *	2016-07-23	2018-02-01	博瑞生物医药（苏州）股份有限公司	核苷氨基磷酸酯类前药的多晶型及其制备方法
CN106946960A (zh) *	2017-03-29	2017-07-14	郑州泰基鸿诺医药股份有限公司	一种吉西他滨前药的晶型、制备方法、用途和药物组合物
GB201709471D0 (en)	2017-06-14	2017-07-26	Nucana Biomed Ltd	Diastereoselective synthesis of hosphate derivatives
CN110806454A (zh) *	2018-08-06	2020-02-18	江苏正大清江制药有限公司	一种盐酸吉西他滨中手性异构体的检测方法
CN110215469B (zh) *	2019-07-08	2021-11-30	绍兴市人民医院	一种治疗胆管癌的药物组合物

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US5728575A (en)	1990-02-01	1998-03-17	Emory University	Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US7462605B2 (en)	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
WO1999037753A1 (en)	1998-01-23	1999-07-29	Newbiotics, Inc.	Enzyme catalyzed therapeutic agents
AU775601B2 (en)	1999-07-22	2004-08-05	Celmed Oncology (Usa) Inc.	Enzyme catalyzed therapeutic activation
GB0317009D0 (en) *	2003-07-21	2003-08-27	Univ Cardiff	Chemical compounds
ES2606332T3 (es)	2005-01-27	2017-03-23	Erimos Pharmaceuticals Llc	Formulaciones orales para la administración de butanos catecólicos incluyendo compuestos de NDGA
CN101287472B (zh)	2005-08-15	2011-10-12	弗·哈夫曼-拉罗切有限公司	抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
CN101605529B (zh)	2006-02-09	2013-03-13	参天制药株式会社	稳定制剂及它们的制备和使用方法
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WO2010081082A2 (en)	2009-01-09	2010-07-15	University College Of Cardiff Consultants Limited	Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
TWI583692B (zh)	2009-05-20	2017-05-21	基利法瑪席特有限責任公司	核苷磷醯胺
JP2013511516A (ja)	2009-11-20	2013-04-04	クラヴィス・ファルマ・アーエスアー	ゲムシタビン誘導体の非経口製剤
CN105061534A (zh)	2010-09-22	2015-11-18	艾丽奥斯生物制药有限公司	取代的核苷酸类似物
CA2828326C (en)	2011-03-01	2019-05-07	Nucana Biomed Limited	Phosphoramidate derivatives of 5 - fluoro - 2' - deoxyuridine for use in the treatment of cancer
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JP2016506371A (ja)	2012-11-16	2016-03-03	ユニバーシティカレッジカーディフコンサルタンツリミテッド	ヌクレオシドプロドラッグを調製する方法
GB2517988A (en) *	2013-09-09	2015-03-11	Redx Pharma Ltd	Compounds
SI3043803T1 (sl)	2013-09-11	2022-09-30	Emory University	Nukleotidne in nukleozidne sestave in njihova uporaba
KR20160099090A (ko) *	2013-11-27	2016-08-19	아이데닉스 파마슈티칼스 엘엘씨	간암의 치료를 위한 뉴클레오티드
SI3160978T1 (sl)	2014-06-25	2020-11-30	NuCana plc	Gemcitabin predzdravila
BR112016025787B1 (pt)	2014-06-25	2022-12-13	NuCana plc	Formulação farmacêutica compreendendo gencitabina-[fenil- (benzóxi-l-alaninil)]-fosfato, seu uso no tratamento de câncer, método de preparação e kit compreendendo a mesma
EP3172218B1 (en)	2014-07-22	2020-10-21	NuCana plc	Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
GB201417644D0 (en)	2014-10-06	2014-11-19	Nucana Biomed Ltd	Method of separating phosphate diastereoisomers
DK3197456T3 (en)	2015-05-14	2018-06-06	NuCana plc	CANCER TREATMENTS
AU2015411525B2 (en)	2015-10-05	2021-08-12	NuCana plc	Combination therapy
JP6889180B2 (ja)	2015-12-11	2021-06-18	ニューカナパブリックリミテッドカンパニー	ホスフェート誘導体及びゲムシタビンプロドラッグｎｕｃ−１０３１のジアステレオ選択性合成
PT3393478T (pt)	2015-12-23	2020-03-24	NuCana plc	Terapia combinada
GB201522771D0 (en)	2015-12-23	2016-02-03	Nucana Biomed Ltd	Crystalline form of a phosphate derivative
WO2017109444A1 (en)	2015-12-23	2017-06-29	Nucana Biomed Limited	Combination therapy

2015
- 2015-06-25 SI SI201531314T patent/SI3160978T1/sl unknown
- 2015-06-25 PL PL15733497T patent/PL3160978T3/pl unknown
- 2015-06-25 LT LTEP15733497.0T patent/LT3160978T/lt unknown
- 2015-06-25 WO PCT/GB2015/051857 patent/WO2015198058A1/en not_active Ceased
- 2015-06-25 KR KR1020167033632A patent/KR102407935B1/ko active Active
- 2015-06-25 MX MX2021001140A patent/MX391758B/es unknown
- 2015-06-25 EP EP20187951.7A patent/EP3757112B1/en active Active
- 2015-06-25 EA EA201692312A patent/EA034890B1/ru unknown
- 2015-06-25 ES ES20187951T patent/ES2948660T3/es active Active
- 2015-06-25 MX MX2016015628A patent/MX2016015628A/es unknown
- 2015-06-25 TW TW104120671A patent/TWI695718B/zh not_active IP Right Cessation
- 2015-06-25 HU HUE15733497A patent/HUE053240T2/hu unknown
- 2015-06-25 HR HRP20230584TT patent/HRP20230584T1/hr unknown
- 2015-06-25 PT PT157334970T patent/PT3160978T/pt unknown
- 2015-06-25 CN CN201580034740.XA patent/CN106459129B/zh active Active
- 2015-06-25 ME MEP-2020-171A patent/ME03817B/me unknown
- 2015-06-25 JP JP2016573536A patent/JP6982957B2/ja not_active Expired - Fee Related
- 2015-06-25 US US15/308,491 patent/US10662213B2/en active Active
- 2015-06-25 TW TW109115415A patent/TWI758728B/zh not_active IP Right Cessation
- 2015-06-25 RS RS20200953A patent/RS60968B1/sr unknown
- 2015-06-25 KR KR1020227019095A patent/KR102563040B1/ko active Active
- 2015-06-25 SM SM20200564T patent/SMT202000564T1/it unknown
- 2015-06-25 EP EP15733497.0A patent/EP3160978B1/en active Active
- 2015-06-25 NZ NZ725205A patent/NZ725205A/en unknown
- 2015-06-25 DK DK15733497.0T patent/DK3160978T3/da active
- 2015-06-25 SG SG11201608808TA patent/SG11201608808TA/en unknown
- 2015-06-25 MY MYPI2016002193A patent/MY183198A/en unknown
- 2015-06-25 ES ES15733497T patent/ES2811268T3/es active Active
- 2015-06-25 HU HUE20187951A patent/HUE062474T2/hu unknown
- 2015-06-25 SG SG10201907898SA patent/SG10201907898SA/en unknown
- 2015-06-25 NZ NZ765508A patent/NZ765508A/en unknown
- 2015-06-25 HR HRP20201264TT patent/HRP20201264T1/hr unknown
- 2015-06-25 CA CA2945938A patent/CA2945938C/en active Active
- 2015-06-25 CN CN202010140546.2A patent/CN111214480A/zh active Pending
- 2015-06-25 AU AU2015278899A patent/AU2015278899B2/en not_active Ceased
2016
- 2016-10-31 IL IL248642A patent/IL248642B/en active IP Right Grant
- 2016-12-20 CL CL2016003260A patent/CL2016003260A1/es unknown
- 2016-12-20 PH PH12016502553A patent/PH12016502553B1/en unknown
2019
- 2019-08-13 AU AU2019216626A patent/AU2019216626B2/en not_active Ceased
2020
- 2020-02-17 IL IL272724A patent/IL272724B/en active IP Right Grant
- 2020-04-22 JP JP2020076384A patent/JP6970236B2/ja not_active Expired - Fee Related
- 2020-05-04 US US16/865,527 patent/US11629164B2/en active Active
- 2020-08-10 CY CY20201100745T patent/CY1123389T1/el unknown

Also Published As

Publication number	Publication date
HRP20230584T1 (hr)	2023-09-15
MY183198A (en)	2021-02-18
IL272724A (en)	2020-04-30
US20170107246A1 (en)	2017-04-20
JP6982957B2 (ja)	2021-12-17
TWI758728B (zh)	2022-03-21
TW201613614A (en)	2016-04-16
CN106459129A (zh)	2017-02-22
EP3160978B1 (en)	2020-07-29
EA034890B1 (ru)	2020-04-02
TW202033204A (zh)	2020-09-16
EP3757112A1 (en)	2020-12-30
CN106459129B (zh)	2020-03-31
NZ765508A (en)	2023-12-22
KR20170043479A (ko)	2017-04-21
PH12016502553A1 (en)	2017-04-10
US11629164B2 (en)	2023-04-18
MX391758B (es)	2025-03-21
AU2019216626A1 (en)	2019-09-05
LT3160978T (lt)	2020-08-25
HRP20201264T1 (hr)	2021-02-05
EP3757112B1 (en)	2023-06-07
CL2016003260A1 (es)	2017-10-06
CA2945938C (en)	2023-04-18
US20200262861A1 (en)	2020-08-20
MX2016015628A (es)	2017-07-04
ES2948660T3 (es)	2023-09-15
WO2015198058A1 (en)	2015-12-30
HUE053240T2 (hu)	2021-06-28
HUE062474T2 (hu)	2023-11-28
IL272724B (en)	2021-06-30
US10662213B2 (en)	2020-05-26
IL248642B (en)	2020-03-31
SMT202000564T1 (it)	2020-11-10
PL3160978T3 (pl)	2020-11-30
NZ725205A (en)	2023-12-22
KR20220080220A (ko)	2022-06-14
ME03817B (me)	2021-04-20
AU2015278899A1 (en)	2016-11-03
EP3160978A1 (en)	2017-05-03
EP3757112C0 (en)	2023-06-07
CA2945938A1 (en)	2015-12-30
CY1123389T1 (el)	2021-12-31
AU2015278899B2 (en)	2019-07-18
SG11201608808TA (en)	2016-11-29
RS60968B1 (sr)	2020-11-30
ES2811268T3 (es)	2021-03-11
EA201692312A1 (ru)	2017-04-28
TWI695718B (zh)	2020-06-11
KR102407935B1 (ko)	2022-06-10
CN111214480A (zh)	2020-06-02
SI3160978T1 (sl)	2020-11-30
AU2019216626B2 (en)	2020-07-23
DK3160978T3 (da)	2020-08-17
IL248642A0 (en)	2017-01-31
MX2021001140A (es)	2022-04-21
KR102563040B1 (ko)	2023-08-02
JP2017519014A (ja)	2017-07-13
JP6970236B2 (ja)	2021-11-24
SG10201907898SA (en)	2019-09-27
JP2020152725A (ja)	2020-09-24
PH12016502553B1 (en)	2021-10-29

Publication	Publication Date	Title
IL248642A0 (en)	2017-01-31	Gemcitabine drug inhibitors
AU361515S (en)	2015-04-30	Dishrack
AU362944S (en)	2015-07-28	Lapboard
EP3119795A4 (en)	2018-03-14	Gemcitabine analogs
IL255516B (en)	2020-02-27	Oxabicycloheptane prodrugs
GB2541867B (en)	2021-08-04	Polytunnel arrangement
GB2545956B (en)	2018-03-07	Vibro-polishing arrangement
GB2540412B (en)	2021-07-28	Polytunnel arrangement
GB2544388B (en)	2021-06-09	Polytunnel Arrangement
ZA201604337B (en)	2017-07-26	Container-drum structural arrangement
AU5585P (en)	2015-03-05	Lanutah Mandevilla sanderi
AU5583P (en)	2015-03-05	Lanminnesota Mandevilla sanderi
AU5584P (en)	2015-03-05	Laniowa Mandevilla sanderi
AU5288P (en)	2016-11-18	FLOMANTOG Mandevilla sanderi
AU5286P (en)	2016-11-11	FLOMANWHW Mandevilla sanderi
AU5285P (en)	2016-11-11	FLOMANRER Mandevilla sanderi
AU5287P (en)	2016-11-18	FLOMANPIW Mandevilla sanderi
AU5289P (en)	2016-11-18	FLOMANFOP Mandevilla sanderi
AU2014299V (en)	2015-01-08	WonderScreen Pittosporum tenuifolium
GB201417347D0 (en)	2014-11-12	Prodrugs of delanzomib
GB201417348D0 (en)	2014-11-12	Prodrugs of lxazomib
SG10201404628TA (en)	2016-03-30	Ball-bond arrangement
GB201411253D0 (en)	2014-08-06	Prodrug
HU4401U (en)	2014-07-28	Panel-safety arrangement
GB201409826D0 (en)	2014-07-16	Project X