SI3043803T1 - Nukleotidne in nukleozidne sestave in njihova uporaba - Google Patents
Nukleotidne in nukleozidne sestave in njihova uporabaInfo
- Publication number
- SI3043803T1 SI3043803T1 SI201431976T SI201431976T SI3043803T1 SI 3043803 T1 SI3043803 T1 SI 3043803T1 SI 201431976 T SI201431976 T SI 201431976T SI 201431976 T SI201431976 T SI 201431976T SI 3043803 T1 SI3043803 T1 SI 3043803T1
- Authority
- SI
- Slovenia
- Prior art keywords
- nucleotide
- nucleoside compositions
- nucleoside
- compositions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361876473P | 2013-09-11 | 2013-09-11 | |
| US201461923317P | 2014-01-03 | 2014-01-03 | |
| US201461986577P | 2014-04-30 | 2014-04-30 | |
| EP14844012.6A EP3043803B1 (en) | 2013-09-11 | 2014-09-10 | Nucleotide and nucleoside compositions and their uses |
| PCT/US2014/054930 WO2015038596A1 (en) | 2013-09-11 | 2014-09-10 | Nucleotide and nucleoside compositions and uses related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3043803T1 true SI3043803T1 (sl) | 2022-09-30 |
Family
ID=52666219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431976T SI3043803T1 (sl) | 2013-09-11 | 2014-09-10 | Nukleotidne in nukleozidne sestave in njihova uporaba |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10149859B2 (sl) |
| EP (2) | EP4094767A1 (sl) |
| JP (4) | JP6762873B2 (sl) |
| DK (1) | DK3043803T3 (sl) |
| ES (1) | ES2927955T3 (sl) |
| HR (1) | HRP20220911T1 (sl) |
| LT (1) | LT3043803T (sl) |
| PL (1) | PL3043803T3 (sl) |
| SI (1) | SI3043803T1 (sl) |
| TW (1) | TW201542581A (sl) |
| UY (1) | UY35732A (sl) |
| WO (1) | WO2015038596A1 (sl) |
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|---|---|---|---|---|
| US9676797B2 (en) | 2015-09-02 | 2017-06-13 | Abbvie Inc. | Anti-viral compounds |
| MX2014014323A (es) | 2012-05-25 | 2015-02-12 | Janssen R & D Ireland | Nucleosidos de espirooxetano de uracilo. |
| CN104903339A (zh) | 2012-11-16 | 2015-09-09 | 卡迪夫大学学院顾问有限公司 | 用于制备核苷前体药物的方法 |
| PL3043803T3 (pl) | 2013-09-11 | 2022-11-07 | Emory University | Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie |
| CN106573011A (zh) * | 2014-06-24 | 2017-04-19 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸和其类似物 |
| US9603863B2 (en) | 2014-06-24 | 2017-03-28 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| PL3160978T3 (pl) | 2014-06-25 | 2020-11-30 | NuCana plc | Proleki gemcytabiny |
| EP3683225A1 (en) * | 2014-11-28 | 2020-07-22 | Nucana PLC | New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds |
| CN107428792B (zh) * | 2014-12-15 | 2023-01-24 | 埃默里大学 | 用于治疗乙型肝炎病毒的磷酰胺 |
| SG11201705069YA (en) | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| MY190867A (en) | 2015-03-06 | 2022-05-13 | Atea Pharmaceuticals Inc | ? -d-2'-deoxy-2'-?-fluoro-2'- ? -c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| CN106674297A (zh) * | 2015-11-11 | 2017-05-17 | 中国科学院生态环境研究中心 | 具有抗癌活性的新型krn7000类似物及合成方法 |
| US20190085013A1 (en) * | 2016-03-07 | 2019-03-21 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| AU2017319260B2 (en) | 2016-08-31 | 2020-01-30 | Fujifilm Corporation | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit |
| PL3512863T3 (pl) | 2016-09-07 | 2022-04-04 | Atea Pharmaceuticals, Inc. | 2'-Podstawione-N6-podstawione nukleotydy purynowe do leczenia zakażeń wirusem RNA |
| US11643432B2 (en) * | 2016-12-16 | 2023-05-09 | National University Corporation Tokai National Higher Education And Research System | Nucleoside derivative and use thereof |
| IL295609B2 (en) | 2017-02-01 | 2023-11-01 | Atea Pharmaceuticals Inc | Nucleotide hemisulfate salt for the treatment of hepatitis C virus |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| US10688112B2 (en) | 2017-07-13 | 2020-06-23 | Emory University | Lipid disulfide prodrugs and uses related thereto |
| CA3080896A1 (en) | 2017-10-31 | 2019-05-09 | Yamasa Corporation | Nucleoside derivative and use thereof |
| GB201720279D0 (en) | 2017-12-05 | 2018-01-17 | Nucana Biomed Ltd | Anticancer compounds |
| PL3706762T3 (pl) | 2017-12-07 | 2025-02-10 | Emory University | N4-hydroksycytydyna i pochodne oraz związane z nimi zastosowania przeciwwirusowe |
| MX2020006864A (es) * | 2017-12-27 | 2020-11-11 | Univ Emory | Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides. |
| US11597745B2 (en) | 2018-03-09 | 2023-03-07 | Japan Science And Technology Agency | β-modified phosphoric acid compound precursor, β-modified phosphoric acid compound, reaction inhibitor and medicine containing the same, and method for inhibiting reaction |
| CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
| CN110655546B (zh) * | 2018-12-18 | 2023-05-16 | 安徽贝克制药股份有限公司 | 索非布韦衍生物及其制备方法和应用 |
| CN109503688A (zh) * | 2018-12-21 | 2019-03-22 | 佛山科学技术学院 | 具有抑制病毒复制活性的核苷磷酸长链酯类似物、制备方法及其药物用途 |
| CN113710680B (zh) * | 2019-04-05 | 2025-01-24 | 株式会社日本触媒 | 交联型人工核苷的制备 |
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| CN110204584B (zh) * | 2019-06-17 | 2022-09-09 | 大连大学 | 一种4-s-2’,3’,5’-o-三乙酰基尿苷合成方法 |
| AU2020334152A1 (en) | 2019-08-22 | 2022-03-24 | Emory University | Nucleoside prodrugs and uses related thereto |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AR121356A1 (es) | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| KR102145197B1 (ko) * | 2020-03-10 | 2020-08-18 | 부광약품 주식회사 | 코로나바이러스를 치료하기 위한 l-뉴클레오사이드의 용도 |
| AR121620A1 (es) | 2020-03-20 | 2022-06-22 | Gilead Sciences Inc | Profármacos de nucleósidos 4-c-sustituidos-2-halo-2-deoxiadenosina y métodos de preparación y uso de los mismos |
| WO2022081823A1 (en) * | 2020-10-14 | 2022-04-21 | Temple University -Of The Commonwealth System Of Higher Education | Pharmacologic approach for suppression of coronaviruses |
| CN112778356B (zh) * | 2020-12-26 | 2022-07-01 | 山东日兴新材料股份有限公司 | 一种三(三溴新戊基)磷酸酯阻燃剂的一锅法合成工艺 |
| CN112661802B (zh) * | 2021-01-25 | 2022-05-13 | 阿里生物新材料（常州）有限公司 | 一种3′-甲氧基鸟苷的合成方法 |
| TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體－免疫賦活化劑共軛物之新穎製造方法 |
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| CN113735927B (zh) * | 2021-10-18 | 2024-06-28 | 厦门蔚扬药业有限公司 | 一种核苷酸类似物及其制备方法和用途 |
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-
2014
- 2014-09-10 PL PL14844012.6T patent/PL3043803T3/pl unknown
- 2014-09-10 SI SI201431976T patent/SI3043803T1/sl unknown
- 2014-09-10 DK DK14844012.6T patent/DK3043803T3/da active
- 2014-09-10 ES ES14844012T patent/ES2927955T3/es active Active
- 2014-09-10 TW TW103131136A patent/TW201542581A/zh unknown
- 2014-09-10 LT LTEPPCT/US2014/054930T patent/LT3043803T/lt unknown
- 2014-09-10 EP EP22170131.1A patent/EP4094767A1/en active Pending
- 2014-09-10 US US14/917,681 patent/US10149859B2/en active Active
- 2014-09-10 WO PCT/US2014/054930 patent/WO2015038596A1/en not_active Ceased
- 2014-09-10 HR HRP20220911TT patent/HRP20220911T1/hr unknown
- 2014-09-10 EP EP14844012.6A patent/EP3043803B1/en active Active
- 2014-09-10 JP JP2016542060A patent/JP6762873B2/ja active Active
- 2014-09-11 UY UY0001035732A patent/UY35732A/es active IP Right Grant
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2018
- 2018-11-21 US US16/198,240 patent/US11166973B2/en active Active
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2020
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2021
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2022
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Also Published As
| Publication number | Publication date |
|---|---|
| TW201542581A (zh) | 2015-11-16 |
| JP2024123107A (ja) | 2024-09-10 |
| EP3043803A1 (en) | 2016-07-20 |
| JP2020143073A (ja) | 2020-09-10 |
| JP7508501B2 (ja) | 2024-07-01 |
| US11166973B2 (en) | 2021-11-09 |
| PL3043803T3 (pl) | 2022-11-07 |
| JP7045411B2 (ja) | 2022-03-31 |
| EP4094767A1 (en) | 2022-11-30 |
| JP6762873B2 (ja) | 2020-09-30 |
| US20220296626A1 (en) | 2022-09-22 |
| DK3043803T3 (da) | 2022-08-01 |
| US12414961B2 (en) | 2025-09-16 |
| HRP20220911T1 (hr) | 2022-10-28 |
| WO2015038596A1 (en) | 2015-03-19 |
| EP3043803B1 (en) | 2022-04-27 |
| JP2016530313A (ja) | 2016-09-29 |
| US20190298750A1 (en) | 2019-10-03 |
| LT3043803T (lt) | 2022-08-10 |
| ES2927955T3 (es) | 2022-11-14 |
| US11857560B2 (en) | 2024-01-02 |
| US20160220595A1 (en) | 2016-08-04 |
| JP2022081641A (ja) | 2022-05-31 |
| EP3043803A4 (en) | 2017-03-29 |
| US10149859B2 (en) | 2018-12-11 |
| UY35732A (es) | 2015-06-30 |
| US20240173345A1 (en) | 2024-05-30 |
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