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CL2016003260A1 - Profármacos de gemcitabina - Google Patents

Profármacos de gemcitabina

Info

Publication number
CL2016003260A1
CL2016003260A1 CL2016003260A CL2016003260A CL2016003260A1 CL 2016003260 A1 CL2016003260 A1 CL 2016003260A1 CL 2016003260 A CL2016003260 A CL 2016003260A CL 2016003260 A CL2016003260 A CL 2016003260A CL 2016003260 A1 CL2016003260 A1 CL 2016003260A1
Authority
CL
Chile
Prior art keywords
gemcitabine
gemcitabine prodrugs
prodrugs
alaninyl
benzoxy
Prior art date
Application number
CL2016003260A
Other languages
English (en)
Inventor
Hugh Griffith
Christopher Mcguigan
Magdalena Slusarczyk
Michaela Serpi
Valentina Ferrari
Original Assignee
Nucana Biomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53499027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016003260(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1411253.6A external-priority patent/GB201411253D0/en
Application filed by Nucana Biomed Ltd filed Critical Nucana Biomed Ltd
Publication of CL2016003260A1 publication Critical patent/CL2016003260A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

<p>Gemcitabina-[fenil(benzoxi-L-alaninil)]-(S/R)-fosfato; formulación farmaceutica y uso en el tratamiento del cancer.</p>
CL2016003260A 2014-06-25 2016-12-20 Profármacos de gemcitabina CL2016003260A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1411253.6A GB201411253D0 (en) 2014-06-25 2014-06-25 Prodrug
IN2050MU2014 2014-06-25

Publications (1)

Publication Number Publication Date
CL2016003260A1 true CL2016003260A1 (es) 2017-10-06

Family

ID=53499027

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003260A CL2016003260A1 (es) 2014-06-25 2016-12-20 Profármacos de gemcitabina

Country Status (29)

Country Link
US (2) US10662213B2 (es)
EP (2) EP3160978B1 (es)
JP (2) JP6982957B2 (es)
KR (2) KR102407935B1 (es)
CN (2) CN106459129B (es)
AU (2) AU2015278899B2 (es)
CA (1) CA2945938C (es)
CL (1) CL2016003260A1 (es)
CY (1) CY1123389T1 (es)
DK (1) DK3160978T3 (es)
EA (1) EA034890B1 (es)
ES (2) ES2811268T3 (es)
HR (2) HRP20230584T1 (es)
HU (2) HUE053240T2 (es)
IL (2) IL248642B (es)
LT (1) LT3160978T (es)
ME (1) ME03817B (es)
MX (2) MX2016015628A (es)
MY (1) MY183198A (es)
NZ (2) NZ725205A (es)
PH (1) PH12016502553B1 (es)
PL (1) PL3160978T3 (es)
PT (1) PT3160978T (es)
RS (1) RS60968B1 (es)
SG (2) SG11201608808TA (es)
SI (1) SI3160978T1 (es)
SM (1) SMT202000564T1 (es)
TW (2) TWI695718B (es)
WO (1) WO2015198058A1 (es)

Families Citing this family (16)

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RS58849B1 (sr) 2012-11-16 2019-07-31 Univ College Cardiff Consultants Ltd Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata
HRP20230584T1 (hr) 2014-06-25 2023-09-15 NuCana plc Prolijekovi gemcitabina
US10117888B2 (en) 2014-06-25 2018-11-06 NuCana plc Formulation comprising a gemcitabine-prodrug
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN106543252A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
CN106543220A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN106539810B (zh) * 2015-09-16 2021-03-09 济南高合医疗科技有限公司 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途
KR20180063075A (ko) 2015-10-05 2018-06-11 뉴카나 피엘씨 조합 요법
CN108779136B (zh) 2015-12-11 2022-07-08 努卡那有限公司 磷酸酯衍生物和吉西他滨前药nuc-1031的非对映选择性合成
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
WO2018019188A1 (zh) * 2016-07-23 2018-02-01 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法
CN106946960A (zh) * 2017-03-29 2017-07-14 郑州泰基鸿诺医药股份有限公司 一种吉西他滨前药的晶型、制备方法、用途和药物组合物
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
CN110806454A (zh) * 2018-08-06 2020-02-18 江苏正大清江制药有限公司 一种盐酸吉西他滨中手性异构体的检测方法
CN110215469B (zh) * 2019-07-08 2021-11-30 绍兴市人民医院 一种治疗胆管癌的药物组合物

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US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
WO1999037753A1 (en) 1998-01-23 1999-07-29 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
MXPA02000763A (es) 1999-07-22 2002-08-12 Newbiotics Inc Activacion terapeutica catalizada por enzima.
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
MX2007009032A (es) 2005-01-27 2008-01-16 Erimos Pharmaceuticals Llc Formulacion para inyeccion de butanos catecolicos incluyendo compuestos ndga en animales.
CA2618335C (en) 2005-08-15 2015-03-31 F.Hoffmann-La Roche Ag Antiviral phosphoramidates of 4'-substituted pronucleotides
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
GB0821994D0 (en) * 2008-12-02 2009-01-07 Ge Healthcare Ltd In viva imaging method
WO2010081082A2 (en) 2009-01-09 2010-07-15 University College Of Cardiff Consultants Limited Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
CA2778432A1 (en) 2009-11-20 2011-05-26 Clavis Pharma Asa Parenteral formulations of gemcitabine derivatives
CN103209987B (zh) 2010-09-22 2017-06-06 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
PT3447061T (pt) 2011-03-01 2021-12-23 NuCana plc Formulação farmacêutica que compreende um derivado de fosforamidato de 5-fluoro-2¿-desoxiuridina para utilização no tratamento de cancro
JP5933033B2 (ja) 2012-01-20 2016-06-08 アラタナ セラピューティクス エン ヴェー 点眼剤組成物
RS58849B1 (sr) 2012-11-16 2019-07-31 Univ College Cardiff Consultants Ltd Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata
GB2517988A (en) * 2013-09-09 2015-03-11 Redx Pharma Ltd Compounds
PL3043803T3 (pl) 2013-09-11 2022-11-07 Emory University Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie
KR20160099090A (ko) * 2013-11-27 2016-08-19 아이데닉스 파마슈티칼스 엘엘씨 간암의 치료를 위한 뉴클레오티드
HRP20230584T1 (hr) 2014-06-25 2023-09-15 NuCana plc Prolijekovi gemcitabina
US10117888B2 (en) 2014-06-25 2018-11-06 NuCana plc Formulation comprising a gemcitabine-prodrug
WO2016012781A1 (en) 2014-07-22 2016-01-28 Nucana Biomed Limited Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
SMT201800303T1 (it) 2015-05-14 2018-07-17 NuCana plc Trattamenti per il cancro
KR20180063075A (ko) 2015-10-05 2018-06-11 뉴카나 피엘씨 조합 요법
CN108779136B (zh) 2015-12-11 2022-07-08 努卡那有限公司 磷酸酯衍生物和吉西他滨前药nuc-1031的非对映选择性合成
MX383988B (es) 2015-12-23 2025-03-14 NuCana plc Terapia de combinación.
US20190381084A1 (en) 2015-12-23 2019-12-19 Nucana Biomed Limited Combination therapy
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative

Also Published As

Publication number Publication date
PT3160978T (pt) 2020-08-24
WO2015198058A1 (en) 2015-12-30
MX2021001140A (es) 2022-04-21
EP3160978A1 (en) 2017-05-03
IL272724A (en) 2020-04-30
RS60968B1 (sr) 2020-11-30
EA201692312A1 (ru) 2017-04-28
SG10201907898SA (en) 2019-09-27
ES2948660T3 (es) 2023-09-15
KR102407935B1 (ko) 2022-06-10
HRP20230584T1 (hr) 2023-09-15
KR20170043479A (ko) 2017-04-21
EP3757112A1 (en) 2020-12-30
AU2019216626B2 (en) 2020-07-23
PH12016502553B1 (en) 2021-10-29
US20200262861A1 (en) 2020-08-20
US10662213B2 (en) 2020-05-26
SMT202000564T1 (it) 2020-11-10
CN111214480A (zh) 2020-06-02
LT3160978T (lt) 2020-08-25
DK3160978T3 (da) 2020-08-17
JP2020152725A (ja) 2020-09-24
SI3160978T1 (sl) 2020-11-30
TWI758728B (zh) 2022-03-21
KR102563040B1 (ko) 2023-08-02
CA2945938A1 (en) 2015-12-30
SG11201608808TA (en) 2016-11-29
ES2811268T3 (es) 2021-03-11
HUE053240T2 (hu) 2021-06-28
TW201613614A (en) 2016-04-16
JP6970236B2 (ja) 2021-11-24
MX391758B (es) 2025-03-21
US11629164B2 (en) 2023-04-18
AU2019216626A1 (en) 2019-09-05
EP3757112C0 (en) 2023-06-07
EP3757112B1 (en) 2023-06-07
TWI695718B (zh) 2020-06-11
US20170107246A1 (en) 2017-04-20
HRP20201264T1 (hr) 2021-02-05
AU2015278899B2 (en) 2019-07-18
MY183198A (en) 2021-02-18
PL3160978T3 (pl) 2020-11-30
CY1123389T1 (el) 2021-12-31
IL272724B (en) 2021-06-30
AU2015278899A1 (en) 2016-11-03
IL248642A0 (en) 2017-01-31
NZ765508A (en) 2023-12-22
NZ725205A (en) 2023-12-22
JP2017519014A (ja) 2017-07-13
HUE062474T2 (hu) 2023-11-28
KR20220080220A (ko) 2022-06-14
IL248642B (en) 2020-03-31
MX2016015628A (es) 2017-07-04
ME03817B (me) 2021-04-20
JP6982957B2 (ja) 2021-12-17
CA2945938C (en) 2023-04-18
CN106459129B (zh) 2020-03-31
CN106459129A (zh) 2017-02-22
EP3160978B1 (en) 2020-07-29
PH12016502553A1 (en) 2017-04-10
EA034890B1 (ru) 2020-04-02
TW202033204A (zh) 2020-09-16

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