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PT2379115T - Produção de mono- e di-peg-il-10; e utilizações - Google Patents

Produção de mono- e di-peg-il-10; e utilizações

Info

Publication number
PT2379115T
PT2379115T PT97747943T PT09774794T PT2379115T PT 2379115 T PT2379115 T PT 2379115T PT 97747943 T PT97747943 T PT 97747943T PT 09774794 T PT09774794 T PT 09774794T PT 2379115 T PT2379115 T PT 2379115T
Authority
PT
Portugal
Prior art keywords
peg
mono
production
Prior art date
Application number
PT97747943T
Other languages
English (en)
Inventor
J Blaisdell Steven
M Cutler Collette
C Paporello Brittany
Ambrogelly Alexandre
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PT2379115T publication Critical patent/PT2379115T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyethers (AREA)
PT97747943T 2008-12-17 2009-12-15 Produção de mono- e di-peg-il-10; e utilizações PT2379115T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13842108P 2008-12-17 2008-12-17
US24518209P 2009-09-23 2009-09-23

Publications (1)

Publication Number Publication Date
PT2379115T true PT2379115T (pt) 2018-01-03

Family

ID=42224354

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97747943T PT2379115T (pt) 2008-12-17 2009-12-15 Produção de mono- e di-peg-il-10; e utilizações

Country Status (14)

Country Link
US (4) US8691205B2 (pt)
EP (2) EP2379115B1 (pt)
JP (5) JP5888980B2 (pt)
CN (2) CN103601800B (pt)
AU (1) AU2009333325B2 (pt)
CA (1) CA2745443C (pt)
DK (1) DK2379115T3 (pt)
ES (2) ES2655364T3 (pt)
HU (1) HUE037936T2 (pt)
NO (1) NO2379115T3 (pt)
PL (1) PL2379115T3 (pt)
PT (1) PT2379115T (pt)
RU (1) RU2549702C2 (pt)
WO (1) WO2010077853A2 (pt)

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WO2015031316A1 (en) * 2013-08-30 2015-03-05 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
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CN106573072A (zh) * 2014-06-02 2017-04-19 阿尔莫生物科技股份有限公司 降低血清胆固醇的方法
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Also Published As

Publication number Publication date
CN103601800B (zh) 2015-10-21
CN102256625B (zh) 2013-11-20
US8691205B2 (en) 2014-04-08
JP6349371B2 (ja) 2018-06-27
JP5888980B2 (ja) 2016-03-22
EP2379115B1 (en) 2017-10-25
RU2011129638A (ru) 2013-01-27
US20150086505A1 (en) 2015-03-26
JP2020019808A (ja) 2020-02-06
HK1190736A1 (zh) 2014-07-11
US20110250163A1 (en) 2011-10-13
US20170202923A1 (en) 2017-07-20
PL2379115T3 (pl) 2018-03-30
WO2010077853A2 (en) 2010-07-08
US10639353B2 (en) 2020-05-05
ES2655364T3 (es) 2018-02-19
CN102256625A (zh) 2011-11-23
RU2549702C2 (ru) 2015-04-27
CA2745443C (en) 2017-02-21
NO2379115T3 (pt) 2018-03-24
JP2018168160A (ja) 2018-11-01
CN103601800A (zh) 2014-02-26
WO2010077853A3 (en) 2010-09-02
AU2009333325A1 (en) 2010-07-08
AU2009333325B2 (en) 2014-07-10
US9566345B2 (en) 2017-02-14
US20160193352A1 (en) 2016-07-07
ES2957546T3 (es) 2024-01-22
EP3348281B1 (en) 2023-07-05
JP6905024B2 (ja) 2021-07-21
DK2379115T3 (da) 2018-01-29
US9259478B2 (en) 2016-02-16
JP2012512250A (ja) 2012-05-31
JP2015221817A (ja) 2015-12-10
EP3348281A1 (en) 2018-07-18
CA2745443A1 (en) 2010-07-08
EP2379115A2 (en) 2011-10-26
HK1258403A1 (en) 2019-11-08
JP2017052780A (ja) 2017-03-16
JP6791906B2 (ja) 2020-11-25
HUE037936T2 (hu) 2018-09-28

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