PT1928840E - 1h-pirazole-4-carboxamidas, a sua preparação e a sua utilização a título de inibidores de 11-betahidroxiesteróide desidrogenase - Google Patents
1h-pirazole-4-carboxamidas, a sua preparação e a sua utilização a título de inibidores de 11-betahidroxiesteróide desidrogenase Download PDFInfo
- Publication number
- PT1928840E PT1928840E PT06725326T PT06725326T PT1928840E PT 1928840 E PT1928840 E PT 1928840E PT 06725326 T PT06725326 T PT 06725326T PT 06725326 T PT06725326 T PT 06725326T PT 1928840 E PT1928840 E PT 1928840E
- Authority
- PT
- Portugal
- Prior art keywords
- carboxamides
- pyrazole
- beta
- preparation
- hydroxysteroid dehydrogenase
- Prior art date
Links
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title 1
- ZVXKYWHJBYIYNI-UHFFFAOYSA-N 1h-pyrazole-4-carboxamide Chemical class NC(=O)C=1C=NNC=1 ZVXKYWHJBYIYNI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66836705P | 2005-04-05 | 2005-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1928840E true PT1928840E (pt) | 2011-10-03 |
Family
ID=36514279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06725326T PT1928840E (pt) | 2005-04-05 | 2006-03-27 | 1h-pirazole-4-carboxamidas, a sua preparação e a sua utilização a título de inibidores de 11-betahidroxiesteróide desidrogenase |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7345058B2 (pt) |
| EP (1) | EP1928840B1 (pt) |
| JP (1) | JP4880671B2 (pt) |
| KR (1) | KR100931411B1 (pt) |
| CN (1) | CN101155783B (pt) |
| AR (1) | AR053203A1 (pt) |
| AT (1) | ATE519744T1 (pt) |
| AU (1) | AU2006232660B2 (pt) |
| BR (1) | BRPI0610459A2 (pt) |
| CA (1) | CA2602781C (pt) |
| DK (1) | DK1928840T3 (pt) |
| ES (1) | ES2369389T3 (pt) |
| IL (1) | IL186118A0 (pt) |
| MX (1) | MX2007012212A (pt) |
| NO (1) | NO20074872L (pt) |
| PL (1) | PL1928840T3 (pt) |
| PT (1) | PT1928840E (pt) |
| RU (1) | RU2381217C2 (pt) |
| TW (1) | TWI309645B (pt) |
| WO (1) | WO2006106052A1 (pt) |
| ZA (1) | ZA200708419B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1953145B1 (en) * | 2005-11-21 | 2015-11-04 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i |
| BRPI0708974A2 (pt) * | 2006-03-22 | 2011-06-21 | Hoffmann La Roche | composto, composição farmacêutica, métodos de tratamento de diabetes, obesidade ou sìndrome metabólica e uso do composto |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CA2659155A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1 |
| TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| JP5319518B2 (ja) * | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| CA2689659C (en) | 2007-05-18 | 2012-10-23 | Shionogi And Co., Ltd. | Nitrogen-containing heterocyclic derivative having 11.beta.-hydroxysteroid dehydrogenase type 1 inhibitory activity |
| JP5189165B2 (ja) | 2007-07-17 | 2013-04-24 | エフ．ホフマン−ラ ロシュ アーゲー | １１β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤 |
| FR2924931B1 (fr) * | 2007-12-12 | 2010-01-15 | Oreal | Utilisations de derives 1-°(1h-pyrazol-4-y!heterocycliques pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute ; nouveaux composes ; compositions les contenant. |
| KR20100126306A (ko) * | 2008-02-04 | 2010-12-01 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-ｔｅｒｔ-부틸-피라졸-1-일]벤조산의 신규한 결정형 |
| CN102300851A (zh) * | 2009-01-30 | 2011-12-28 | 阿斯利康(瑞典)有限公司 | 制备含羧基的吡唑酰氨基化合物597的新方法 |
| TWI531571B (zh) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| WO2013189904A1 (en) | 2012-06-20 | 2013-12-27 | F. Hoffmann-La Roche Ag | Pyranopyridone inhibitors of tankyrase |
| ES2743620T3 (es) | 2013-11-25 | 2020-02-20 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro |
| US9273254B2 (en) * | 2013-12-20 | 2016-03-01 | Ecolab Usa Inc. | Amino acetals and ketals as hydrogen sulfide and mercaptan scavengers |
| CN103772282B (zh) * | 2014-02-26 | 2015-09-23 | 上海毕得医药科技有限公司 | 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法 |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN113490496A (zh) | 2019-02-22 | 2021-10-08 | 科赛普特治疗学股份有限公司 | 一种杂芳基-酮稠合氮杂萘烷糖皮质激素受体调节剂瑞拉可兰的治疗用途 |
| KR20220113767A (ko) | 2019-12-11 | 2022-08-16 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법 |
| JP7536118B2 (ja) * | 2020-05-27 | 2024-08-19 | コーセプト セラピューティクス， インコーポレイテッド | グルココルチコイド受容体モジュレーターレラコリラントおよびｃｙｐ２ｃ８基質の併用投与 |
| CN114560811B (zh) * | 2022-03-11 | 2023-09-01 | 上海立森印迹医药技术有限公司 | 1,3,5-三取代-吡唑-4羧酸衍生物及其制备方法和应用 |
| AU2023367284A1 (en) | 2022-10-28 | 2025-05-29 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
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| ATA210876A (de) * | 1975-03-25 | 1979-01-15 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung von neuen nidrofuryl- pyrazolderivaten |
| US4620865A (en) | 1983-11-07 | 1986-11-04 | Eli Lilly And Company | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides |
| US4792565A (en) * | 1986-04-24 | 1988-12-20 | Mitsui Toatsu Chemicals, Inc. | Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds |
| JPH0768220B2 (ja) * | 1986-04-24 | 1995-07-26 | 三井東圧化学株式会社 | 新規ピラゾ−ル誘導体、その製造法およびそれらを含有する農園芸用殺菌剤 |
| IL91418A (en) * | 1988-09-01 | 1997-11-20 | Rhone Poulenc Agrochimie | (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| JP2002003410A (ja) | 2000-06-27 | 2002-01-09 | Fuji Photo Film Co Ltd | 芳香族ハロゲン化物の製造方法。 |
| WO2002044133A1 (en) | 2000-11-28 | 2002-06-06 | Pfizer Products Inc. | Preparation of sodium-hydrogen exchanger type-1 inhibitors |
| GB0107383D0 (en) | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
| CN1633428A (zh) | 2001-11-22 | 2005-06-29 | 比奥维特罗姆股份公司 | 11－β－羟基类固醇脱氢酶1型抑制剂 |
| AU2002353717B2 (en) | 2001-11-22 | 2006-08-03 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| MXPA04004779A (es) | 2001-11-22 | 2004-07-30 | Biovitrum Ab | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| EP1456181A1 (en) | 2001-12-19 | 2004-09-15 | Pfizer Products Inc. | Methods for preparing sodium-hydrogen exchanger type-1 inhibitors |
| WO2003059267A2 (en) | 2001-12-21 | 2003-07-24 | Rhode Island Hospital | SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF |
| EP1474139B1 (en) | 2002-02-01 | 2007-11-21 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| EP1482794A1 (en) | 2002-03-06 | 2004-12-08 | Merck & Co., Inc. | Method of treatment or prevention of obesity |
| AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| US7754738B2 (en) * | 2002-06-13 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Pyrazole and pyrrole carboxamide insecticides |
| BR0312957A (pt) | 2002-07-27 | 2005-06-14 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável deste, uso do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, em necessidade de tal tratamento |
| CA2501611A1 (en) | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
| EP1562574A1 (en) | 2002-11-07 | 2005-08-17 | Astrazeneca AB | 2-oxo-ethanesulfonamide derivates |
| US20040122033A1 (en) | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| WO2004089415A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST |
| EP1618090A1 (en) | 2003-04-11 | 2006-01-25 | Novo Nordisk A/S | 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| EP1615697A2 (en) | 2003-04-11 | 2006-01-18 | Novo Nordisk A/S | New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof |
| JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法 |
| AU2004240885A1 (en) | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I |
| EP1638947B1 (en) | 2003-05-29 | 2010-08-04 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 |
| SE0301883D0 (sv) | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use II |
| SE0301886D0 (sv) | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use V |
| EP1653949A4 (en) * | 2003-08-07 | 2009-04-22 | Merck & Co Inc | PYRAZOL CARBOXAMIDE AS AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 |
| WO2005037199A2 (en) * | 2003-10-10 | 2005-04-28 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
-
2006
- 2006-03-27 JP JP2008504736A patent/JP4880671B2/ja not_active Expired - Fee Related
- 2006-03-27 WO PCT/EP2006/061057 patent/WO2006106052A1/en not_active Ceased
- 2006-03-27 ES ES06725326T patent/ES2369389T3/es active Active
- 2006-03-27 EP EP06725326A patent/EP1928840B1/en not_active Not-in-force
- 2006-03-27 AT AT06725326T patent/ATE519744T1/de active
- 2006-03-27 RU RU2007140737/04A patent/RU2381217C2/ru not_active IP Right Cessation
- 2006-03-27 CN CN2006800111775A patent/CN101155783B/zh not_active Expired - Fee Related
- 2006-03-27 DK DK06725326.0T patent/DK1928840T3/da active
- 2006-03-27 PT PT06725326T patent/PT1928840E/pt unknown
- 2006-03-27 AU AU2006232660A patent/AU2006232660B2/en not_active Ceased
- 2006-03-27 PL PL06725326T patent/PL1928840T3/pl unknown
- 2006-03-27 KR KR1020077022649A patent/KR100931411B1/ko not_active Expired - Fee Related
- 2006-03-27 BR BRPI0610459-2A patent/BRPI0610459A2/pt not_active IP Right Cessation
- 2006-03-27 CA CA2602781A patent/CA2602781C/en not_active Expired - Fee Related
- 2006-03-27 MX MX2007012212A patent/MX2007012212A/es active IP Right Grant
- 2006-03-31 US US11/395,763 patent/US7345058B2/en not_active Expired - Fee Related
- 2006-04-03 TW TW095111719A patent/TWI309645B/zh not_active IP Right Cessation
- 2006-04-03 AR ARP060101312A patent/AR053203A1/es unknown
-
2007
- 2007-09-20 IL IL186118A patent/IL186118A0/en unknown
- 2007-09-25 NO NO20074872A patent/NO20074872L/no not_active Application Discontinuation
- 2007-10-02 ZA ZA200708419A patent/ZA200708419B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2602781A1 (en) | 2006-10-12 |
| ZA200708419B (en) | 2008-11-26 |
| ATE519744T1 (de) | 2011-08-15 |
| CA2602781C (en) | 2011-02-08 |
| JP2008534647A (ja) | 2008-08-28 |
| NO20074872L (no) | 2007-10-30 |
| AR053203A1 (es) | 2007-04-25 |
| IL186118A0 (en) | 2008-01-20 |
| BRPI0610459A2 (pt) | 2010-06-22 |
| EP1928840A1 (en) | 2008-06-11 |
| PL1928840T3 (pl) | 2012-01-31 |
| JP4880671B2 (ja) | 2012-02-22 |
| RU2007140737A (ru) | 2009-05-20 |
| MX2007012212A (es) | 2007-12-07 |
| WO2006106052A1 (en) | 2006-10-12 |
| DK1928840T3 (da) | 2011-09-12 |
| US20060223852A1 (en) | 2006-10-05 |
| RU2381217C2 (ru) | 2010-02-10 |
| EP1928840B1 (en) | 2011-08-10 |
| AU2006232660B2 (en) | 2010-03-25 |
| US7345058B2 (en) | 2008-03-18 |
| KR20070108937A (ko) | 2007-11-13 |
| AU2006232660A1 (en) | 2006-10-12 |
| CN101155783B (zh) | 2012-01-04 |
| TW200643013A (en) | 2006-12-16 |
| TWI309645B (en) | 2009-05-11 |
| KR100931411B1 (ko) | 2009-12-10 |
| ES2369389T3 (es) | 2011-11-30 |
| CN101155783A (zh) | 2008-04-02 |
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