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PT1380301E - Combinação farmacêutica compreendendo etinilestradiol e drospirenona para utilização como contraceptivo - Google Patents

Combinação farmacêutica compreendendo etinilestradiol e drospirenona para utilização como contraceptivo Download PDF

Info

Publication number
PT1380301E
PT1380301E PT03017743T PT03017743T PT1380301E PT 1380301 E PT1380301 E PT 1380301E PT 03017743 T PT03017743 T PT 03017743T PT 03017743 T PT03017743 T PT 03017743T PT 1380301 E PT1380301 E PT 1380301E
Authority
PT
Portugal
Prior art keywords
drospirenone
ethinylstradiol
contraceptive
combination
component composition
Prior art date
Application number
PT03017743T
Other languages
English (en)
Inventor
Jurgen Hilmann
Ralph Lipp
Wolfgang Heil
Renate Heithecker
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26153359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1380301(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PT1380301E publication Critical patent/PT1380301E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT03017743T 1999-08-31 2000-08-31 Combinação farmacêutica compreendendo etinilestradiol e drospirenona para utilização como contraceptivo PT1380301E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38627499A 1999-08-31 1999-08-31
EP99202826 1999-08-31

Publications (1)

Publication Number Publication Date
PT1380301E true PT1380301E (pt) 2009-03-30

Family

ID=26153359

Family Applications (3)

Application Number Title Priority Date Filing Date
PT03017743T PT1380301E (pt) 1999-08-31 2000-08-31 Combinação farmacêutica compreendendo etinilestradiol e drospirenona para utilização como contraceptivo
PT05076943T PT1598069E (pt) 1999-08-31 2000-08-31 Combinação farmacêutica de etinilestradiol e drospirenona para utilização como um contraceptivo
PT00953387T PT1214076E (pt) 1999-08-31 2000-08-31 Combinacao farmaceutica de etinilestradiol e drospirenona para utilizacao como um contraceptivo

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT05076943T PT1598069E (pt) 1999-08-31 2000-08-31 Combinação farmacêutica de etinilestradiol e drospirenona para utilização como um contraceptivo
PT00953387T PT1214076E (pt) 1999-08-31 2000-08-31 Combinacao farmaceutica de etinilestradiol e drospirenona para utilizacao como um contraceptivo

Country Status (26)

Country Link
EP (4) EP2044941A1 (pt)
JP (2) JP4354667B2 (pt)
KR (2) KR100857344B1 (pt)
AT (3) ATE429231T1 (pt)
AU (4) AU780330B2 (pt)
BG (1) BG66114B1 (pt)
BR (1) BR0014159A (pt)
CY (3) CY1108990T1 (pt)
CZ (1) CZ300514B6 (pt)
DE (5) DE122009000007I2 (pt)
DK (3) DK1598069T3 (pt)
EE (1) EE05128B1 (pt)
ES (3) ES2319750T3 (pt)
HK (1) HK1047247B (pt)
HR (1) HRP20070188B1 (pt)
HU (1) HU227207B1 (pt)
IL (1) IL148339A0 (pt)
ME (2) ME00329B (pt)
NO (1) NO326860B1 (pt)
NZ (1) NZ517845A (pt)
PL (1) PL199028B1 (pt)
PT (3) PT1380301E (pt)
RS (3) RS50262B2 (pt)
SI (3) SI1214076T1 (pt)
TW (1) TWI276436B (pt)
WO (1) WO2001015701A1 (pt)

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Publication number Priority date Publication date Assignee Title
ES2319750T3 (es) * 1999-08-31 2009-05-12 Bayer Schering Pharma Aktiengesellschaft Composicion farmaceutica que comprende etinilestradiol y drospirenona para usar como anticonceptivo.
EE05533B1 (et) * 2000-01-18 2012-04-16 Schering Aktiengesellschaft Farmatseutiline kompositsioon ja preparaat, mis sisaldab mikroniseeritud drospirenooni ja ”strogeeni ning nende kasutamine
JO2334B1 (en) * 2000-01-18 2006-06-28 باير شيرنغ فارما اكتنجيسيلشافت Drospirenone for hormone replacement therapy
JP5350572B2 (ja) * 2000-12-20 2013-11-27 バイエル ファーマ アクチエンゲゼルシャフト シクロデキストリン−ドロスピレノン封入複合体
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
PL372055A1 (en) * 2002-04-26 2005-07-11 Schering Aktiengesellschaft Treatment of hypertension in women receiving hormone replacement therapy
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
MY142989A (en) * 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
EP1748756B1 (en) * 2004-03-10 2009-04-29 Bayer Schering Pharma Aktiengesellschaft Compositions comprising drospirenone molecularly dispersed
MY151322A (en) * 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
EP1625849A1 (en) * 2004-08-09 2006-02-15 Liconsa, Liberacion Controlada de Sustancias Activas, S.A. Pharmaceutical composition comprising drospirenone and ethynylestradiol
EP1871363A4 (en) * 2005-03-30 2009-01-21 Genpharm Inc COMBINED STAGE PROCESS FOR PHARMACEUTICAL COMPOSITIONS
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
EP1767194A1 (de) * 2005-06-09 2007-03-28 Helm AG Verfahren zur Herstellung von Adsorbaten des Drospirenons
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CA2662956A1 (en) * 2006-09-16 2008-03-20 Bayer Schering Pharma Aktiengesellschaft Oral modified release formulations
EP1900359A1 (en) * 2006-09-16 2008-03-19 KAIROSmed GmbH Oral modified release formulations containing drospirenon and 8-prenylnaringenin for use in female contraception
MX2009010763A (es) * 2007-04-05 2009-10-28 Bayer Schering Pharma Ag NUEVO REGIMEN DE DROSPIRENONA/17ß-ESTRADIOL, PRODUCTO FARMACEUTICO COMBINADO Y CONJUNTO DE ELEMENTOS (KIT) PARA SU APLICACION.
HUP0700826A3 (en) * 2007-12-20 2010-03-29 Richter Gedeon Nyrt Coated tablet containing drospirenone and process for producing the same
TW200942242A (en) * 2008-03-10 2009-10-16 Rolf Schurmann New drospirenone/17β-estradiol regimen, pharmaceutical combination product and kit for performing this regimen
TW200946542A (en) * 2008-03-10 2009-11-16 Vladimir Hanes New drospirenone/17β-estradiol regimen, pharmaceutical combination product and kit for performing this regimen
WO2009138224A1 (en) * 2008-05-14 2009-11-19 Helm Ag Pharmaceutical composition comprising drospirenone
DE102008037025C5 (de) 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
EP2398461A1 (en) 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
MX356702B (es) * 2010-04-15 2018-06-11 Bayer Ip Gmbh Formas de dosificación sólidas orales con dosis muy bajas para la hrt.
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
IT202100008834A1 (it) 2021-04-08 2022-10-08 Ind Chimica Srl Processo per la preparazione di drospirenone come polvere fine tramite duplice cambio di forma cristallina
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DE19540253C2 (de) * 1995-10-28 1998-06-04 Jenapharm Gmbh Mehrphasenpräparat zur Kontrazeption auf der Basis natürlicher Estrogene
AU726091B2 (en) * 1996-07-26 2000-11-02 Wyeth Monophasic contraceptive method and kit comprising a combination of a progestin and estrogen
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BR9710565A (pt) * 1996-07-26 1999-08-17 American Home Prod Contraceptivo oral
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DE19651000A1 (de) 1996-12-01 1998-06-04 Schering Ag Oxyiminopregnancarbolactone
ES2319750T3 (es) * 1999-08-31 2009-05-12 Bayer Schering Pharma Aktiengesellschaft Composicion farmaceutica que comprende etinilestradiol y drospirenona para usar como anticonceptivo.
EE05533B1 (et) * 2000-01-18 2012-04-16 Schering Aktiengesellschaft Farmatseutiline kompositsioon ja preparaat, mis sisaldab mikroniseeritud drospirenooni ja ”strogeeni ning nende kasutamine

Also Published As

Publication number Publication date
DK1380301T3 (da) 2009-04-20
IL148339A0 (en) 2002-09-12
HK1047247B (en) 2004-07-23
ATE420648T1 (de) 2009-01-15
DE60041421D1 (de) 2009-03-05
WO2001015701A1 (en) 2001-03-08
NO20020801D0 (no) 2002-02-19
PT1214076E (pt) 2004-04-30
AU780330B2 (en) 2005-03-17
SI1214076T1 (en) 2004-06-30
SI1380301T1 (sl) 2009-06-30
KR20020040798A (ko) 2002-05-30
EP1214076B1 (en) 2003-11-19
AU2009200247A1 (en) 2009-02-19
BR0014159A (pt) 2002-05-07
MEP36008A (hr) 2011-02-10
ES2325589T3 (es) 2009-09-09
DE122009000006I2 (de) 2012-03-22
HU227207B1 (en) 2010-11-29
CY2009015I2 (el) 2014-02-12
ME00329B (me) 2011-05-10
DE122009000007I1 (de) 2009-05-07
HUP0202500A2 (en) 2002-10-28
TWI276436B (en) 2007-03-21
PT1598069E (pt) 2009-07-20
CZ300514B6 (cs) 2009-06-03
AU2005202046B2 (en) 2008-11-20
DE60042089D1 (de) 2009-06-04
EP1598069A3 (en) 2006-04-05
JP2003508441A (ja) 2003-03-04
EE200200110A (et) 2003-06-16
HRP20070188B1 (hr) 2015-06-19
KR101019361B1 (ko) 2011-03-07
YU14502A (sh) 2006-01-16
KR100857344B1 (ko) 2008-09-05
CZ2002615A3 (cs) 2002-08-14
NZ517845A (en) 2004-12-24
JP2009143959A (ja) 2009-07-02
PL199028B1 (pl) 2008-08-29
EP2044941A1 (en) 2009-04-08
HK1047247A1 (en) 2003-02-14
AU2009200247B2 (en) 2010-07-01
DE122009000007I2 (de) 2011-07-21
CY2009015I1 (el) 2014-02-12
CY1109252T1 (el) 2014-07-02
AU6589500A (en) 2001-03-26
DE122009000006I1 (de) 2009-05-07
RS50262B2 (sr) 2018-10-31
CY1108990T1 (el) 2014-02-12
JP4354667B2 (ja) 2009-10-28
HK1082432A1 (en) 2006-06-09
HUP0202500A3 (en) 2004-04-28
SI1598069T1 (sl) 2009-10-31
EP1380301B1 (en) 2009-01-14
NO326860B1 (no) 2009-03-02
DK1598069T3 (da) 2009-07-06
RS20090134A (sr) 2009-11-10
AU2010226924A1 (en) 2010-10-28
EP1380301A1 (en) 2004-01-14
DE60006692T2 (de) 2004-09-23
RS50262B (sr) 2009-07-15
EP1214076A1 (en) 2002-06-19
DK1214076T3 (da) 2004-02-23
KR20070067248A (ko) 2007-06-27
BG66114B1 (bg) 2011-05-31
ES2211580T3 (es) 2004-07-16
ES2319750T3 (es) 2009-05-12
EE05128B1 (et) 2009-02-16
AU2005202046A1 (en) 2005-06-09
DE60006692D1 (de) 2003-12-24
NO20020801L (no) 2002-04-26
HRP20070188A2 (en) 2007-07-31
ATE254464T1 (de) 2003-12-15
HK1061968A1 (en) 2004-10-15
EP1598069B1 (en) 2009-04-22
EP1598069A2 (en) 2005-11-23
PL354406A1 (pl) 2004-01-12
AU2005202046B9 (en) 2008-12-11
ATE429231T1 (de) 2009-05-15

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