PL378576A1 - Wytwarzanie podstawionych chinazolin - Google Patents

Wytwarzanie podstawionych chinazolin

Info

Publication number: PL378576A1
Authority: PL; Poland
Prior art keywords: preparation; substituted quinazolines; quinazolines; substituted
Prior art date: 2003-02-05

Application number

PL378576A

Other languages

English (en)

Inventor

Hubert Gangolf Klemens Barth

Alexander James Bridges

Ronald Joseph Heemstra

Nicole Marcia Horne

Robert Craig Hughes

Thomas Elliott Jacks

Dennis Joseph Mcnamara

Simon Schneider

Klaus Irenaus Steiner

Peter Laurence Toogood

Roy Thomas Winters

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-05

Filing date

2004-02-03

Publication date

2006-05-02

2004-02-03 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2006-05-02 Publication of PL378576A1 publication Critical patent/PL378576A1/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL378576A 2003-02-05 2004-02-03 Wytwarzanie podstawionych chinazolin PL378576A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44509503P	2003-02-05	2003-02-05

Publications (1)

Publication Number	Publication Date
PL378576A1 true PL378576A1 (pl)	2006-05-02

Family

ID=32850969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL378576A PL378576A1 (pl)	2003-02-05	2004-02-03	Wytwarzanie podstawionych chinazolin

Country Status (18)

Country	Link
US (1)	US20040158065A1 (pl)
EP (1)	EP1618095A2 (pl)
JP (1)	JP2006517959A (pl)
KR (1)	KR20050095916A (pl)
CN (1)	CN1745073A (pl)
AR (1)	AR043027A1 (pl)
AU (1)	AU2004209452A1 (pl)
BR (1)	BRPI0407249A (pl)
CA (1)	CA2514933A1 (pl)
MX (1)	MXPA05007831A (pl)
NL (3)	NL1025414C2 (pl)
PA (1)	PA8595201A1 (pl)
PE (1)	PE20040945A1 (pl)
PL (1)	PL378576A1 (pl)
RU (1)	RU2005122322A (pl)
TW (1)	TW200420544A (pl)
UY (1)	UY28177A1 (pl)
WO (1)	WO2004069791A2 (pl)

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MEP45508A (en) *	1999-06-21	2011-02-10	Boehringer Ingelheim Pharma	Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
US7019012B2 (en) *	2000-12-20	2006-03-28	Boehringer Ingelheim International Pharma Gmbh & Co. Kg	Quinazoline derivatives and pharmaceutical compositions containing them
NZ545459A (en) *	2003-08-14	2009-12-24	Array Biopharma Inc	Quinazoline analogs as receptor tyrosine kinase inhibitors
US7501427B2 (en) *	2003-08-14	2009-03-10	Array Biopharma, Inc.	Quinazoline analogs as receptor tyrosine kinase inhibitors
DE10349113A1 (de) *	2003-10-17	2005-05-12	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Aminocrotonylverbindungen
RS52119B (sr) *	2004-05-06	2012-08-31	Warner-Lambert Company Llc	4-fenilamino-hinazolin-6-il-amidi
KR100735639B1 (ko) *	2004-12-29	2007-07-04	한미약품 주식회사	암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
KR100832593B1 (ko) *	2005-11-08	2008-05-27	한미약품 주식회사	신호전달 저해제로서의 퀴나졸린 유도체 및 이의 제조방법
EP3173084B1 (en)	2005-11-11	2019-10-23	Boehringer Ingelheim International GmbH	Quinazoline derivatives for the treatment of cancer diseases
DE602006009968D1 (de)	2005-11-15	2009-12-03	Array Biopharma Inc	N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i-rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten
SI2068880T1 (sl) *	2006-09-18	2012-08-31	Boehringer Ingelheim Int	Postopek za zdravljenje raka, ki vsebuje mutacije EGFR
EP2190287B1 (en)	2007-09-10	2014-10-29	Curis, Inc.	Tartrate salts or complexes of quinazoline based egfr inhibitors containing a zinc binding moiety
WO2009094216A1 (en) *	2008-01-22	2009-07-30	Concert Pharmaceuticals Inc.	Derivatives of gefitinib
WO2009094210A1 (en) *	2008-01-22	2009-07-30	Concert Pharmaceuticals Inc.	Vandetanib derivatives
MX2011002484A (es) *	2008-09-05	2011-09-26	Avila Therapeutics Inc	Algoritmo para diseñar inhibidores irreversibles.
HRP20191005T1 (hr)	2009-07-06	2019-08-23	Boehringer Ingelheim International Gmbh	Postupak sušenja bibw2992, njegovih soli i čvrstih farmaceutskih formulacija koje sadrže taj djelatni sastojak
NZ620174A (en)	2009-09-16	2016-08-26	Celgene Avilomics Res Inc	Protein kinase conjugates and inhibitors
EP2519664A4 (en)	2009-12-30	2014-03-12	Avila Therapeutics Inc	LIGAND-RELATED COVALENTS MODIFYING A PROTEIN
CN102382106A (zh) *	2010-08-30	2012-03-21	黄振华	苯胺取代的喹唑啉衍生物
JP6437820B2 (ja) *	2011-07-27	2018-12-12	シャンハイファーマシューティカルズホールディングカンパニー，リミティド	キナゾリン誘導体、その製造方法、中間体、組成物及びその適用
WO2013053206A1 (en)	2011-10-12	2013-04-18	Teligene Ltd	Quinazoline derivatives as kinases inhibitors and methods of use thereof
KR20150005698A (ko)	2012-05-07	2015-01-14	텔리진 엘티디.	키나제 저해제로서 유용한 치환된 아미노퀴나졸린
CN103965120B (zh) *	2013-01-25	2016-08-17	上海医药集团股份有限公司	喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用
CN103242244B (zh) *	2013-05-16	2015-03-25	苏州明锐医药科技有限公司	一种卡奈替尼的制备方法
CN105408334B (zh)	2013-05-21	2017-10-10	江苏迈度药物研发有限公司	作为激酶抑制剂的取代的吡唑并嘧啶类化合物
US9242965B2 (en)	2013-12-31	2016-01-26	Boehringer Ingelheim International Gmbh	Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
JP7068280B2 (ja)	2016-09-23	2022-05-16	シャンハイファーマシューティカルズホールディングカンパニー，リミティド	キナゾリン誘導体の塩、その製造方法および使用
RS63124B1 (sr)	2018-03-08	2022-05-31	Incyte Corp	Aminopirazin diol jedinjenja kao pi3k-y inhibitori
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
CA3113241A1 (en)	2018-09-25	2020-04-02	Black Diamond Therapeutics, Inc.	Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
MX2021010669A (es) *	2019-03-07	2021-09-28	BioNTech SE	Proceso para la preparacion de una imidazoquinolina sustituida.
KR20220047810A (ko)	2019-08-15	2022-04-19	블랙 다이아몬드 테라퓨틱스, 인코포레이티드	알키닐 퀴나졸린 화합물
KR20220147021A (ko) *	2021-04-22	2022-11-02	보로노이 주식회사	헤테로아릴 유도체 화합물 및 이의 용도
WO2023044364A1 (en)	2021-09-15	2023-03-23	Enko Chem, Inc.	Protoporphyrinogen oxidase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA001595B1 (ru) *	1996-04-12	2001-06-25	Варнер-Ламберт Компани	Необратимые ингибиторы тирозинкиназ
US6664390B2 (en) *	2000-02-02	2003-12-16	Warner-Lambert Company Llc	Method for the simplified production of (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine or (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazoline-4-yl]-amine
DE10009267A1 (de) *	2000-02-26	2001-08-30	Goedecke Ag	Verfahren zur einfachen Herstellung von (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazolin-4-yl]-amin
US6627634B2 (en) *	2000-04-08	2003-09-30	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them
DE10063435A1 (de) *	2000-12-20	2002-07-04	Boehringer Ingelheim Pharma	Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

2004
- 2004-02-02 PE PE2004000120A patent/PE20040945A1/es not_active Application Discontinuation
- 2004-02-03 EP EP04707601A patent/EP1618095A2/en not_active Withdrawn
- 2004-02-03 AU AU2004209452A patent/AU2004209452A1/en not_active Abandoned
- 2004-02-03 MX MXPA05007831A patent/MXPA05007831A/es unknown
- 2004-02-03 KR KR1020057014036A patent/KR20050095916A/ko not_active Ceased
- 2004-02-03 RU RU2005122322/04A patent/RU2005122322A/ru not_active Application Discontinuation
- 2004-02-03 WO PCT/IB2004/000321 patent/WO2004069791A2/en not_active Ceased
- 2004-02-03 BR BR0407249-9A patent/BRPI0407249A/pt not_active IP Right Cessation
- 2004-02-03 PL PL378576A patent/PL378576A1/pl not_active Application Discontinuation
- 2004-02-03 CN CNA2004800032079A patent/CN1745073A/zh active Pending
- 2004-02-03 JP JP2006502417A patent/JP2006517959A/ja not_active Abandoned
- 2004-02-03 TW TW093102396A patent/TW200420544A/zh unknown
- 2004-02-03 CA CA002514933A patent/CA2514933A1/en not_active Abandoned
- 2004-02-04 UY UY28177A patent/UY28177A1/es not_active Application Discontinuation
- 2004-02-04 AR ARP040100350A patent/AR043027A1/es unknown
- 2004-02-04 US US10/771,774 patent/US20040158065A1/en not_active Abandoned
- 2004-02-05 PA PA20048595201A patent/PA8595201A1/es unknown
- 2004-02-05 NL NL1025414A patent/NL1025414C2/nl not_active IP Right Cessation
2005
- 2005-08-18 NL NL1029763A patent/NL1029763C2/nl not_active IP Right Cessation
- 2005-08-18 NL NL1029762A patent/NL1029762C2/nl not_active IP Right Cessation

Also Published As

Publication number	Publication date
NL1025414A1 (nl)	2004-08-06
TW200420544A (en)	2004-10-16
EP1618095A2 (en)	2006-01-25
WO2004069791A3 (en)	2004-12-16
AU2004209452A1 (en)	2004-08-19
RU2005122322A (ru)	2006-03-10
PA8595201A1 (es)	2004-09-16
CA2514933A1 (en)	2004-08-19
WO2004069791A2 (en)	2004-08-19
US20040158065A1 (en)	2004-08-12
MXPA05007831A (es)	2005-10-18
NL1029763C2 (nl)	2006-03-06
NL1029763A1 (nl)	2005-10-13
AR043027A1 (es)	2005-07-13
NL1025414C2 (nl)	2005-11-01
NL1029762A1 (nl)	2005-10-13
NL1029762C2 (nl)	2006-03-06
PE20040945A1 (es)	2004-12-14
JP2006517959A (ja)	2006-08-03
CN1745073A (zh)	2006-03-08
BRPI0407249A (pt)	2006-01-31
UY28177A1 (es)	2004-09-30
KR20050095916A (ko)	2005-10-04

Publication	Publication Date	Title
PL378576A1 (pl)	2006-05-02	Wytwarzanie podstawionych chinazolin
ZA200605348B (en)	2007-04-25	Solid forms of anti-EGFR-antibodies
GB0322409D0 (en)	2003-10-29	Quinazoline derivatives
IL174534A0 (en)	2006-08-01	Quinazoline derivatives
EP1745573A4 (en)	2010-05-26	PROCESS FOR PREPARING 2-DEOXY-BETA-L-NUCLEOSIDES
GB0321648D0 (en)	2003-10-15	Quinazoline derivatives
ZA200602264B (en)	2007-12-26	Quinazoline derivatives
IL174257A0 (en)	2006-08-01	Quinazoline derivatives
GB0421149D0 (en)	2004-10-27	Preparation of oxycodone
GB0200744D0 (en)	2002-02-27	Preparation of nanoparticles
IL174390A0 (en)	2011-08-01	Quinazoline derivatives
GB0330002D0 (en)	2004-01-28	Quinazoline derivatives
GB0326459D0 (en)	2003-12-17	Quinazoline derivatives
AU152108S (en)	2003-06-30	Set of pavers
GB0321621D0 (en)	2003-10-15	Quinazoline derivatives
GB0304555D0 (en)	2003-04-02	Compounds and methods of manufacture
AU2003298725A8 (en)	2004-06-23	Preparation of metallotexaphyrins
GB0321620D0 (en)	2003-10-15	Quinazoline derivatives
PL377902A1 (pl)	2006-02-20	Nowe zastosowanie kompleksu fosfor-azot-metal
ZA200505214B (en)	2008-08-27	Preparation of quinapril hydrochloride
IL165356A0 (en)	2006-01-15	Preparation of 4-haloalkylkylnicotinamides
GB0318915D0 (en)	2003-09-17	Construction of aerials
TW561865U (en)	2003-11-11	Improvement of curtain
TW553243U (en)	2003-09-11	Structure of clotheshanger
TW595396U (en)	2004-06-21	Structure of multi-layered pot

Legal Events

Date	Code	Title	Description
2012-06-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)