[go: up one dir, main page]

NL1029763A1 - Bereiding van gesubstitueerde chinazolinen. - Google Patents

Bereiding van gesubstitueerde chinazolinen.

Info

Publication number
NL1029763A1
NL1029763A1 NL1029763A NL1029763A NL1029763A1 NL 1029763 A1 NL1029763 A1 NL 1029763A1 NL 1029763 A NL1029763 A NL 1029763A NL 1029763 A NL1029763 A NL 1029763A NL 1029763 A1 NL1029763 A1 NL 1029763A1
Authority
NL
Netherlands
Prior art keywords
preparation
substituted quinazolines
quinazolines
substituted
Prior art date
Application number
NL1029763A
Other languages
English (en)
Other versions
NL1029763C2 (nl
Inventor
Alexander James Bridges
Ronald Joseph Heemstra
Nicole Marcia Horne
Robert Craig Hughes
Thomas Elliott Jacks
Dennis Joseph Mcnamara
Simon Schneider
Klaus Irenous Steiner
Peter Laurence Toogood
Roy Thomas Winters
Hubert Gangolf Klemens Barth
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NL1029763A1 publication Critical patent/NL1029763A1/nl
Application granted granted Critical
Publication of NL1029763C2 publication Critical patent/NL1029763C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NL1029763A 2003-02-05 2005-08-18 Bereiding van gesubstitueerde chinazolinen. NL1029763C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44509503P 2003-02-05 2003-02-05
US44509503 2003-02-05

Publications (2)

Publication Number Publication Date
NL1029763A1 true NL1029763A1 (nl) 2005-10-13
NL1029763C2 NL1029763C2 (nl) 2006-03-06

Family

ID=32850969

Family Applications (3)

Application Number Title Priority Date Filing Date
NL1025414A NL1025414C2 (nl) 2003-02-05 2004-02-05 Bereiding van gesubstitueerde chinazolinen.
NL1029762A NL1029762C2 (nl) 2003-02-05 2005-08-18 Bereiding van gesubstitueerde chinazolinen.
NL1029763A NL1029763C2 (nl) 2003-02-05 2005-08-18 Bereiding van gesubstitueerde chinazolinen.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NL1025414A NL1025414C2 (nl) 2003-02-05 2004-02-05 Bereiding van gesubstitueerde chinazolinen.
NL1029762A NL1029762C2 (nl) 2003-02-05 2005-08-18 Bereiding van gesubstitueerde chinazolinen.

Country Status (18)

Country Link
US (1) US20040158065A1 (nl)
EP (1) EP1618095A2 (nl)
JP (1) JP2006517959A (nl)
KR (1) KR20050095916A (nl)
CN (1) CN1745073A (nl)
AR (1) AR043027A1 (nl)
AU (1) AU2004209452A1 (nl)
BR (1) BRPI0407249A (nl)
CA (1) CA2514933A1 (nl)
MX (1) MXPA05007831A (nl)
NL (3) NL1025414C2 (nl)
PA (1) PA8595201A1 (nl)
PE (1) PE20040945A1 (nl)
PL (1) PL378576A1 (nl)
RU (1) RU2005122322A (nl)
TW (1) TW200420544A (nl)
UY (1) UY28177A1 (nl)
WO (1) WO2004069791A2 (nl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04748B1 (et) * 1999-06-21 2006-12-15 Boehringer Ingelheim Pharma Kg Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
RU2350605C2 (ru) * 2003-08-14 2009-03-27 Эррей Байофарма Инк. Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
RS52119B (sr) * 2004-05-06 2012-08-31 Warner-Lambert Company Llc 4-fenilamino-hinazolin-6-il-amidi
KR100735639B1 (ko) * 2004-12-29 2007-07-04 한미약품 주식회사 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
KR100832593B1 (ko) * 2005-11-08 2008-05-27 한미약품 주식회사 신호전달 저해제로서의 퀴나졸린 유도체 및 이의 제조방법
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
WO2007059257A2 (en) 2005-11-15 2007-05-24 Array Biopharma Inc. N4-phenyl-quinaz0line-4 -amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
ES2385613T3 (es) * 2006-09-18 2012-07-27 Boehringer Ingelheim International Gmbh Método para tratar cánceres que portan mutaciones de EGFR
ES2526718T3 (es) 2007-09-10 2015-01-14 Curis, Inc. Inhibidores de EGFR basados en sales de tartrato o complejos de quinazolina que contienen un resto que se une al cinc
WO2009094210A1 (en) * 2008-01-22 2009-07-30 Concert Pharmaceuticals Inc. Vandetanib derivatives
US7855204B2 (en) * 2008-01-22 2010-12-21 Concert Pharmaceuticals Inc. Derivatives of gefitinib
EP2352827A4 (en) * 2008-09-05 2016-07-20 Celgene Avilomics Res Inc ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS
SI2451445T1 (sl) 2009-07-06 2019-07-31 Boehringer Ingelheim International Gmbh Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino
IN2012DN02534A (nl) 2009-09-16 2015-08-28 Avila Therapeutics Inc
SG181965A1 (en) 2009-12-30 2012-08-30 Avila Therapeutics Inc Ligand-directed covalent modification of protein
CN102382106A (zh) 2010-08-30 2012-03-21 黄振华 苯胺取代的喹唑啉衍生物
WO2013013640A1 (zh) * 2011-07-27 2013-01-31 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
JP2014532063A (ja) * 2011-10-12 2014-12-04 テリジェン リミテッドＴｅｌｉｇｅｎｅ Ｌｔｄ キナーゼ阻害剤としてのキナゾリン誘導体およびその使用方法
US9388170B2 (en) 2012-05-07 2016-07-12 Teligene Ltd. Substituted aminoquinazolines useful as kinases inhibitors
CN103965120B (zh) * 2013-01-25 2016-08-17 上海医药集团股份有限公司 喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用
CN103242244B (zh) * 2013-05-16 2015-03-25 苏州明锐医药科技有限公司 一种卡奈替尼的制备方法
WO2014187319A1 (en) 2013-05-21 2014-11-27 Jiangsu Medolution Ltd Substituted pyrazolopyrimidines as kinases inhibitors
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN107868058B (zh) * 2016-09-23 2023-02-14 上海医药集团股份有限公司 一种喹唑啉衍生物的盐、其制备方法及应用
PE20251292A1 (es) 2018-03-08 2025-05-14 Incyte Corp Compuestos diolicos de aminopirazina como inhibidores de pi3k-gamma
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
BR112021005513A2 (pt) 2018-09-25 2021-06-22 Black Diamond Therapeutics, Inc. derivados de quinazolina como inibidor de tirosina quinase, composições, métodos de fabricação e uso dos mesmos
ES2992926T3 (en) * 2019-03-07 2024-12-19 BioNTech SE Process for the preparation of a substituted imidazoquinoline
CA3150701A1 (en) 2019-08-15 2021-02-18 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
CN117693505A (zh) * 2021-04-22 2024-03-12 沃若诺伊公司 杂芳基衍生物化合物及其用途
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE213730T1 (de) * 1996-04-12 2002-03-15 Warner Lambert Co Umkehrbare inhibitoren von tyrosin kinasen
DE10009267A1 (de) * 2000-02-26 2001-08-30 Goedecke Ag Verfahren zur einfachen Herstellung von (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazolin-4-yl]-amin
US6664390B2 (en) * 2000-02-02 2003-12-16 Warner-Lambert Company Llc Method for the simplified production of (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazoline-4-yl]-amine or (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazoline-4-yl]-amine
US6627634B2 (en) * 2000-04-08 2003-09-30 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them
DE10063435A1 (de) * 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
NL1029762C2 (nl) 2006-03-06
UY28177A1 (es) 2004-09-30
EP1618095A2 (en) 2006-01-25
AR043027A1 (es) 2005-07-13
RU2005122322A (ru) 2006-03-10
PA8595201A1 (es) 2004-09-16
PE20040945A1 (es) 2004-12-14
CA2514933A1 (en) 2004-08-19
KR20050095916A (ko) 2005-10-04
NL1029763C2 (nl) 2006-03-06
NL1025414A1 (nl) 2004-08-06
JP2006517959A (ja) 2006-08-03
BRPI0407249A (pt) 2006-01-31
NL1025414C2 (nl) 2005-11-01
NL1029762A1 (nl) 2005-10-13
AU2004209452A1 (en) 2004-08-19
TW200420544A (en) 2004-10-16
US20040158065A1 (en) 2004-08-12
PL378576A1 (pl) 2006-05-02
WO2004069791A2 (en) 2004-08-19
MXPA05007831A (es) 2005-10-18
WO2004069791A3 (en) 2004-12-16
CN1745073A (zh) 2006-03-08

Similar Documents

Publication Publication Date Title
NL1025414A1 (nl) Bereiding van gesubstitueerde chinazolinen.
DK1667992T3 (da) Quinazolinderivater
DE602004022180D1 (de) Chinazolinderivate
DE602004007458D1 (de) Symmetrierglied
DE602004007220D1 (de) Verbinder
DK1474420T3 (da) Quinazolinforbindelser
DK1644002T3 (da) Multipartikler
MX266708B (es) Formulaciones de microparticulas de pantoprazol.
DE502004011106D1 (de) 6-arylmethyl-substituierte pyrazolopyrimidine
DE60311073D1 (de) Belüftungseinrichtung
DK1636288T3 (da) Tværbindende vandige polyurethandispersioner
EP1596222A4 (en) LASER RADAR
ATE366242T1 (de) 5-substituierte chinazolinonderivate
DE602004003978D1 (de) Verbinder
DE502004003715D1 (de) Selbstsperrender gurtaufroller
ATE444953T1 (de) Substituierte spirobenzazepine
DE502004001587D1 (de) Arretierelement
DE502004009935D1 (de) Substituierte dihydrochinazoline ii
DE60322439D1 (de) Anschlussstück
DE60316553D1 (de) Verbinder
CL2004000538A1 (es) Deshumificador de ambientes.
DE602004000496D1 (de) Verbinder
DE602004001824D1 (de) Fahrzeugvorderbau
DE602004029860D1 (de) Verbinder
ITRM20030053A1 (it) Associazione di farmaci antidiabetici.

Legal Events

Date Code Title Description
AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)

Effective date: 20051102

PD2B A search report has been drawn up
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20080901