PL3494120T3 - Pochodne oksadiazolopirydyny do zastosowania jako inhibitory o-acylotransferazy greliny (goat) - Google Patents
Pochodne oksadiazolopirydyny do zastosowania jako inhibitory o-acylotransferazy greliny (goat)Info
- Publication number
- PL3494120T3 PL3494120T3 PL17743064T PL17743064T PL3494120T3 PL 3494120 T3 PL3494120 T3 PL 3494120T3 PL 17743064 T PL17743064 T PL 17743064T PL 17743064 T PL17743064 T PL 17743064T PL 3494120 T3 PL3494120 T3 PL 3494120T3
- Authority
- PL
- Poland
- Prior art keywords
- ghrelin
- goat
- inhibitors
- acyl transferase
- oxadiazolopyridine derivatives
- Prior art date
Links
- 241000283707 Capra Species 0.000 title 1
- 102100038752 Ghrelin O-acyltransferase Human genes 0.000 title 1
- 101710205760 Ghrelin O-acyltransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- RWXCVESEMJNNMF-UHFFFAOYSA-N oxadiazolo[5,4-b]pyridine Chemical class C1=CN=C2ON=NC2=C1 RWXCVESEMJNNMF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183047 | 2016-08-05 | ||
| EP17743064.2A EP3494120B1 (en) | 2016-08-05 | 2017-07-31 | Oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| PCT/EP2017/069274 WO2018024653A1 (en) | 2016-08-05 | 2017-07-31 | Oxadiazolopyridine derivates for use as ghrelin o-acyl transferase (goat) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3494120T3 true PL3494120T3 (pl) | 2021-09-20 |
Family
ID=56609762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17743064T PL3494120T3 (pl) | 2016-08-05 | 2017-07-31 | Pochodne oksadiazolopirydyny do zastosowania jako inhibitory o-acylotransferazy greliny (goat) |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US9994591B2 (pl) |
| EP (1) | EP3494120B1 (pl) |
| JP (1) | JP6651054B2 (pl) |
| KR (1) | KR102496075B1 (pl) |
| CN (1) | CN109843891B (pl) |
| AR (1) | AR109296A1 (pl) |
| AU (1) | AU2017307033B2 (pl) |
| CL (1) | CL2019000274A1 (pl) |
| CO (1) | CO2019000601A2 (pl) |
| CY (1) | CY1124381T1 (pl) |
| DK (1) | DK3494120T3 (pl) |
| EA (1) | EA037277B1 (pl) |
| ES (1) | ES2874587T3 (pl) |
| HR (1) | HRP20210908T1 (pl) |
| HU (1) | HUE054928T2 (pl) |
| IL (1) | IL264506B (pl) |
| LT (1) | LT3494120T (pl) |
| MA (1) | MA45843B1 (pl) |
| MX (1) | MX384847B (pl) |
| MY (1) | MY197064A (pl) |
| PE (1) | PE20190414A1 (pl) |
| PH (1) | PH12019500254A1 (pl) |
| PL (1) | PL3494120T3 (pl) |
| PT (1) | PT3494120T (pl) |
| RS (1) | RS61937B1 (pl) |
| SA (1) | SA519401039B1 (pl) |
| SG (1) | SG11201811804QA (pl) |
| SI (1) | SI3494120T1 (pl) |
| TW (1) | TWI749042B (pl) |
| UA (1) | UA124267C2 (pl) |
| WO (1) | WO2018024653A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20200332A (es) * | 2018-02-02 | 2020-09-03 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina sustitidos con bencilo, (piridin-3-il)metilo o (piridin-4-il)metilo como inhibidores de ghrelin o-aciltransferasa (goat) |
| JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体 |
| EA202091804A1 (ru) * | 2018-02-02 | 2020-12-24 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероциклил-замещенные оксадиазолопиридиновые производные для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| US11136337B2 (en) | 2018-02-02 | 2021-10-05 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| ES2991340T3 (es) | 2020-05-22 | 2024-12-03 | Boehringer Ingelheim Int | Procedimiento continuo de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo |
| DK4153599T3 (da) | 2020-05-22 | 2024-06-17 | Boehringer Ingelheim Int | Fremgangsmåde til at fremstille alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-carboxylat |
| CN112014340A (zh) * | 2020-09-01 | 2020-12-01 | 广西玮美生物科技有限公司 | 非人灵长类动物胃饥饿素的检测方法 |
| CN118652261B (zh) * | 2024-05-29 | 2025-02-07 | 南京理工大学 | 一种耐热荧光活性含能化合物及其合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241496B1 (es) | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| CL2007003580A1 (es) | 2006-12-11 | 2009-03-27 | Boehringer Ingelheim Int | Compuestos derivados de piridazina, antagonistas de mch; composicion farmaceutica que comprende a dicho compuesto; procedimiento de preparacion; y uso del compuesto en el tratamiento de trastornos metabolicos y/o trastornos alimentarios como obesidad, bulimia, anorexia, hiperfagia, diabetes. |
| BRPI0807728A2 (pt) | 2007-02-15 | 2012-04-17 | Univ Indiana Res & Tech Corp | co-agonistas de receptor glucagon/glp-1 |
| WO2008152403A1 (en) | 2007-06-15 | 2008-12-18 | Zealand Pharma A/S | Glucagon analogues |
| DK2370460T3 (da) | 2008-12-15 | 2014-08-04 | Zealand Pharma As | Glucagon analoger |
| ES2439499T3 (es) | 2008-12-15 | 2014-01-23 | Zealand Pharma A/S | Análogos de glucagón |
| JP5635529B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| JP5635532B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| KR101809024B1 (ko) | 2009-07-13 | 2017-12-14 | 질랜드 파마 에이/에스 | 아실화 글루카곤 유사체 |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| BR112012033225A2 (pt) | 2010-06-24 | 2017-06-20 | Zealand Pharma As | análogos do glucagon |
| IN2014CN04401A (pl) | 2011-12-23 | 2015-09-04 | Zealand Pharma As | |
| WO2013125732A1 (en) | 2012-02-24 | 2013-08-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| US20170275249A1 (en) * | 2014-09-17 | 2017-09-28 | The Regents Of The University Of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
| AR104673A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| AR104672A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| EA202091804A1 (ru) | 2018-02-02 | 2020-12-24 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероциклил-замещенные оксадиазолопиридиновые производные для применения в качестве ингибиторов грелин-о-ацилтрансферазы (goat) |
| CR20200332A (es) | 2018-02-02 | 2020-09-03 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina sustitidos con bencilo, (piridin-3-il)metilo o (piridin-4-il)metilo como inhibidores de ghrelin o-aciltransferasa (goat) |
| JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体 |
| US11136337B2 (en) * | 2018-02-02 | 2021-10-05 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
-
2017
- 2017-07-31 US US15/664,119 patent/US9994591B2/en active Active
- 2017-07-31 CN CN201780047100.1A patent/CN109843891B/zh active Active
- 2017-07-31 MA MA45843A patent/MA45843B1/fr unknown
- 2017-07-31 RS RS20210702A patent/RS61937B1/sr unknown
- 2017-07-31 PT PT177430642T patent/PT3494120T/pt unknown
- 2017-07-31 HR HRP20210908TT patent/HRP20210908T1/hr unknown
- 2017-07-31 MX MX2019001427A patent/MX384847B/es unknown
- 2017-07-31 AU AU2017307033A patent/AU2017307033B2/en active Active
- 2017-07-31 ES ES17743064T patent/ES2874587T3/es active Active
- 2017-07-31 HU HUE17743064A patent/HUE054928T2/hu unknown
- 2017-07-31 MY MYPI2018002719A patent/MY197064A/en unknown
- 2017-07-31 LT LTEP17743064.2T patent/LT3494120T/lt unknown
- 2017-07-31 JP JP2019506164A patent/JP6651054B2/ja active Active
- 2017-07-31 SI SI201730770T patent/SI3494120T1/sl unknown
- 2017-07-31 EP EP17743064.2A patent/EP3494120B1/en active Active
- 2017-07-31 DK DK17743064.2T patent/DK3494120T3/da active
- 2017-07-31 KR KR1020197006448A patent/KR102496075B1/ko active Active
- 2017-07-31 SG SG11201811804QA patent/SG11201811804QA/en unknown
- 2017-07-31 PL PL17743064T patent/PL3494120T3/pl unknown
- 2017-07-31 EA EA201990418A patent/EA037277B1/ru not_active IP Right Cessation
- 2017-07-31 WO PCT/EP2017/069274 patent/WO2018024653A1/en not_active Ceased
- 2017-07-31 PE PE2019000271A patent/PE20190414A1/es unknown
- 2017-07-31 UA UAA201901840A patent/UA124267C2/uk unknown
- 2017-08-04 TW TW106126319A patent/TWI749042B/zh active
- 2017-08-04 AR ARP170102213A patent/AR109296A1/es active IP Right Grant
-
2018
- 2018-05-09 US US15/974,882 patent/US10308667B2/en not_active Ceased
-
2019
- 2019-01-22 CO CONC2019/0000601A patent/CO2019000601A2/es unknown
- 2019-01-28 IL IL264506A patent/IL264506B/en active IP Right Grant
- 2019-02-01 CL CL2019000274A patent/CL2019000274A1/es unknown
- 2019-02-05 SA SA519401039A patent/SA519401039B1/ar unknown
- 2019-02-06 PH PH12019500254A patent/PH12019500254A1/en unknown
-
2020
- 2020-10-14 US US17/069,940 patent/USRE49446E1/en active Active
-
2021
- 2021-06-14 CY CY20211100525T patent/CY1124381T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL268614A (en) | Aminotriazolopyridines as kinase inhibitors | |
| ZA201705527B (en) | TGF-ß INHIBITORS | |
| SI3494120T1 (sl) | Oksadiazolopiridinski derivati za uporabo kot inhibitorji grelin o-acil transferaze (GOAT) | |
| IL276145A (en) | Triazolopyrimidine history for use as ghrelin O-acyltransferase inhibitors | |
| SG11202003194YA (en) | Methods for the administration of certain vmat2 inhibitors | |
| IL274207A (en) | Aminoimidazopyridazines as kinase inhibitors | |
| IL276137A (en) | Heterocyclyl-converted oxadiazolopyridine compounds for use as ghrelin O-acyltransferase inhibitors | |
| ZA201907136B (en) | Ip6k inhibitors | |
| ZA201705675B (en) | Ghrelin o-acyl transferase inhibitors | |
| ZA201705678B (en) | Ghrelin o-acyl transferase inhibitors | |
| EP3405477C0 (en) | TRANSGLUTAMINASE INHIBITORS | |
| ZA201701575B (en) | Pyrrolidinone derivatives as metap-2 inhibitors | |
| EP3193939A4 (en) | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase | |
| IL265139B (en) | Dopamine-b-hydroxylase inhibitors | |
| PT3458448T (pt) | Inibidores fasn para uso no tratamento de esteato-hepatite não-alcoólica | |
| GB201708457D0 (en) | Inhibitors of metallo-beta-lactamases | |
| IL274550A (en) | Dopamine-B-hydroxylase inhibitors | |
| IL258438B (en) | 2-Aminoquinoline derivatives as p70s6 kinase inhibitors | |
| IL252986A0 (en) | 5,3-diaminopyrazole kinase inhibitors | |
| GB201708451D0 (en) | Inhibitors of metallo-beta-lactamases | |
| GB201721465D0 (en) | Inhibitors | |
| HK40002992A (en) | Oxadiazolopyridine derivates for use as ghrelin o-acyl transferase (goat) inhibitors | |
| HK40040194A (en) | Heterocyclyl-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors | |
| HK40040195A (en) | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors | |
| GB201720189D0 (en) | Dopamine-B-hydroxylase inhibitors |