AR104672A1 - Inhibidores de grelina o-aciltransferasa - Google Patents
Inhibidores de grelina o-aciltransferasaInfo
- Publication number
- AR104672A1 AR104672A1 ARP160100865A ARP160100865A AR104672A1 AR 104672 A1 AR104672 A1 AR 104672A1 AR P160100865 A ARP160100865 A AR P160100865A AR P160100865 A ARP160100865 A AR P160100865A AR 104672 A1 AR104672 A1 AR 104672A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- grelina
- aciltransferasa
- inhibitors
- oxazolyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1), en donde R se selecciona de -alquilo C₁₋₃ opcionalmente sustituido con -OH; -O-alquilo C₁₋₄; pirazolilo, oxazolilo, tiazolilo o tiadiazolilo, en donde pirazolilo, oxazolilo o tiazolilo pueden estar cada uno opcionalmente sustituidos una a dos veces con -CH₃; piridinilo, piridazinilo o pirazinilo, en donde cada uno puede estar opcionalmente sustituido con -Cl; y fenilo opcionalmente sustituido con -OCH₃; o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382180 | 2015-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104672A1 true AR104672A1 (es) | 2017-08-09 |
Family
ID=52991669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160100865A AR104672A1 (es) | 2015-04-15 | 2016-03-31 | Inhibidores de grelina o-aciltransferasa |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10093651B2 (es) |
| EP (1) | EP3283473B1 (es) |
| JP (1) | JP6458168B2 (es) |
| KR (1) | KR20170123693A (es) |
| CN (1) | CN107428723B (es) |
| AR (1) | AR104672A1 (es) |
| AU (1) | AU2016247901A1 (es) |
| BR (1) | BR112017017835A2 (es) |
| CA (1) | CA2976636A1 (es) |
| EA (1) | EA201791992A1 (es) |
| ES (1) | ES2715763T3 (es) |
| IL (1) | IL253969A0 (es) |
| MX (1) | MX2017013073A (es) |
| TW (1) | TWI589574B (es) |
| WO (1) | WO2016168222A1 (es) |
| ZA (1) | ZA201705675B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA45843B1 (fr) | 2016-08-05 | 2021-06-30 | Boehringer Ingelheim Int | Dérivés d'oxadiazolopyridine utilisés comme inhibiteurs de la ghréline o-acyl transférase (chèvre) |
| EP3746449B1 (en) | 2018-02-02 | 2022-03-30 | Boehringer Ingelheim International GmbH | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体 |
| CN111655700B (zh) * | 2018-02-02 | 2023-07-18 | 勃林格殷格翰国际有限公司 | 作为饥饿素o-酰基转移酶(goat)抑制剂的噁二唑并吡啶衍生物 |
| JP7150032B2 (ja) | 2018-02-02 | 2022-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害薬として使用するためのヘテロシクリル置換オキサジアゾロピリジン誘導体 |
| CN108610337A (zh) * | 2018-05-30 | 2018-10-02 | 王丽萍 | 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用 |
| BR112022017039A2 (pt) | 2020-02-28 | 2022-11-16 | Kallyope Inc | Agonistas de gpr40 |
| CN115916789B (zh) | 2020-05-22 | 2025-06-27 | 勃林格殷格翰国际有限公司 | 制备烷基7-氨基-5-甲基-[1,2,5]噁二唑并[3,4-b]吡啶羧酸酯的连续方法 |
| ES2984466T3 (es) | 2020-05-22 | 2024-10-29 | Boehringer Ingelheim Int | Procedimiento de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005026211A2 (en) | 2003-09-05 | 2005-03-24 | Eli Lilly And Company | Anti-ghrelin antibodies |
| US20050070712A1 (en) * | 2003-09-26 | 2005-03-31 | Christi Kosogof | Pyrimidine derivatives as ghrelin receptor modulators |
| JP2008515771A (ja) | 2004-07-14 | 2008-05-15 | イーライ リリー アンド カンパニー | 抗グレリン抗体 |
| CA2587627A1 (en) | 2004-11-15 | 2006-05-26 | Eli Lilly And Company | Desacyl ghrelin antibodies and therapeutic uses thereof |
| US7479271B2 (en) | 2005-02-23 | 2009-01-20 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| JP6106179B2 (ja) | 2012-02-24 | 2017-03-29 | 武田薬品工業株式会社 | 芳香環化合物 |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
-
2016
- 2016-03-31 AR ARP160100865A patent/AR104672A1/es unknown
- 2016-04-01 TW TW105110655A patent/TWI589574B/zh not_active IP Right Cessation
- 2016-04-13 CA CA2976636A patent/CA2976636A1/en not_active Abandoned
- 2016-04-13 JP JP2017553922A patent/JP6458168B2/ja not_active Expired - Fee Related
- 2016-04-13 ES ES16717800T patent/ES2715763T3/es active Active
- 2016-04-13 WO PCT/US2016/027177 patent/WO2016168222A1/en not_active Ceased
- 2016-04-13 EA EA201791992A patent/EA201791992A1/ru unknown
- 2016-04-13 MX MX2017013073A patent/MX2017013073A/es unknown
- 2016-04-13 KR KR1020177028709A patent/KR20170123693A/ko not_active Withdrawn
- 2016-04-13 US US15/561,159 patent/US10093651B2/en active Active
- 2016-04-13 EP EP16717800.3A patent/EP3283473B1/en active Active
- 2016-04-13 BR BR112017017835A patent/BR112017017835A2/pt not_active Application Discontinuation
- 2016-04-13 AU AU2016247901A patent/AU2016247901A1/en not_active Abandoned
- 2016-04-13 CN CN201680013097.7A patent/CN107428723B/zh not_active Expired - Fee Related
-
2017
- 2017-08-13 IL IL253969A patent/IL253969A0/en unknown
- 2017-08-21 ZA ZA2017/05675A patent/ZA201705675B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201705675B (en) | 2019-07-31 |
| AU2016247901A1 (en) | 2017-09-14 |
| IL253969A0 (en) | 2017-10-31 |
| ES2715763T3 (es) | 2019-06-06 |
| BR112017017835A2 (pt) | 2018-04-10 |
| EP3283473A1 (en) | 2018-02-21 |
| JP6458168B2 (ja) | 2019-01-23 |
| KR20170123693A (ko) | 2017-11-08 |
| US20180086732A1 (en) | 2018-03-29 |
| CA2976636A1 (en) | 2016-10-20 |
| US10093651B2 (en) | 2018-10-09 |
| JP2018511630A (ja) | 2018-04-26 |
| WO2016168222A1 (en) | 2016-10-20 |
| EA201791992A1 (ru) | 2018-03-30 |
| MX2017013073A (es) | 2017-12-04 |
| CN107428723A (zh) | 2017-12-01 |
| TW201704225A (zh) | 2017-02-01 |
| CN107428723B (zh) | 2020-05-05 |
| EP3283473B1 (en) | 2019-01-02 |
| TWI589574B (zh) | 2017-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |