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PL3303564T3 - Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) - Google Patents

Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Info

Publication number
PL3303564T3
PL3303564T3 PL16804350T PL16804350T PL3303564T3 PL 3303564 T3 PL3303564 T3 PL 3303564T3 PL 16804350 T PL16804350 T PL 16804350T PL 16804350 T PL16804350 T PL 16804350T PL 3303564 T3 PL3303564 T3 PL 3303564T3
Authority
PL
Poland
Prior art keywords
mda
methods
central brain
vitro differential
dopamine neurones
Prior art date
Application number
PL16804350T
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja KRIKS
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of PL3303564T3 publication Critical patent/PL3303564T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/415—Wnt; Frizzeled
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL16804350T 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) PL3303564T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562169444P 2015-06-01 2015-06-01
US201562169379P 2015-06-01 2015-06-01
EP16804350.3A EP3303564B1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons
PCT/US2016/035312 WO2016196661A1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons

Publications (1)

Publication Number Publication Date
PL3303564T3 true PL3303564T3 (pl) 2022-05-09

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16804350T PL3303564T3 (pl) 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Country Status (19)

Country Link
US (3) US10858625B2 (pl)
EP (3) EP3303564B1 (pl)
JP (4) JP6974180B2 (pl)
KR (4) KR20250118858A (pl)
AU (2) AU2016270793B2 (pl)
CA (1) CA2987617A1 (pl)
CY (1) CY1125423T1 (pl)
DK (1) DK3303564T3 (pl)
ES (1) ES2910032T3 (pl)
HR (1) HRP20220482T1 (pl)
HU (1) HUE058258T2 (pl)
IL (4) IL291532B2 (pl)
LT (1) LT3303564T (pl)
PL (1) PL3303564T3 (pl)
PT (1) PT3303564T (pl)
RS (1) RS63157B1 (pl)
SI (1) SI3303564T1 (pl)
SM (1) SMT202200263T1 (pl)
WO (1) WO2016196661A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107438669B (zh) * 2015-04-09 2022-09-27 拜奥拉米那公司 用于治疗神经退行性疾病的干细胞衍生多巴胺能细胞的生产方法和组合物
KR20250118858A (ko) * 2015-06-01 2025-08-06 메모리얼 슬로안 케터링 캔서 센터 중간뇌 도파민(mda) 뉴런의 시험관내 분화 방법
WO2017136834A1 (en) 2016-02-05 2017-08-10 Memorial Sloan-Ketering Cancer Center Methods of differentiating stem cell-derived ectodermal lineage precursors
WO2018035214A1 (en) * 2016-08-16 2018-02-22 Cellular Dynamics International., Inc. Methods for differentiating pluripotent cells
CA3061165A1 (en) * 2017-04-26 2018-11-01 Memorial Sloan-Kettering Cancer Center Ready-to-use cryopreserved cells
CN111213057A (zh) * 2017-07-17 2020-05-29 美天施生物科技有限两合公司 用于底板中脑多巴胺能祖细胞的单细胞蛋白质表达谱分析的方法
US20200248139A1 (en) * 2017-08-08 2020-08-06 Regents Of The University Of Minnesota Methods for generating and using organoids and cells thereof
JP2022514298A (ja) 2018-12-19 2022-02-10 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ オルガノイドおよびその組織を作製および使用するための方法
WO2020237104A1 (en) * 2019-05-23 2020-11-26 The Mclean Hospital Corporation Autologous cell replacement therapy for parkinson's disease
BR112022001315A2 (pt) 2019-07-25 2022-04-12 Aspen Neuroscience Inc Métodos para identificação de neurônios dopaminérgicos e células progenitoras
WO2021042027A1 (en) * 2019-08-29 2021-03-04 Memorial Sloan-Kettering Cancer Center Methods of generating and isolating midbrain dopamine neurons
CN114867849B (zh) * 2019-09-20 2024-07-12 韩国生命工学研究院 使用直接重编程的诱导性多巴胺能神经元祖细胞的生产方法
MX2022011831A (es) 2020-03-25 2023-01-04 Sana Biotechnology Inc Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
US20230165909A1 (en) 2020-04-21 2023-06-01 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
CA3183958A1 (en) * 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
CN114292814A (zh) * 2020-09-22 2022-04-08 上海跃赛生物科技有限公司 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法
US20240219375A1 (en) * 2021-04-07 2024-07-04 FUJIFILM Cellular Dynamics, Inc. Dopaminergic precursor cells and methods of use
US20230081881A1 (en) 2021-07-21 2023-03-16 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
US20250082686A1 (en) 2021-07-21 2025-03-13 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
AU2022387671B2 (en) 2021-11-12 2024-11-07 Axent Biosciences Inc. Methods for production of functional neurons
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
WO2024259119A2 (en) * 2023-06-13 2024-12-19 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
CN117448271B (zh) * 2023-12-22 2024-07-16 上海元戊医学技术有限公司 一种诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法
WO2025166063A1 (en) 2024-01-31 2025-08-07 Bluerock Therapeutics Lp Igfbp2 in cell culture

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE347617T1 (de) 1999-05-06 2006-12-15 Sinai School Medicine Steganographie auf dna basis
AU2001263199B2 (en) 2000-05-17 2004-09-16 Asterias Biotherapeutics, Inc. Neural progenitor cell populations
JP2008511304A (ja) * 2004-09-02 2008-04-17 ニューロ セラピューティクス エービー ドーパミンニューロンの増強産生に関する方法と材料
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
AP2949A (en) 2006-03-07 2014-07-31 Shroff Geeta Compositions comprising human embryonic stem cellsand their derivatives, methods of use, and method s of preparation
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
DK2577318T3 (da) 2010-05-25 2019-10-07 Memorial Sloan Kettering Cancer Center Fremgangsmåde til nociceptor-differentiering af humane embryoniske stamceller og anvendelser deraf
US20110296542A1 (en) 2010-05-28 2011-12-01 Kevin Ka-Wang Wang Exogenous matrix-supported topical application of stem cells to organ surface
CN110684734A (zh) * 2011-11-04 2020-01-14 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺（da）神经元
US20150159135A1 (en) 2012-06-15 2015-06-11 Baylor College Of Medicine Perineurium Derived Adult Stem Cells and Methods of Use
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
KR101696874B1 (ko) 2013-07-31 2017-01-16 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법
JP6419073B2 (ja) * 2013-08-06 2018-11-07 武田薬品工業株式会社 ドパミン神経細胞の製造方法
SG11201601720RA (en) * 2013-09-05 2016-04-28 Univ Kyoto New method for inducing dopamine-producing neural precursor cells
CA2931334A1 (en) 2013-11-21 2015-05-28 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
ES2939807T3 (es) * 2014-03-21 2023-04-27 Fujifilm Cellular Dynamics Inc Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización
KR20250118858A (ko) * 2015-06-01 2025-08-06 메모리얼 슬로안 케터링 캔서 센터 중간뇌 도파민(mda) 뉴런의 시험관내 분화 방법

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IL255992B (en) 2022-04-01
JP2023181494A (ja) 2023-12-21
IL313799B2 (en) 2025-09-01
US10858625B2 (en) 2020-12-08
AU2016270793A1 (en) 2017-12-14
JP2022031961A (ja) 2022-02-22
EP4070803B1 (en) 2025-10-08
CY1125423T1 (el) 2024-12-13
DK3303564T3 (da) 2022-04-04
EP3303564B1 (en) 2022-02-23
US20240400987A1 (en) 2024-12-05
ES2910032T3 (es) 2022-05-11
IL313799A (en) 2024-08-01
EP4079314B1 (en) 2025-10-29
PT3303564T (pt) 2022-06-02
AU2016270793B2 (en) 2022-06-09
IL255992A (en) 2018-01-31
JP2020146060A (ja) 2020-09-17
US12084679B2 (en) 2024-09-10
IL291532B2 (en) 2024-12-01
IL291532A (en) 2022-05-01
KR20240101884A (ko) 2024-07-02
AU2022228216A1 (en) 2022-10-06
KR102358878B1 (ko) 2022-02-08
CA2987617A1 (en) 2016-12-08
EP4070803A1 (en) 2022-10-12
EP3303564A1 (en) 2018-04-11
EP4079314A1 (en) 2022-10-26
JP7737787B2 (ja) 2025-09-11
EP3303564A4 (en) 2018-10-31
IL313799B1 (en) 2025-05-01
SI3303564T1 (sl) 2022-07-29
JP2018522538A (ja) 2018-08-16
WO2016196661A1 (en) 2016-12-08
HRP20220482T1 (hr) 2022-07-08
US20210123018A1 (en) 2021-04-29
US20180094242A1 (en) 2018-04-05
IL320440A (en) 2025-06-01
KR20220020416A (ko) 2022-02-18
HUE058258T2 (hu) 2022-07-28
IL291532B1 (en) 2024-08-01
KR102841407B1 (ko) 2025-08-01
RS63157B1 (sr) 2022-05-31
KR20250118858A (ko) 2025-08-06
JP6974180B2 (ja) 2021-12-01
SMT202200263T1 (it) 2022-07-21
LT3303564T (lt) 2022-05-10
KR102679619B1 (ko) 2024-07-01
KR20180014743A (ko) 2018-02-09

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