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PL2771003T3 - Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby - Google Patents

Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby

Info

Publication number
PL2771003T3
PL2771003T3 PL12801442T PL12801442T PL2771003T3 PL 2771003 T3 PL2771003 T3 PL 2771003T3 PL 12801442 T PL12801442 T PL 12801442T PL 12801442 T PL12801442 T PL 12801442T PL 2771003 T3 PL2771003 T3 PL 2771003T3
Authority
PL
Poland
Prior art keywords
treatment
bile acid
liver diseases
cholestatic liver
acid recycling
Prior art date
Application number
PL12801442T
Other languages
English (en)
Inventor
Bronislava Gedulin
Michael Grey
Niall O'donnell
Original Assignee
Lumena Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48168608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2771003(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumena Pharmaceuticals Llc filed Critical Lumena Pharmaceuticals Llc
Publication of PL2771003T3 publication Critical patent/PL2771003T3/pl

Links

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    • AHUMAN NECESSITIES
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K9/1629Organic macromolecular compounds
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom

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  • Medicinal Chemistry (AREA)
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  • Nutrition Science (AREA)
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  • Diabetes (AREA)
  • Zoology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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PL12801442T 2011-10-28 2012-10-26 Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby PL2771003T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607487P 2012-03-06 2012-03-06
US201261607503P 2012-03-06 2012-03-06
EP12801442.0A EP2771003B1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
PCT/US2012/062284 WO2013063512A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

Publications (1)

Publication Number Publication Date
PL2771003T3 true PL2771003T3 (pl) 2017-10-31

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PL12801442T PL2771003T3 (pl) 2011-10-28 2012-10-26 Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby

Country Status (23)

Country Link
US (10) US20140243281A1 (pl)
EP (2) EP2771003B1 (pl)
JP (4) JP6217938B2 (pl)
KR (2) KR102051030B1 (pl)
CN (2) CN107375932B (pl)
AU (3) AU2012328526B2 (pl)
BR (1) BR112014010223B8 (pl)
CA (1) CA2853285C (pl)
DK (1) DK2771003T3 (pl)
EA (2) EA030839B1 (pl)
ES (1) ES2633766T3 (pl)
FI (1) FIC20230019I1 (pl)
FR (1) FR23C1022I2 (pl)
HK (1) HK1248117A1 (pl)
IL (2) IL232150A (pl)
MX (3) MX369466B (pl)
NL (1) NL301234I2 (pl)
NO (1) NO2023023I1 (pl)
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