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SG10201407013QA - Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases - Google Patents

Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

Info

Publication number
SG10201407013QA
SG10201407013QA SG10201407013QA SG10201407013QA SG10201407013QA SG 10201407013Q A SG10201407013Q A SG 10201407013QA SG 10201407013Q A SG10201407013Q A SG 10201407013QA SG 10201407013Q A SG10201407013Q A SG 10201407013QA SG 10201407013Q A SG10201407013Q A SG 10201407013QA
Authority
SG
Singapore
Prior art keywords
pediatric
treatment
bile acid
cholestatic liver
acid recycling
Prior art date
Application number
SG10201407013QA
Inventor
Bronislava Gedulin
Michael Grey
Niall O'donnell
Original Assignee
Lumena Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48168608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201407013Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumena Pharmaceuticals Inc filed Critical Lumena Pharmaceuticals Inc
Publication of SG10201407013QA publication Critical patent/SG10201407013QA/en

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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER Provided herein are pediatric dosage forms for use in the treatment of a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of the pediatric dosage form comprising an Apical Sodium- dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutical^ acceptable salt thereof. Also provided are said pediatric dosage form for use in the treatment of pediatric liver a disease, for use in decreasing the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritis, for use in reducing liver enzymes or bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof. FIG. 5 174
SG10201407013QA 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases SG10201407013QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607503P 2012-03-06 2012-03-06
US201261607487P 2012-03-06 2012-03-06

Publications (1)

Publication Number Publication Date
SG10201407013QA true SG10201407013QA (en) 2014-12-30

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ID=48168608

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