DK0573848T3 - Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler - Google Patents
Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidlerInfo
- Publication number
- DK0573848T3 DK0573848T3 DK93108559T DK93108559T DK0573848T3 DK 0573848 T3 DK0573848 T3 DK 0573848T3 DK 93108559 T DK93108559 T DK 93108559T DK 93108559 T DK93108559 T DK 93108559T DK 0573848 T3 DK0573848 T3 DK 0573848T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- pharmaceuticals
- acid derivatives
- bile acid
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Motorcycle And Bicycle Frame (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4219274 | 1992-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0573848T3 true DK0573848T3 (da) | 1998-08-10 |
Family
ID=6460884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93108559T DK0573848T3 (da) | 1992-06-12 | 1993-05-27 | Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5428182A (da) |
| EP (1) | EP0573848B1 (da) |
| JP (1) | JP3403218B2 (da) |
| KR (1) | KR100319562B1 (da) |
| AT (1) | ATE160783T1 (da) |
| AU (1) | AU663592B2 (da) |
| CA (1) | CA2098256C (da) |
| CY (1) | CY2117B1 (da) |
| CZ (1) | CZ285104B6 (da) |
| DE (1) | DE59307759D1 (da) |
| DK (1) | DK0573848T3 (da) |
| ES (1) | ES2111092T3 (da) |
| FI (1) | FI106801B (da) |
| GR (1) | GR3025799T3 (da) |
| HU (1) | HU216636B (da) |
| IL (1) | IL105980A (da) |
| NO (1) | NO304653B1 (da) |
| NZ (1) | NZ247827A (da) |
| SK (1) | SK280819B6 (da) |
| TW (1) | TW228004B (da) |
| ZA (1) | ZA934150B (da) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0624593A3 (de) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| DE4432708A1 (de) | 1994-09-14 | 1996-03-21 | Hoechst Ag | Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5840879A (en) * | 1996-12-06 | 1998-11-24 | Wang; Edge R. | Reagents and solid supports for improved synthesis and labeling of polynucleotides |
| GB2355009A (en) | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| JP4584987B2 (ja) | 2004-04-30 | 2010-11-24 | アルニラム ファーマスーティカルズ インコーポレイテッド | Ｃ５修飾ピリミジンを含むオリゴヌクレオチド |
| ES2318922B1 (es) * | 2005-05-30 | 2010-02-12 | Universidade De Santiago De Compostela | Nuevos dimeros derivados de acidos biliares funcionalizados en la posicion 3 del anillo a. metodo para la sintesis y aplicaciones. |
| KR100800312B1 (ko) * | 2006-01-25 | 2008-02-04 | (주)테크윙 | 테스트핸들러 및 테스트핸들러의 로딩방법 |
| CN101078006B (zh) | 2006-05-26 | 2012-06-06 | 上海凯信生物科技有限公司 | 一株高产四甲基吡嗪的短小芽孢杆菌 |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| DK2637668T3 (da) | 2010-11-04 | 2016-08-29 | Albireo Ab | Ibat-inhibitorer til behandling af leversygdomme |
| DK2637646T3 (da) | 2010-11-08 | 2016-08-29 | Albireo Ab | Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel |
| MX382960B (es) | 2011-10-28 | 2025-03-13 | Shire Human Genetic Therapies | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
| EA030839B1 (ru) | 2011-10-28 | 2018-10-31 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
| CA2907214A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| KR20230152818A (ko) | 2013-03-15 | 2023-11-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CA2952406A1 (en) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Solid formulation and method for preventing or reducing coloration thereof |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| WO2017138877A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| ES2874546T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| EP3664782B1 (en) | 2017-08-09 | 2025-01-29 | Albireo AB | Cholestyramine pellets, oral cholestyramine formulations and medical use thereof |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| ES2942443T3 (es) | 2018-06-05 | 2023-06-01 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares |
| UA128761C2 (uk) | 2018-06-20 | 2024-10-16 | Альбірео Аб | Кристалічні модифікації одевіксибату |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| EP3921027B1 (en) | 2019-02-06 | 2023-07-19 | Albireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| HRP20230039T1 (hr) | 2019-02-06 | 2023-06-09 | Albireo Ab | Benzotiadiazepinski spojevi i njihova uporaba kao modulatora žučnih kiselina |
| AU2020221834B2 (en) | 2019-02-12 | 2025-10-23 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| ES2972045T3 (es) | 2019-12-04 | 2024-06-10 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| TWI867107B (zh) | 2019-12-04 | 2024-12-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
| CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
| WO2021110887A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| TWI871392B (zh) | 2019-12-04 | 2025-02-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2021110883A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| JP7748451B2 (ja) | 2020-08-03 | 2025-10-02 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| KR20230117393A (ko) | 2020-12-04 | 2023-08-08 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의용도 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| JP2025524362A (ja) | 2022-06-09 | 2025-07-30 | アルビレオ・アクチボラグ | 肝炎の処置 |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US20240207286A1 (en) | 2022-12-09 | 2024-06-27 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2931817A (en) * | 1956-05-31 | 1960-04-05 | Monsanto Chemicals | Steroid sulfite ester polymers |
| DE1768345B2 (de) * | 1968-05-03 | 1976-12-02 | Hoechst Ag, 6000 Frankfurt | Dimere steroid-21-alkylcarbonate und verfahren zu ihrer herstellung |
| US3916002A (en) * | 1973-12-17 | 1975-10-28 | Taubert Hans Dieter | Oligomeric steroid esters, process for their production, and therapeutic compositions containing the same |
| NL7415669A (nl) * | 1974-12-02 | 1976-06-04 | Akzo Nv | Werkwijze ter bereiding van een nieuwe ester van 19-nor-testosteron. |
| ATE144988T1 (de) * | 1990-12-06 | 1996-11-15 | Hoechst Ag | Gallensäurederivate, verfahren zu ihrer herstellung und verwendung dieser verbindung als arzneimittel |
| EP0548793A3 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Ag | Ethylenic-unsaturated bile acid derivatives, process for their production and preliminary processes therefor |
| TW289021B (da) * | 1993-05-08 | 1996-10-21 | Hoechst Ag |
-
1993
- 1993-05-27 ES ES93108559T patent/ES2111092T3/es not_active Expired - Lifetime
- 1993-05-27 DK DK93108559T patent/DK0573848T3/da active
- 1993-05-27 AT AT93108559T patent/ATE160783T1/de not_active IP Right Cessation
- 1993-05-27 DE DE59307759T patent/DE59307759D1/de not_active Expired - Lifetime
- 1993-05-27 EP EP93108559A patent/EP0573848B1/de not_active Expired - Lifetime
- 1993-06-05 TW TW082104487A patent/TW228004B/zh active
- 1993-06-09 NZ NZ247827A patent/NZ247827A/en unknown
- 1993-06-10 CZ CZ931134A patent/CZ285104B6/cs not_active IP Right Cessation
- 1993-06-10 SK SK585-93A patent/SK280819B6/sk unknown
- 1993-06-10 US US08/074,753 patent/US5428182A/en not_active Expired - Lifetime
- 1993-06-10 FI FI932659A patent/FI106801B/fi active
- 1993-06-10 IL IL105980A patent/IL105980A/xx not_active IP Right Cessation
- 1993-06-11 NO NO931379A patent/NO304653B1/no unknown
- 1993-06-11 ZA ZA934150A patent/ZA934150B/xx unknown
- 1993-06-11 JP JP14037593A patent/JP3403218B2/ja not_active Expired - Lifetime
- 1993-06-11 AU AU40180/93A patent/AU663592B2/en not_active Ceased
- 1993-06-11 KR KR1019930010579A patent/KR100319562B1/ko not_active Expired - Fee Related
- 1993-06-11 HU HU9301716A patent/HU216636B/hu not_active IP Right Cessation
- 1993-06-11 CA CA002098256A patent/CA2098256C/en not_active Expired - Lifetime
-
1997
- 1997-12-30 GR GR970403445T patent/GR3025799T3/el unknown
-
1998
- 1998-09-29 CY CY9800035A patent/CY2117B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0573848A2 (de) | 1993-12-15 |
| AU663592B2 (en) | 1995-10-12 |
| EP0573848A3 (de) | 1995-06-07 |
| US5428182A (en) | 1995-06-27 |
| CA2098256C (en) | 2004-08-24 |
| HU9301716D0 (en) | 1993-09-28 |
| IL105980A (en) | 1997-11-20 |
| EP0573848B1 (de) | 1997-12-03 |
| KR100319562B1 (ko) | 2002-05-13 |
| AU4018093A (en) | 1993-12-16 |
| NO304653B1 (no) | 1999-01-25 |
| ZA934150B (en) | 1994-01-13 |
| CZ113493A3 (en) | 1994-01-19 |
| HUT64772A (en) | 1994-02-28 |
| NZ247827A (en) | 1995-08-28 |
| SK280819B6 (sk) | 2000-08-14 |
| JP3403218B2 (ja) | 2003-05-06 |
| HU216636B (hu) | 1999-07-28 |
| CA2098256A1 (en) | 1993-12-13 |
| NO932159L (no) | 1993-12-13 |
| CY2117B1 (en) | 2002-04-26 |
| ATE160783T1 (de) | 1997-12-15 |
| FI106801B (fi) | 2001-04-12 |
| SK58593A3 (en) | 1994-03-09 |
| DE59307759D1 (de) | 1998-01-15 |
| TW228004B (da) | 1994-08-11 |
| JPH0687884A (ja) | 1994-03-29 |
| FI932659A0 (fi) | 1993-06-10 |
| GR3025799T3 (en) | 1998-03-31 |
| CZ285104B6 (cs) | 1999-05-12 |
| ES2111092T3 (es) | 1998-03-01 |
| NO932159D0 (no) | 1993-06-11 |
| IL105980A0 (en) | 1993-10-20 |
| KR940005652A (ko) | 1994-03-22 |
| FI932659L (fi) | 1993-12-13 |
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