PL2444392T3 - Pochodna (aza)indolu podstawiona w pozycji 5 - Google Patents

Pochodna (aza)indolu podstawiona w pozycji 5

Info

Publication number: PL2444392T3
Authority: PL; Poland
Prior art keywords: aza; intermediary; indole derivative; derivative substituted; substituted
Prior art date: 2007-12-28

Application number

PL11194457T

Other languages

English (en)

Inventor

Maria Alessandra Alisi

Guido Furlotti

Nicola Cazzolla

Caterina Maugeri

Patrizia Dragone

Barbara Garofalo

Isabella Coletta

Giorgina Mangano

Beatrice Garrone

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-28

Filing date

2008-12-16

Publication date

2015-03-31

2008-12-16 Application filed by Acraf filed Critical Acraf

2015-03-31 Publication of PL2444392T3 publication Critical patent/PL2444392T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL11194457T 2007-12-28 2008-12-16 Pochodna (aza)indolu podstawiona w pozycji 5 PL2444392T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07425830A EP2078711A1 (en)	2007-12-28	2007-12-28	(Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
EP11194457.5A EP2444392B1 (en)	2007-12-28	2008-12-16	Intermediary (aza)indole derivative substituted in position 5
EP08868725A EP2234968B1 (en)	2007-12-28	2008-12-16	(aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Publications (1)

Publication Number	Publication Date
PL2444392T3 true PL2444392T3 (pl)	2015-03-31

Family

ID=39167787

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL11194457T PL2444392T3 (pl)	2007-12-28	2008-12-16	Pochodna (aza)indolu podstawiona w pozycji 5
PL08868725T PL2234968T3 (pl)	2007-12-28	2008-12-16	Pochodna (aza)indolu podstawiona w pozycji 5, zawierające ją kompozycje farmaceutyczne, związki pośrednie i sposób jej wytwarzania

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL08868725T PL2234968T3 (pl)	2007-12-28	2008-12-16	Pochodna (aza)indolu podstawiona w pozycji 5, zawierające ją kompozycje farmaceutyczne, związki pośrednie i sposób jej wytwarzania

Country Status (20)

Country	Link
US (2)	US8399477B2 (pl)
EP (3)	EP2078711A1 (pl)
JP (1)	JP5698985B2 (pl)
KR (2)	KR20160029861A (pl)
CN (1)	CN101910127B (pl)
AR (1)	AR069961A1 (pl)
AU (1)	AU2008342705B2 (pl)
BR (1)	BRPI0821450A2 (pl)
CA (1)	CA2707339C (pl)
DK (2)	DK2444392T3 (pl)
EA (1)	EA020373B1 (pl)
ES (2)	ES2523167T3 (pl)
GE (1)	GEP20125547B (pl)
IL (1)	IL206062A (pl)
PL (2)	PL2444392T3 (pl)
PT (2)	PT2234968E (pl)
SG (1)	SG187400A1 (pl)
SI (2)	SI2234968T1 (pl)
UA (1)	UA100867C2 (pl)
WO (1)	WO2009083436A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101365824B1 (ko)	2010-10-22	2014-02-20	엘지디스플레이 주식회사	유기전계발광소자
KR102408261B1 (ko)	2014-02-03	2022-06-10	비타이 파마슈티컬즈, 엘엘씨	Ror-감마의 디하이드로피롤로피리딘 저해제
DK3133068T3 (da) *	2014-04-14	2021-01-11	Shanghai hengrui pharmaceutical co ltd	Amidderivater og farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling deraf og medicinske anvendelser deraf
US9663515B2 (en)	2014-11-05	2017-05-30	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3331876B1 (en)	2015-08-05	2020-10-07	Vitae Pharmaceuticals, LLC	Modulators of ror-gamma
KR20180086221A (ko)	2015-11-20	2018-07-30	비타이 파마슈티컬즈, 인코포레이티드	Ror-감마의 조절물질
TWI757266B (zh)	2016-01-29	2022-03-11	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
CN107033026A (zh) *	2017-06-07	2017-08-11	李博强	一种对硝基苯肼盐酸盐的制备方法
WO2019018975A1 (en)	2017-07-24	2019-01-31	Vitae Pharmaceuticals, Inc.	INHIBITORS OF ROR GAMMA
IL298639A (en)	2017-07-24	2023-01-01	Vitae Pharmaceuticals Llc	Inhibitors of gamma ror
US12465588B2 (en)	2019-08-26	2025-11-11	Kukje Pharma Co., Ltd.	Indole carboxamide derivative and pharmaceutical composition containing same
CN114605303A (zh) *	2022-03-14	2022-06-10	武汉工程大学	一种地拉韦啶及其中间体的合成方法
CN119019389A (zh) *	2024-06-05	2024-11-26	四川大学	7-氮杂吲哚类化合物及其合成方法和用途
CN119101040B (zh) *	2024-11-08	2025-03-21	杭州澳赛诺医药技术有限公司	一种通过去对称化合成芳基取代的手性四氢吡喃环的方法

Family Cites Families (15)

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FR2354766A1 (fr) *	1976-06-17	1978-01-13	Labaz	Derives n-aminoalkyles d'indole et procedes pour les preparer
AU2720199A (en) *	1998-02-03	1999-08-23	Boehringer Ingelheim Pharma Kg	Five-membered, benzo-condensed heterocycles used as antithrombotic agents
US6114532A (en) *	1998-02-03	2000-09-05	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
DE19834751A1 (de) *	1998-08-01	2000-02-03	Boehringer Ingelheim Pharma	Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2001070743A1 (en) *	2000-03-20	2001-09-27	Axys Pharmaceuticals, Inc.	Non-amidine containing protease inhibitors
US20020052373A1 (en) *	2000-10-26	2002-05-02	Zorn Stevin H.	Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease
IL140096A0 (en) *	2000-12-05	2002-02-10	Internat Specialty Products Is	Process for preparation of zafirlukast
DE10147672A1 (de) *	2001-09-27	2003-04-10	Bayer Ag	Substituierte 2,5-Diamidoindole und ihre Verwendung
US20060183753A1 (en) *	2002-12-20	2006-08-17	Bayer Healthcare Ag	Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
SE0300908D0 (sv)	2003-03-31	2003-03-31	Astrazeneca Ab	Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
EP1833829A2 (en) *	2004-12-23	2007-09-19	F. Hoffmann-Roche AG	Benzamide substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
US20090258917A1 (en) *	2005-10-12	2009-10-15	Benjamin Pelcman	Benzoxazoles Useful in the Treatment of Inflammation
PL2007756T3 (pl) *	2006-04-07	2016-01-29	Vertex Pharma	Modulatory transporterów posiadających kasetę wiążącą ATP
JP2008006663A (ja) *	2006-06-28	2008-01-17	Pilot Ink Co Ltd	出没式筆記具
ITMI20061368A1 (it) *	2006-07-14	2008-01-15	Acraf	Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo

2007
- 2007-12-28 EP EP07425830A patent/EP2078711A1/en not_active Withdrawn
2008
- 2008-12-16 AU AU2008342705A patent/AU2008342705B2/en not_active Ceased
- 2008-12-16 UA UAA201006371A patent/UA100867C2/uk unknown
- 2008-12-16 KR KR1020167004925A patent/KR20160029861A/ko not_active Ceased
- 2008-12-16 SI SI200830950T patent/SI2234968T1/sl unknown
- 2008-12-16 DK DK11194457.5T patent/DK2444392T3/en active
- 2008-12-16 BR BRPI0821450-6A patent/BRPI0821450A2/pt not_active IP Right Cessation
- 2008-12-16 CA CA2707339A patent/CA2707339C/en not_active Expired - Fee Related
- 2008-12-16 JP JP2010540098A patent/JP5698985B2/ja not_active Expired - Fee Related
- 2008-12-16 WO PCT/EP2008/067622 patent/WO2009083436A1/en not_active Ceased
- 2008-12-16 PL PL11194457T patent/PL2444392T3/pl unknown
- 2008-12-16 DK DK08868725.6T patent/DK2234968T3/da active
- 2008-12-16 CN CN2008801227655A patent/CN101910127B/zh not_active Expired - Fee Related
- 2008-12-16 ES ES11194457.5T patent/ES2523167T3/es active Active
- 2008-12-16 SI SI200831326T patent/SI2444392T1/sl unknown
- 2008-12-16 PL PL08868725T patent/PL2234968T3/pl unknown
- 2008-12-16 US US12/745,356 patent/US8399477B2/en not_active Expired - Fee Related
- 2008-12-16 GE GEAP200811899A patent/GEP20125547B/en unknown
- 2008-12-16 PT PT88687256T patent/PT2234968E/pt unknown
- 2008-12-16 ES ES08868725T patent/ES2408955T3/es active Active
- 2008-12-16 SG SG2012095667A patent/SG187400A1/en unknown
- 2008-12-16 EP EP11194457.5A patent/EP2444392B1/en not_active Not-in-force
- 2008-12-16 EP EP08868725A patent/EP2234968B1/en not_active Not-in-force
- 2008-12-16 KR KR1020107015290A patent/KR101671874B1/ko not_active Expired - Fee Related
- 2008-12-16 PT PT111944575T patent/PT2444392E/pt unknown
- 2008-12-16 EA EA201070804A patent/EA020373B1/ru not_active IP Right Cessation
- 2008-12-23 AR ARP080105698A patent/AR069961A1/es not_active Application Discontinuation
2010
- 2010-05-30 IL IL206062A patent/IL206062A/en not_active IP Right Cessation
2013
- 2013-02-15 US US13/768,013 patent/US8871948B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SI2234968T1 (sl)	2013-06-28
US20100286189A1 (en)	2010-11-11
SI2444392T1 (sl)	2014-12-31
IL206062A0 (en)	2010-11-30
KR101671874B1 (ko)	2016-11-03
GEP20125547B (en)	2012-05-25
ES2408955T3 (es)	2013-06-24
AU2008342705B2 (en)	2013-11-14
US20130158269A1 (en)	2013-06-20
CN101910127A (zh)	2010-12-08
CN101910127B (zh)	2013-01-23
PT2234968E (pt)	2013-06-03
DK2444392T3 (en)	2014-12-08
ES2523167T3 (es)	2014-11-21
IL206062A (en)	2015-08-31
EP2078711A1 (en)	2009-07-15
BRPI0821450A2 (pt)	2015-06-16
EP2444392B1 (en)	2014-09-24
KR20100103569A (ko)	2010-09-27
AR069961A1 (es)	2010-03-03
HK1145172A1 (en)	2011-04-08
EA201070804A1 (ru)	2010-12-30
EP2234968A1 (en)	2010-10-06
UA100867C2 (uk)	2013-02-11
PT2444392E (pt)	2014-11-19
CA2707339C (en)	2018-05-01
JP2011507929A (ja)	2011-03-10
EP2444392A1 (en)	2012-04-25
US8871948B2 (en)	2014-10-28
PL2234968T3 (pl)	2013-08-30
CA2707339A1 (en)	2009-07-09
EA020373B1 (ru)	2014-10-30
JP5698985B2 (ja)	2015-04-08
HK1165410A1 (en)	2012-10-05
EP2234968B1 (en)	2013-03-27
DK2234968T3 (da)	2013-06-17
WO2009083436A1 (en)	2009-07-09
AU2008342705A1 (en)	2009-07-09
US8399477B2 (en)	2013-03-19
SG187400A1 (en)	2013-02-28
KR20160029861A (ko)	2016-03-15

Publication	Publication Date	Title
SI2444392T1 (sl)	2014-12-31	Intermediarni (aza)indolni derivat, substituiran na poloĹľaju 5
IL188039A0 (en)	2008-03-20	Oxindole derivatives
GB0713259D0 (en)	2007-08-15	Pyrazine derivatives 954
IL196854A0 (en)	2009-11-18	Indole compouds
SI2017278T1 (sl)	2017-05-31	Derivat dihidropirazolopirimidinona
EP2009005A4 (en)	2010-06-02	AZOLECARBOXAMIDE DERIVATIVE
IL196543A0 (en)	2009-11-18	Pyridizinone derivatives
IL195132A0 (en)	2009-09-22	Substituted azaspiro derivatives
IL193641A0 (en)	2009-05-04	Spiroindolinone derivatives
IL193175A0 (en)	2009-02-11	Pyridine-2-carboxamide derivatives
IL192401A0 (en)	2008-12-29	Indol-3-yl-carbonyl-spiro-piperidine derivatives
IL194391A0 (en)	2009-08-03	5-amido-2-carboxamide indoles
IL207684A0 (en)	2010-12-30	Substituted indole derivatives
IL184841A0 (en)	2007-12-03	Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives
IL193210A0 (en)	2009-02-11	Amino indazole derivatives
ZA200905265B (en)	2010-04-28	Indole derivatives
ZA201002213B (en)	2011-06-29	"6-pyrimidinyl-pyrimid-4-one derivative"
IL198633A0 (en)	2010-02-17	Indoles
ZA200900843B (en)	2010-03-31	Indole compounds
ZA200903997B (en)	2010-04-28	Fused substituted aminopyrrolidine derivative
PL2097400T3 (pl)	2013-11-29	Skondensowane podstawione pochodne aminopirolidyny
TWI365186B (en)	2012-06-01	Indole derivatives
IL194873A0 (en)	2009-08-03	Methods for reducing 7/9-nitrotetracycline derivatives
EP2130829A4 (en)	2010-12-01	NEW HYDROXYINDOLE DERIVATIVE
GB0618761D0 (en)	2006-11-01	Derivatives 2