PL2398785T3 - Oczyszczanie 1-[2-(2,4-dimetylpfenylosulfanylo)fenylo]piperazyny - Google Patents
Oczyszczanie 1-[2-(2,4-dimetylpfenylosulfanylo)fenylo]piperazynyInfo
- Publication number
- PL2398785T3 PL2398785T3 PL10704890T PL10704890T PL2398785T3 PL 2398785 T3 PL2398785 T3 PL 2398785T3 PL 10704890 T PL10704890 T PL 10704890T PL 10704890 T PL10704890 T PL 10704890T PL 2398785 T3 PL2398785 T3 PL 2398785T3
- Authority
- PL
- Poland
- Prior art keywords
- dimethylphenylsulfanyl
- piperazine
- purification
- phenyl
- Prior art date
Links
- 238000000746 purification Methods 0.000 title 1
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20797209P | 2009-02-17 | 2009-02-17 | |
| DKPA200900223 | 2009-02-17 | ||
| EP10704890.2A EP2398785B1 (en) | 2009-02-17 | 2010-02-16 | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]-piperazine |
| PCT/DK2010/050039 WO2010094285A1 (en) | 2009-02-17 | 2010-02-16 | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2398785T3 true PL2398785T3 (pl) | 2014-07-31 |
Family
ID=42101395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10704890T PL2398785T3 (pl) | 2009-02-17 | 2010-02-16 | Oczyszczanie 1-[2-(2,4-dimetylpfenylosulfanylo)fenylo]piperazyny |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8598348B2 (pl) |
| EP (1) | EP2398785B1 (pl) |
| JP (1) | JP5738774B2 (pl) |
| KR (1) | KR101639833B1 (pl) |
| CN (1) | CN102317272B (pl) |
| AR (1) | AR075436A1 (pl) |
| AU (1) | AU2010214956B2 (pl) |
| BR (1) | BRPI1006975B1 (pl) |
| CA (1) | CA2751498C (pl) |
| CL (1) | CL2011001992A1 (pl) |
| CO (1) | CO6400224A2 (pl) |
| DK (1) | DK2398785T3 (pl) |
| EA (1) | EA020473B1 (pl) |
| ES (1) | ES2441079T3 (pl) |
| HR (1) | HRP20131236T1 (pl) |
| IL (1) | IL214178A (pl) |
| MX (1) | MX2011008661A (pl) |
| NZ (1) | NZ594658A (pl) |
| PL (1) | PL2398785T3 (pl) |
| PT (1) | PT2398785E (pl) |
| RS (1) | RS53074B (pl) |
| SG (1) | SG173735A1 (pl) |
| SI (1) | SI2398785T1 (pl) |
| SM (1) | SMT201400010B (pl) |
| TW (1) | TW201033181A (pl) |
| WO (1) | WO2010094285A1 (pl) |
| ZA (1) | ZA201105992B (pl) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9133144B2 (en) * | 2012-01-03 | 2015-09-15 | H. Lundbeck A/S | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
| CA2885266C (en) | 2012-09-19 | 2020-05-12 | Sandoz Ag | Novel crystalline form of vortioxetine hydrobromide |
| KR102171152B1 (ko) | 2012-12-13 | 2020-10-29 | 하. 룬드벡 아크티에셀스카브 | 보르티옥세틴 및 도네페질을 포함하는 조성물 |
| AU2014220735B2 (en) * | 2013-02-22 | 2017-06-22 | H. Lundbeck A/S | Vortioxetine manufacturing process |
| US20160200698A1 (en) * | 2013-09-12 | 2016-07-14 | Hangzhou Pushai Pharmaceutical Technology Co., Ltd | Vortioxetine salt and crystal thereof, their preparation method, pharmaceutical compositions and usage |
| IN2013MU03121A (pl) | 2013-09-30 | 2015-07-17 | Cadila Healthcare Ltd | |
| EP2878596A1 (en) * | 2013-11-29 | 2015-06-03 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates |
| CN103788019B (zh) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| CN103788020B (zh) * | 2014-01-22 | 2015-11-04 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
| WO2015114395A1 (en) | 2014-01-31 | 2015-08-06 | Egis Gyógyszergyár Zrt. | Process for the preparation of vortioxetine salts |
| CN104059030B (zh) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| CN105218482B (zh) * | 2014-06-24 | 2018-04-06 | 杭州和泽医药科技有限公司 | 沃替西汀氢溴酸盐β晶型的制备方法 |
| US9687484B2 (en) | 2014-07-18 | 2017-06-27 | Dipharma Francis S.R.L. | Crystalline forms of an antidepressant compound |
| WO2016079751A2 (en) | 2014-11-17 | 2016-05-26 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
| CN105669594A (zh) * | 2014-11-19 | 2016-06-15 | 康普药业股份有限公司 | 抗抑郁症药1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪的制备方法 |
| CN105801517A (zh) * | 2014-12-30 | 2016-07-27 | 上海奥博生物医药技术有限公司 | 一种沃替西汀氢溴酸盐新晶型及其制备方法 |
| WO2016125190A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Novel crystalline forms of vortioxetine, premixes, and processes for the preparation thereof |
| WO2016151328A1 (en) | 2015-03-26 | 2016-09-29 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN105439980B (zh) * | 2015-05-08 | 2017-10-24 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀一仲丁醇合物及其制备方法 |
| CN105367515B (zh) * | 2015-05-08 | 2017-10-27 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀α晶型的制备方法 |
| CN106316985B (zh) * | 2015-06-18 | 2021-11-09 | 郑州深蓝海生物医药科技有限公司 | 一种β型高效氢溴酸沃替西汀转晶方法 |
| US20190194154A1 (en) * | 2016-01-20 | 2019-06-27 | Amneal Pharmaceuticals Company Gmbh | Polymorphic Forms Of Vortioxetine Hydrobromide Tert-Butanolate |
| WO2018002115A1 (en) | 2016-07-01 | 2018-01-04 | H. Lundbeck A/S | Vortioxetine dosing regimes for fast onset of antidepressant effect |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| US11124491B2 (en) * | 2017-04-25 | 2021-09-21 | H. Lundbeck A/S | Process for the manufacture of vortioxetine HBr alpha-form |
| CN108017595A (zh) * | 2017-12-20 | 2018-05-11 | 安徽源久源科技有限公司 | 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法 |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN112125868B (zh) * | 2020-09-25 | 2021-08-03 | 中山万远新药研发有限公司 | 一种氢溴酸伏硫西汀晶型及其制备方法、组合物与用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB852974A (en) | 1958-04-17 | 1960-11-02 | Parke Davis & Co | Ethers and means for producing the same |
| FR2186237B1 (pl) | 1972-05-03 | 1975-10-31 | Synthelabo | |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| EP2439201B1 (en) * | 2006-06-16 | 2013-08-07 | H. Lundbeck A/S | Compounds with combined sert, 5-ht3 and 5-ht1a activity |
| HRP20110412T1 (hr) * | 2006-06-16 | 2011-06-30 | H. Lundbeck A/S | Kristalni oblici 4-[2-4-(4-metilfenilsulfanil)fenil]piperidina sa kombiniranom inhibicijom reapsorpcije serotonina i norepinefrina za liječenje neuropatskih bolova |
| TW200848411A (en) * | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
-
2010
- 2010-02-04 TW TW099103300A patent/TW201033181A/zh unknown
- 2010-02-16 RS RS20130554A patent/RS53074B/sr unknown
- 2010-02-16 AU AU2010214956A patent/AU2010214956B2/en active Active
- 2010-02-16 EA EA201171065A patent/EA020473B1/ru not_active IP Right Cessation
- 2010-02-16 WO PCT/DK2010/050039 patent/WO2010094285A1/en not_active Ceased
- 2010-02-16 MX MX2011008661A patent/MX2011008661A/es active IP Right Grant
- 2010-02-16 KR KR1020117019067A patent/KR101639833B1/ko active Active
- 2010-02-16 NZ NZ594658A patent/NZ594658A/xx not_active IP Right Cessation
- 2010-02-16 SG SG2011059227A patent/SG173735A1/en unknown
- 2010-02-16 CN CN201080007947.5A patent/CN102317272B/zh active Active
- 2010-02-16 PL PL10704890T patent/PL2398785T3/pl unknown
- 2010-02-16 PT PT107048902T patent/PT2398785E/pt unknown
- 2010-02-16 SI SI201030444T patent/SI2398785T1/sl unknown
- 2010-02-16 US US13/148,088 patent/US8598348B2/en active Active
- 2010-02-16 HR HRP20131236AT patent/HRP20131236T1/hr unknown
- 2010-02-16 CA CA2751498A patent/CA2751498C/en not_active Expired - Fee Related
- 2010-02-16 AR ARP100100441A patent/AR075436A1/es not_active Application Discontinuation
- 2010-02-16 EP EP10704890.2A patent/EP2398785B1/en active Active
- 2010-02-16 JP JP2011549435A patent/JP5738774B2/ja active Active
- 2010-02-16 ES ES10704890.2T patent/ES2441079T3/es active Active
- 2010-02-16 DK DK10704890.2T patent/DK2398785T3/da active
- 2010-02-16 BR BRPI1006975-5A patent/BRPI1006975B1/pt active IP Right Grant
-
2011
- 2011-07-19 IL IL214178A patent/IL214178A/en active IP Right Grant
- 2011-08-05 CO CO11099111A patent/CO6400224A2/es not_active Application Discontinuation
- 2011-08-16 CL CL2011001992A patent/CL2011001992A1/es unknown
- 2011-08-16 ZA ZA2011/05992A patent/ZA201105992B/en unknown
-
2014
- 2014-01-22 SM SM201400010T patent/SMT201400010B/xx unknown
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