PL2391620T3 - Alkiloamino-podstawione dicyjanopirydyny i ich estrowe proleki aminokwasów - Google Patents

Alkiloamino-podstawione dicyjanopirydyny i ich estrowe proleki aminokwasów

Info

Publication number: PL2391620T3
Authority: PL; Poland
Prior art keywords: alkylamine; amino acid; acid ester; ester prodrugs; dicyanopyridine
Prior art date: 2009-01-29

Application number

PL10700508T

Other languages

English (en)

Inventor

Alexandros Vakalopoulos

Daniel Meibom

Barbara Albrecht-Küpper

Katja Zimmermann

Joerg Keldenich

Hans-Georg Lerchen

Peter Nell

Frank Süssmeier

Ursula Krenz

Original Assignee

Bayer Ip Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-29

Filing date

2010-01-19

Publication date

2014-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41724154&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2391620(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-01-19 Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh

2014-09-30 Publication of PL2391620T3 publication Critical patent/PL2391620T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Crystallography & Structural Chemistry (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

PL10700508T 2009-01-29 2010-01-19 Alkiloamino-podstawione dicyjanopirydyny i ich estrowe proleki aminokwasów PL2391620T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102009006602A DE102009006602A1 (de)	2009-01-29	2009-01-29	Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
EP10700508.4A EP2391620B1 (de)	2009-01-29	2010-01-19	Alkylamino-substituierte dicyanopyridine und deren aminosäureester-prodrugs
PCT/EP2010/000262 WO2010086101A1 (de)	2009-01-29	2010-01-19	Alkylamino-substituierte dicyanopyridine und deren aminosäureester-prodrugs

Publications (1)

Publication Number	Publication Date
PL2391620T3 true PL2391620T3 (pl)	2014-09-30

Family

ID=41724154

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL10700508T PL2391620T3 (pl)	2009-01-29	2010-01-19	Alkiloamino-podstawione dicyjanopirydyny i ich estrowe proleki aminokwasów
PL14155583T PL2743270T3 (pl)	2009-01-29	2010-01-19	Alkiloamino-podstawione dicyjanopirydyny i ich proleki estrowe aminokwasów

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL14155583T PL2743270T3 (pl)	2009-01-29	2010-01-19	Alkiloamino-podstawione dicyjanopirydyny i ich proleki estrowe aminokwasów

Country Status (42)

Country	Link
US (3)	US8420825B2 (pl)
EP (2)	EP2391620B1 (pl)
JP (2)	JP5693469B2 (pl)
KR (2)	KR101833188B1 (pl)
CN (2)	CN104844687B (pl)
AR (1)	AR075050A1 (pl)
AU (1)	AU2010207786B2 (pl)
BR (1)	BRPI1007308A2 (pl)
CA (2)	CA2750769C (pl)
CO (1)	CO6400193A2 (pl)
CR (1)	CR20110407A (pl)
CU (1)	CU24037B1 (pl)
CY (2)	CY1115403T1 (pl)
DE (1)	DE102009006602A1 (pl)
DK (2)	DK2743270T3 (pl)
DO (1)	DOP2011000243A (pl)
EA (1)	EA019275B1 (pl)
EC (1)	ECSP11011235A (pl)
ES (2)	ES2473966T3 (pl)
GT (1)	GT201100205A (pl)
HK (1)	HK1211308A1 (pl)
HN (1)	HN2011002037A (pl)
HR (2)	HRP20140714T1 (pl)
HU (1)	HUE032008T2 (pl)
IL (1)	IL214019A0 (pl)
JO (1)	JO2927B1 (pl)
LT (1)	LT2743270T (pl)
MA (1)	MA33000B1 (pl)
MX (1)	MX2011007800A (pl)
MY (1)	MY156434A (pl)
NZ (1)	NZ594267A (pl)
PE (2)	PE20120430A1 (pl)
PL (2)	PL2391620T3 (pl)
PT (2)	PT2743270T (pl)
RS (1)	RS53448B (pl)
SG (1)	SG172968A1 (pl)
SI (2)	SI2391620T1 (pl)
TN (1)	TN2011000370A1 (pl)
TW (2)	TWI457126B (pl)
UA (1)	UA104613C2 (pl)
UY (1)	UY32393A (pl)
WO (1)	WO2010086101A1 (pl)

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DE102008013587A1 (de)	2008-03-11	2009-09-17	Bayer Schering Pharma Aktiengesellschaft	Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
EP2297104B1 (de)	2008-05-29	2013-08-07	Bayer Intellectual Property GmbH	2-alkoxy-substituierte dicyanopyridine und ihre verwendung
DE102008062567A1 (de)	2008-12-16	2010-06-17	Bayer Schering Pharma Aktiengesellschaft	Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) *	2009-01-29	2010-08-05	Bayer Schering Pharma Aktiengesellschaft	Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
DE102010030688A1 (de)	2010-06-30	2012-01-05	Bayer Schering Pharma Aktiengesellschaft	Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) *	2010-09-02	2012-03-08	Bayer Pharma Aktiengesellschaft	Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
MA38276B1 (fr)	2012-12-21	2018-03-30	Sanofi Sa	Dérivés de l'exendine 4 pour l’utilisation dans le traitement des troubles du syndrome metabolique, y compris le diabete et l'obesite, ainsi que la reduction de l'apport alimentaire excessif.
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WO2017137528A1 (en)	2016-02-12	2017-08-17	Charité - Universitätsmedizin Berlin	Adenosine a1 receptor agonist for use in treatment of status epilepticus
WO2018108884A1 (de)	2016-12-16	2018-06-21	Bayer Pharma Aktiengesellschaft	Pharmazeutische tablettenformulierung
WO2018153897A1 (de)	2017-02-22	2018-08-30	Bayer Pharma Aktiengesellschaft	Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern
WO2018153900A1 (de) *	2017-02-22	2018-08-30	Bayer Aktiengesellschaft	Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern
WO2018153899A1 (de)	2017-02-22	2018-08-30	Bayer Pharma Aktiengesellschaft	Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc)
WO2018153898A1 (de) *	2017-02-22	2018-08-30	Bayer Pharma Aktiengesellschaft	Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten
WO2018153895A1 (de)	2017-02-22	2018-08-30	Bayer Pharma Aktiengesellschaft	Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten
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2009
- 2009-01-29 DE DE102009006602A patent/DE102009006602A1/de not_active Withdrawn
2010
- 2010-01-19 DK DK14155583.9T patent/DK2743270T3/en active
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Also Published As

Publication number	Publication date
ES2473966T3 (es)	2014-07-08
DK2391620T3 (da)	2014-08-11
KR20110108377A (ko)	2011-10-05
DOP2011000243A (es)	2017-10-15
EA019275B1 (ru)	2014-02-28
EP2743270A1 (de)	2014-06-18
TW201039821A (en)	2010-11-16
JP2012516290A (ja)	2012-07-19
PL2743270T3 (pl)	2017-04-28
CU20110153A7 (es)	2012-02-15
US20140296515A1 (en)	2014-10-02
CA2750769C (en)	2018-08-21
ES2614702T3 (es)	2017-06-01
US20130267700A1 (en)	2013-10-10
TN2011000370A1 (en)	2013-03-27
SI2391620T1 (sl)	2014-08-29
LT2743270T (lt)	2017-02-27
UY32393A (es)	2010-08-31
MX2011007800A (es)	2011-11-18
TWI457126B (zh)	2014-10-21
AU2010207786A1 (en)	2011-08-25
KR20170029029A (ko)	2017-03-14
HRP20170206T1 (hr)	2017-04-07
PT2391620E (pt)	2014-06-25
CN104844687B (zh)	2019-04-02
KR101833188B1 (ko)	2018-02-27
JP5693469B2 (ja)	2015-04-01
PT2743270T (pt)	2017-02-15
US8772498B2 (en)	2014-07-08
WO2010086101A1 (de)	2010-08-05
CY1118601T1 (el)	2017-07-12
AR075050A1 (es)	2011-03-02
IL214019A0 (en)	2011-08-31
US20100197609A1 (en)	2010-08-05
UA104613C2 (en)	2014-02-25
DK2743270T3 (en)	2017-02-20
BRPI1007308A2 (pt)	2016-02-10
CA2962039A1 (en)	2010-08-05
TW201504235A (zh)	2015-02-01
GT201100205A (es)	2013-08-21
CY1115403T1 (el)	2017-01-04
EP2743270B1 (de)	2016-12-21
JO2927B1 (en)	2015-09-15
RS53448B (sr)	2014-12-31
CU24037B1 (es)	2014-11-27
JP5908620B2 (ja)	2016-04-26
HK1168353A1 (en)	2012-12-28
MA33000B1 (fr)	2012-01-02
CN102388040A (zh)	2012-03-21
CA2750769A1 (en)	2010-08-05
CN104844687A (zh)	2015-08-19
NZ594267A (en)	2013-09-27
DE102009006602A1 (de)	2010-08-05
HUE032008T2 (en)	2017-08-28
KR101717305B1 (ko)	2017-03-16
TWI511968B (zh)	2015-12-11
CO6400193A2 (es)	2012-03-15
EP2391620A1 (de)	2011-12-07
HN2011002037A (es)	2013-12-02
PE20120430A1 (es)	2012-04-21
SG172968A1 (en)	2011-08-29
HRP20140714T1 (hr)	2014-11-21
SI2743270T1 (sl)	2017-03-31
EA201101111A1 (ru)	2012-02-28
US8420825B2 (en)	2013-04-16
JP2015120727A (ja)	2015-07-02
MY156434A (en)	2016-02-26
CN102388040B (zh)	2015-05-13
AU2010207786B2 (en)	2015-10-22
EP2391620B1 (de)	2014-05-07
CR20110407A (es)	2012-01-02
ECSP11011235A (es)	2011-10-31
HK1211308A1 (en)	2016-05-20
PE20150636A1 (es)	2015-05-08

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