PL2350093T3 - Podstawione 4,5,6,7-tetrahydrotienopirydyny jako modulatory KCNQ2/3 do leczenia bólu, padaczki i nietrzymania moczu - Google Patents
Podstawione 4,5,6,7-tetrahydrotienopirydyny jako modulatory KCNQ2/3 do leczenia bólu, padaczki i nietrzymania moczuInfo
- Publication number
- PL2350093T3 PL2350093T3 PL09747793T PL09747793T PL2350093T3 PL 2350093 T3 PL2350093 T3 PL 2350093T3 PL 09747793 T PL09747793 T PL 09747793T PL 09747793 T PL09747793 T PL 09747793T PL 2350093 T3 PL2350093 T3 PL 2350093T3
- Authority
- PL
- Poland
- Prior art keywords
- tetrahydrothienopyridines
- kcnq2
- epilepsy
- modulators
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08018617 | 2008-10-24 | ||
| EP09747793A EP2350093B1 (de) | 2008-10-24 | 2009-10-22 | Substituierte 4,5,6,7-tetrahydrothienopyridine als kcnq2/3 modulatoren zur behandlung von schmerz, epilepsie und harninkontinenz |
| PCT/EP2009/007567 WO2010046108A1 (de) | 2008-10-24 | 2009-10-22 | Substituierte 4,5,6,7-tetrahydrothienopyridine als kcnq2/3 modulatoren zur behandlung von schmerz, epilepsie und harninkontinenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2350093T3 true PL2350093T3 (pl) | 2013-01-31 |
Family
ID=40383750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09747793T PL2350093T3 (pl) | 2008-10-24 | 2009-10-22 | Podstawione 4,5,6,7-tetrahydrotienopirydyny jako modulatory KCNQ2/3 do leczenia bólu, padaczki i nietrzymania moczu |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100105722A1 (pl) |
| EP (1) | EP2350093B1 (pl) |
| JP (1) | JP2012506395A (pl) |
| AU (1) | AU2009306722A1 (pl) |
| BR (1) | BRPI0919898A2 (pl) |
| CA (1) | CA2739740A1 (pl) |
| CY (1) | CY1113373T1 (pl) |
| DK (1) | DK2350093T3 (pl) |
| ES (1) | ES2392758T3 (pl) |
| HR (1) | HRP20120822T1 (pl) |
| MX (1) | MX2011003849A (pl) |
| PL (1) | PL2350093T3 (pl) |
| PT (1) | PT2350093E (pl) |
| SI (1) | SI2350093T1 (pl) |
| WO (1) | WO2010046108A1 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2013000748A (es) | 2010-08-27 | 2013-03-05 | Gruenenthal Gmbh | 2-amino-quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| PT2609086E (pt) | 2010-08-27 | 2015-06-30 | Gruenenthal Gmbh | 2-oxo- e 2-tioxo-di-hidroquinolina-3-carboxamidas substituídas como moduladores de kcnq2/3 |
| US8445512B2 (en) | 2010-08-27 | 2013-05-21 | Gruenenthal Gmbh | Substituted quinoline-3-carboxamides as KCNQ2/3 modulators |
| JP5837933B2 (ja) * | 2010-08-27 | 2015-12-24 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換された２−オキシ−キノリン−３−カルボキサミド |
| MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| ES2678899T3 (es) | 2010-10-20 | 2018-08-20 | Grünenthal GmbH | 6-Amino-nicotinamidas sustituidas como moduladores de KCNQ2/3 |
| US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| AU2013235487B2 (en) | 2012-03-23 | 2017-09-07 | Memorial Sloan-Kettering Cancer Center | Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines |
| LT2888233T (lt) | 2012-04-18 | 2017-01-10 | Grünenthal GmbH | Pakeistieji 6-amino-nikotinamidai, turintys oh-turinčią grupę, kaip kcnq2/3 moduliatoriai |
| AU2013248638A1 (en) | 2012-04-18 | 2014-12-04 | Grünenthal GmbH | Substituted 4-aminobenzamides as KCNQ2/3 modulators |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| EP2951156A1 (en) | 2012-11-28 | 2015-12-09 | Grünenthal GmbH | Specific carboxamides as kcnq2/3 modulators |
| CA2892652A1 (en) | 2012-11-28 | 2014-06-05 | Grunenthal Gmbh | Heteroquinoline-3-carboxamides as kcnq2/3 modulators |
| EP4135698A4 (en) * | 2020-04-17 | 2024-08-14 | The Trustees of Indiana University | SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS |
| US11931356B1 (en) | 2022-11-30 | 2024-03-19 | The Trustees Of Indiana University | Compositions and methods for treating human papilloma virus infections |
| WO2025153715A1 (en) * | 2024-01-19 | 2025-07-24 | Scenic Biotech Bv | Heterocyclic pla2g15 inhibitors and their use in therapy, in the treatment of diseases characterized by lysosomal dysregulation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| WO2002072088A2 (en) * | 2001-02-20 | 2002-09-19 | Bristol-Myers Squibb Company | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| US7723523B2 (en) * | 2004-05-28 | 2010-05-25 | 4Sc Ag | Tetrahydropyridothiophenes |
| CA2569623A1 (en) * | 2004-06-11 | 2005-12-22 | Altana Pharma Ag | Novel compounds and use of tetrahydropyridothiophenes |
| DE102006049452A1 (de) * | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| WO2009001128A1 (en) * | 2007-06-26 | 2008-12-31 | Astrazeneca Ab | 1,2-cycl0hexane dicarboxamides as cathepsin inhibitors |
-
2009
- 2009-10-22 PT PT09747793T patent/PT2350093E/pt unknown
- 2009-10-22 JP JP2011532538A patent/JP2012506395A/ja active Pending
- 2009-10-22 BR BRPI0919898A patent/BRPI0919898A2/pt not_active IP Right Cessation
- 2009-10-22 AU AU2009306722A patent/AU2009306722A1/en not_active Abandoned
- 2009-10-22 ES ES09747793T patent/ES2392758T3/es active Active
- 2009-10-22 SI SI200930353T patent/SI2350093T1/sl unknown
- 2009-10-22 CA CA2739740A patent/CA2739740A1/en not_active Abandoned
- 2009-10-22 DK DK09747793.9T patent/DK2350093T3/da active
- 2009-10-22 MX MX2011003849A patent/MX2011003849A/es active IP Right Grant
- 2009-10-22 EP EP09747793A patent/EP2350093B1/de not_active Not-in-force
- 2009-10-22 WO PCT/EP2009/007567 patent/WO2010046108A1/de not_active Ceased
- 2009-10-22 PL PL09747793T patent/PL2350093T3/pl unknown
- 2009-10-22 HR HRP20120822AT patent/HRP20120822T1/hr unknown
- 2009-10-23 US US12/604,534 patent/US20100105722A1/en not_active Abandoned
-
2012
- 2012-11-05 CY CY20121101053T patent/CY1113373T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2350093T1 (sl) | 2012-11-30 |
| EP2350093A1 (de) | 2011-08-03 |
| US20100105722A1 (en) | 2010-04-29 |
| CA2739740A1 (en) | 2010-04-29 |
| JP2012506395A (ja) | 2012-03-15 |
| AU2009306722A1 (en) | 2010-04-29 |
| HRP20120822T1 (hr) | 2012-11-30 |
| DK2350093T3 (da) | 2012-11-12 |
| BRPI0919898A2 (pt) | 2016-02-16 |
| EP2350093B1 (de) | 2012-10-03 |
| WO2010046108A1 (de) | 2010-04-29 |
| ES2392758T3 (es) | 2012-12-13 |
| CY1113373T1 (el) | 2016-06-22 |
| PT2350093E (pt) | 2012-11-02 |
| MX2011003849A (es) | 2011-05-23 |
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