[go: up one dir, main page]

PL2016080T3 - Pochodne dihydropirazolopirymidynonu - Google Patents

Pochodne dihydropirazolopirymidynonu

Info

Publication number
PL2016080T3
PL2016080T3 PL07742843T PL07742843T PL2016080T3 PL 2016080 T3 PL2016080 T3 PL 2016080T3 PL 07742843 T PL07742843 T PL 07742843T PL 07742843 T PL07742843 T PL 07742843T PL 2016080 T3 PL2016080 T3 PL 2016080T3
Authority
PL
Poland
Prior art keywords
dihydropyrazolopyrimidinone
derivatives
dihydropyrazolopyrimidinone derivatives
Prior art date
Application number
PL07742843T
Other languages
English (en)
Inventor
Toshihiro Sakamoto
Satoshi Sunami
Fuyuki Yamamoto
Kenji Niiyama
Makoto Bamba
Keiji Takahashi
Hidetomo Furuyama
Takeshi Sagara
Sachie Otsuki
Toshihide Nishibata
Takashi Yoshizumi
Hiroshi Hirai
Original Assignee
Msd Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38655640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2016080(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Kk filed Critical Msd Kk
Publication of PL2016080T3 publication Critical patent/PL2016080T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL07742843T 2006-04-27 2007-04-25 Pochodne dihydropirazolopirymidynonu PL2016080T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006124208 2006-04-27
PCT/JP2007/059408 WO2007126122A1 (en) 2006-04-27 2007-04-25 Dihydropyrazolopyrimidinone derivatives
EP07742843A EP2016080B1 (en) 2006-04-27 2007-04-25 Dihydropyrazolopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
PL2016080T3 true PL2016080T3 (pl) 2011-03-31

Family

ID=38655640

Family Applications (2)

Application Number Title Priority Date Filing Date
PL07742851T PL2017278T3 (pl) 2006-04-27 2007-04-25 Pochodne dihydropirazolopirymidynonu
PL07742843T PL2016080T3 (pl) 2006-04-27 2007-04-25 Pochodne dihydropirazolopirymidynonu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL07742851T PL2017278T3 (pl) 2006-04-27 2007-04-25 Pochodne dihydropirazolopirymidynonu

Country Status (38)

Country Link
US (4) US7834019B2 (pl)
EP (2) EP2017278B1 (pl)
JP (2) JP4513919B2 (pl)
KR (1) KR101409161B1 (pl)
CN (1) CN101432284B (pl)
AR (1) AR060635A1 (pl)
AT (1) ATE475662T1 (pl)
AU (1) AU2007244185B2 (pl)
BR (1) BRPI0710081A2 (pl)
CA (1) CA2650119C (pl)
CR (1) CR10359A (pl)
CY (2) CY1111069T1 (pl)
DE (1) DE602007008085D1 (pl)
DK (2) DK2017278T3 (pl)
DO (1) DOP2007000084A (pl)
EC (1) ECSP088812A (pl)
ES (2) ES2348751T3 (pl)
GT (1) GT200800211A (pl)
HN (1) HN2008001532A (pl)
HR (2) HRP20161763T1 (pl)
HU (1) HUE032987T2 (pl)
IL (1) IL194367A (pl)
LT (1) LT2017278T (pl)
MA (1) MA30428B1 (pl)
MX (1) MX2008013063A (pl)
MY (1) MY145408A (pl)
NO (1) NO341617B1 (pl)
NZ (1) NZ571196A (pl)
PE (1) PE20080695A1 (pl)
PL (2) PL2017278T3 (pl)
PT (2) PT2016080E (pl)
RU (1) RU2437885C2 (pl)
SI (2) SI2017278T1 (pl)
SV (1) SV2009003060A (pl)
TW (1) TWI409262B (pl)
UA (1) UA96152C2 (pl)
WO (2) WO2007126122A1 (pl)
ZA (1) ZA200807748B (pl)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR060635A1 (es) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
JP5411847B2 (ja) * 2007-04-25 2014-02-12 Msd株式会社 Weelキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形
WO2008141385A1 (en) * 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
EP2213673B1 (en) * 2007-10-23 2013-06-05 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
EP2303885B1 (en) * 2008-06-12 2013-07-03 Merck Sharp & Dohme Corp. Process for producing bicycloaniline derivatives
CA2745959A1 (en) * 2008-12-12 2010-06-17 Msd K.K. Dihydropyrimidopyrimidine derivatives
WO2010076887A1 (en) * 2009-01-05 2010-07-08 Banyu Pharmaceutical Co.,Ltd. Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor
CA2750716A1 (en) * 2009-02-25 2010-09-02 Msd K.K. Pyrimidopyrimidoindazole derivative
EP2473633A4 (en) * 2009-09-02 2013-03-06 Msd Kk USE OF ONE OR MORE BIOMARKERS TO IDENTIFY A WEE1 DISEASED PATIENT AND PROCEDURE FOR TREATING CANCER MEDIATED BY DYSFUNCTIONAL OR ABERRANT P53 BY ADMINISTERING A WEE1 HEMMER
US8703779B2 (en) 2009-09-15 2014-04-22 Merck Sharp & Dohme Corp. Preparation of crystalline forms of dihydropyrazolopyrimidinone
EP2640386B1 (en) 2010-11-16 2017-01-18 Array Biopharma Inc. Combination of checkpoint kinase 1 inhibitors and wee 1 kinase inhibitors
EP4223746A1 (en) * 2011-04-27 2023-08-09 Zeon Corporation Polymerizable compound, polymerizable composition, polymer, and optically anisotropic material
US8796289B2 (en) 2011-07-19 2014-08-05 Abbvie Inc. Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases
WO2013039854A1 (en) 2011-09-15 2013-03-21 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
JP2014530867A (ja) 2011-10-20 2014-11-20 アッヴィ・インコーポレイテッド キナーゼのピリドピリミジノン阻害剤
CA2864142A1 (en) * 2012-02-23 2013-08-29 Abbvie Inc. Pyridopyrimidinone inhibitors of kinases
WO2014062454A1 (en) * 2012-10-15 2014-04-24 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
DK2925888T3 (en) * 2012-11-28 2017-12-18 Merck Sharp & Dohme COMPOSITIONS AND METHODS OF CANCER TREATMENT
CA2909160C (en) 2013-04-09 2021-05-25 Lixte Biotechnology, Inc. Formulations of oxabicycloheptanes and oxabicycloheptenes
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
JP6023902B1 (ja) * 2014-12-17 2016-11-09 Delta−Fly Pharma株式会社 高齢又は末期の癌患者を治療又は寛解するための医薬組成物
TW201706258A (zh) 2015-04-17 2017-02-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
AR104291A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
TW201702247A (zh) 2015-04-17 2017-01-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
DK3345907T3 (da) * 2015-09-01 2020-06-22 Taiho Pharmaceutical Co Ltd Pyrazolo[3,4-d]pyrimidinforbindelser eller salte deraf
CN105130986B (zh) * 2015-09-30 2017-07-18 广州科擎新药开发有限公司 嘧啶或吡啶并吡啶酮类化合物及其应用
CA3003737C (en) * 2015-11-01 2021-09-14 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of making and using the same
GB201612092D0 (en) * 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
WO2018052772A1 (en) 2016-09-15 2018-03-22 Boehringer Ingelheim International Gmbh Heteroaryl carboxamide compounds as inhibitors of ripk2
CN106719769A (zh) * 2016-11-28 2017-05-31 山东农业大学 一种含香菇多糖、苯醚甲环唑和噻虫啉的病虫兼治农药组合物
JP7246309B2 (ja) 2016-12-08 2023-03-27 リクスト・バイオテクノロジー,インコーポレイテッド 免疫応答を調節するためのオキサビシクロヘプタン
CN110198943B (zh) * 2017-01-23 2021-04-16 石家庄智康弘仁新药开发有限公司 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物
GB201703881D0 (en) * 2017-03-10 2017-04-26 Almac Discovery Ltd Pharmaceutical compounds
US11248006B2 (en) 2017-03-23 2022-02-15 Shanghai De Novo Pharmatech Co., Ltd. Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
SG11201908788YA (en) 2017-03-31 2019-10-30 Seattle Genetics Inc Combinations of chk1- and wee1 - inhibitors
WO2019028008A1 (en) * 2017-08-01 2019-02-07 Zeno Royalties & Milestones, LLC 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDIN-3-ONE ANALOGUES
CN109422754A (zh) * 2017-08-24 2019-03-05 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
WO2019074979A1 (en) * 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
AU2018347307A1 (en) 2017-10-09 2020-04-23 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2019085933A1 (zh) 2017-11-01 2019-05-09 南京明德新药研发股份有限公司 作为Wee1抑制剂的大环类化合物及其应用
CN109810111B (zh) * 2017-11-20 2023-10-27 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
CN111315747B (zh) * 2018-01-05 2023-05-02 四川科伦博泰生物医药股份有限公司 二氢吡唑酮并嘧啶类化合物及其制备方法和用途
US11479555B2 (en) * 2018-02-23 2022-10-25 Newave Pharmaceutical Inc. Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
WO2019169065A2 (en) * 2018-02-28 2019-09-06 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of treating cancer using the same
EP3762385B1 (en) * 2018-03-09 2025-02-12 Recurium IP Holdings, LLC Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
CN108653282B (zh) * 2018-06-28 2020-08-14 中国科学院昆明植物研究所 苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用
US12180184B2 (en) 2018-10-26 2024-12-31 Wuxi Biocity Biopharmaceutics Co., Ltd. Pyrimidopyrazolone derivative as Wee1 inhibitor and use thereof
CN113480541B (zh) * 2019-03-07 2022-09-02 湖南化工研究院有限公司 咪唑并吡啶化合物及其中间体的制备方法
KR102697799B1 (ko) * 2019-03-22 2024-08-23 쇼우야오 홀딩스 (베이징) 코., 엘티디. Wee1 억제제 및 이의 제조 및 용도
CN113939296A (zh) 2019-04-09 2022-01-14 诺维逊生物股份有限公司 杂环化合物及其用途
US20220220115A1 (en) * 2019-04-09 2022-07-14 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2020210320A1 (en) * 2019-04-11 2020-10-15 Recurium Ip Holdings, Llc Substituted l,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
HRP20241008T1 (hr) 2019-04-30 2024-11-08 Wuxi Biocity Biopharmaceutics Co., Ltd. Kristalni oblik spoja inhibitora wee1 i njegova uporaba
CN112142748B (zh) 2019-06-28 2023-07-04 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
CN112142747B (zh) * 2019-06-28 2024-03-01 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
CN114599399A (zh) 2019-10-25 2022-06-07 阿斯利康(瑞典)有限公司 治疗癌症的方法
WO2021127047A1 (en) * 2019-12-20 2021-06-24 Recurium Ip Holdings, Llc Combinations
CN113387962A (zh) * 2020-03-12 2021-09-14 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
CN115698006B (zh) * 2020-06-17 2024-03-29 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的吡唑并[3,4-d]嘧啶-3-酮衍生物
KR102549484B1 (ko) * 2020-12-08 2023-06-29 한국화학연구원 피라졸로피리미딘 설폰아마이드 유도체 및 이를 유효성분으로 포함하는 암 관련 질환의 예방 또는 치료용 약학적 조성물
WO2022171088A1 (zh) * 2021-02-09 2022-08-18 微境生物医药科技(上海)有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物
CN116848118A (zh) * 2021-02-09 2023-10-03 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的吡唑并[3,4-d]嘧啶-3-酮衍生物
WO2022171126A1 (zh) * 2021-02-09 2022-08-18 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的稠环化合物
CN115197221B (zh) * 2021-04-02 2024-05-24 轩竹(北京)医药科技有限公司 二氢吡唑并嘧啶酮类大环衍生物及其用途
EP4329815A1 (en) 2021-04-29 2024-03-06 Novartis AG Deubiquitinase-targeting chimeras and related methods
JP2024515318A (ja) 2021-04-30 2024-04-08 ウィゲン・バイオメディシン・テクノロジー・(シャンハイ)・カンパニー・リミテッド Wee-1阻害剤としての縮合環状化合物、その調製方法およびその使用
CN115403582A (zh) 2021-05-28 2022-11-29 江苏天士力帝益药业有限公司 Wee1抑制剂及其用途
CN115838375A (zh) * 2021-09-18 2023-03-24 优领医药科技(香港)有限公司 含嘧啶并二氢吡唑啉酮类衍生物、其药学上可接受的盐及其制备方法和应用
CN113880844B (zh) * 2021-09-29 2023-02-14 武汉九州钰民医药科技有限公司 Wee1蛋白激酶抑制剂adavosertib的化学合成方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN118176195A (zh) * 2021-11-01 2024-06-11 正大天晴药业集团股份有限公司 吡唑[3,4-d]嘧啶-3-酮类化合物及其医药用途
CN116462687B (zh) * 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CN116836184B (zh) * 2022-03-25 2025-07-25 药雅科技(上海)有限公司 Wee1激酶抑制剂的制备及其应用
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CN115073460B (zh) * 2022-07-13 2023-07-25 苏州施安鼎泰生物医药技术有限公司 一种嘧啶并[5,4-c][2,6]萘啶衍生物及其制备方法以及药物组合物和应用
WO2024012549A1 (zh) * 2022-07-15 2024-01-18 映恩生物制药(苏州)有限公司 一种嘧啶并五元杂环化合物、其制备方法和用途
CN119798282A (zh) * 2023-10-11 2025-04-11 智擎生技制药股份有限公司 基于稠合吡啶环的Myt1抑制剂
TW202519226A (zh) 2023-11-08 2025-05-16 美商艾克塞里克斯公司 使用抑制pkmyt1之化合物治療癌症之方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA07174A (fr) 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JP2628707B2 (ja) * 1987-08-26 1997-07-09 三井製薬工業株式会社 ピリミジン類及びその薬学的に許容される塩類
US5223608A (en) 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
HUT70024A (en) 1990-09-28 1995-09-28 Smithkline Beecham Corp Process for preparing water soluble camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5200524A (en) 1990-12-20 1993-04-06 North Carolina State University Camptothecin intermediates and method of making same
US5247089A (en) 1990-12-20 1993-09-21 North Carolina State University Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs
US5191082A (en) 1990-12-20 1993-03-02 North Carolina State University Camptothecin intermediate and method of making camptothecin intermediates
US5243050A (en) 1990-12-20 1993-09-07 North Carolina State University Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs
EP1238986B1 (en) 1992-10-28 2008-06-25 Genentech, Inc. Use of Vascular endothelial cell growth factor antagonists
JP3025602B2 (ja) 1993-05-21 2000-03-27 デビオファーム エス.アー. 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
JP3154399B2 (ja) 1996-07-04 2001-04-09 デビオファーム エス.アー. 白金化合物の製造方法
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
SE0103649D0 (sv) 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
AU2003224341A1 (en) 2002-04-26 2003-11-10 Warner-Lambert Company Llc Inhibitors of checkpoint kinases (wee1 and chk1)
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
WO2004065378A1 (en) 2003-01-17 2004-08-05 Warner-Lambert Company Llc 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation
US7407962B2 (en) * 2003-02-07 2008-08-05 Vertex Pharmaceuticals Incorporated Heteroaryl compounds useful as inhibitors or protein kinases
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US20050250836A1 (en) 2004-05-03 2005-11-10 Pfizer Inc Inhibitors of checkpoint kinases (Wee1 and Chk1)
CA2569530C (en) 2004-07-01 2013-07-30 Daiichi Asubio Pharma Co.,Ltd. Thienopyrazole derivative having pde 7 inhibitory activity
AU2006205851A1 (en) * 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. 5-membered annelated heterocyclic pyrimidines as kinase inhibitors
WO2006091737A1 (en) 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
AR060635A1 (es) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer

Also Published As

Publication number Publication date
PT2017278T (pt) 2017-01-03
US20070254892A1 (en) 2007-11-01
SI2017278T1 (sl) 2017-05-31
WO2007126122A1 (en) 2007-11-08
JP4513919B2 (ja) 2010-07-28
ES2348751T3 (es) 2010-12-13
SV2009003060A (es) 2009-04-28
MY145408A (en) 2012-02-15
CN101432284B (zh) 2012-08-15
US7935708B2 (en) 2011-05-03
CY1111069T1 (el) 2012-05-23
KR20090017491A (ko) 2009-02-18
SI2016080T1 (sl) 2011-03-31
AU2007244185A1 (en) 2007-11-08
HK1132498A1 (en) 2010-02-26
EP2016080A4 (en) 2009-05-13
DK2017278T3 (en) 2017-02-13
HRP20100563T1 (hr) 2010-11-30
HUE032987T2 (en) 2017-11-28
RU2437885C2 (ru) 2011-12-27
DE602007008085D1 (en) 2010-09-09
CR10359A (es) 2009-02-19
CA2650119A1 (en) 2007-11-08
IL194367A0 (en) 2009-08-03
AR060635A1 (es) 2008-07-02
HRP20161763T1 (hr) 2017-02-24
EP2017278A1 (en) 2009-01-21
AU2007244185B2 (en) 2012-10-04
JPWO2007126128A1 (ja) 2009-09-17
JP2010132689A (ja) 2010-06-17
CY1118526T1 (el) 2017-07-12
US8791125B2 (en) 2014-07-29
MA30428B1 (fr) 2009-05-04
RU2008146759A (ru) 2010-06-10
DOP2007000084A (es) 2007-12-31
ECSP088812A (es) 2008-11-27
EP2016080A1 (en) 2009-01-21
EP2016080B1 (en) 2010-07-28
CA2650119C (en) 2017-03-14
PL2017278T3 (pl) 2017-10-31
CN101432284A (zh) 2009-05-13
PT2016080E (pt) 2010-10-14
TWI409262B (zh) 2013-09-21
KR101409161B1 (ko) 2014-06-19
ZA200807748B (en) 2009-10-28
HN2008001532A (es) 2009-06-10
UA96152C2 (en) 2011-10-10
NO20084968L (no) 2008-11-26
US20110189130A1 (en) 2011-08-04
DK2016080T3 (da) 2010-11-22
PE20080695A1 (es) 2008-06-28
WO2007126128A1 (ja) 2007-11-08
MX2008013063A (es) 2008-12-16
ATE475662T1 (de) 2010-08-15
US20140303178A1 (en) 2014-10-09
TW200811176A (en) 2008-03-01
EP2017278B1 (en) 2016-11-02
BRPI0710081A2 (pt) 2011-08-02
JP5167291B2 (ja) 2013-03-21
IL194367A (en) 2014-12-31
ES2609087T3 (es) 2017-04-18
US20100063024A1 (en) 2010-03-11
NZ571196A (en) 2011-03-31
GT200800211A (es) 2009-04-07
NO341617B1 (no) 2017-12-11
LT2017278T (lt) 2017-01-25
EP2017278A4 (en) 2009-04-22
US7834019B2 (en) 2010-11-16

Similar Documents

Publication Publication Date Title
ZA200807748B (en) Dihydropyrazolopyrimidinone derivatives
IL196543A0 (en) Pyridizinone derivatives
IL193641A0 (en) Spiroindolinone derivatives
IL195013A0 (en) Pyridopyrimidinone derivatives
IL198319A0 (en) Spiroindolinone derivatives
IL195422A0 (en) 2-pyrazinecarboxamide derivatives
ZA200805574B (en) Indol-3-yl-carbonyl-spiro-piperidine derivatives
EP2009005A4 (en) AZOLECARBOXAMIDE DERIVATIVE
IL202020A0 (en) Spiroindolinone derivatives
IL196364A0 (en) Aminoindazolylurea derivatives
IL198059A0 (en) 2-aminocarbonyl-pyridine derivatives
ZA200809800B (en) 2-Thioxanthine derivatives acting as Mpo-inhibitors
IL200618A0 (en) Aza-pyridopyrimidinone derivatives
IL193211A0 (en) Indazole-heteroaryl derivatives
IL198645A0 (en) 5-hydroxymethyl-oxazolidin-2-one derivatives
IL197152A0 (en) 5-phenyl-nicotinamide derivatives
EP2133347A4 (en) 1-BIARYLAZETIDINONDERIVATE
IL202463A0 (en) Sulfonyl-quinoline derivatives
IL202159A0 (en) Piperidine-amide derivatives
ZA200807460B (en) Spiroindolinone derivatives
IL197239A0 (en) Phenyloxyaniline derivatives
GB0614154D0 (en) Novel Pyriazine Derivatives
GB0610018D0 (en) Benzotriazepinone derivatives
IL198973A0 (en) Sulfamatobenzothiophene derivatives
GB0610019D0 (en) Benzotriazepinone derivatives