PL1992618T3 - Policykliczna pochodna cynamidowa - Google Patents
Policykliczna pochodna cynamidowaInfo
- Publication number
- PL1992618T3 PL1992618T3 PL07738023T PL07738023T PL1992618T3 PL 1992618 T3 PL1992618 T3 PL 1992618T3 PL 07738023 T PL07738023 T PL 07738023T PL 07738023 T PL07738023 T PL 07738023T PL 1992618 T3 PL1992618 T3 PL 1992618T3
- Authority
- PL
- Poland
- Prior art keywords
- polycyclic
- cinnamide derivative
- derivative
- polycyclic cinnamide
- cinnamide
- Prior art date
Links
- -1 Polycyclic cinnamide derivative Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78051706P | 2006-03-09 | 2006-03-09 | |
| JP2006063562 | 2006-03-09 | ||
| US86170206P | 2006-11-30 | 2006-11-30 | |
| JP2006322728 | 2006-11-30 | ||
| PCT/JP2007/054532 WO2007102580A1 (ja) | 2006-03-09 | 2007-03-08 | 多環式シンナミド誘導体 |
| EP07738023A EP1992618B1 (en) | 2006-03-09 | 2007-03-08 | Polycyclic cinnamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1992618T3 true PL1992618T3 (pl) | 2012-06-29 |
Family
ID=38474999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07738023T PL1992618T3 (pl) | 2006-03-09 | 2007-03-08 | Policykliczna pochodna cynamidowa |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1992618B1 (pl) |
| KR (1) | KR101464651B1 (pl) |
| AR (1) | AR059955A1 (pl) |
| AU (1) | AU2007223158B2 (pl) |
| CA (1) | CA2643796A1 (pl) |
| CY (1) | CY1112767T1 (pl) |
| EA (1) | EA016464B1 (pl) |
| GE (1) | GEP20115139B (pl) |
| HN (1) | HN2008001374A (pl) |
| HR (1) | HRP20120174T1 (pl) |
| IL (1) | IL193770A (pl) |
| MA (1) | MA30268B1 (pl) |
| MX (1) | MX2008011221A (pl) |
| PL (1) | PL1992618T3 (pl) |
| WO (1) | WO2007102580A1 (pl) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7667041B2 (en) | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
| ATE458729T1 (de) | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| KR20080069221A (ko) | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모르폴린 타입의 신나미드 화합물 |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| CA2677296A1 (en) * | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
| US20080207900A1 (en) | 2007-02-28 | 2008-08-28 | Teiji Kimura | Two cyclic oxomorphorin derivatives |
| DE602008004769D1 (en) | 2007-05-11 | 2011-03-10 | Hoffmann La Roche | Hetarylaniline als modulatoren für amyloid beta |
| CA2689948A1 (en) * | 2007-06-01 | 2008-12-18 | Schering Corporation | Gamma secretase modulators |
| TW200916469A (en) * | 2007-08-31 | 2009-04-16 | Eisai R & Amp D Man Co Ltd | Multi-cyclic compounds |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| US8487099B2 (en) | 2007-11-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| MX2010006379A (es) * | 2007-12-11 | 2010-09-07 | Schering Corp | Moduladores de la secretasa gamma. |
| KR20100135711A (ko) | 2007-12-20 | 2010-12-27 | 엔비보 파마슈티칼즈, 인코퍼레이티드 | 사중치환된 벤젠 |
| CA2705411A1 (en) | 2007-12-21 | 2009-07-02 | F. Hoffmann-La Roche Ag | Heteroaryl derivatives as orexin receptor antagonists |
| WO2009087127A1 (en) | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| ES2428716T3 (es) | 2008-02-22 | 2013-11-11 | F. Hoffmann-La Roche Ag | Moduladores de beta-amiloide |
| MX2011002002A (es) * | 2008-08-27 | 2011-03-29 | Eisai R&D Man Co Ltd | Proceso para preparar ciertos compuestos de cinnamida. |
| JP5502089B2 (ja) | 2008-10-09 | 2014-05-28 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβのモジュレーター |
| JP2012508181A (ja) * | 2008-11-06 | 2012-04-05 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| EP2356124A1 (en) * | 2008-11-06 | 2011-08-17 | Schering Corporation | Gamma secretase modulators |
| WO2010052199A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| JP2012508748A (ja) | 2008-11-13 | 2012-04-12 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| AR074701A1 (es) | 2008-12-22 | 2011-02-02 | Schering Corp | Moduladores de gamma secretasa |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051807A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| EP2401276B1 (en) * | 2009-02-26 | 2013-06-05 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
| US8703954B2 (en) | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
| JP2012051805A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
| WO2011007756A1 (ja) | 2009-07-13 | 2011-01-20 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| US8871760B2 (en) * | 2009-09-21 | 2014-10-28 | Roche Palo Alto Llc | [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators |
| US9145399B2 (en) * | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| US8822699B2 (en) | 2010-09-02 | 2014-09-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP2014012641A (ja) * | 2010-10-29 | 2014-01-23 | Dainippon Sumitomo Pharma Co Ltd | 新規ピリジン誘導体 |
| EP2665362B1 (en) * | 2011-01-17 | 2016-03-30 | Karyopharm Therapeutics, Inc. | Olefin containing nuclear transport modulators and uses thereof |
| CA2842364A1 (en) | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| ES2655645T3 (es) | 2011-07-29 | 2018-02-21 | Karyopharm Therapeutics, Inc. | Moduladores de transporte nuclear que contienen hidrazida y usos de los mismos |
| US9708276B2 (en) | 2011-10-12 | 2017-07-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
| PL3404027T3 (pl) | 2012-05-09 | 2020-09-21 | Biogen Ma Inc. | Modulatory transportu jądrowego i ich zastosowania |
| ES2585009T3 (es) | 2012-05-16 | 2016-10-03 | Janssen Pharmaceuticals, Inc. | Derivados de 3,4-dihidro-2H-pirido[1,2-a]pirazina-1,6-diona sustituidos útiles para el tratamiento de (inter alia) enfermedad de Alzheimer |
| EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
| CA2889249C (en) | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
| AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| LT3010892T (lt) | 2013-06-21 | 2019-04-10 | Karyopharm Therapeutics Inc. | 1,2,4-triazolai kaip branduolio transporto moduliatoriai ir jų panaudojimas |
| US10882834B2 (en) | 2013-09-20 | 2021-01-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compounds for treating prostate cancer |
| US20160257657A1 (en) | 2013-09-20 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| DK3180331T3 (da) | 2014-08-15 | 2022-09-12 | Karyopharm Therapeutics Inc | Polymorfer af selinexor |
| MA43530A (fr) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics Inc | Modulateurs de transport nucléaire et leurs utilisations |
| EP3397633A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| CN108699080B (zh) * | 2016-02-23 | 2021-05-14 | 辉瑞公司 | 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物 |
| US10980806B2 (en) | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE288898T1 (de) * | 2000-12-04 | 2005-02-15 | Hoffmann La Roche | Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten |
| EP1594847A2 (en) * | 2003-02-12 | 2005-11-16 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| EP1730118A1 (en) * | 2004-02-12 | 2006-12-13 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| US7667041B2 (en) * | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
-
2007
- 2007-03-08 PL PL07738023T patent/PL1992618T3/pl unknown
- 2007-03-08 WO PCT/JP2007/054532 patent/WO2007102580A1/ja not_active Ceased
- 2007-03-08 EA EA200870336A patent/EA016464B1/ru not_active IP Right Cessation
- 2007-03-08 AU AU2007223158A patent/AU2007223158B2/en not_active Ceased
- 2007-03-08 EP EP07738023A patent/EP1992618B1/en active Active
- 2007-03-08 KR KR1020087023309A patent/KR101464651B1/ko not_active Expired - Fee Related
- 2007-03-08 HR HR20120174T patent/HRP20120174T1/hr unknown
- 2007-03-08 GE GEAP200710893A patent/GEP20115139B/en unknown
- 2007-03-08 AR ARP070100958A patent/AR059955A1/es not_active Application Discontinuation
- 2007-03-08 MX MX2008011221A patent/MX2008011221A/es active IP Right Grant
- 2007-03-08 CA CA002643796A patent/CA2643796A1/en not_active Abandoned
-
2008
- 2008-08-28 IL IL193770A patent/IL193770A/en not_active IP Right Cessation
- 2008-09-05 HN HN2008001374A patent/HN2008001374A/es unknown
- 2008-09-08 MA MA31220A patent/MA30268B1/fr unknown
-
2012
- 2012-02-16 CY CY20121100165T patent/CY1112767T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA016464B1 (ru) | 2012-05-30 |
| AR059955A1 (es) | 2008-05-14 |
| CY1112767T1 (el) | 2016-02-10 |
| AU2007223158B2 (en) | 2012-04-12 |
| KR20080108481A (ko) | 2008-12-15 |
| EP1992618A1 (en) | 2008-11-19 |
| IL193770A0 (en) | 2009-05-04 |
| EA200870336A1 (ru) | 2009-02-27 |
| CA2643796A1 (en) | 2007-09-13 |
| HRP20120174T1 (hr) | 2012-03-31 |
| HK1128085A1 (en) | 2009-10-16 |
| GEP20115139B (en) | 2011-01-10 |
| WO2007102580A1 (ja) | 2007-09-13 |
| IL193770A (en) | 2012-10-31 |
| KR101464651B1 (ko) | 2014-11-24 |
| EP1992618B1 (en) | 2012-01-18 |
| HK1122027A1 (en) | 2009-05-08 |
| MX2008011221A (es) | 2008-09-11 |
| HN2008001374A (es) | 2011-03-15 |
| MA30268B1 (fr) | 2009-03-02 |
| EP1992618A4 (en) | 2010-11-10 |
| AU2007223158A1 (en) | 2007-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL193770A0 (en) | Polycyclic cinnamide derivative | |
| HUS2400041I1 (hu) | 4-Pirimidin-szulfamid-származék | |
| HUS1900033I1 (hu) | Szubsztituált enaminokarbonil vegyületek | |
| ZA201000474B (en) | Polycyclic compound | |
| SI2017278T1 (sl) | Derivat dihidropirazolopirimidinona | |
| EP2009005A4 (en) | AZOLECARBOXAMIDE DERIVATIVE | |
| IL202262A0 (en) | Bicycloaniline derivative | |
| GB0602424D0 (en) | Compounds | |
| IL195296A0 (en) | Heterocyclic type cinnamide derivative | |
| GB0602046D0 (en) | Compounds | |
| EP1984379A4 (en) | ANTI-ARENAVIRAL COMPOUNDS | |
| EP2163554A4 (en) | PYRIMIDODIAZEPINONE DERIVATIVE | |
| EP2082022A4 (en) | COMPOUNDS | |
| ZA200810499B (en) | Ruthenium II compounds | |
| EP2228362A4 (en) | 4-HYDROXYPHENYLALKYLAMINE DERIVATIVE | |
| EP2004174A4 (en) | NAPHTHALENEDIONED COMPOUNDS | |
| ZA200901570B (en) | Substituted azolin-2-YL-amino compounds | |
| GB0602042D0 (en) | Compounds | |
| GB0600427D0 (en) | Compounds | |
| GB0602560D0 (en) | Compounds | |
| AU2007906908A0 (en) | Leg assembly | |
| GB0602451D0 (en) | Compounds | |
| GB0602559D0 (en) | Compounds | |
| GB0602134D0 (en) | Compounds | |
| GB0600929D0 (en) | Compounds |