PL1614687T3 - Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem - Google Patents

Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem

Info

Publication number: PL1614687T3
Authority: PL; Poland
Prior art keywords: ivabradine; benzazepin; tetrahydro; synthesis; derivatives
Prior art date: 2004-04-13

Application number

PL05290383T

Other languages

English (en)

Inventor

Jean-Michel Lerestif

Jean-Pierre Lecouve

Jean-Claude Souvie

Daniel Brigot

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-13

Filing date

2005-02-21

Publication date

2010-04-30

2005-02-21 Application filed by Servier Lab filed Critical Servier Lab

2010-04-30 Publication of PL1614687T3 publication Critical patent/PL1614687T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL05290383T 2004-04-13 2005-02-21 Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem PL1614687T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0403828A FR2868775B1 (fr)	2004-04-13	2004-04-13	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP05290383A EP1614687B1 (fr)	2004-04-13	2005-02-21	Nouveau procédé de synthèse de dérivés de la 1,3,4,5-tétrahydro-2H-3-benzazépin-2-one, et application à la synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable

Publications (1)

Publication Number	Publication Date
PL1614687T3 true PL1614687T3 (pl)	2010-04-30

Family

ID=34941961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05290383T PL1614687T3 (pl)	2004-04-13	2005-02-21	Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem

Country Status (32)

Country	Link
US (1)	US7064200B2 (pl)
EP (1)	EP1614687B1 (pl)
JP (2)	JP4515933B2 (pl)
KR (1)	KR100636499B1 (pl)
CN (1)	CN100348585C (pl)
AR (1)	AR047707A1 (pl)
AT (1)	ATE448221T1 (pl)
AU (1)	AU2005200884B2 (pl)
BR (1)	BRPI0500590B8 (pl)
CA (1)	CA2496712C (pl)
CY (1)	CY1109740T1 (pl)
DE (1)	DE602005017541D1 (pl)
DK (1)	DK1614687T3 (pl)
EA (1)	EA007743B1 (pl)
EG (1)	EG25619A (pl)
ES (1)	ES2336461T3 (pl)
FR (1)	FR2868775B1 (pl)
GE (1)	GEP20074136B (pl)
HR (1)	HRP20100024T1 (pl)
MA (1)	MA27598A1 (pl)
MX (1)	MXPA05003696A (pl)
MY (1)	MY140904A (pl)
NO (1)	NO329861B1 (pl)
NZ (1)	NZ538328A (pl)
PL (1)	PL1614687T3 (pl)
PT (1)	PT1614687E (pl)
RS (1)	RS51232B (pl)
SG (1)	SG116574A1 (pl)
SI (1)	SI1614687T1 (pl)
UA (1)	UA81773C2 (pl)
WO (1)	WO2005111027A1 (pl)
ZA (1)	ZA200501468B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GT200500185A (es) *	2004-08-09	2006-04-10		Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
EP2162438A4 (en)	2007-05-30	2011-07-06	Ind Swift Lab Ltd	PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE
CN102264689B (zh)	2008-12-22	2014-12-31	新梅斯托克尔卡公司	制备伊伐布雷定的方法
FR2940287B1 (fr) *	2008-12-24	2010-12-24	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
SI23290A (sl)	2010-02-12	2011-08-31	Krka D.D., Novo Mesto	Nove oblike ivabradin hidroklorida
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2971507B1 (fr) *	2011-02-14	2013-01-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) *	2012-07-17	2014-10-31	Servier Lab	Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3519735A1 (de) *	1985-06-01	1986-12-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr not_active Expired - Lifetime
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en not_active Expired - Lifetime
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en not_active Expired
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en not_active IP Right Cessation
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh not_active Expired - Lifetime
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt not_active IP Right Cessation
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja not_active Expired - Lifetime
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko not_active Expired - Lifetime
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de not_active Expired - Lifetime
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es not_active Expired - Lifetime
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr not_active Ceased
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr not_active Expired - Lifetime
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja not_active Expired - Lifetime
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown

Also Published As

Publication number	Publication date
CN1683343A (zh)	2005-10-19
SG116574A1 (en)	2005-11-28
FR2868775B1 (fr)	2008-04-11
DE602005017541D1 (de)	2009-12-24
NZ538328A (en)	2005-10-28
EA200500240A1 (ru)	2005-10-27
CN100348585C (zh)	2007-11-14
US7064200B2 (en)	2006-06-20
BRPI0500590B8 (pt)	2021-05-25
EP1614687A1 (fr)	2006-01-11
DK1614687T3 (da)	2010-03-29
WO2005111027A1 (fr)	2005-11-24
CY1109740T1 (el)	2014-09-10
FR2868775A1 (fr)	2005-10-14
RS51232B (sr)	2010-12-31
UA81773C2 (uk)	2008-02-11
PT1614687E (pt)	2009-12-02
JP2010047577A (ja)	2010-03-04
CA2496712A1 (fr)	2005-10-13
KR20060042117A (ko)	2006-05-12
NO20050888D0 (no)	2005-02-18
CA2496712C (fr)	2010-04-06
HK1079777A1 (zh)	2006-04-13
GEP20074136B (en)	2007-06-25
BRPI0500590A (pt)	2005-11-16
SI1614687T1 (sl)	2010-01-29
EP1614687B1 (fr)	2009-11-11
JP2005298478A (ja)	2005-10-27
AR047707A1 (es)	2006-02-08
JP4515933B2 (ja)	2010-08-04
AU2005200884B2 (en)	2010-07-15
NO329861B1 (no)	2011-01-17
ZA200501468B (en)	2005-11-30
ES2336461T3 (es)	2010-04-13
US20050228178A1 (en)	2005-10-13
JP5277130B2 (ja)	2013-08-28
ATE448221T1 (de)	2009-11-15
EG25619A (en)	2012-03-26
MXPA05003696A (es)	2006-01-24
MA27598A1 (fr)	2005-11-01
NO20050888L (no)	2005-10-14
EA007743B1 (ru)	2006-12-29
BRPI0500590B1 (pt)	2018-10-09
KR100636499B1 (ko)	2006-10-18
MY140904A (en)	2010-01-29
AU2005200884A1 (en)	2005-10-27
HRP20100024T1 (hr)	2010-02-28

Publication	Publication Date	Title
SI1589005T1 (sl)	2007-08-31	Postopek sinteze ivabradina in njegovih farmacevtsko sprejemljivih kislinskih adicijskih soli
PL1598333T3 (pl)	2006-12-29	Sposób syntezy (1S)-4,5-dimetoksy-1-(metyloaminometylo)benzocyklobutanu i jego soli addycyjnych, oraz zastosowanie do syntezy iwabradyny i jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem
HUP0402588A3 (en)	2009-09-28	Quinazoline derivatives, pharmaceutical compositions containing them, process for producing them and their use
AU2003233010A8 (en)	2003-12-19	Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
FR2891827B1 (fr)	2007-12-28	Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
HUP0101336A3 (en)	2003-03-28	Process for the preparation of perindopril and their pharmaceutically acceptable salts
MA28626B1 (fr)	2007-06-01	Forme cristalline delta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1806149A4 (en)	2012-12-05	SOLID MEDICINAL PREPARATION IMPROVED IN TERMS OF SOLUBILITY AND STABILITY AND METHOD FOR PRODUCING SAME
HUE037069T2 (hu)	2018-08-28	Eljárás nagy tisztaságú 2,4'-metiléndifenildiizocianát elõállítására
PL1614687T3 (pl)	2010-04-30	Sposób syntezy pochodnych 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onu i ich zastosowania do syntezy iwabradyny oraz jej soli addycyjnych z dopuszczalnym farmaceutycznie kwasem
HUP0401522A2 (en)	2006-04-28	New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
ZA200704246B (en)	2009-09-30	Solid medicinal preparation improved in solubility and stability and process for producing the same
EP1731139A4 (en)	2008-12-03	PHARMACEUTICAL PREPARATION OF THE S / O TYPE AND MANUFACTURING METHOD THEREFOR
ZA200510324B (en)	2007-03-28	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
PL1589014T3 (pl)	2008-01-31	Sposób syntezy pochodnych 1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do wytwarzania iwabradyny i jej dopuszczalnych farmaceutycznie soli
PT1753720E (pt)	2014-08-04	Processo para a preparação de perindopril e sais do mesmo
SI1403275T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PL379625A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
PL379631A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
SG150544A1 (en)	2009-03-30	Novel dichloro-phenyl-pyrido [2,3-d] pyrimidine derivatives, their manufacture and use as pharmaceutical agents
IL175282A0 (en)	2006-09-05	Preparation of pharmaceutical salts of [1,4]-bipiperidine
SG117528A1 (en)	2005-12-29	New process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof, with