PH14163A - Derivatives of 4-desacetyl vlb c-3 carboxhydrazide - Google Patents

Derivatives of 4-desacetyl vlb c-3 carboxhydrazide

Info

Publication number: PH14163A
Authority: PH; Philippines
Prior art keywords: carboxhydrazide; derivatives; desacetyl vlb; desacetyl; vlb
Prior art date: 1978-04-20

Application number

PH23391A

Other languages

English (en)

Inventor

Koert Gerzon

G Cullinan

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-17

Publication date

1981-03-19

1979-04-17 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1981-03-19 Publication of PH14163A publication Critical patent/PH14163A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PH23391A 1978-04-20 1979-04-17 Derivatives of 4-desacetyl vlb c-3 carboxhydrazide PH14163A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
PH14163A true PH14163A (en)	1981-03-19

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH23391A PH14163A (en)	1978-04-20	1979-04-17	Derivatives of 4-desacetyl vlb c-3 carboxhydrazide

Country Status (32)

Country	Link
US (1)	US4166810A (ro)
EP (1)	EP0005051B1 (ro)
JP (1)	JPS54141798A (ro)
AR (1)	AR228940A1 (ro)
AT (1)	AT369010B (ro)
AU (1)	AU527109B2 (ro)
BE (1)	BE875652A (ro)
BG (3)	BG33297A3 (ro)
CA (1)	CA1097629A (ro)
CH (1)	CH643269A5 (ro)
CS (3)	CS218584B2 (ro)
DD (1)	DD143075A5 (ro)
DE (1)	DE2964130D1 (ro)
DK (1)	DK147484C (ro)
EG (1)	EG14867A (ro)
ES (2)	ES479753A1 (ro)
FI (1)	FI791286A7 (ro)
FR (1)	FR2423495A1 (ro)
GB (1)	GB2019396B (ro)
GR (1)	GR69987B (ro)
HU (1)	HU181431B (ro)
IE (1)	IE48213B1 (ro)
IL (1)	IL57168A (ro)
LU (1)	LU81166A1 (ro)
NZ (1)	NZ190213A (ro)
PH (1)	PH14163A (ro)
PL (3)	PL125470B1 (ro)
PT (1)	PT69496A (ro)
RO (3)	RO80084A (ro)
SU (3)	SU1225490A3 (ro)
YU (1)	YU93179A (ro)
ZA (1)	ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (en) *	1983-03-30	1990-10-03	Lilly Industries Limited	Vincaleukoblastine derivatives
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US7875612B2 (en)	2001-04-24	2011-01-25	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
DE60326833D1 (de) *	2002-05-15	2009-05-07	Endocyte Inc	Vitamin-mitomycin-konjugate
AR042942A1 (es)	2003-01-27	2005-07-06	Endocyte Inc	Conjugados de administracion de drogas de union de receptores de vitaminas
CN101098854B (zh)	2004-07-23	2012-12-05	恩多塞特公司	二价连接体及其轭合物
CN101175757B (zh) *	2005-03-16	2012-11-14	恩多塞特公司	蝶酸及其缀合物的合成和纯化
EP2374480A3 (en)	2005-08-19	2013-05-01	Endocyte, Inc.	Mutli-drug ligand conjugates
WO2007022493A2 (en) *	2005-08-19	2007-02-22	Endocyte, Inc.	Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
NZ599239A (en) *	2007-03-14	2013-10-25	Endocyte Inc	Binding ligand linked drug delivery conjugates of tubulysins
US9138484B2 (en)	2007-06-25	2015-09-22	Endocyte, Inc.	Conjugates containing hydrophilic spacer linkers
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
US9187521B2 (en) *	2007-10-25	2015-11-17	Endocyte, Inc.	Tubulysins and processes for preparing
RU2543639C2 (ru) *	2009-09-07	2015-03-10	Нипро Пэтч Ко., Лтд.	Чрескожно всасывающийся препарат
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
US9662402B2 (en)	2012-10-16	2017-05-30	Endocyte, Inc.	Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 FI FI791286A patent/FI791286A7/fi not_active Application Discontinuation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
FR2423495A1 (fr)	1979-11-16
CS218584B2 (en)	1983-02-25
RO81114B (ro)	1983-01-30
AR228940A1 (es)	1983-05-13
PL215911A1 (ro)	1980-03-24
RO81037B (ro)	1983-01-30
YU93179A (en)	1983-01-21
AU527109B2 (en)	1983-02-17
CA1097629A (en)	1981-03-17
IL57168A0 (en)	1979-07-25
DK160679A (da)	1979-10-21
AU4609779A (en)	1979-10-25
HU181431B (en)	1983-07-28
GR69987B (ro)	1982-07-22
GB2019396B (en)	1982-09-15
BG33297A3 (bg)	1983-01-14
JPS6245873B2 (ro)	1987-09-29
RO81037A (ro)	1983-02-01
NZ190213A (en)	1982-12-21
LU81166A1 (fr)	1979-09-07
IE790795L (en)	1979-10-20
DK147484B (da)	1984-08-27
IL57168A (en)	1983-10-31
RO80084A (ro)	1983-02-01
DK147484C (da)	1985-03-25
ZA791856B (en)	1980-11-26
FR2423495B1 (ro)	1983-02-11
ES479754A1 (es)	1980-08-16
ES479753A1 (es)	1980-08-16
EP0005051B1 (en)	1982-12-01
CS218583B2 (en)	1983-02-25
PT69496A (en)	1979-05-01
EP0005051A1 (en)	1979-10-31
DD143075A5 (de)	1980-07-30
SU1225490A3 (ru)	1986-04-15
BG33296A3 (bg)	1983-01-14
SU893135A3 (ru)	1981-12-23
AT369010B (de)	1982-11-25
PL119416B1 (en)	1981-12-31
GB2019396A (en)	1979-10-31
PL125470B1 (en)	1983-05-31
BG33294A3 (bg)	1983-01-14
IE48213B1 (en)	1984-10-31
DE2964130D1 (en)	1983-01-05
SU1061698A3 (ru)	1983-12-15
CH643269A5 (fr)	1984-05-30
RO80084B (ro)	1983-01-30
US4166810A (en)	1979-09-04
EG14867A (en)	1986-09-30
CS218585B2 (en)	1983-02-25
JPS54141798A (en)	1979-11-05
FI791286A7 (fi)	1981-01-01
BE875652A (fr)	1979-10-18
ATA291279A (de)	1982-04-15
RO81114A (ro)	1983-02-01

Publication	Publication Date	Title
PH14163A (en)	1981-03-19	Derivatives of 4-desacetyl vlb c-3 carboxhydrazide
GB2017101B (en)	1982-12-22	Production of maytansinoids
JPS5585394A (en)	1980-06-27	Production of nnsubstituted derivative of 11desoxynozilimycin
GB2017681B (en)	1982-08-04	Derivatives of 3-phenyl-3-phenoxy-propanamine
ZA7830B (en)	1978-11-29	Derivatives of thio-methylcarbamates
GB2045756B (en)	1983-01-26	Hydroxy derivatives of 2-isopropylamino-prorimidine
JPS5540676A (en)	1980-03-22	Manufacture of proline derivative
JPS5513293A (en)	1980-01-30	Derivative of nntrifluoloacetyllnnphosphono methylglycinate
GB2025417B (en)	1983-03-02	Derivatives of 1 - phenyl - 1 - propanol
GB2025422B (en)	1983-05-05	17-acetylene derivatives of androst-4-ene
GB2039892B (en)	1982-11-17	Production of narwedine-type derivatives
AU528337B2 (en)	1983-04-28	Derivatives of pyrrolidinecarboxaldehyde
JPS55145670A (en)	1980-11-13	Manufacture of hydroxy derivative of isopropylaminopyrimidine
CU35135A (en)	1982-08-24	Derivatives of dichlohexadiene
JPS554369A (en)	1980-01-12	Synthesis of 22hydroxyy22methylcyclopentoo 22eneeone
JPS5513298A (en)	1980-01-30	Imidazolylethoxy derivative of pyrazolopyridine methanol and its manufacture
JPS5655391A (en)	1981-05-15	Imidazolylethoxymethyl derivative of dioxoloquinoline
JPS54125661A (en)	1979-09-29	Manufacture of isooxazol derivative
IL56815A0 (en)	1979-05-31	Isomerisation of 3-vinyl-piperidine derivatives
GB2017088B (en)	1982-10-20	Derivatives of eburnamonine
JPS5573641A (en)	1980-06-03	Manufacture of nitroodiphenylamine derivative
IL54308A0 (en)	1978-06-15	Derivatives of 9-fluoroprednisolone
GB2028825B (en)	1983-02-02	Synthesis of steroid
JPS5531081A (en)	1980-03-05	Manufacture of 22aminobenzophenone derivative
JPS5526379A (en)	1980-02-25	Handraillinterlocked piece of