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ES479753A1 - Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina. - Google Patents

Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina.

Info

Publication number
ES479753A1
ES479753A1 ES479753A ES479753A ES479753A1 ES 479753 A1 ES479753 A1 ES 479753A1 ES 479753 A ES479753 A ES 479753A ES 479753 A ES479753 A ES 479753A ES 479753 A1 ES479753 A1 ES 479753A1
Authority
ES
Spain
Prior art keywords
alkaloids
vlb
carboxhydrazides
treatment
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479753A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES479753A1 publication Critical patent/ES479753A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Alcaloides naturales que se obtienen de la Vinca rosea son activos en el tratamiento de los tumores malignos experimentales de los animales. Entre estos se encuentran la leurosina, la vincaleucoblastina (vinblastina) a la que nos referiremos en adelante com oVLB, leuroformina, leurosidina (vinrosidina) y leurocristina; desoxi VLB "A" y "B", Tetrahedron Letters; 4-desacetoxivinblastina; 4-desacetoxi-3''-hidroxivinblastina; leurocolombina y vincadiolina. Dos de estos alcaloides, VLB y vincristina, son ahora comercializados como fármacos para el tratamiento de las enfermedades malignas, especialmente las leucemis y enfermedades similares en el hombre. Los dos alcaloides comercializados son habitualmente administrados por vía intravenosa.
ES479753A 1978-04-20 1979-04-19 Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina. Expired ES479753A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
ES479753A1 true ES479753A1 (es) 1980-08-16

Family

ID=25410402

Family Applications (2)

Application Number Title Priority Date Filing Date
ES479754A Expired ES479754A1 (es) 1978-04-20 1979-04-19 Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina.
ES479753A Expired ES479753A1 (es) 1978-04-20 1979-04-19 Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES479754A Expired ES479754A1 (es) 1978-04-20 1979-04-19 Un procedimiento para la preparacion de una carboxihidrazidac-3 de 4-desacetil-vincaleucoblastina.

Country Status (32)

Country Link
US (1) US4166810A (es)
EP (1) EP0005051B1 (es)
JP (1) JPS54141798A (es)
AR (1) AR228940A1 (es)
AT (1) AT369010B (es)
AU (1) AU527109B2 (es)
BE (1) BE875652A (es)
BG (3) BG33297A3 (es)
CA (1) CA1097629A (es)
CH (1) CH643269A5 (es)
CS (3) CS218584B2 (es)
DD (1) DD143075A5 (es)
DE (1) DE2964130D1 (es)
DK (1) DK147484C (es)
EG (1) EG14867A (es)
ES (2) ES479754A1 (es)
FI (1) FI791286A7 (es)
FR (1) FR2423495A1 (es)
GB (1) GB2019396B (es)
GR (1) GR69987B (es)
HU (1) HU181431B (es)
IE (1) IE48213B1 (es)
IL (1) IL57168A (es)
LU (1) LU81166A1 (es)
NZ (1) NZ190213A (es)
PH (1) PH14163A (es)
PL (3) PL125470B1 (es)
PT (1) PT69496A (es)
RO (3) RO81037A (es)
SU (3) SU893135A3 (es)
YU (1) YU93179A (es)
ZA (1) ZA791856B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
ATE57187T1 (de) * 1983-03-30 1990-10-15 Lilly Industries Ltd Vincaleukoblastin-derivate.
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
ES2324708T3 (es) * 2002-05-15 2009-08-13 Endocyte, Inc. Conjugados de vitamina-mitomicina.
EP1592457B1 (en) 2003-01-27 2012-07-25 Endocyte, Inc. Folate-vinblastine conjugate as medicament
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
CN103893779A (zh) 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
EP1948240A2 (en) * 2005-08-19 2008-07-30 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs and derivatives
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN101678124A (zh) * 2007-03-14 2010-03-24 恩多塞特公司 结合配体连接的微管溶素递药缀合物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN104383553A (zh) 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
AU2008316835B2 (en) * 2007-10-25 2015-07-16 Endocyte, Inc. Tubulysins and processes for preparing
JP5780961B2 (ja) * 2009-09-07 2015-09-16 ニプロパッチ株式会社 経皮吸収型製剤
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
US9662402B2 (en) 2012-10-16 2017-05-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
SU1061698A3 (ru) 1983-12-15
GB2019396B (en) 1982-09-15
AT369010B (de) 1982-11-25
AU527109B2 (en) 1983-02-17
AU4609779A (en) 1979-10-25
JPS54141798A (en) 1979-11-05
PH14163A (en) 1981-03-19
RO81037A (ro) 1983-02-01
RO81114A (ro) 1983-02-01
EG14867A (en) 1986-09-30
YU93179A (en) 1983-01-21
BG33297A3 (bg) 1983-01-14
GR69987B (es) 1982-07-22
FR2423495B1 (es) 1983-02-11
BG33294A3 (bg) 1983-01-14
DD143075A5 (de) 1980-07-30
CH643269A5 (fr) 1984-05-30
RO80084A (ro) 1983-02-01
SU1225490A3 (ru) 1986-04-15
DK147484C (da) 1985-03-25
GB2019396A (en) 1979-10-31
IE790795L (en) 1979-10-20
RO80084B (ro) 1983-01-30
CA1097629A (en) 1981-03-17
PL215911A1 (es) 1980-03-24
FR2423495A1 (fr) 1979-11-16
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
BG33296A3 (bg) 1983-01-14
HU181431B (en) 1983-07-28
FI791286A7 (fi) 1981-01-01
PL119416B1 (en) 1981-12-31
EP0005051B1 (en) 1982-12-01
BE875652A (fr) 1979-10-18
PL125470B1 (en) 1983-05-31
IL57168A0 (en) 1979-07-25
SU893135A3 (ru) 1981-12-23
AR228940A1 (es) 1983-05-13
JPS6245873B2 (es) 1987-09-29
IE48213B1 (en) 1984-10-31
RO81114B (ro) 1983-01-30
CS218584B2 (en) 1983-02-25
DE2964130D1 (en) 1983-01-05
IL57168A (en) 1983-10-31
CS218585B2 (en) 1983-02-25
RO81037B (ro) 1983-01-30
NZ190213A (en) 1982-12-21
CS218583B2 (en) 1983-02-25
US4166810A (en) 1979-09-04
PT69496A (en) 1979-05-01
ZA791856B (en) 1980-11-26
EP0005051A1 (en) 1979-10-31
ATA291279A (de) 1982-04-15
DK147484B (da) 1984-08-27
LU81166A1 (fr) 1979-09-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204