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PE99798A1 - Proceso para preparar intermediarios de florfenicol - Google Patents

Proceso para preparar intermediarios de florfenicol

Info

Publication number
PE99798A1
PE99798A1 PE1997000728A PE00072897A PE99798A1 PE 99798 A1 PE99798 A1 PE 99798A1 PE 1997000728 A PE1997000728 A PE 1997000728A PE 00072897 A PE00072897 A PE 00072897A PE 99798 A1 PE99798 A1 PE 99798A1
Authority
PE
Peru
Prior art keywords
compound
formula
alkyl
iii
reaction container
Prior art date
Application number
PE1997000728A
Other languages
English (en)
Inventor
C Towson James
B Vashi Dhiru
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE99798(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE99798A1 publication Critical patent/PE99798A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL COMPUESTO (I), QUE COMPRENDE: (1) CONTACTAR UN COMPUESTO DE FORMULA (II) CON UN AGENTE REDUCTOR COMO BOROHIDRURO DE POTASIO, EN UN RECIPIENTE DE REACCION ADECUADO, PARA OBTENER UN COMPUESTO (III); (2) HACER REACCIONAR EN EL MISMO RECIPIENTE DE REACCION, UN COMPUESTO DE FORMULA (III) CON R"-CN. ESTE PROCESO ELIMINA AISLAR EL COMPUESTO (III), YA QUE AMBOS PASOS (1) Y (2), SON LLEVADOS A CABO EN EL MISMO RECIPIENTE. LOS COMPUESTOS OBTENIDOS DE FORMULA (I), EN DONDE LA CONFIGURACION DEL ANILLO OXAZOLIDINA ES 4R TRANS; R ES H, NO2, CH3S, CH3SO2 o ALQUILO C4-C6; R" ES ARILO, HALOARILO, BENCILO, BENCILO SUSTITUIDO, ALQUILO C1-C6, HALOALQUILO, CICLOALQUILO C3-C7, DE PREFERENCIA R ES SO2CH3 Y R" ES FENILO o CHCl2, SON COMPUESTOS INTERMEDIOS EN EL PROCESO DE OBTENCION DEL [R-(R*,S*)]-2,2-DICLORO-N-[1-(FLUOROMETIL)-2-HIDROXI-2-[4-(METILSULFONIL)FENIL]ETIL]ACETAMIDA, CONOCIDO COMO FLORFENICOL, EL CUAL ES UN AGENTE ANTIBACTERIANO DE AMPLIO ESPECTRO EN EL TRATAMIENTO DE INFECCIONES CAUSADAS POR MICROORGANISMOS GRAM POSITIVOS, GRAM NEGATIVOS Y RICKETSIA
PE1997000728A 1996-08-19 1997-08-18 Proceso para preparar intermediarios de florfenicol PE99798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/699,271 US5663361A (en) 1996-08-19 1996-08-19 Process for preparing intermediates to florfenicol

Publications (1)

Publication Number Publication Date
PE99798A1 true PE99798A1 (es) 1998-12-28

Family

ID=24808601

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000728A PE99798A1 (es) 1996-08-19 1997-08-18 Proceso para preparar intermediarios de florfenicol

Country Status (30)

Country Link
US (1) US5663361A (es)
EP (1) EP0922040B2 (es)
JP (1) JP3274868B2 (es)
KR (1) KR100286851B1 (es)
CN (1) CN1097583C (es)
AR (1) AR008298A1 (es)
AT (1) ATE283847T1 (es)
AU (1) AU714495B2 (es)
BR (1) BR9711318B1 (es)
CA (1) CA2264116C (es)
CO (1) CO4560550A1 (es)
CZ (1) CZ297915B6 (es)
DE (1) DE69731835T3 (es)
DK (1) DK0922040T3 (es)
ES (1) ES2234026T5 (es)
HU (1) HU229610B1 (es)
ID (1) ID18047A (es)
IL (1) IL128574A (es)
MY (1) MY115679A (es)
NO (1) NO312962B1 (es)
NZ (1) NZ334111A (es)
PE (1) PE99798A1 (es)
PL (2) PL196454B1 (es)
PT (1) PT922040E (es)
SI (1) SI0922040T1 (es)
SK (1) SK286124B6 (es)
TR (2) TR200800474T2 (es)
TW (1) TW381075B (es)
WO (1) WO1998007709A1 (es)
ZA (1) ZA977406B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173933C (zh) * 2001-06-01 2004-11-03 中国科学院上海有机化学研究所 一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
CN1649829A (zh) * 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
MY146351A (en) 2003-05-29 2012-08-15 Schering Plough Ltd Compositions for treating infection in cattle and swine
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
PE20060489A1 (es) 2004-08-13 2006-06-19 Schering Plough Ltd Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticosteroide
ATE406348T1 (de) 2004-09-23 2008-09-15 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
MX2007006072A (es) * 2004-11-19 2007-07-11 Schering Plough Ltd Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
ES2315942T3 (es) * 2004-12-21 2009-04-01 Intervet International Bv Composicion veterinaria inyectable que contiene florfenicol.
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
AU2006287696A1 (en) 2005-09-07 2007-03-15 Schering-Plough Pty. Limited A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to Florfenicol
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
KR20100028537A (ko) * 2007-04-27 2010-03-12 쉐링-프라우 리미티드 사이클로덱스트린을 사용하여 플로르페니콜 및 구조적으로 관련된 항생제의 용해도를 증진시키기 위한 화합물 및 방법
CA2688432A1 (en) * 2007-05-30 2008-12-11 Schering-Plough Ltd. A process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2957284T3 (en) 2007-06-27 2018-02-05 Du Pont PROCEDURE TO CHECK ANIMALS FOR ANIMALS
WO2009015111A2 (en) * 2007-07-25 2009-01-29 Intervet Intermatonal B.V. Process for preparing oxazolidine-and oxazolidinone-aminodiols and related intermediates
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
MX2010005087A (es) * 2007-11-09 2010-05-21 Intervet Int Bv Formulacion solida de liberacion rapida, preparacion y uso de la misma.
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
MX2012001651A (es) 2009-08-05 2012-03-16 Du Pont Pesticidas mesoionicos.
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
US20120122680A1 (en) 2009-08-05 2012-05-17 E.I. Du Pont De Nemours And Company Mesoionic pesticides
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) * 2013-04-19 2016-04-06 浙江科技学院 一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN106631872A (zh) * 2016-12-13 2017-05-10 浙江普洛家园药业有限公司 一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) * 2019-05-08 2022-05-03 江南大学 一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) * 2023-12-28 2024-03-22 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2759001A (en) 1952-03-01 1956-08-14 Parke Davis & Co Process for the production of delta2-oxazolines
US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0130633B1 (en) * 1983-06-02 1996-10-09 ZAMBON GROUP S.p.A. Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
KR920701469A (ko) † 1989-05-15 1992-08-11 스테이너 브이. 캔스태드 향균성 화합물 및 이의 중간물질의 제조방법
NZ250394A (en) * 1990-10-25 1994-10-26 Schering Corp Fluorinated and hydroxylated oxazoline compounds

Also Published As

Publication number Publication date
CN1233244A (zh) 1999-10-27
TR200800474T2 (tr) 2008-04-21
HK1017890A1 (en) 1999-12-03
CZ54099A3 (cs) 1999-07-14
NO990756L (no) 1999-02-18
HUP9904166A3 (en) 2001-11-28
CN1097583C (zh) 2003-01-01
JP3274868B2 (ja) 2002-04-15
IL128574A0 (en) 2000-01-31
SK286124B6 (sk) 2008-04-07
TW381075B (en) 2000-02-01
CA2264116C (en) 2002-07-02
AR008298A1 (es) 1999-12-29
ATE283847T1 (de) 2004-12-15
DE69731835T2 (de) 2005-07-21
CA2264116A1 (en) 1998-02-26
BR9711318A (pt) 1999-08-17
IL128574A (en) 2002-04-21
KR20000068178A (ko) 2000-11-25
HUP9904166A2 (hu) 2000-05-28
JP2000501424A (ja) 2000-02-08
ID18047A (id) 1998-02-19
SK19999A3 (en) 2000-02-14
PT922040E (pt) 2005-02-28
PL196454B1 (pl) 2008-01-31
AU714495B2 (en) 2000-01-06
PL198553B1 (pl) 2008-06-30
EP0922040A1 (en) 1999-06-16
DE69731835D1 (de) 2005-01-05
BR9711318B1 (pt) 2009-01-13
HU229610B1 (en) 2014-03-28
KR100286851B1 (ko) 2001-04-16
US5663361A (en) 1997-09-02
DK0922040T3 (da) 2005-04-04
EP0922040B2 (en) 2013-07-17
WO1998007709A1 (en) 1998-02-26
DE69731835T3 (de) 2013-12-05
MY115679A (en) 2003-08-30
SI0922040T1 (en) 2005-02-28
NZ334111A (en) 1999-10-28
EP0922040B1 (en) 2004-12-01
AU4063897A (en) 1998-03-06
ZA977406B (en) 1998-02-18
NO312962B1 (no) 2002-07-22
NO990756D0 (no) 1999-02-18
PL331644A1 (en) 1999-08-02
CZ297915B6 (cs) 2007-04-25
ES2234026T3 (es) 2005-06-16
CO4560550A1 (es) 1998-02-10
TR199900354T2 (xx) 1999-05-21
ES2234026T5 (es) 2013-11-12

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed