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PE57194A1 - Hidroxiurea de fenoxifenil ciclopentenil - Google Patents

Hidroxiurea de fenoxifenil ciclopentenil

Info

Publication number
PE57194A1
PE57194A1 PE1994248312A PE24831294A PE57194A1 PE 57194 A1 PE57194 A1 PE 57194A1 PE 1994248312 A PE1994248312 A PE 1994248312A PE 24831294 A PE24831294 A PE 24831294A PE 57194 A1 PE57194 A1 PE 57194A1
Authority
PE
Peru
Prior art keywords
phenoxifenil
ciclopentenil
hydroxyurea
hydrogen
dextrogiratory
Prior art date
Application number
PE1994248312A
Other languages
English (en)
Inventor
Rodney W Stevens
Akiyoshi Kawai
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE57194A1 publication Critical patent/PE57194A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: a) R1 ES HIDROGENO, FLUOR, CLORO; b) R2 ES HIDROGENO, METILO; PREFIRIENDOSE EL ISOMERO DEXTROGIRATORIO, EL CUAL INHIBE A LA ENZIMA 5-LIPOXIGENASA QUE ESTA RELACIONADA CON LA FORMACION DE LEUCOTRIENOS Y PUEDE SER UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y ALERGICAS
PE1994248312A 1993-08-19 1994-08-11 Hidroxiurea de fenoxifenil ciclopentenil PE57194A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20545393 1993-08-19

Publications (1)

Publication Number Publication Date
PE57194A1 true PE57194A1 (es) 1995-02-07

Family

ID=16507136

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994248312A PE57194A1 (es) 1993-08-19 1994-08-11 Hidroxiurea de fenoxifenil ciclopentenil

Country Status (27)

Country Link
US (1) US5792882A (es)
EP (1) EP0720598B1 (es)
JP (1) JP2794343B2 (es)
KR (1) KR0170623B1 (es)
CN (1) CN1077568C (es)
AT (1) ATE171939T1 (es)
AU (1) AU674776B2 (es)
BR (1) BR9407314A (es)
CA (1) CA2169066C (es)
CO (1) CO4230229A1 (es)
CZ (1) CZ288358B6 (es)
DE (1) DE69413831T2 (es)
DK (1) DK0720598T3 (es)
EC (1) ECSP941144A (es)
EG (1) EG20530A (es)
ES (1) ES2121218T3 (es)
FI (1) FI114466B (es)
IL (1) IL110628A (es)
MY (1) MY111140A (es)
NO (1) NO305595B1 (es)
NZ (1) NZ269849A (es)
PE (1) PE57194A1 (es)
PL (1) PL176223B1 (es)
RU (1) RU2125987C1 (es)
TW (2) TW418089B (es)
WO (1) WO1995005360A1 (es)
ZA (1) ZA946253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL317873A1 (en) * 1994-06-27 1997-04-28 Cytomed Inc Compounds for and method of treating cardiovascular, inflammatory and immunological disorders
ATE184272T1 (de) * 1994-11-10 1999-09-15 Pfizer Aryloxycycloalkenyl- und aryloxyiminocycloalkenyl-hydroxyharnstoffe mit 5-lipoxygenase inhibierender wirkung
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
EP1741424B1 (en) 1997-08-11 2018-10-03 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailabilty
US6121323A (en) * 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
KR100879423B1 (ko) 2004-12-02 2009-01-19 (주)아모레퍼시픽 Ｔｎｆ-알파의 생산을 저해하는 2-사이클로펜텐-1-온 옥심유도체
KR101494488B1 (ko) 2007-12-03 2015-02-24 (주)아모레퍼시픽 2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 지방대사질환 예방 및 치료용 약학 조성물
MX2011008303A (es) 2009-04-03 2011-11-29 Plexxikon Inc Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas.
US8512464B2 (en) * 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
US5026729A (en) * 1987-02-10 1991-06-25 Abbott Laboratories Lipoxygenase inhibiting compounds
FI900536A7 (fi) * 1989-02-03 1990-08-04 The Wellcome Foundation Ltd Tulehdusta ehkäiseviä aryyliyhdisteitä
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
US5037853A (en) * 1989-12-28 1991-08-06 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5149097A (en) * 1991-05-01 1992-09-22 Tonello John H Crossword puzzle aid
JPH05163229A (ja) * 1991-12-13 1993-06-29 Pfizer Pharmaceut Co Ltd 新規なシクロプロピル誘導体
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Also Published As

Publication number Publication date
NO305595B1 (no) 1999-06-28
US5792882A (en) 1998-08-11
FI943799L (fi) 1995-02-20
WO1995005360A1 (en) 1995-02-23
CZ48396A3 (en) 1996-07-17
CA2169066A1 (en) 1995-02-23
BR9407314A (pt) 1996-04-16
PL176223B1 (pl) 1999-05-31
JPH08511031A (ja) 1996-11-19
AU674776B2 (en) 1997-01-09
DE69413831T2 (de) 1999-02-25
CN1077568C (zh) 2002-01-09
ECSP941144A (es) 1995-02-27
JP2794343B2 (ja) 1998-09-03
IL110628A (en) 1998-12-27
EG20530A (en) 1999-07-31
NZ269849A (en) 1997-10-24
PL313037A1 (en) 1996-05-27
CO4230229A1 (es) 1995-10-19
CZ288358B6 (en) 2001-05-16
TW418089B (en) 2001-01-11
CN1129440A (zh) 1996-08-21
ZA946253B (en) 1996-02-19
FI943799A0 (fi) 1994-08-18
EP0720598A1 (en) 1996-07-10
CA2169066C (en) 1999-06-22
FI114466B (fi) 2004-10-29
TW448144B (en) 2001-08-01
AU7350994A (en) 1995-03-14
NO960631L (no) 1996-02-16
DE69413831D1 (de) 1998-11-12
ES2121218T3 (es) 1998-11-16
ATE171939T1 (de) 1998-10-15
KR960703845A (ko) 1996-08-31
KR0170623B1 (ko) 1999-03-30
DK0720598T3 (da) 1999-06-21
EP0720598B1 (en) 1998-10-07
NO960631D0 (no) 1996-02-16
MY111140A (en) 1999-08-30
IL110628A0 (en) 1994-11-11
RU2125987C1 (ru) 1999-02-10

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