[go: up one dir, main page]

ES2121218T3 - Fenoxifenilciclopentenilhidroxiureas. - Google Patents

Fenoxifenilciclopentenilhidroxiureas.

Info

Publication number
ES2121218T3
ES2121218T3 ES94922374T ES94922374T ES2121218T3 ES 2121218 T3 ES2121218 T3 ES 2121218T3 ES 94922374 T ES94922374 T ES 94922374T ES 94922374 T ES94922374 T ES 94922374T ES 2121218 T3 ES2121218 T3 ES 2121218T3
Authority
ES
Spain
Prior art keywords
treatment
los
compounds
mostuesos
lipoxigenasa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94922374T
Other languages
English (en)
Inventor
Akiyoshi Kawai
Rodney W Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2121218T3 publication Critical patent/ES2121218T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

CIERTOS COMPUESTOS NUEVOS DE CICLOPENTENILHIDROXIUREAS SUSTITUIDAS CON FENILO PUEDEN INHIBIR LA ENZIMA 5-LIPOXIGENASA Y SER LOS ISOMEROS DEXTROGIROS DE LOS COMPUESTOS QUE TIENEN LA FORMULA (II) Y DE LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN DONDE R{SUP,1} ES HIDROGENO, FLUORO O CLORO; Y R{SUP,2} ES HIDROGENO O METILO. ESTOS COMPUESTOS SON UTILES PARA LA PREVENCION, TRATAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, ALERGIAS Y ENFERMEDADES CARDIOVASCULARES DE MAMIFEROS, Y COMO EL INGREDIENTE ACTIVO DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ESTADOS.
ES94922374T 1993-08-19 1994-08-15 Fenoxifenilciclopentenilhidroxiureas. Expired - Lifetime ES2121218T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20545393 1993-08-19

Publications (1)

Publication Number Publication Date
ES2121218T3 true ES2121218T3 (es) 1998-11-16

Family

ID=16507136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94922374T Expired - Lifetime ES2121218T3 (es) 1993-08-19 1994-08-15 Fenoxifenilciclopentenilhidroxiureas.

Country Status (27)

Country Link
US (1) US5792882A (es)
EP (1) EP0720598B1 (es)
JP (1) JP2794343B2 (es)
KR (1) KR0170623B1 (es)
CN (1) CN1077568C (es)
AT (1) ATE171939T1 (es)
AU (1) AU674776B2 (es)
BR (1) BR9407314A (es)
CA (1) CA2169066C (es)
CO (1) CO4230229A1 (es)
CZ (1) CZ288358B6 (es)
DE (1) DE69413831T2 (es)
DK (1) DK0720598T3 (es)
EC (1) ECSP941144A (es)
EG (1) EG20530A (es)
ES (1) ES2121218T3 (es)
FI (1) FI114466B (es)
IL (1) IL110628A (es)
MY (1) MY111140A (es)
NO (1) NO305595B1 (es)
NZ (1) NZ269849A (es)
PE (1) PE57194A1 (es)
PL (1) PL176223B1 (es)
RU (1) RU2125987C1 (es)
TW (2) TW418089B (es)
WO (1) WO1995005360A1 (es)
ZA (1) ZA946253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL317873A1 (en) * 1994-06-27 1997-04-28 Cytomed Inc Compounds for and method of treating cardiovascular, inflammatory and immunological disorders
ATE184272T1 (de) * 1994-11-10 1999-09-15 Pfizer Aryloxycycloalkenyl- und aryloxyiminocycloalkenyl-hydroxyharnstoffe mit 5-lipoxygenase inhibierender wirkung
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
EP1741424B1 (en) 1997-08-11 2018-10-03 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailabilty
US6121323A (en) * 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
KR100879423B1 (ko) 2004-12-02 2009-01-19 (주)아모레퍼시픽 Ｔｎｆ-알파의 생산을 저해하는 2-사이클로펜텐-1-온 옥심유도체
KR101494488B1 (ko) 2007-12-03 2015-02-24 (주)아모레퍼시픽 2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 지방대사질환 예방 및 치료용 약학 조성물
MX2011008303A (es) 2009-04-03 2011-11-29 Plexxikon Inc Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas.
US8512464B2 (en) * 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
US5026729A (en) * 1987-02-10 1991-06-25 Abbott Laboratories Lipoxygenase inhibiting compounds
FI900536A7 (fi) * 1989-02-03 1990-08-04 The Wellcome Foundation Ltd Tulehdusta ehkäiseviä aryyliyhdisteitä
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
US5037853A (en) * 1989-12-28 1991-08-06 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5149097A (en) * 1991-05-01 1992-09-22 Tonello John H Crossword puzzle aid
JPH05163229A (ja) * 1991-12-13 1993-06-29 Pfizer Pharmaceut Co Ltd 新規なシクロプロピル誘導体
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Also Published As

Publication number Publication date
NO305595B1 (no) 1999-06-28
US5792882A (en) 1998-08-11
FI943799L (fi) 1995-02-20
WO1995005360A1 (en) 1995-02-23
CZ48396A3 (en) 1996-07-17
CA2169066A1 (en) 1995-02-23
BR9407314A (pt) 1996-04-16
PL176223B1 (pl) 1999-05-31
JPH08511031A (ja) 1996-11-19
AU674776B2 (en) 1997-01-09
DE69413831T2 (de) 1999-02-25
CN1077568C (zh) 2002-01-09
ECSP941144A (es) 1995-02-27
JP2794343B2 (ja) 1998-09-03
IL110628A (en) 1998-12-27
EG20530A (en) 1999-07-31
NZ269849A (en) 1997-10-24
PL313037A1 (en) 1996-05-27
CO4230229A1 (es) 1995-10-19
CZ288358B6 (en) 2001-05-16
TW418089B (en) 2001-01-11
PE57194A1 (es) 1995-02-07
CN1129440A (zh) 1996-08-21
ZA946253B (en) 1996-02-19
FI943799A0 (fi) 1994-08-18
EP0720598A1 (en) 1996-07-10
CA2169066C (en) 1999-06-22
FI114466B (fi) 2004-10-29
TW448144B (en) 2001-08-01
AU7350994A (en) 1995-03-14
NO960631L (no) 1996-02-16
DE69413831D1 (de) 1998-11-12
ATE171939T1 (de) 1998-10-15
KR960703845A (ko) 1996-08-31
KR0170623B1 (ko) 1999-03-30
DK0720598T3 (da) 1999-06-21
EP0720598B1 (en) 1998-10-07
NO960631D0 (no) 1996-02-16
MY111140A (en) 1999-08-30
IL110628A0 (en) 1994-11-11
RU2125987C1 (ru) 1999-02-10

Similar Documents

Publication Publication Date Title
ES2069410T3 (es) Nuevos derivados del acido hidroxamico y n-hidroxiurea y su uso.
ES2186015T3 (es) Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol.
NO2017045I1 (no) Farmasøøytisk preparat inneholdende 2-(2-nitro-4-ifluormetylbenzoyl)-1,3-cykloheksandion eller et farmasøytisk godtagbart salt derav
ES2161291T3 (es) N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa.
ES2171543T3 (es) Composiciones administrables topicamente que contienen derivados del acido 3-benzoilfenilacetico para el tratamiento de trastornos inflamatorios oftalmicos.
GT199700095A (es) Derivados 6,5-heterobiciclicos sustituidos.
ES2192213T3 (es) Arilalquil-diazinonas como inhibidores de fosfodiesterasa iv.
ES2191070T3 (es) Arilalquil-piridazinonas.
ES2121218T3 (es) Fenoxifenilciclopentenilhidroxiureas.
ES2102994T3 (es) Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa.
ES2073755T3 (es) Acidos hidroxamicos y n-hidroxiureas antiinflamatorios.
MX9306234A (es) Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen.
ES2063578T3 (es) Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa.
ES2138211T3 (es) N-hidroxiureas como agentes antiinflamatorios.
ES2062407T3 (es) Compuestos de 2-hidroxi-3-fenoxipropilamino.
ES2059204T3 (es) Derivados del acido hidroxamico inhibidores de lipoxigenasa.
ES2057505T3 (es) Agentes para la proteccion de las plantas contra las enfermedades.
ES2161916T3 (es) Derivados de la tiazolidinona o de la oxazolidinona para el tratamiento de la angina de pecho y composiciones que las contienen como ingrediente activo.
EP0806204A4 (en) Inflammatory cytokine production inhibitor containing polyprenyl derivative as active ingredient
CO5271694A1 (es) Inhibidores beta di-sustituidos de las metaloproteasas, composiciones farmaceuticas que los contienen y procedimientos para su aplicacion
MX9304441A (es) Derivados de indolinil n-hidroxiurea y acido n-hidroxamico antiinflamatorio.
ES2139890T3 (es) Alquil esteres de dl- di- o tri-hidroxifenilglicina para el tratamiento de estados inflamatorios y alergicos.
PT966455E (pt) Acidos oxiranocarboxilicos para o tratamento da diabetes
ES2082474T3 (es) Derivados de tetrahidrobenzazepina que inhiben la lipoxigenasa.
IT1255219B (it) Derivati del tiadiazolo per la cura degli stati depressivi

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 720598

Country of ref document: ES