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PE20252269A1 - Compuestos de carbamoilpiridona triciclicos en puente y usos de estos - Google Patents

Compuestos de carbamoilpiridona triciclicos en puente y usos de estos

Info

Publication number
PE20252269A1
PE20252269A1 PE2025001474A PE2025001474A PE20252269A1 PE 20252269 A1 PE20252269 A1 PE 20252269A1 PE 2025001474 A PE2025001474 A PE 2025001474A PE 2025001474 A PE2025001474 A PE 2025001474A PE 20252269 A1 PE20252269 A1 PE 20252269A1
Authority
PE
Peru
Prior art keywords
compounds
haloalkyl
alkyl
independently
tricyclic
Prior art date
Application number
PE2025001474A
Other languages
English (en)
Inventor
Hang Chu
Buenrostro Ana Z Gonzales
Xiaochun Han
Anna E Hurtley
Lan Jiang
Jiayao Li
Gregg M Schwarzwalder
Devleena M Shivakumar
Bargen Matthew J Von
Qiaoyin Wu
Hong Yang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20252269A1 publication Critical patent/PE20252269A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se relaciona con compuestos de la Formula (I), tambien se describen composiciones farmaceuticas que comprenden dichos compuestos y metodos para elaborar dichos compuestos que son utiles para tratar o prevenir la infeccion por el virus de inmunodeficiencia humana (VIH). Se refiere a un compuesto de Formula (I) o una sal farmaceuticamente aceptable de este, en donde R1 es H, arilo C6-10 o heteroarilo de 5 a 10 miembros que contiene 1, 2, 3, o 4 heteroatomos independientemente seleccionados de N, O, S, entre otros; R2 es H, alquilo C1-6 o haloalquilo C1-4; L es -C(O)-, -SO2-, -CH2-CH2-, entre otros; W1 es un enlace o -CR4aR4b-; W2 es -O-, -C(O)-, -C(O)O-, entre otros; Y es -C(O)NH-, (I.1), (I-2), entre otros; A encerrado en lineas punteadas es un anillo espiro de tres a siete miembros que contiene 1, 2 o 3 heteroatomos seleccionados de N, O, y S; Z es -CR9aR9b-, -CR9aR9bCR9cR9d- o -CR10a=CR10b-; R4a y R4b son independientemente H, alquilo C1-6, haloalquilo C1-4, o halo; R9a, R9b, R9c, y R9d son cada uno independientemente H, alquilo C1-6, haloalquilo C1-4, halo, entre otros.
PE2025001474A 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos PE20252269A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263328061P 2022-04-06 2022-04-06
US202263476873P 2022-12-22 2022-12-22
PCT/US2023/065401 WO2023196875A1 (en) 2022-04-06 2023-04-05 Bridged tricyclic carbamoylpyridone compounds and uses thereof

Publications (1)

Publication Number Publication Date
PE20252269A1 true PE20252269A1 (es) 2025-09-15

Family

ID=86330110

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2025001474A PE20252269A1 (es) 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos
PE2024002156A PE20250151A1 (es) 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos
PE2025001469A PE20252272A1 (es) 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos

Family Applications After (2)

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PE2024002156A PE20250151A1 (es) 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos
PE2025001469A PE20252272A1 (es) 2022-04-06 2023-04-05 Compuestos de carbamoilpiridona triciclicos en puente y usos de estos

Country Status (26)

Country Link
US (3) US12054496B2 (es)
EP (3) EP4310087B1 (es)
JP (3) JP7668428B2 (es)
KR (1) KR20250002321A (es)
CN (2) CN120081853A (es)
AU (3) AU2023249631B2 (es)
CA (1) CA3245817A1 (es)
CL (1) CL2024002988A1 (es)
CO (1) CO2024013492A2 (es)
CR (1) CR20240405A (es)
DK (2) DK4310087T3 (es)
DO (1) DOP2024000195A (es)
ES (2) ES2988416T3 (es)
FI (2) FI4305034T3 (es)
HR (2) HRP20240986T1 (es)
HU (2) HUE067983T2 (es)
IL (1) IL315684A (es)
LT (2) LT4305034T (es)
MX (1) MX2024011695A (es)
PE (3) PE20252269A1 (es)
PL (2) PL4305034T3 (es)
PT (2) PT4310087T (es)
SI (2) SI4305034T1 (es)
TW (3) TWI843506B (es)
WO (1) WO2023196875A1 (es)
ZA (2) ZA202406990B (es)

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TW202515549A (zh) * 2023-10-11 2025-04-16 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
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