PE20250675A1 - Compuestos de pirrolopiridazina como antihelminticos - Google Patents
Compuestos de pirrolopiridazina como antihelminticosInfo
- Publication number
- PE20250675A1 PE20250675A1 PE2024000936A PE2024000936A PE20250675A1 PE 20250675 A1 PE20250675 A1 PE 20250675A1 PE 2024000936 A PE2024000936 A PE 2024000936A PE 2024000936 A PE2024000936 A PE 2024000936A PE 20250675 A1 PE20250675 A1 PE 20250675A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- compounds
- pyrrolopyridazine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a compuestos de pirrolopiridazina de formula I, o una sal de los mismos, en donde L es L1, L2, L3, entre otros, en los cuales R', es alquilo, cicloalquilo o aralquilo opcionalmente sustituidos y dos R' en el mismo L forman un heterociclo; R1' es hidrogeno, halogeno, alquilo o haloalquilo; R1, R2 y R3 es alquinilo, alquilaminoalquilo opcionalmente sustituidos, entre otros; R4, R5 y R5' son alquilaminocarbonilo, dialquilaminocarbonilo opcionalmente sustituidos, entre otros; R6 y R7 son en forma independiente hidrogeno, halogeno, entre otros; R5 con R5' y R6 con R7 forman juntos una cadena de 2-6 miembros con uno a mas heteroatomos seleccionados de N, O, Si y S para formar un anillo carbociclico o heterociclico; R8 es hidrogeno o C1-C4-alquilo; R9 es haloalquilo, cicloalquilo, entre otros; Q es C-R9 o N; X es O, S o N-R'; Y1 y Y6 son N, C, o -CR5; Y2, Y3, Y4 y Y5 son N, NR', S, O, -CR5- o CR5R5'; W, W1 y Z son CR6, CR6R7, O, SOp, N o N-R8; q es 0 o 1; p es 0,1 o 2; y las lineas de guiones representan una union simple o doble. Tambien, refiere al uso de los compuestos en la preparacion de un medicamento para el tratamiento, control y/o prevencion de una infeccion parasitaria en un animal que lo necesite; una composicion farmaceutica que comprende a un compuesto de pirrolopiridazina, uno o mas agentes adicionales y un vehiculo farmaceuticamente aceptable; y metodos para el tratamiento, control y/o prevencion de una infeccion parasitaria.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163263367P | 2021-11-01 | 2021-11-01 | |
| PCT/IB2022/060405 WO2023073641A1 (en) | 2021-11-01 | 2022-10-28 | Anthelmintic pyrrolopyridazine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20250675A1 true PE20250675A1 (es) | 2025-03-04 |
Family
ID=84332330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2024000936A PE20250675A1 (es) | 2021-11-01 | 2022-10-28 | Compuestos de pirrolopiridazina como antihelminticos |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11999742B2 (es) |
| EP (1) | EP4426699A1 (es) |
| JP (1) | JP2024540166A (es) |
| KR (1) | KR20240112282A (es) |
| CN (1) | CN118339164A (es) |
| AR (1) | AR127495A1 (es) |
| AU (1) | AU2022377394A1 (es) |
| CA (1) | CA3236894A1 (es) |
| CL (1) | CL2024001314A1 (es) |
| CO (1) | CO2024005447A2 (es) |
| CR (1) | CR20240207A (es) |
| IL (1) | IL312412A (es) |
| MX (1) | MX2024005264A (es) |
| PE (1) | PE20250675A1 (es) |
| TW (1) | TW202333665A (es) |
| UY (1) | UY39995A (es) |
| WO (1) | WO2023073641A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025027117A1 (en) | 2023-08-02 | 2025-02-06 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
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| JP2023528822A (ja) | 2020-05-29 | 2023-07-06 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性複素環式化合物 |
| EP4196476A4 (en) | 2020-08-12 | 2024-08-07 | Jubilant Epipad LLC | METHOD AND COMPOUND FOR USE IN THE TREATMENT AND/OR PREVENTION OF NETOSIS |
| WO2022106469A2 (en) | 2020-11-18 | 2022-05-27 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| EP4259606A1 (en) | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| WO2022122988A1 (en) | 2020-12-11 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| GB202100635D0 (en) | 2021-01-18 | 2021-03-03 | Liverpool School Tropical Medicine | Compounds and methods for treating or preventing dirofilaria infection in a mammal |
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2022
- 2022-10-28 EP EP22802266.1A patent/EP4426699A1/en active Pending
- 2022-10-28 CA CA3236894A patent/CA3236894A1/en active Pending
- 2022-10-28 CN CN202280079374.XA patent/CN118339164A/zh active Pending
- 2022-10-28 CR CR20240207A patent/CR20240207A/es unknown
- 2022-10-28 UY UY0001039995A patent/UY39995A/es unknown
- 2022-10-28 KR KR1020247018246A patent/KR20240112282A/ko active Pending
- 2022-10-28 US US18/050,567 patent/US11999742B2/en active Active
- 2022-10-28 MX MX2024005264A patent/MX2024005264A/es unknown
- 2022-10-28 PE PE2024000936A patent/PE20250675A1/es unknown
- 2022-10-28 TW TW111141183A patent/TW202333665A/zh unknown
- 2022-10-28 AU AU2022377394A patent/AU2022377394A1/en active Pending
- 2022-10-28 JP JP2024525606A patent/JP2024540166A/ja active Pending
- 2022-10-28 IL IL312412A patent/IL312412A/en unknown
- 2022-10-28 AR ARP220102942A patent/AR127495A1/es unknown
- 2022-10-28 WO PCT/IB2022/060405 patent/WO2023073641A1/en not_active Ceased
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2024
- 2024-03-29 US US18/622,428 patent/US20240254133A1/en active Pending
- 2024-04-29 CO CONC2024/0005447A patent/CO2024005447A2/es unknown
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| Publication number | Publication date |
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| AU2022377394A1 (en) | 2024-06-13 |
| KR20240112282A (ko) | 2024-07-18 |
| WO2023073641A9 (en) | 2024-02-29 |
| AR127495A1 (es) | 2024-01-31 |
| CR20240207A (es) | 2024-06-25 |
| CN118339164A (zh) | 2024-07-12 |
| EP4426699A1 (en) | 2024-09-11 |
| JP2024540166A (ja) | 2024-10-31 |
| US20240254133A1 (en) | 2024-08-01 |
| US11999742B2 (en) | 2024-06-04 |
| TW202333665A (zh) | 2023-09-01 |
| UY39995A (es) | 2023-05-15 |
| MX2024005264A (es) | 2024-05-14 |
| IL312412A (en) | 2024-06-01 |
| CA3236894A1 (en) | 2023-05-04 |
| CO2024005447A2 (es) | 2024-05-10 |
| CL2024001314A1 (es) | 2024-10-25 |
| WO2023073641A1 (en) | 2023-05-04 |
| US20230159543A1 (en) | 2023-05-25 |
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