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AR060405A1 - Compuestos organicos y sus usos en tratamientos de infeccion por el virus de hepatitis c - Google Patents

Compuestos organicos y sus usos en tratamientos de infeccion por el virus de hepatitis c

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Publication number
AR060405A1
AR060405A1 ARP070101503A ARP070101503A AR060405A1 AR 060405 A1 AR060405 A1 AR 060405A1 AR P070101503 A ARP070101503 A AR P070101503A AR P070101503 A ARP070101503 A AR P070101503A AR 060405 A1 AR060405 A1 AR 060405A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
ring
cycloalkyl
amino
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Application number
ARP070101503A
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English (en)
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38617501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR060405(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR060405A1 publication Critical patent/AR060405A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07K5/06—Dipeptides
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Diabetes (AREA)
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  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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  • Pyridine Compounds (AREA)

Abstract

Se describen compuestos orgánicos, que son utiles para el tratamiento, la prevencion y/o el alivio de enfermedades humanas asociadas con el virus de la hepatitis C. Reivindicacion 1: Un compuesto de la formula 1 y las sales farmacéuticamente aceptables y estereoisomeros de! mismo; en donde y es 0 o 1; n y p se seleccionan cada uno independientemente a partir de 0, 1, o 2; R14 es C(O) o SO2; R1, R2, W, R13, y V se seleccionan cada uno independientemente a partir de hidrogeno o a partir del grupo que consiste en alquilo, alquil-arilo, heteroalquilo, heterociclilo, heteroarilo, aril-heteroarilo, alquil-heteroarilo, cicloalquilo, alquiloxilo, alquil-ariloxilo, ariloxilo, heteroariloxilo, heterocicliloxilo, cicloalquiloxilo, amino, alquil-amino, aril-amino, alquil-aril-amino, aril-amino, heteroaril-amino, cicloalquil-amino, carboxi-alquil-amino, mono- y di-alquil-carboxamida, aril-alquiloxilo, y heterociclil-amino; cada uno de los cuales puede estar además independientemente sustituido una o más veces por X1 y X2; en donde X1 es alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, heterociclilo, heterociclil-alquilo, arilo, alquil-arilo, aralquilo, ariloxilo, tioarilo, aril-heteroarilo, heteroarilo, heterociclil-amino, alquil-heteroarilo, o heteroaralquilo; en donde X1 puede estar independientemente sustituido con una o más fracciones X2, las cuales pueden ser iguales o diferentes, y se seleccionan de una manera independiente; en donde X2 es hidroxilo, oxo, alquilo, cicloalquilo, espiro-cicloalquilo, heterociclo-alquilo, arilo, heteroarilo, alcoxilo, ariloxilo, tio, tioalquilo, amino, mono- y di-alquil-amino, aril-amino, alquilsulfonilo, aril-sulfonilo, alquil-sulfonamido, aril- sulfonamido, carboxilo, carbalcoxilo, carboxamido, alcoxi-carbonil-amino, alcoxicarbonilo, alcoxi-carboniloxilo, alquil-ureido, aril-ureido, halogeno, ciano, o nitro; en donde cada residuo X2 seleccionado como alquilo, alcoxilo, y arilo puede estar insustituido o de manera opcional independientemente sustituido con una o más fracciones, las cuales pueden ser iguales o diferentes, y s seleccionan independientemente a partir de alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, heterociclilo, heterociclil-alquilo, arilo, alquil-arilo, aralquilo, aril-heteroarilo, heteroarilo, heterociclilamino, alquil-heteroarilo, y heteroaralquilo; W también se selecciona a partir del grupo que consiste en C(O)-C(O)H, C(=N-O-R24)-C(O)- amina, C(O)-C(O)-amina, C(O)NR24S(O)pR24, C(O)NR24S(O)pN(R24)2 y C(O)-[C(O)]a-heterociclo, en donde el heterociclo puede estar independientemente sustituido una o más veces con arilo, alquilo C1-4, alquilo C1-4 sustituido por uno o más átomos de halogeno, y cicloalquilo C3-6, en donde a es 0 o 1, en donde cada R24 se selecciona independientemente a partir de hidrogeno o a partir del grupo que consiste en alquilo C1-4, cicloalquilo C3-6-alquilo C0-4, arilo sustituido o insustituido, y heterociclo sustituido o insustituido, cada uno de los cuales puede estar independientemente sustituido una o más veces con un átomo de halogeno o alquilo C1-4; V también se selecciona a partir del grupo que consiste en -Q1-Q2, en donde Q1 está ausente, o es C(O), N(H). N(alquilo C1-4), C=N(CN), C=N(SO2CH3), C=N-COH-alquilo C1-4, o C=N-COH, y Q2 es hidrogeno, o se selecciona a partir del grupo que consiste en alquilo C1-4, O-alquilo C1-4, NH2, N(H)-alquilo C1-4, N(alquilo C1-4)2, SO2- arilo, SO2-alquilo C1-4, cicloalquilo C3-6 -alquilo C0-4, arilo, heteroarilo, y heterociclo, cada uno de los cuales puede estar independientemente sustituido una o más veces con un átomo de halogeno, alquilo C1-4, alquilo C1-4 sustituido por uno o más átomos de halogeno, o cicloalquilo C3-6; o R1 y R2 pueden formar juntos un anillo de 3, 4, 5, 6, o 7 miembros, que es aromático o no aromático, y puede contener uno o más heteroátomos, en donde el anillo puede estar adicionalmente sustituido una o más veces; R3 se selecciona a partir del grupo que consiste en hidrogeno, alquilo C1-4, y cicloalquilo C3-6-alquilo C0-4; X es O, S, N, NR5, CR5, 6 CR5R5a; R4 representa de 0 a 4 sustituyentes, cada uno de los cuales se selecciona independientemente a partir de hidrogeno, o a partir del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, arilo, heterociclo, y heteroarilo, cada uno de los cuales puede estar independientemente sustituido una o más veces con un átomo de halogeno o alquilo C1-4; R5 se selecciona a partir de hidrogeno u oxo, o a partir del grupo que consiste en hidroxilo, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8 -alquilo C0-4, aril-alquilo C0-4, heterociclo- alquilo C0-4, heteroaril- alquilo C0-4, cicloalquiloxilo C3-8, ariloxilo, y hetero-ariloxilo, cada uno de los cuales puede estar independientemente sustituido una o más veces con un átomo de halogeno, arilo, trihalo-metilo, o alquilo C1-4; R5a es hidrogeno, o se selecciona a partir del grupo que consiste en hidroxilo, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8-alquilo C0-4, aril-alquilo C0-4, y heteroaril-alquilo C0-4; o R4 y R5 pueden formar juntos un anillo de dimetil-ciclopropilo fusionado, un anillo de ciclopentano fusionado, un anillo de fenilo fusionado, o un anillo de piridilo fusionado, cada uno de los cuales puede estar sustituido con un átomo de halogeno, arilo, trihalometilo, o alquilo C1-4; o R5 y R6 pueden formar juntos un anillo de dimetil-ciclopropilo fusionado, un anillo de ciclopentano fusionado, un anillo de fenilo fusionado, o un anillo de piridilo fusionado, cada uno de los cuales puede estar sustituido con un átomo de halogeno, arilo; trihalometilo, o alquilo C1-4; o R5 y R5a pueden formar juntos un anillo espirocíclico que tiene entre 3 y 7 átomos del anillo, y que tiene 0, 1, o 2 heteroátomos del anillo, el cual está opcionalmente sustituido por 0 a 4 sustituyentes seleccionados a partir de ciano, halogeno, hidroxilo, amino, tiol, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxilo C1-8-alquilo C0-4, haloalquilo C1-8, haloalquenilo C2-8, haloalquinilo C2-8, haloalcoxilo C1-8, tioalquilo C1-8, alquilo C1-8-sulfonilo, alquilo C1-8- sulfoxilo, alcanoilo C1-8, alcoxilo C1-8-carbonilo, cicloalquilo C3-7-alquilo C0-4, aril-alquilo C0-4, heteroaril-alquilo C0-4, COOH, C(O)NH2, mono- y di-alquilo C1-4-carboxamida, mono- y di-alquilo C1-4 -amino-alquilo C0-4, SO3H, SO2NH2, y mono- y di-alquilo C1-4sulfonamida, o dos de estos 0 a 4 sustituyentes, tomados juntos, forman un anillo fusionado o espirocíclico de 3 a 7 miembros que tiene 0, 1, o 2 heteroátomos del anillo seleccionados a partir de N, O, y S, cuyo anillo fusionado o espirocíclico tiene de 0 a 2 sustituyentes independientemente seleccionados a partir de ciano, halogeno, hidroxilo, amino, tiol, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxilo C1-8-alquilo C0-4, haloalquilo C1-8, haloalquenilo C2-8, haloalquinilo C2-8, haloalcoxilo C1-8, tioalquilo C1-8, alquilo C1-8-sulfonilo, alquilo C1-8-sulfoxilo, alcanoilo C1-8, alcoxilo C1-8-carbonilo, cicloalquilo C3-7-alquilo C0-4, aril-alquilo C0-4, heteroaril-alquilo C0-4, COOH, C(O)NH2, mono- y di- alquilo C1-4-carboxamida, mono- y di-alquilo C1-4-amino-alquilo C0-4, SO3H, SO2NH, y mono- y di-alquilo C1-4-sulfonamida; R6 y R7 se seleccionan cada uno independientemente a partir del grupo que consiste en hidrogeno, hidroxilo, amino, alquilo C1- 4, alcoxilo C1-4, y mono- y di-alquilo C1-4-amino, y cicloalquilo C3-6-alquilo C0-4; R8, R9, R10, R11 y R12 se seleccionan cada uno independientemente a partir del grupo que consiste en hidrogeno, alquilo C1-4, y cicloalquilo C3-6-alquilo C0-4; o R6 y R7 pueden formar juntos un anillo espirocíclico que tiene entre 3 y 7 átomos del anillo, y. que tiene 0, 1, o 2 heteroátomos del anillo, el cual está opcionalmente sustituido por 0 a 4 sustituyentes seleccionados a partir de ciano, halogeno, hidroxilo, amino, tiol, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxilo C1-8-alquilo C0-4, haloalquilo C1-8, haloalquenilo C2-8, haloalquinilo C2-8, haloalcoxilo C1-8, tioalquilo C1-8, alquilo C1-8-sulfonilo, alquilo C1-8-sulfoxilo, alcanoilo C1-8, alcoxilo C1-8-carbonilo, cicloalquilo C3-7-alquilo C0-4, arilalquilo C0-4, heteroaril-alquilo C0-4, COOH, C(O)NH2, mono- y di-alquilo C1-4-carboxamida, mono- y di-alquilo C1-4-amino-alquilo C0-4, SO3H, SO2NH2, y mono- y di-alquilo C1- 4sulfonamida, o dos sustituyentes, tomados juntos, forman un anillo fusionado o espirocíclico de 3 a 7 miembros que tiene 0, 1, o 2 heteroátomos del anillo seleccionados a partir de N, O, y S, cuyo anillo fusionado o espirocíclico tiene de 0 a 2 sustituyentes independientemente seleccionados a partir de halogeno, alquilo C1-4, alcoxilo C1-4, alcanoílo C1-4, mono- y di-alquilo C1-4-amino, mono- y di-alquilo C1-4-carboxamida, alcoxilo C1-4carbonilo, y fenilo; o R3 y W pueden formar juntos un anillo de 3, 4, 5, 6, o 7 miembros, que es aromático o no aromático, y puede contener uno o más heteroátomos, en donde el anillo puede estar adicionalmente sustituido una o más veces; y o cuando y es 0, R10 y V pueden formar juntos un anillo de 3, 4, 5, 6, o 7 miembros, que es aromático o no aromático, y puede contener uno o más heteroátomos, en donde el anillo puede estar adicionalmente sustituido una o más veces.
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ565059A (en) 2005-07-25 2011-08-26 Intermune Inc Novel macrocyclic inhibitors of hepatitus C virus replication
BRPI0617274A2 (pt) 2005-10-11 2011-07-19 Intermune Inc compostos e métodos para a inibição de replicação viral de hepatite c
EP2007789B1 (en) * 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
RU2008152171A (ru) 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) Новые ингибиторы вирусной репликации гепатита с
AU2008251425A1 (en) * 2007-05-10 2008-11-20 Array Biopharma, Inc. Novel peptide inhibitors of hepatitis C virus replication
AU2008309589B2 (en) * 2007-10-10 2012-07-05 Novartis Ag Spiropyrrolidines and their use against HCV and HIV infection
EP2279011B1 (en) 2008-04-30 2017-10-25 Siemens Medical Solutions USA, Inc. Substrate based pet imaging agents
US20090285774A1 (en) * 2008-05-15 2009-11-19 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US20110182850A1 (en) * 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) * 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
CA2811799A1 (en) * 2010-10-08 2012-04-12 Novartis Ag Vitamin e formulations of sulfamide ns3 inhibitors
BR112013008388A2 (pt) * 2010-10-08 2016-06-14 Novartis Ag sais e polimorfos de inibidores de ns3 de sulfamida
WO2013025858A1 (en) * 2011-08-16 2013-02-21 Glaxosmithkline Llc 5-benzyl-n-phenyethyl-1,3,4-oxadiazole-2-carboxamide derivatives
ES2607752T3 (es) * 2013-11-12 2017-04-03 Acousia Therapeutics Gmbh Compuestos nuevos para regeneración de células y tejidos terminalmente diferenciados
CN105769860A (zh) * 2016-04-18 2016-07-20 乔海灵 氯美噻唑作为预防和治疗肝脏及食管疾病药物的应用
EP3472149B1 (en) 2016-06-21 2023-08-30 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
CA3032453A1 (en) * 2016-08-08 2018-02-15 Signum Biosciences, Inc. Pharmaceutical formulations and their use
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
USRE29835E (en) 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (ja) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
US5041426A (en) 1987-12-21 1991-08-20 Brigham Young University Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
DE3803225A1 (de) * 1988-02-04 1989-08-17 Hoechst Ag Aminosaeureamide mit psychotroper wirkung, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5026687A (en) 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
CA2079105C (en) 1990-04-04 2000-06-13 Michael Houghton Hepatitis c virus protease
KR100217483B1 (ko) 1990-04-06 1999-09-01 프랭크 쿵 C형 간염 바이러스 에피토프
ES2095926T5 (es) 1990-11-02 2001-02-16 Novartis Ag Cyclosporins.
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5610054A (en) 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5604229A (en) 1992-10-21 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
KR100187613B1 (ko) 1992-12-29 1999-06-01 스티븐 에프. 웨인스톡 레트로바이러스성 프로테이제 억제 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
US5496546A (en) 1993-02-24 1996-03-05 Jui H. Wang Compositions and methods of application of reactive antiviral polyadenylic acid derivatives
CA2167537A1 (en) 1993-07-19 1995-02-02 Tsuneo Ozeki Hepatitis c virus proliferation inhibitor
KR960705579A (ko) 1993-11-10 1996-11-08 에릭에스. 딕커 개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates)
DE4447588C2 (de) 1994-05-03 1997-11-20 Omer Osama Dr Dr Med Pflanzliches Arzneimittel zur Behandlung von chronischen und allergischen Rhino-Sino-Bronchitiden
EP0778263B1 (en) 1994-08-22 2002-01-09 Welfide Corporation Benzene compound and medicinal use thereof
DE4432623A1 (de) 1994-09-14 1996-03-21 Huels Chemische Werke Ag Verfahren zur Bleichung von wäßrigen Tensidlösungen
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JP3786447B2 (ja) 1995-03-31 2006-06-14 エーザイ株式会社 Ｃ型肝炎の予防・治療剤
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
JP2000506010A (ja) 1996-02-29 2000-05-23 イミューソル インコーポレイテッド Ｃ型肝炎ウイルスリボザイム
US5633388A (en) 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5830905A (en) 1996-03-29 1998-11-03 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
PL192628B1 (pl) 1996-04-23 2006-11-30 Vertex Pharma Pochodne mocznika, kompozycje farmaceutyczne i zastosowanie związku i kompozycji
US5990276A (en) 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
US5891874A (en) 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5837257A (en) 1996-07-09 1998-11-17 Sage R&D Use of plant extracts for treatment of HIV, HCV and HBV infections
JP3927630B2 (ja) 1996-09-27 2007-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウイルス感染症の予防・治療剤
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
DE69709671T2 (de) 1996-10-18 2002-08-22 Vertex Pharmaceuticals Inc., Cambridge Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
WO1998040381A1 (en) 1997-03-14 1998-09-17 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
SI1319651T1 (en) 1997-04-04 2005-10-31 Mitsubishi Pharma Corporation 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
ES2200358T3 (es) 1997-06-30 2004-03-01 MERZ PHARMA GMBH & CO. KGAA 1-amino-alquilciclohexanos antagonistas del receptor de nmda.
DE69827956T2 (de) 1997-08-11 2005-04-14 Boehringer Ingelheim (Canada) Ltd., Laval Peptidanaloga mit inhibitorischer wirkung auf hepatitis c
PT1058686E (pt) 1998-02-25 2007-01-31 Raymond F Schinazi 2'-fluoronucleósidos
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
MXPA01001507A (es) 1998-08-10 2003-09-10 Novirio Pharmaceuticals Ltd °l-2'desoxi-nucleosidos para el tratamiento de hepatitis b.
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AU769383B2 (en) 1999-03-19 2004-01-22 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
NZ514466A (en) 1999-04-07 2004-10-29 Pfizer Prod Inc Use of CYP2D6 inhibitors in combination therapies
DE20015444U1 (de) 1999-09-06 2001-02-15 Innovationen zur Verbrennungstechnik GmbH, 38446 Wolfsburg Kraftfahrzeug-Verbrennungsmotor
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
KR20030005197A (ko) 2000-02-18 2003-01-17 샤이어 바이오켐 인코포레이티드 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법
US7094770B2 (en) 2000-04-13 2006-08-22 Pharmasset, Ltd. 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
SK152003A3 (en) 2000-07-13 2004-07-07 Sankyo Co Amino alcohol derivatives
ES2341534T3 (es) 2000-07-21 2010-06-22 Schering Corporation Peptidos como inhibidores de la serina proteasa ns3 del virus de la hepatitis c.
AU8063701A (en) 2000-07-21 2002-02-05 Schering Corp Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
AR029851A1 (es) * 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
CA2418199A1 (en) 2000-07-21 2002-01-31 Corvas International, Inc. Peptides as ns3-serine protease inhibitors of hepatitis c virus
AU2001255070A1 (en) 2000-08-28 2002-03-13 Jin-Sub Kim Generator of two-wheeled vehicle and lighting system thereby
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
WO2002018395A1 (en) 2000-08-31 2002-03-07 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
KR20090089922A (ko) 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
PE20020707A1 (es) 2000-11-20 2002-08-11 Bristol Myers Squibb Co Compuestos tripeptidicos como inhibidores de la proteasa ns3 del virus de hepatitis c
DE60138567D1 (de) 2000-12-12 2009-06-10 Schering Corp Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus
WO2002048116A2 (en) 2000-12-13 2002-06-20 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
AU2002230764A1 (en) 2000-12-13 2002-06-24 Bristol-Myers Squibb Pharma Company Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
US20040266723A1 (en) 2000-12-15 2004-12-30 Otto Michael J. Antiviral agents for treatment of Flaviviridae infections
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
DE10102928B4 (de) 2001-01-23 2004-03-04 Infineon Technologies Ag Viterbi-Decoder und Verfahren zur Decodierung
IL157773A0 (en) 2001-03-26 2004-03-28 Novartis Ag 2-amino-propanol derivatives
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
CN1329372C (zh) 2001-09-27 2007-08-01 杏林制药株式会社 二芳基硫醚衍生物及其加成盐和免疫抑制剂
WO2003029184A1 (en) 2001-09-27 2003-04-10 Kyorin Pharmaceutical Co., Ltd. Diaryl ether derivative, addition salt thereof, and immunosuppressant
AU2002330154A1 (en) * 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
IL162137A0 (en) 2001-11-27 2005-11-20 Anadys Pharmaceuticals Inc D-ribofuranosylthiazolo -3-Ä4,5-dÜpyridimine nucl eosides and uses thereof
US6973322B2 (en) 2001-12-22 2005-12-06 International Business Machines Corporation Personal travel agent using push services
WO2003062252A1 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
WO2003062248A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
KR20040077767A (ko) 2002-01-23 2004-09-06 쉐링 코포레이션 Ｃ형 간염 바이러스 감염 치료용 ｎｓ3-세린 프로테아제억제제로서의 프롤린 화합물
RU2004133044A (ru) 2002-04-11 2006-01-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Ингибиторы сериновых протеаз, в частности, протеазы ns3-ns4a hcv
MY140680A (en) * 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
EP1631554A2 (en) 2003-06-04 2006-03-08 Genelabs Technologies, Inc. Nitrogen-containing heteroaryl derivatives for the treatment of hcv-infection
CN1805931B (zh) 2003-06-17 2010-06-23 先灵公司 制备(1r,2s,5s)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸酯或其盐的方法和中间体
US7109172B2 (en) * 2003-07-18 2006-09-19 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
ZA200600424B (en) 2003-08-01 2007-05-30 Genelabs Tech Inc Bicyclic imidazol derivatives against flaviviridae
CA2536570A1 (en) 2003-08-26 2005-03-10 Schering Corporation Novel peptidomimetic ns3-serine protease inhibitors of hepatitis c virus
MY148123A (en) 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
ES2342069T4 (es) 2003-09-05 2011-01-26 Anadys Pharmaceuticals, Inc. Ligandos de tlr7 para el tratamiento de la hepatitis c.
US20050119189A1 (en) 2003-09-18 2005-06-02 Cottrell Kevin M. Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
RU2006115558A (ru) * 2003-10-10 2007-11-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы
US20060003942A1 (en) 2003-10-27 2006-01-05 Roger Tung Combinations for HCV treatment
CA2549167A1 (en) 2003-12-11 2005-06-30 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease
JP2008505849A (ja) 2004-02-04 2008-02-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド セリンプロテアーゼ、特に、ｈｃｖ、ｎｓ３−ｎｓ４ａプロテアーゼの阻害剤
EP1729795B1 (en) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Albumin fusion proteins
NZ549223A (en) 2004-02-27 2010-10-29 Schering Corp Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
WO2005087721A2 (en) 2004-02-27 2005-09-22 Schering Corporation Compounds as inhibitors of hepatitis c virus ns3 serine protease
AU2005219859A1 (en) 2004-02-27 2005-09-15 Schering Corporation Inhibitors of hepatitis C virus NS3 protease
ATE514691T1 (de) 2004-02-27 2011-07-15 Schering Corp Neue ketoamide mit cyclischen p4 als inhibitoren der ns3-serinprotease von hepatitis-c-virus
ES2328589T3 (es) 2004-02-27 2009-11-16 Schering Corporation Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c.
US7635694B2 (en) 2004-02-27 2009-12-22 Schering Corporation Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease
PE20060309A1 (es) 2004-05-06 2006-04-13 Schering Corp (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2s)-2[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.o]hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de l
CN1964985A (zh) 2004-06-07 2007-05-16 阿纳迪斯药物公司 3－β－D－呋喃核糖基噻唑并[4,5－d]嘧啶核苷类及其应用
AR049297A1 (es) 2004-06-08 2006-07-12 Vertex Pharma Una composicion farmaceutica y dispersiones solidas de vx-950 (inhibidor de la proteasa de hcv ns3/4a) y proceso de obtencion
EP2457895A1 (en) * 2004-07-12 2012-05-30 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
CA2577812A1 (en) 2004-08-27 2006-03-09 Schering Corporation Acylsulfonamide compounds as inhibitors of hepatitis c virus ns3 serine protease
JP4892486B2 (ja) 2004-10-01 2012-03-07 デビオファーム ソシエテ アノニム Ｃ型肝炎感染の治療のための［ｄ−ｍｅａｌａ］３−［ｅｔｖａｌ］４−シクロスポリンの使用、及び当該［ｄ−ｍｅａｌａ］３−［ｅｔｖａｌ］４−シクロスポリンを含む医薬組成物
SI1802650T1 (sl) 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
JP2008514723A (ja) 2004-10-01 2008-05-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ｈｃｖｎｓ３−ｎｓ４ａプロテアーゼの阻害
TWI437990B (zh) 2004-10-29 2014-05-21 Vertex Pharma Vx-950之醫藥用途
MX2007008587A (es) 2005-01-14 2007-09-07 Genelabs Tech Inc Derivados de indol para tratamiento de infecciones virales.
WO2006130666A2 (en) 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
US20070004635A1 (en) 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
US20070021351A1 (en) 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
WO2006130626A2 (en) 2005-06-02 2006-12-07 Schering Corporation Method for modulating activity of hcv protease through use of a novel hcv protease inhibitor to reduce duration of treatment period
WO2006130686A2 (en) 2005-06-02 2006-12-07 Schering Corporation Hcv protease inhibitors in combination with food
US7608592B2 (en) 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
WO2007016589A2 (en) 2005-08-02 2007-02-08 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US20070265281A1 (en) 2006-04-11 2007-11-15 Sylvain Cottens Organic Compounds and Their Uses
BRPI0710153A2 (pt) 2006-04-11 2011-08-02 Novartis Ag compostos orgánicos e seus usos
EP2007789B1 (en) * 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
WO2007120595A2 (en) 2006-04-11 2007-10-25 Novartis Ag Amines for the treatment of hcv
AU2008309589B2 (en) * 2007-10-10 2012-07-05 Novartis Ag Spiropyrrolidines and their use against HCV and HIV infection
US8512690B2 (en) * 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors

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