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PE20210451A1 - Oligonucleotidos para inducir la expresion paterna de ube3a - Google Patents

Oligonucleotidos para inducir la expresion paterna de ube3a

Info

Publication number
PE20210451A1
PE20210451A1 PE2020000810A PE2020000810A PE20210451A1 PE 20210451 A1 PE20210451 A1 PE 20210451A1 PE 2020000810 A PE2020000810 A PE 2020000810A PE 2020000810 A PE2020000810 A PE 2020000810A PE 20210451 A1 PE20210451 A1 PE 20210451A1
Authority
PE
Peru
Prior art keywords
ube3a
oligonucleotides
induce
expression
relates
Prior art date
Application number
PE2020000810A
Other languages
English (en)
Inventor
Veronica Costa
Maj Hedtjarn
Marius Hoener
Ravi Jagasia
Mads Aaboe Jensen
Søren Vestergaard Rasmussen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57345910&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20210451(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20210451A1 publication Critical patent/PE20210451A1/es

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Abstract

La presente invencion se refiere a oligonucleotidos que son capaces de inducir la expresion de la ubiquitin-proteina ligasa E3A (UBE3A) a partir del alelo parterno en neuronas animales o humanas. Los oligonucleotidos con diana en el supresor del alelo paterno de UBE3A mediante hibridacion con el ARN no codificante largo de SNHG14 cadena abajo de SNORD109B. Asimismo, la presente invencion se refiere a composiciones y metodos farmaceuticos para el tratamiento del sindrome de Angelman.
PE2020000810A 2015-11-12 2016-11-11 Oligonucleotidos para inducir la expresion paterna de ube3a PE20210451A1 (es)

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PCT/EP2016/077383 WO2017081223A1 (en) 2015-11-12 2016-11-11 Oligonucleotides for inducing paternal ube3a expression

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JP2025024060A (ja) 2025-02-19
HK1258309A1 (zh) 2019-11-08
MX2022016376A (es) 2023-01-30
EP4220360B1 (en) 2024-06-26
PL3374509T3 (pl) 2021-05-04
MX2018004978A (es) 2018-07-06
CR20220077A (es) 2023-04-11
BR112018007633A2 (pt) 2018-11-06
WO2017081250A1 (en) 2017-05-18
EP4220360A3 (en) 2023-08-23
HRP20210227T1 (hr) 2021-03-19
IL281211A (en) 2021-04-29
AU2016352836A1 (en) 2018-04-26
US20190310244A1 (en) 2019-10-10
LT4220360T (lt) 2024-09-10
KR20230008233A (ko) 2023-01-13
US20240085402A1 (en) 2024-03-14
IL281211B1 (en) 2023-09-01
US20190144824A1 (en) 2019-05-16
KR20180070611A (ko) 2018-06-26
SI4220360T1 (sl) 2024-10-30
CN108291226B (zh) 2022-11-04
KR20200137027A (ko) 2020-12-08
EP3374499A1 (en) 2018-09-19
HK1253325A1 (zh) 2019-06-14
AU2022211910A1 (en) 2022-11-10
HRP20241138T1 (hr) 2024-11-22
DK4220360T3 (da) 2024-09-16

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