PE20190761A1 - Inhibidores de procesos metabolicos celulares - Google Patents
Inhibidores de procesos metabolicos celularesInfo
- Publication number
- PE20190761A1 PE20190761A1 PE2019000437A PE2019000437A PE20190761A1 PE 20190761 A1 PE20190761 A1 PE 20190761A1 PE 2019000437 A PE2019000437 A PE 2019000437A PE 2019000437 A PE2019000437 A PE 2019000437A PE 20190761 A1 PE20190761 A1 PE 20190761A1
- Authority
- PE
- Peru
- Prior art keywords
- metabolic process
- cellular metabolic
- inhibitors
- alkyl
- refers
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000019522 cellular metabolic process Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 101000947881 Homo sapiens S-adenosylmethionine synthase isoform type-2 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100035947 S-adenosylmethionine synthase isoform type-2 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Se refiere a un compuesto de formula IA o una de sus sales farmaceuticamente aceptables, en donde: RA es H, alquilo C1-C6, entre otros; RB es H, alquenilo C2-C6 y alquilo C1-C6; RC, RD y RE son por separado carbociclo C3-C14, arilo C6-C14 y heterociclo de 3 a 14 miembros (1 a 4 de estos miembros son N, O o S). Tambien se refiere a una composicion farmaceutica y a metodos de preparacion. Dichos compuestos son inhibidores de la enzima MAT2A (metionina adenosiltransferasa 2A) y son utiles en el tratamiento de cancer
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/097524 WO2018039972A1 (en) | 2016-08-31 | 2016-08-31 | Inhibitors of cellular metabolic processes |
| US201762548738P | 2017-08-22 | 2017-08-22 | |
| PCT/US2017/049439 WO2018045071A1 (en) | 2016-08-31 | 2017-08-30 | Inhibitors of cellular metabolic processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190761A1 true PE20190761A1 (es) | 2019-06-05 |
Family
ID=59846695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000437A PE20190761A1 (es) | 2016-08-31 | 2017-08-30 | Inhibidores de procesos metabolicos celulares |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10329298B2 (es) |
| EP (1) | EP3507290A1 (es) |
| JP (2) | JP6832430B2 (es) |
| KR (1) | KR102411150B1 (es) |
| CN (1) | CN109890822B (es) |
| AU (2) | AU2017319500C1 (es) |
| CA (1) | CA3034705C (es) |
| CL (1) | CL2019000511A1 (es) |
| CO (1) | CO2019002237A2 (es) |
| CR (1) | CR20190157A (es) |
| IL (1) | IL265115B (es) |
| MA (1) | MA46092A (es) |
| MX (1) | MX390277B (es) |
| NI (1) | NI201900019A (es) |
| PE (1) | PE20190761A1 (es) |
| SG (1) | SG11201901747VA (es) |
| TW (1) | TWI762505B (es) |
| UA (1) | UA125852C2 (es) |
| WO (1) | WO2018045071A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20190761A1 (es) | 2016-08-31 | 2019-06-05 | Agios Pharmaceuticals Inc | Inhibidores de procesos metabolicos celulares |
| WO2019040499A2 (en) * | 2017-08-21 | 2019-02-28 | Navigen, Inc. | ARF6 INHIBITORS AND ASSOCIATED METHODS |
| BR112020003676A2 (pt) | 2017-09-15 | 2020-09-01 | Aduro Biotech, Inc. | compostos de pirazolopirimidinona e usos dos mesmos |
| AU2019243289B2 (en) | 2018-03-30 | 2023-01-12 | Les Laboratoires Servier | Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer |
| CN113166078B (zh) * | 2018-12-10 | 2024-11-19 | 伊迪亚生物科学有限公司 | 2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂 |
| CR20210409A (es) * | 2018-12-27 | 2022-01-24 | Les Laboratoires Servier Sas | Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncer |
| SI3902803T1 (sl) | 2018-12-27 | 2023-06-30 | Les Laboratoires Servier | Aza-heterobiciklični inhibitorji mat2a in postopki uporabe za zdravljenje raka |
| WO2020167952A1 (en) * | 2019-02-12 | 2020-08-20 | Mirati Therapeutics, Inc. | Mat2a inhibitors |
| TW202045155A (zh) | 2019-02-13 | 2020-12-16 | 美商阿吉歐斯製藥公司 | 用於治療癌症之組合療法 |
| WO2021023609A1 (en) | 2019-08-02 | 2021-02-11 | Glaxosmithkline Intellectual Property Development Limited | Combination of a type i protein arginine methyltransferase (type i prmt) inhibitor and a methionine adenosyltransferase ii alpha (mat2a) inhibitor |
| BR112022010054A2 (pt) | 2019-11-25 | 2022-08-16 | Amgen Inc | Compostos heterocíclicos como inibidores de delta-5 dessaturase e métodos de uso |
| WO2021139775A1 (zh) * | 2020-01-10 | 2021-07-15 | 江苏先声药业有限公司 | 吡啶酮化合物及应用 |
| WO2021158792A1 (en) * | 2020-02-04 | 2021-08-12 | Agios Pharmaceuticals, Inc. | Methods of treating autoimmune or inflammatory diseases or disorders |
| CN116406271B (zh) * | 2020-07-14 | 2024-09-24 | 南京再明医药有限公司 | 双环类化合物 |
| CN113999232B (zh) * | 2020-07-28 | 2025-01-07 | 南京正大天晴制药有限公司 | Mat2a抑制剂 |
| IL300147A (en) * | 2020-07-31 | 2023-03-01 | Tango Therapeutics Inc | History Piperidin-1-yl-N-pyridin-3-yl-2-oxaacetamide is useful for the treatment of MTAP-deficient and/or MTA-accumulating cancer |
| AR123227A1 (es) * | 2020-08-12 | 2022-11-09 | Servier Pharmaceuticals Llc | Terapias combinadas para su uso en el tratamiento del cáncer |
| TW202227446A (zh) | 2020-08-12 | 2022-07-16 | 美商施維雅製藥有限公司 | 有機化合物之固態形式 |
| WO2022063128A1 (zh) * | 2020-09-24 | 2022-03-31 | 上海凌达生物医药有限公司 | 一类芳环或芳基杂环并吡啶酮类化合物、药物组合物及其应用 |
| CN116782903A (zh) * | 2020-10-15 | 2023-09-19 | 南京再明医药有限公司 | 取代的吡啶酮化合物及应用 |
| TW202237610A (zh) * | 2020-11-25 | 2022-10-01 | 法商施維雅藥廠 | 新穎有機化合物 |
| WO2022143864A1 (zh) | 2020-12-31 | 2022-07-07 | 江苏先声药业有限公司 | 三环类化合物及用途 |
| US20240075017A1 (en) | 2021-03-08 | 2024-03-07 | Technische Universität München | Treatment of coronavirus infections using sam cycle inhibitors |
| EP4313988A4 (en) * | 2021-03-26 | 2025-03-19 | Orphagen Pharmaceuticals, Inc. | PYRAZOLOPYRIMIDINONE COMPOUNDS |
| AR125304A1 (es) * | 2021-04-08 | 2023-07-05 | Genentech Inc | Compuestos de oxazepina acíclicos y usos de los mismos |
| JP2024116429A (ja) * | 2021-07-06 | 2024-08-28 | 国立研究開発法人産業技術総合研究所 | 組織の老化を予防または治療するための組成物 |
| CN115716831B (zh) * | 2021-08-25 | 2024-07-02 | 中国科学院分子细胞科学卓越创新中心 | 一种mat2a抑制剂及其在抗病毒中的应用 |
| WO2023083210A1 (zh) * | 2021-11-09 | 2023-05-19 | 上海海雁医药科技有限公司 | 取代的萘啶酮衍生物、其药物组合物及应用 |
| WO2023086934A1 (en) * | 2021-11-12 | 2023-05-19 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a taxane |
| CN116283994B (zh) * | 2021-12-20 | 2025-01-07 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的杂环化合物 |
| WO2023116696A1 (zh) | 2021-12-21 | 2023-06-29 | 南京正大天晴制药有限公司 | 蛋氨酸腺苷转移酶2a的杂环抑制剂 |
| GB202204913D0 (en) | 2022-04-04 | 2022-05-18 | Cambridge Entpr Ltd | antiviral therapy |
| CN116987084A (zh) * | 2022-04-26 | 2023-11-03 | 上海交通大学 | 吡唑并嘧啶类化合物及其盐、溶剂合物、组合物和应用 |
| PE20251525A1 (es) | 2022-10-13 | 2025-06-05 | Hanmi Pharmaceutical Co Ltd | Compuesto derivado triciclico novedoso y usos del mismo descripcion |
| EP4619104A1 (en) * | 2022-11-16 | 2025-09-24 | Novartis AG | Bicyclic heterocycles and their use as wrn inhibitors |
| CN116425751B (zh) * | 2022-12-19 | 2024-01-23 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的多环类化合物 |
| CN116425721B (zh) * | 2022-12-19 | 2024-02-02 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的双环类化合物 |
| WO2024153244A1 (zh) * | 2023-01-20 | 2024-07-25 | 南京再明医药有限公司 | 含氮类化合物 |
| WO2024230828A1 (en) * | 2023-05-11 | 2024-11-14 | InventisBio Co., Ltd. | Compounds, preparation methods and uses thereof |
| WO2025064750A1 (en) | 2023-09-20 | 2025-03-27 | Ideaya Biosciences, Inc. | Combination therapy with a parg inhibitor |
| WO2025072544A1 (en) | 2023-09-27 | 2025-04-03 | Ideaya Biosciences, Inc. | Sulfonamino indazole compounds as inhibitors of parg |
| WO2025166229A1 (en) | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Tricyclic amidino compounds as prmt5 inhibitors |
| WO2025166257A1 (en) | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Amide substituted triheterocyclic guanidino compounds as prmt5 inhibitors |
| WO2025166260A1 (en) | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Amide substituted tricyclic guanidino compounds as prmt5 inhibitors |
| WO2025166274A1 (en) | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Tricyclic guanidino compounds as prmt5 inhibitors |
| WO2025166215A1 (en) | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Triheterocyclic guanidino compounds as prmt5 inhibitors |
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