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PE20181402A1 - Anticuerpos anti-c5 y metodos de uso - Google Patents

Anticuerpos anti-c5 y metodos de uso

Info

Publication number
PE20181402A1
PE20181402A1 PE2018001137A PE2018001137A PE20181402A1 PE 20181402 A1 PE20181402 A1 PE 20181402A1 PE 2018001137 A PE2018001137 A PE 2018001137A PE 2018001137 A PE2018001137 A PE 2018001137A PE 20181402 A1 PE20181402 A1 PE 20181402A1
Authority
PE
Peru
Prior art keywords
seq
hvr
sequence
amino acids
refers
Prior art date
Application number
PE2018001137A
Other languages
English (en)
Inventor
Zenjiro Sampei
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of PE20181402A1 publication Critical patent/PE20181402A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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Abstract

SE REFIERE A UN ANTICUERPO AISLADO QUE SE UNE A C5 QUE COMPRENDE A) UNA HVR-H1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 126; B) UNA HVR-H2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 127; C) UNA HVR-H3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 128; D) UNA HVR-L1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 129; E) UNA HVR-L2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 130; Y F) UNA HVR-L3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 131, DONDE DICHO ANTICUERPO PRESENTA UNA SECUENCIA DE VH DE SEQ ID NO: 10, 106- 110 Y UNA SECUENCIA DE VL DE SEQ ID NO: 20, 111-113. TAMBIEN SE REFIRE A UNA FORMULACION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE ARTRITIS REUMATOIDE, LUPUS ERITEMATOSO, SINDROME UREMICO HEMOLITICO
PE2018001137A 2015-12-18 2016-12-16 Anticuerpos anti-c5 y metodos de uso PE20181402A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015247069 2015-12-18

Publications (1)

Publication Number Publication Date
PE20181402A1 true PE20181402A1 (es) 2018-09-07

Family

ID=58186002

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2022002449A PE20240365A1 (es) 2015-12-18 2016-12-16 Anticuerpos anti-c5 y metodos de uso
PE2018001137A PE20181402A1 (es) 2015-12-18 2016-12-16 Anticuerpos anti-c5 y metodos de uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
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Country Status (36)

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EP (2) EP4342529A3 (es)
JP (5) JP6088703B1 (es)
KR (2) KR102467124B1 (es)
CN (2) CN108401431B (es)
AR (1) AR107077A1 (es)
AU (1) AU2016372930B2 (es)
BR (1) BR112018009067A8 (es)
CA (1) CA3005592C (es)
CL (1) CL2018001577A1 (es)
CO (1) CO2018007374A2 (es)
CR (1) CR20180364A (es)
DK (1) DK3390442T5 (es)
EA (1) EA036756B1 (es)
ES (1) ES2969440T3 (es)
FI (2) FI3390442T3 (es)
FR (1) FR24C1044I2 (es)
HR (1) HRP20231456T1 (es)
HU (2) HUE065073T2 (es)
IL (1) IL259256B2 (es)
LT (2) LT3390442T (es)
MA (1) MA44081B1 (es)
MX (2) MX2018007144A (es)
MY (1) MY186948A (es)
NL (1) NL301300I2 (es)
PE (2) PE20240365A1 (es)
PH (1) PH12018501282A1 (es)
PL (1) PL3390442T3 (es)
PT (1) PT3390442T (es)
RS (1) RS64998B1 (es)
RU (1) RU2742606C2 (es)
SA (1) SA518391704B1 (es)
SG (2) SG10201709415WA (es)
SI (1) SI3390442T1 (es)
TW (4) TWI747936B (es)
UA (1) UA123774C2 (es)
WO (1) WO2017104779A1 (es)

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WO2007114319A1 (ja) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha 抗体の血中動態を制御する方法
SI2202245T1 (sl) 2007-09-26 2016-10-28 Chugai Seiyaku Kabushiki Kaisha Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR
ES2978400T3 (es) 2008-04-11 2024-09-11 Chugai Pharmaceutical Co Ltd Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
EP4600372A3 (en) 2014-12-19 2025-11-19 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
EP3233921B1 (en) 2014-12-19 2021-09-29 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use
AR107077A1 (es) * 2015-12-18 2018-03-21 Chugai Pharmaceutical Co Ltd Anticuerpos anti-c5 y métodos para su uso
JP7141336B2 (ja) 2015-12-25 2022-09-22 中外製薬株式会社 抗ミオスタチン抗体および使用方法
SMT202400269T1 (it) 2016-06-14 2024-07-09 Regeneron Pharma Anticorpi anti-c5 e loro usi
CN115960223A (zh) * 2016-06-17 2023-04-14 中外制药株式会社 抗-c5抗体及使用方法
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES
CN111630065A (zh) 2017-12-13 2020-09-04 瑞泽恩制药公司 抗c5抗体组合及其用途
US12098190B2 (en) 2018-09-06 2024-09-24 The Trustees Of The University Of Pennsylvania And Humanized anti-C5 antibodies and uses thereof
US20220204602A1 (en) * 2019-04-24 2022-06-30 The Trustees Of The University Of Pennsylvania Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof
CR20220041A (es) 2019-07-31 2022-03-02 Hoffmann La Roche Régimen de dosificación y administración para el tratamiento o prevención de enfermedades relacionadas con c5 mediante el uso del anticuerpo anti-c5 crovalimab
CA3144921A1 (en) 2019-07-31 2021-02-04 F. Hoffmann-La Roche Ag Dosage and administration regimen for the treatment or prevention of c5-related diseases by the use of the anti-c5 antibody crovalimab
JP2024506991A (ja) 2021-02-24 2024-02-15 エフ． ホフマン－ラ ロシュ アーゲー デプスフィルタの再生および複数回使用

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