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PE20180193A1 - Anticuerpos anti-cd40 y sus usos - Google Patents

Anticuerpos anti-cd40 y sus usos

Info

Publication number
PE20180193A1
PE20180193A1 PE2017002472A PE2017002472A PE20180193A1 PE 20180193 A1 PE20180193 A1 PE 20180193A1 PE 2017002472 A PE2017002472 A PE 2017002472A PE 2017002472 A PE2017002472 A PE 2017002472A PE 20180193 A1 PE20180193 A1 PE 20180193A1
Authority
PE
Peru
Prior art keywords
antibodies
activity
portions
human
hcd40
Prior art date
Application number
PE2017002472A
Other languages
English (en)
Inventor
Lorenzo Benautil
Maria A Argiriadi
Bradford L Mcrae
Chung Ming Hsieh
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20180193A1 publication Critical patent/PE20180193A1/es

Links

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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Abstract

La presente invencion engloba anticuerpos anti-CD40 antagonistas y porciones de union al antigeno de estos. En concreto, la invencion se refiere a anticuerpos anti-CD40 humanizados. En ciertas realizaciones, los anticuerpos de la invencion neutralizan la actividad de CD40 humano (hCD40). Los anticuerpos, o porciones de anticuerpos, de la invencion son utiles para detectar CD40 y para inhibir la actividad de CD40, p. ej., en un sujeto humano que padece un trastorno en el que la actividad de CD40 resulta perjudicial.
PE2017002472A 2015-05-29 2016-05-27 Anticuerpos anti-cd40 y sus usos PE20180193A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562168425P 2015-05-29 2015-05-29

Publications (1)

Publication Number Publication Date
PE20180193A1 true PE20180193A1 (es) 2018-01-26

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PE2017002472A PE20180193A1 (es) 2015-05-29 2016-05-27 Anticuerpos anti-cd40 y sus usos

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US (3) US10174121B2 (es)
EP (3) EP3303395B1 (es)
JP (3) JP6518917B2 (es)
KR (2) KR20240056663A (es)
CN (2) CN113603782A (es)
AR (1) AR104809A1 (es)
AU (2) AU2016270640B2 (es)
CA (1) CA2987051A1 (es)
CL (1) CL2017003007A1 (es)
CO (1) CO2017012286A2 (es)
CR (1) CR20170592A (es)
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DK (1) DK3303395T3 (es)
DO (1) DOP2017000273A (es)
EC (1) ECSP17085333A (es)
ES (1) ES2774016T3 (es)
HR (1) HRP20200262T1 (es)
HU (1) HUE048284T2 (es)
IL (1) IL255961B (es)
LT (1) LT3303395T (es)
MX (1) MX392748B (es)
PE (1) PE20180193A1 (es)
PH (1) PH12017502161A1 (es)
PL (1) PL3303395T3 (es)
PT (1) PT3303395T (es)
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UY (1) UY36692A (es)
WO (1) WO2016196314A1 (es)
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