|
US6696251B1
(en)
*
|
1996-05-31 |
2004-02-24 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
|
US6759243B2
(en)
*
|
1998-01-20 |
2004-07-06 |
Board Of Trustees Of The University Of Illinois |
High affinity TCR proteins and methods
|
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
|
JP4368196B2
(ja)
*
|
2000-11-17 |
2009-11-18 |
ユニバーシティー オブ ロチェスター |
真核細胞において免疫グロブリン分子を製造および同定するインビトロにおける方法
|
|
US20050196755A1
(en)
*
|
2000-11-17 |
2005-09-08 |
Maurice Zauderer |
In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
|
|
EP1355666B1
(en)
|
2000-12-22 |
2012-06-13 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Use of repulsive guidance molecule (RGM) and its modulators
|
|
US20090137416A1
(en)
|
2001-01-16 |
2009-05-28 |
Regeneron Pharmaceuticals, Inc. |
Isolating Cells Expressing Secreted Proteins
|
|
WO2002086096A2
(en)
*
|
2001-01-23 |
2002-10-31 |
University Of Rochester Medical Center |
Methods of producing or identifying intrabodies in eukaryotic cells
|
|
CA2462113C
(en)
|
2001-10-01 |
2013-01-29 |
Dyax Corp. |
Multi-chain eukaryotic display vectors and uses thereof
|
|
US20040067532A1
(en)
*
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
|
JP2007524348A
(ja)
|
2003-01-07 |
2007-08-30 |
ダイアックス、コープ |
クニッツドメインライブラリー
|
|
DE10303974A1
(de)
|
2003-01-31 |
2004-08-05 |
Abbott Gmbh & Co. Kg |
Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
|
|
DK1678314T3
(da)
|
2003-10-22 |
2012-12-03 |
Keck Graduate Inst |
Fremgangsmåde til syntetisering af heteromultimere polypeptider i gær ved anvendelse af en haploid parringsstrategi
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
AU2004309373A1
(en)
|
2003-12-22 |
2005-07-14 |
Amgen Inc. |
Methods for identifying functional antibodies
|
|
ATE414718T1
(de)
|
2005-01-05 |
2008-12-15 |
F Star Biotech Forsch & Entw |
Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften
|
|
BRPI0611714A2
(pt)
*
|
2005-06-30 |
2009-01-13 |
Abbott Lab |
proteÍnas de ligaÇço a il-12/p40
|
|
AU2006283532B2
(en)
|
2005-08-19 |
2012-04-26 |
Abbvie Inc. |
Dual variable domain immunoglobin and uses thereof
|
|
US20090215992A1
(en)
*
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
|
EP2500357A3
(en)
|
2005-08-19 |
2012-10-24 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
CA2624562A1
(en)
|
2005-09-30 |
2007-04-12 |
Abbott Gmbh & Co. Kg |
Binding domains of proteins of the repulsive guidance molecule (rgm) protein family and functional fragments thereof, and their use
|
|
CN101331223A
(zh)
*
|
2005-10-14 |
2008-12-24 |
米迪缪尼有限公司 |
细胞展示抗体文库
|
|
DK1976877T4
(da)
|
2005-11-30 |
2017-01-16 |
Abbvie Inc |
Monoklonale antistoffer mod amyloid-beta-protein og anvendelser heraf
|
|
CA2628703C
(en)
|
2005-11-30 |
2019-10-29 |
Abbott Laboratories |
Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
|
|
US7845537B2
(en)
|
2006-01-31 |
2010-12-07 |
Ethicon Endo-Surgery, Inc. |
Surgical instrument having recording capabilities
|
|
US8992422B2
(en)
|
2006-03-23 |
2015-03-31 |
Ethicon Endo-Surgery, Inc. |
Robotically-controlled endoscopic accessory channel
|
|
CA2651111A1
(en)
*
|
2006-05-04 |
2007-11-15 |
Abmaxis Inc. |
Cross-species and multi-species display systems
|
|
EP2402437B1
(en)
|
2006-07-05 |
2016-06-01 |
Catalyst Biosciences, Inc. |
Protease screening methods and proteases identified thereby
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
KR101625961B1
(ko)
|
2006-09-08 |
2016-05-31 |
애브비 바하마스 리미티드 |
인터루킨-13 결합 단백질
|
|
US7732195B2
(en)
|
2006-11-01 |
2010-06-08 |
Facet Biotech Corporation |
Tethered vectors for cell surface immunoglobulin display
|
|
US8455626B2
(en)
|
2006-11-30 |
2013-06-04 |
Abbott Laboratories |
Aβ conformer selective anti-aβ globulomer monoclonal antibodies
|
|
EP2068914A4
(en)
*
|
2007-02-09 |
2011-07-20 |
Medimmune Llc |
PRESENTATION OF ANTIBODY BANK BY PLASMA MEMBRANES OF YEAST CELLS
|
|
WO2008104386A2
(en)
|
2007-02-27 |
2008-09-04 |
Abbott Gmbh & Co. Kg |
Method for the treatment of amyloidoses
|
|
JP5754135B2
(ja)
|
2007-03-26 |
2015-07-29 |
アジェナス インコーポレイテッド |
関心対象のタンパク質の細胞表面ディスプレイ、スクリーニング、および産生
|
|
US8026083B2
(en)
|
2007-04-03 |
2011-09-27 |
Oxyrane Uk Limited |
Yarrowia lipolytica and Pichia pastoris HAC1 nucleic acids
|
|
US20090175847A1
(en)
*
|
2007-05-30 |
2009-07-09 |
Abbott Laboratories |
Humanized antibodies to ab (20-42) globulomer and uses thereof
|
|
US20090232801A1
(en)
*
|
2007-05-30 |
2009-09-17 |
Abbot Laboratories |
Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
|
|
HUE066143T2
(hu)
|
2007-06-26 |
2024-07-28 |
F Star Therapeutics Ltd |
Kötõágensek megjelenítése
|
|
JP2011504722A
(ja)
|
2007-08-21 |
2011-02-17 |
モルフォシス・アー・ゲー |
ジスルフィド結合形成のための改良された方法
|
|
US8877688B2
(en)
*
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
CN101855242B
(zh)
|
2007-09-14 |
2014-07-30 |
阿迪马布有限责任公司 |
合理设计的合成抗体文库及其用途
|
|
US7947495B2
(en)
|
2007-11-01 |
2011-05-24 |
Abbott Biotherapeutics Corp. |
Immunoglobulin display vectors
|
|
US8637435B2
(en)
*
|
2007-11-16 |
2014-01-28 |
Merck Sharp & Dohme Corp. |
Eukaryotic cell display systems
|
|
US8716437B2
(en)
|
2007-12-07 |
2014-05-06 |
Steven A. Goldstein |
Identification of toxin ligands
|
|
EP2235181A1
(en)
*
|
2008-01-11 |
2010-10-06 |
MorphoSys AG |
Display vectors and methods and uses thereof
|
|
US8962803B2
(en)
|
2008-02-29 |
2015-02-24 |
AbbVie Deutschland GmbH & Co. KG |
Antibodies against the RGM A protein and uses thereof
|
|
JP5731827B2
(ja)
*
|
2008-03-03 |
2015-06-10 |
グライコフィ, インコーポレイテッド |
下等真核生物中での組換えタンパク質の表面ディスプレイ
|
|
EP2098536A1
(en)
|
2008-03-05 |
2009-09-09 |
4-Antibody AG |
Isolation and identification of antigen- or ligand-specific binding proteins
|
|
US9873957B2
(en)
|
2008-03-13 |
2018-01-23 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR3 designs
|
|
AU2009240481B2
(en)
|
2008-04-24 |
2015-07-30 |
Takeda Pharmaceutical Company Limited |
Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs
|
|
EP2310415B8
(en)
|
2008-04-25 |
2017-12-13 |
Dyax Corp. |
Antibodies against fcrn and use thereof
|
|
EP2899209A1
(en)
|
2008-04-29 |
2015-07-29 |
Abbvie Inc. |
Dual Variable Domain Immunoglobulins and uses thereof
|
|
EP2113255A1
(en)
|
2008-05-02 |
2009-11-04 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Cytotoxic immunoglobulin
|
|
CA2723219A1
(en)
|
2008-05-09 |
2009-11-12 |
Abbott Gmbh & Co. Kg |
Antibodies to receptor of advanced glycation end products (rage) and uses thereof
|
|
EP2297208A4
(en)
|
2008-06-03 |
2012-07-11 |
Abbott Lab |
DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
|
|
BRPI0913406A2
(pt)
|
2008-06-03 |
2018-01-09 |
Abbott Lab |
imunoglobulinas de domínio variável duplo e usos das mesmas
|
|
US8822645B2
(en)
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
BRPI0915825A2
(pt)
|
2008-07-08 |
2015-11-03 |
Abbott Lab |
proteínas de ligação à prostaglandina e2 usos das mesmas
|
|
US8067339B2
(en)
|
2008-07-09 |
2011-11-29 |
Merck Sharp & Dohme Corp. |
Surface display of whole antibodies in eukaryotes
|
|
JP2012504424A
(ja)
|
2008-10-03 |
2012-02-23 |
ゾーマ テクノロジー リミテッド |
トリプルタグ配列およびその使用方法
|
|
CA2740440A1
(en)
|
2008-10-14 |
2010-04-22 |
Dyax Corp. |
Use of igf-ii/igf-iie binding proteins for the treatment and prevention of systemic sclerosis-associated pulmonary fibrosis
|
|
WO2010065882A1
(en)
*
|
2008-12-04 |
2010-06-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2010069913A1
(en)
*
|
2008-12-16 |
2010-06-24 |
Novartis Ag |
Yeast display systems
|
|
WO2010079189A1
(en)
*
|
2009-01-09 |
2010-07-15 |
Morphosys Ag |
Display vectors and methods and uses thereof
|
|
BRPI1007371A2
(pt)
*
|
2009-01-29 |
2018-03-27 |
Abbott Lab |
proteínas de ligação a il-1
|
|
US20110165063A1
(en)
*
|
2009-01-29 |
2011-07-07 |
Abbott Laboratories |
Il-1 binding proteins
|
|
US8030026B2
(en)
|
2009-02-24 |
2011-10-04 |
Abbott Laboratories |
Antibodies to troponin I and methods of use thereof
|
|
TW201613969A
(en)
|
2009-03-05 |
2016-04-16 |
Abbvie Inc |
IL-17 binding proteins
|
|
SG175407A1
(en)
|
2009-05-29 |
2011-11-28 |
Morphosys Ag |
A collection and methods for its use
|
|
CA2771575A1
(en)
|
2009-08-29 |
2011-03-03 |
Abbott Laboratories |
Therapeutic dll4 binding proteins
|
|
RU2012112550A
(ru)
|
2009-09-01 |
2013-10-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
|
US20110082054A1
(en)
|
2009-09-14 |
2011-04-07 |
Dyax Corp. |
Libraries of genetic packages comprising novel hc cdr3 designs
|
|
WO2011035205A2
(en)
|
2009-09-18 |
2011-03-24 |
Calmune Corporation |
Antibodies against candida, collections thereof and methods of use
|
|
WO2011039634A2
(en)
|
2009-09-29 |
2011-04-07 |
Universiteit Gent |
Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
|
|
US8716450B2
(en)
|
2009-10-15 |
2014-05-06 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
US8420083B2
(en)
*
|
2009-10-31 |
2013-04-16 |
Abbvie Inc. |
Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof
|
|
US9244063B2
(en)
|
2009-11-11 |
2016-01-26 |
Gentian As |
Immunoassay for assessing related analytes of different origin
|
|
CN102834509A
(zh)
|
2009-11-19 |
2012-12-19 |
奥克西雷恩英国有限公司 |
生成哺乳动物样复合n-聚糖的酵母菌株
|
|
BR112012013734A2
(pt)
|
2009-12-08 |
2017-01-10 |
Abbott Gmbh & Co Kg |
anticorpos monoclonais contra a proteína rgm a para uso no tratamento da degeneração da camada de fibras nervosas da retina.
|
|
EP4011917A1
(en)
|
2010-01-06 |
2022-06-15 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein binding proteins
|
|
WO2011089527A1
(en)
*
|
2010-01-21 |
2011-07-28 |
Oxyrane Uk Limited |
Methods and compositions for displaying a poypeptide on a yeast cell surface
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
CA2791631A1
(en)
|
2010-03-02 |
2011-09-09 |
Abbvie Inc. |
Therapeutic dll4 binding proteins
|
|
CN104744591B
(zh)
|
2010-04-15 |
2022-09-27 |
Abbvie德国有限责任两合公司 |
β淀粉样蛋白结合蛋白
|
|
US8841417B2
(en)
|
2010-05-14 |
2014-09-23 |
Abbvie Inc. |
IL-1 binding proteins
|
|
WO2012006500A2
(en)
|
2010-07-08 |
2012-01-12 |
Abbott Laboratories |
Monoclonal antibodies against hepatitis c virus core protein
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
EP3336225B1
(en)
|
2010-07-16 |
2020-02-19 |
Adimab, LLC |
Antibody libraries
|
|
TW201206473A
(en)
|
2010-08-03 |
2012-02-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2012024187A1
(en)
|
2010-08-14 |
2012-02-23 |
Abbott Laboratories |
Amyloid-beta binding proteins
|
|
EP3333188B1
(en)
|
2010-08-19 |
2022-02-09 |
Zoetis Belgium S.A. |
Anti-ngf antibodies and their use
|
|
PE20140229A1
(es)
|
2010-08-26 |
2014-03-27 |
Abbvie Inc |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
EP2622088A2
(en)
|
2010-09-29 |
2013-08-07 |
Oxyrane UK Limited |
Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
|
|
SG189110A1
(en)
|
2010-09-29 |
2013-05-31 |
Oxyrane Uk Ltd |
De-mannosylation of phosphorylated n-glycans
|
|
WO2012052391A1
(en)
|
2010-10-19 |
2012-04-26 |
Glaxo Group Limited |
Polypeptide with jmjd3 catalytic activity
|
|
NZ609707A
(en)
|
2010-11-19 |
2014-12-24 |
Morphosys Ag |
A collection and methods for its use
|
|
US20120275996A1
(en)
|
2010-12-21 |
2012-11-01 |
Abbott Laboratories |
IL-1 Binding Proteins
|
|
KR20130133247A
(ko)
|
2010-12-21 |
2013-12-06 |
애브비 인코포레이티드 |
Il-1-알파 및 -베타 이특이적 이원 가변 도메인 면역글로불린 및 이의 용도
|
|
EP2966089B1
(en)
|
2011-06-02 |
2020-03-25 |
Dyax Corp. |
Fc receptor binding proteins
|
|
CN103857411A
(zh)
|
2011-07-13 |
2014-06-11 |
阿布维公司 |
使用抗il-13抗体治疗哮喘的方法和组合物
|
|
IN2014CN03936A
(da)
|
2011-10-24 |
2015-09-04 |
Abbvie Inc |
|
|
CN104203978A
(zh)
|
2011-10-24 |
2014-12-10 |
艾伯维股份有限公司 |
针对硬化蛋白的免疫结合剂
|
|
WO2013078377A1
(en)
|
2011-11-23 |
2013-05-30 |
Igenica, Inc. |
Anti-cd98 antibodies and methods of use thereof
|
|
EP2791175A2
(en)
|
2011-12-14 |
2014-10-22 |
Abbvie Deutschland GmbH & Co. KG |
Composition and method for the diagnosis and treatment of iron-related disorders
|
|
JP6342812B2
(ja)
|
2011-12-14 |
2018-06-13 |
アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー |
鉄関連障害を診断および治療するための組成物および方法
|
|
TW201333035A
(zh)
|
2011-12-30 |
2013-08-16 |
Abbvie Inc |
針對il-13及/或il-17之雙特異性結合蛋白
|
|
EP2807192B1
(en)
|
2012-01-27 |
2018-04-18 |
Abbvie Deutschland GmbH & Co. KG |
Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
|
|
RU2644258C2
(ru)
|
2012-03-15 |
2018-02-08 |
Оксирейн Юкей Лимитед |
Способы и материалы для лечения болезни помпе
|
|
EP2644693A1
(en)
*
|
2012-03-29 |
2013-10-02 |
IP Bewertungs AG (IPB) |
Biologically active polypertide expressed on the surface of a cell
|
|
ES2894852T3
(es)
|
2012-06-06 |
2022-02-16 |
Zoetis Services Llc |
Anticuerpos anti-NGF caninizados y métodos de los mismos
|
|
UY34905A
(es)
|
2012-07-12 |
2014-01-31 |
Abbvie Inc |
Proteínas de unión a il-1
|
|
SG11201502757QA
(en)
|
2012-10-09 |
2015-05-28 |
Igenica Biotherapeutics Inc |
Anti-c16orf54 antibodies and methods of use thereof
|
|
UY35110A
(es)
|
2012-11-01 |
2014-05-30 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
|
|
TWI745610B
(zh)
|
2012-11-14 |
2021-11-11 |
美商再生元醫藥公司 |
重組細胞表面捕捉蛋白質
|
|
US9550986B2
(en)
|
2012-12-21 |
2017-01-24 |
Abbvie Inc. |
High-throughput antibody humanization
|
|
WO2014143342A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbott Laboratories |
Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
|
|
US9194873B2
(en)
|
2013-03-14 |
2015-11-24 |
Abbott Laboratories |
HCV antigen-antibody combination assay and methods and compositions for use therein
|
|
WO2014143343A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbott Laboratories |
Hcv core lipid binding domain monoclonal antibodies
|
|
EP2968304B1
(en)
|
2013-03-14 |
2018-10-10 |
The Trustees of Columbia University in the City of New York |
4-phenylpiperidines, their preparation and use
|
|
CA2904448A1
(en)
|
2013-03-15 |
2014-09-18 |
Tariq Ghayur |
Dual specific binding proteins directed against il-1.beta. and/or il-17
|
|
US9469686B2
(en)
|
2013-03-15 |
2016-10-18 |
Abbott Laboratories |
Anti-GP73 monoclonal antibodies and methods of obtaining the same
|
|
CA2914566A1
(en)
|
2013-06-07 |
2014-12-11 |
Duke University |
Inhibitors of complement factor h
|
|
WO2015090230A1
(en)
|
2013-12-19 |
2015-06-25 |
Novartis Ag |
Human mesothelin chimeric antigen receptors and uses thereof
|
|
SI3097122T1
(sl)
|
2014-01-24 |
2020-07-31 |
Ngm Biopharmaceuticals, Inc. |
Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo
|
|
JP6814634B2
(ja)
|
2014-02-05 |
2021-01-20 |
モレキュラー テンプレーツ, インク.Molecular Templates, Inc. |
リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
|
|
US10816554B2
(en)
|
2014-04-04 |
2020-10-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Ligand discovery for T cell receptors
|
|
EP3722316A1
(en)
|
2014-07-21 |
2020-10-14 |
Novartis AG |
Treatment of cancer using a cd33 chimeric antigen receptor
|
|
US10851149B2
(en)
|
2014-08-14 |
2020-12-01 |
The Trustees Of The University Of Pennsylvania |
Treatment of cancer using GFR α-4 chimeric antigen receptor
|
|
ES2791248T3
(es)
|
2014-08-19 |
2020-11-03 |
Novartis Ag |
Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
|
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
|
UY36692A
(es)
|
2015-05-29 |
2016-12-30 |
Abbvie Inc |
Anticuerpos anti-cd40 y usos de los mismos
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
EP3355920A4
(en)
|
2015-09-29 |
2019-05-15 |
Celgene Corporation |
PD-1 BINDING PROTEINS AND METHOD OF USE THEREOF
|
|
US11384354B2
(en)
*
|
2015-12-21 |
2022-07-12 |
Zumutor Biologics Inc. |
Method of generating an antibody naïve library, said library and application(s) thereof
|
|
RU2683549C1
(ru)
*
|
2015-12-29 |
2019-03-28 |
Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) |
СИСТЕМА ДЛЯ ЭКСПРЕССИИ FAB-ФРАГМЕНТОВ АНТИТЕЛ В МЕТИЛОТРОФНЫХ ДРОЖЖАХ PICHIAPASTORIS, НА ОСНОВЕ РЕКОМБИНАНТНЫХ ПЛАЗМИДНЫХ ДНК Ab-HCh-HIS/pPICZ_α_A И Ab-LCh-LAMBDA/pPICZα_A, ПРЕДНАЗНАЧЕННЫХ ДЛЯ КЛОНИРОВАНИЯ ВАРИАБЕЛЬНЫХ ДОМЕНОВ ТЯЖЕЛОЙ И ЛЕГКОЙ ЦЕПЕЙ АНТИТЕЛ, СООТВЕТСТВЕННО
|
|
US20170205421A1
(en)
*
|
2016-01-15 |
2017-07-20 |
University Of Washington |
Synthetic yeast agglutination
|
|
US10988759B2
(en)
|
2016-01-15 |
2021-04-27 |
University Of Washington |
High throughput protein-protein interaction screening in yeast liquid culture
|
|
CN110461315B
(zh)
|
2016-07-15 |
2025-05-02 |
诺华股份有限公司 |
使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征
|
|
AU2017329024A1
(en)
|
2016-09-19 |
2019-03-21 |
Celgene Corporation |
Methods of treating immune disorders using pd-1 binding proteins
|
|
US10766958B2
(en)
|
2016-09-19 |
2020-09-08 |
Celgene Corporation |
Methods of treating vitiligo using PD-1 binding antibodies
|
|
CN110383068A
(zh)
|
2016-10-03 |
2019-10-25 |
雅培实验室 |
评估患者样品中uch-l1状态的改进方法
|
|
WO2018067992A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
US10550429B2
(en)
|
2016-12-22 |
2020-02-04 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10815525B2
(en)
|
2016-12-22 |
2020-10-27 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
WO2018130660A1
(en)
|
2017-01-13 |
2018-07-19 |
Academia Sinica |
Reloadable hydrogel system for treating myocardial infarction
|
|
TWI659751B
(zh)
|
2017-01-13 |
2019-05-21 |
中央研究院 |
用以治療腦部疾病之可重複裝載之改良水膠系統
|
|
CA3052513A1
(en)
|
2017-03-23 |
2018-09-27 |
Abbott Laboratories |
Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
|
|
US10877048B2
(en)
|
2017-04-15 |
2020-12-29 |
Abbott Laboratories |
Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
|
|
WO2018200823A1
(en)
|
2017-04-28 |
2018-11-01 |
Abbott Laboratories |
Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
|
|
US10865238B1
(en)
|
2017-05-05 |
2020-12-15 |
Duke University |
Complement factor H antibodies
|
|
CN110651190A
(zh)
|
2017-05-25 |
2020-01-03 |
雅培实验室 |
用早期生物标记物帮助确定是否对已遭受或可能已遭受头部损伤的人受试者执行成像的方法
|
|
WO2018222783A1
(en)
|
2017-05-30 |
2018-12-06 |
Abbott Laboratories |
Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers
|
|
CA3068041C
(en)
|
2017-07-03 |
2024-06-25 |
Abbott Laboratories |
Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
|
|
LT3652215T
(lt)
|
2017-07-14 |
2021-05-25 |
Immatics Biotechnologies Gmbh |
Pagerinta dvejopo savitumo polipeptido molekulė
|
|
KR20210027230A
(ko)
|
2017-10-04 |
2021-03-10 |
옵코 파마슈티칼스, 엘엘씨 |
암의 개인 맞춤형 치료에 관한 물품 및 방법
|
|
IL312910A
(en)
|
2017-10-27 |
2024-07-01 |
Univ New York |
Anti-galectin-9 antibodies and uses thereof
|
|
CN111094983A
(zh)
|
2017-12-09 |
2020-05-01 |
雅培实验室 |
使用胶质细胞原纤维酸性蛋白(gfap)和/或泛素羧基末端水解酶l1(uch-l1)帮助诊断和评价已遭受骨科损伤并已遭受或可能已遭受头部损伤诸如轻度创伤性脑损伤(tbi)的患者的方法
|
|
JP7379165B2
(ja)
|
2017-12-09 |
2023-11-14 |
アボット・ラボラトリーズ |
Gfapとuch-l1との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
|
|
WO2019157529A1
(en)
|
2018-02-12 |
2019-08-15 |
10X Genomics, Inc. |
Methods characterizing multiple analytes from individual cells or cell populations
|
|
MX2020009526A
(es)
|
2018-03-12 |
2020-10-28 |
Zoetis Services Llc |
Anticuerpos anti-ngf y metodos de estos.
|
|
WO2019217758A1
(en)
|
2018-05-10 |
2019-11-14 |
10X Genomics, Inc. |
Methods and systems for molecular library generation
|
|
AU2019269628A1
(en)
*
|
2018-05-17 |
2020-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Receptor inhibition by phosphatase recruitment
|
|
CN112888712A
(zh)
|
2018-09-20 |
2021-06-01 |
华盛顿大学 |
工程化的微生物及其制造和使用方法
|
|
TW202028237A
(zh)
|
2018-09-27 |
2020-08-01 |
美商西建公司 |
SIRPα結合蛋白及其使用方法
|
|
CN112839957A
(zh)
|
2018-09-28 |
2021-05-25 |
协和麒麟株式会社 |
Il-36抗体及其用途
|
|
AU2020212563A1
(en)
|
2019-01-23 |
2021-09-16 |
New York University |
Antibodies specific to delta 1 chain of T cell receptor
|
|
KR20210153674A
(ko)
|
2019-04-22 |
2021-12-17 |
디디바이오. 코포레이션 엘티디.,(상하이) |
파지 라이브러리 제조방법
|
|
IL295387A
(en)
|
2020-02-05 |
2022-10-01 |
Larimar Therapeutics Inc |
Tat peptide binding proteins and uses thereof
|
|
US12449419B1
(en)
|
2020-02-12 |
2025-10-21 |
10X Genomics, Inc. |
Methods for detecting binding of peptide-MHC monomers to T cells
|
|
EP4136459A1
(en)
|
2020-04-13 |
2023-02-22 |
Abbott Laboratories |
Methods, complexes and kits for detecting or determining an amount of a ss-coronavirus antibody in a sample
|
|
IL298006B2
(en)
|
2020-05-11 |
2024-10-01 |
A Alpha Bio Inc |
High-throughput screening methods to identify small molecule targets
|
|
EP4149548A4
(en)
|
2020-05-13 |
2024-05-08 |
Disc Medicine, Inc. |
ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
|
|
KR102563799B1
(ko)
|
2020-06-01 |
2023-08-03 |
에이-알파 바이오, 인크. |
단백질-단백질 상호작용 특징화 및 조작 방법
|
|
KR20230060501A
(ko)
|
2020-08-03 |
2023-05-04 |
얀센 바이오테크 인코포레이티드 |
바이러스 치료제에서 다방성 생체이동을 위한 재료 및 방법
|
|
KR20230042301A
(ko)
|
2020-08-04 |
2023-03-28 |
애벗트 라보라토리이즈 |
샘플에서 sars-cov-2 단백질을 검출하기 위한 개선된 방법 및 키트
|
|
CN112646833A
(zh)
*
|
2020-11-05 |
2021-04-13 |
杭州阿诺生物医药科技有限公司 |
一种全人源抗体酵母展示技术的设计与构建
|
|
CA3198161A1
(en)
|
2020-12-01 |
2022-06-09 |
Beth MCQUISTON |
Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
|
|
WO2023102384A1
(en)
|
2021-11-30 |
2023-06-08 |
Abbott Laboratories |
Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
|
|
EP4271998A1
(en)
|
2020-12-30 |
2023-11-08 |
Abbott Laboratories |
Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
|
|
WO2022147463A2
(en)
|
2020-12-31 |
2022-07-07 |
Alamar Biosciences, Inc. |
Binder molecules with high affinity and/ or specificity and methods of making and use thereof
|
|
WO2022233956A1
(en)
|
2021-05-05 |
2022-11-10 |
Immatics Biotechnologies Gmbh |
Antigen binding proteins specifically binding prame
|
|
JP2024519858A
(ja)
|
2021-05-18 |
2024-05-21 |
アボット・ラボラトリーズ |
小児対象における脳損傷を査定する方法
|
|
CA3222291A1
(en)
|
2021-06-14 |
2022-12-22 |
Jaime MARINO |
Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
|
|
JP2024534849A
(ja)
|
2021-08-31 |
2024-09-26 |
アボット・ラボラトリーズ |
脳の損傷を診断する方法及びシステム
|
|
CN118715440A
(zh)
|
2021-08-31 |
2024-09-27 |
雅培实验室 |
诊断脑损伤的方法和系统
|
|
EP4144898A1
(de)
*
|
2021-09-07 |
2023-03-08 |
New/era/mabs GmbH |
Verfahren zur selektion oder screenen von antikörpern aus einer antikörperbibliothek
|
|
WO2023056268A1
(en)
|
2021-09-30 |
2023-04-06 |
Abbott Laboratories |
Methods and systems of diagnosing brain injury
|
|
JP2025503439A
(ja)
|
2021-12-17 |
2025-02-04 |
アボット・ラボラトリーズ |
血液試料におけるuch-l1、gfap及び他のバイオマーカーを決定するためのシステム及び方法
|
|
UY40097A
(es)
|
2022-01-07 |
2023-07-14 |
Johnson & Johnson Entpr Innovation Inc |
Materiales y métodos de proteínas de unión a il-1b
|
|
CN119256227A
(zh)
|
2022-02-04 |
2025-01-03 |
雅培实验室 |
用于检测样品中泛素羧基末端水解酶l1和/或胶质纤维酸性蛋白的存在或测量其量的侧向流方法、测定和装置
|
|
ES2955461B2
(es)
*
|
2022-05-24 |
2024-12-27 |
Univ Valencia Politecnica |
Levadura y plasmido para la exposicion de proteinas en superficie
|
|
CN120167040A
(zh)
|
2022-06-29 |
2025-06-17 |
雅培实验室 |
用于确定生物样本中的gfap的磁性定点照护型系统和测定
|
|
JP2025525530A
(ja)
|
2022-07-15 |
2025-08-05 |
ヤンセン バイオテツク,インコーポレーテツド |
抗原結合可変領域の改善された生物工学による対合のための材料及び方法
|
|
WO2024059708A1
(en)
|
2022-09-15 |
2024-03-21 |
Abbott Laboratories |
Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
|
|
WO2024211475A1
(en)
|
2023-04-04 |
2024-10-10 |
Abbott Laboratories |
Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)
|
|
WO2024226971A1
(en)
|
2023-04-28 |
2024-10-31 |
Abbott Point Of Care Inc. |
Improved assays, cartridges, and kits for detection of biomarkers, including brain injury biomarkers
|