PE20151654A1 - Inhibidores de cdc7 - Google Patents
Inhibidores de cdc7Info
- Publication number
- PE20151654A1 PE20151654A1 PE2015001925A PE2015001925A PE20151654A1 PE 20151654 A1 PE20151654 A1 PE 20151654A1 PE 2015001925 A PE2015001925 A PE 2015001925A PE 2015001925 A PE2015001925 A PE 2015001925A PE 20151654 A1 PE20151654 A1 PE 20151654A1
- Authority
- PE
- Peru
- Prior art keywords
- cdc7 inhibitors
- cdc7
- inhibitors
- isoindolinone
- cancer
- Prior art date
Links
- 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 title abstract 2
- 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
La presente invencion se refiere a compuestos de 5 isoindolinona, o una sal del mismo farmaceuticamente aceptable, que inhiben CDC7 Y, por lo tanto pueden ser utiles en el tratamiento de cancer
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782798P | 2013-03-14 | 2013-03-14 | |
| US201361789108P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151654A1 true PE20151654A1 (es) | 2015-11-12 |
Family
ID=50382704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015001925A PE20151654A1 (es) | 2013-03-14 | 2014-03-07 | Inhibidores de cdc7 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US9156824B2 (es) |
| EP (1) | EP2970221B1 (es) |
| JP (1) | JP6064079B2 (es) |
| KR (1) | KR101718645B1 (es) |
| CN (1) | CN105008351B (es) |
| AP (1) | AP2015008734A0 (es) |
| AU (1) | AU2014228374B2 (es) |
| BR (1) | BR112015020466B1 (es) |
| CA (1) | CA2900773C (es) |
| CL (1) | CL2015002530A1 (es) |
| CR (1) | CR20150416A (es) |
| CY (1) | CY1119199T1 (es) |
| DK (1) | DK2970221T3 (es) |
| EA (1) | EA027012B1 (es) |
| ES (1) | ES2639793T3 (es) |
| GT (1) | GT201500263A (es) |
| HR (1) | HRP20171151T1 (es) |
| HU (1) | HUE033482T2 (es) |
| IL (1) | IL240962B (es) |
| JO (1) | JO3383B1 (es) |
| LT (1) | LT2970221T (es) |
| ME (1) | ME02805B (es) |
| MX (1) | MX363438B (es) |
| MY (1) | MY188145A (es) |
| NZ (1) | NZ710392A (es) |
| PE (1) | PE20151654A1 (es) |
| PH (1) | PH12015502091B1 (es) |
| PL (1) | PL2970221T3 (es) |
| PT (1) | PT2970221T (es) |
| RS (1) | RS56122B1 (es) |
| SG (1) | SG11201507541PA (es) |
| SI (1) | SI2970221T1 (es) |
| TN (1) | TN2015000349A1 (es) |
| TW (1) | TWI622396B (es) |
| UA (1) | UA116125C2 (es) |
| WO (1) | WO2014143601A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013333534B2 (en) * | 2012-10-15 | 2016-04-14 | Pfizer Ireland Pharmaceuticals | Process for the preparation of voriconazole and analogues thereof |
| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| EA035929B1 (ru) | 2013-01-15 | 2020-09-02 | Инсайт Холдингс Корпорейшн | ТИАЗОЛКАРБОКСАМИДЫ И ПИРИДИНКАРБОКСАМИДЫ, ИСПОЛЬЗУЕМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Pim-КИНАЗЫ |
| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| WO2014152537A1 (en) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | P2x7 modulators |
| WO2014152589A1 (en) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | P2x7 modulators |
| AP2015008601A0 (en) | 2013-03-14 | 2015-07-31 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1] heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | Ｐ２ｘ７調節劑 |
| SG11201601259YA (en) | 2013-08-23 | 2016-03-30 | Incyte Corp | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| NZ728684A (en) | 2014-09-12 | 2022-09-30 | Boehringer Ingelheim Int | Spirocyclic inhibitors of cathepsin c |
| EP3191488B1 (en) | 2014-09-12 | 2019-08-14 | Janssen Pharmaceutica NV | P2x7 modulating n-acyl-triazolopyrazines |
| JP6592510B2 (ja) | 2014-09-12 | 2019-10-16 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｐ２ｘ７調節因子 |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
| WO2018055402A1 (en) * | 2016-09-22 | 2018-03-29 | Cancer Research Technology Limited | Preparation and uses of pyrimidinone derivatives |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| CN108383771A (zh) * | 2018-01-08 | 2018-08-10 | 华东师范大学 | 手性3,3-二取代异吲哚啉-1-酮衍生物及其合成方法和应用 |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| WO2020065614A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| CR20210153A (es) | 2018-09-28 | 2021-05-11 | Janssen Pharmaceutica Nv | Moduladores de monoacilglicerol lipasa |
| US20220220125A1 (en) * | 2019-04-16 | 2022-07-14 | Janssen Pharmaceutica Nv | Fused isoindolin-1-one derivatives useful as grk2 inhibitors |
| CA3156100A1 (en) | 2019-09-30 | 2021-04-08 | Janssen Pharmaceutica Nv | Radiolabelled mgl pet ligands |
| US11891387B2 (en) | 2020-03-26 | 2024-02-06 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| US7576082B2 (en) * | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| CN101631546A (zh) * | 2006-10-12 | 2010-01-20 | 泽农医药公司 | 螺-吲哚酮化合物作为治疗剂的用途 |
| CN101790526A (zh) * | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
-
2014
- 2014-03-04 JO JOP/2014/0067A patent/JO3383B1/ar active
- 2014-03-05 TW TW103107546A patent/TWI622396B/zh active
- 2014-03-07 SG SG11201507541PA patent/SG11201507541PA/en unknown
- 2014-03-07 ES ES14712966.2T patent/ES2639793T3/es active Active
- 2014-03-07 HU HUE14712966A patent/HUE033482T2/en unknown
- 2014-03-07 JP JP2016500764A patent/JP6064079B2/ja active Active
- 2014-03-07 MY MYPI2015703062A patent/MY188145A/en unknown
- 2014-03-07 AU AU2014228374A patent/AU2014228374B2/en active Active
- 2014-03-07 UA UAA201508675A patent/UA116125C2/uk unknown
- 2014-03-07 WO PCT/US2014/021466 patent/WO2014143601A1/en not_active Ceased
- 2014-03-07 EA EA201591509A patent/EA027012B1/ru not_active IP Right Cessation
- 2014-03-07 AP AP2015008734A patent/AP2015008734A0/xx unknown
- 2014-03-07 CA CA2900773A patent/CA2900773C/en active Active
- 2014-03-07 DK DK14712966.2T patent/DK2970221T3/en active
- 2014-03-07 BR BR112015020466-0A patent/BR112015020466B1/pt active IP Right Grant
- 2014-03-07 PL PL14712966T patent/PL2970221T3/pl unknown
- 2014-03-07 KR KR1020157024644A patent/KR101718645B1/ko active Active
- 2014-03-07 US US14/200,141 patent/US9156824B2/en active Active
- 2014-03-07 HR HRP20171151TT patent/HRP20171151T1/hr unknown
- 2014-03-07 PE PE2015001925A patent/PE20151654A1/es active IP Right Grant
- 2014-03-07 EP EP14712966.2A patent/EP2970221B1/en active Active
- 2014-03-07 ME MEP-2017-173A patent/ME02805B/me unknown
- 2014-03-07 MX MX2015012583A patent/MX363438B/es unknown
- 2014-03-07 PT PT147129662T patent/PT2970221T/pt unknown
- 2014-03-07 RS RS20170791A patent/RS56122B1/sr unknown
- 2014-03-07 CN CN201480011202.4A patent/CN105008351B/zh active Active
- 2014-03-07 SI SI201430280T patent/SI2970221T1/sl unknown
- 2014-03-07 LT LTEP14712966.2T patent/LT2970221T/lt unknown
- 2014-03-07 NZ NZ710392A patent/NZ710392A/en unknown
-
2015
- 2015-08-12 TN TN2015000349A patent/TN2015000349A1/en unknown
- 2015-08-14 CR CR20150416A patent/CR20150416A/es unknown
- 2015-08-31 IL IL240962A patent/IL240962B/en active IP Right Grant
- 2015-09-09 GT GT201500263A patent/GT201500263A/es unknown
- 2015-09-09 CL CL2015002530A patent/CL2015002530A1/es unknown
- 2015-09-14 PH PH12015502091A patent/PH12015502091B1/en unknown
-
2017
- 2017-08-10 CY CY20171100861T patent/CY1119199T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |