[go: up one dir, main page]

PE20130211A1 - Modificador del sabor dulce - Google Patents

Modificador del sabor dulce

Info

Publication number
PE20130211A1
PE20130211A1 PE2012001811A PE2012001811A PE20130211A1 PE 20130211 A1 PE20130211 A1 PE 20130211A1 PE 2012001811 A PE2012001811 A PE 2012001811A PE 2012001811 A PE2012001811 A PE 2012001811A PE 20130211 A1 PE20130211 A1 PE 20130211A1
Authority
PE
Peru
Prior art keywords
amino
aryl
carboxyl acid
sweet flavor
compounds
Prior art date
Application number
PE2012001811A
Other languages
English (en)
Inventor
Catherine Tachdjian
Xio-Qing Tang
Donald S Karanewsky
Guy Servant
Xiaodong Li
Feng Zhang
Quing Chen
Hong Zhang
Timothy Davis
Vincent Darmohusodo
Melissa Wong
Victor Selchau
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of PE20130211A1 publication Critical patent/PE20130211A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/205—Heterocyclic compounds
    • A23L27/2054—Heterocyclic compounds having nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) O (I') DONDE A ES OR1, NR1C(O)R2, NHOR1, NR1R2, ENTRE OTROS; B ES H, ALQUILO, ARILO, ACILO, HETEROALQUILO, ENTRE OTROS; C ES OR7, SO3R7, CO2R7, ENTRE OTROS; D ES UN ANILLO ARILO, HETEROARILO, CICLOALQUILO, CICLOHETEROALQUILO, ENTRE OTROS, EN DONDE R1, R2 Y R7 SON CADA UNO H, ALQUILO, ARILO, ARILALQUILO, ACILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 4-AMINO-5-(2-(3-HIDROXIBENZAMIDO)-2-METILPROPOXI)-2-METILQUINOLIN-3-CARBOXILICO; ACIDO 4-AMINO-2,5-DIMETILQUINOLIN-3-CARBOXILICO; ACIDO 4-AMINO-5-(2,2-DIMETIL-3-OXO-3-(PROPILAMINO)PROPOXI)-2-METIL-QUINOLIN-3-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA INGERIBLE. DICHOS COMPUESTOS SON MEJORADORES DEL SABOR DULCE
PE2012001811A 2010-04-02 2011-03-31 Modificador del sabor dulce PE20130211A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32052810P 2010-04-02 2010-04-02
US42234110P 2010-12-13 2010-12-13

Publications (1)

Publication Number Publication Date
PE20130211A1 true PE20130211A1 (es) 2013-03-22

Family

ID=44710373

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012001811A PE20130211A1 (es) 2010-04-02 2011-03-31 Modificador del sabor dulce
PE2017001251A PE20171345A1 (es) 2010-04-02 2011-03-31 Modificador del sabor dulce

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2017001251A PE20171345A1 (es) 2010-04-02 2011-03-31 Modificador del sabor dulce

Country Status (22)

Country Link
US (4) US8592592B2 (es)
EP (1) EP2552207B1 (es)
JP (1) JP5988506B2 (es)
KR (1) KR101810265B1 (es)
CN (1) CN102933081B (es)
AR (1) AR081814A1 (es)
AU (1) AU2011235069B2 (es)
BR (1) BR112012025167B1 (es)
CA (1) CA2792068A1 (es)
CL (1) CL2012002477A1 (es)
CO (1) CO6630147A2 (es)
ES (1) ES2753523T3 (es)
IL (1) IL222219A0 (es)
MX (1) MX2012011386A (es)
MY (1) MY175079A (es)
NZ (1) NZ603332A (es)
PE (2) PE20130211A1 (es)
PH (1) PH12012501846A1 (es)
RU (1) RU2605549C2 (es)
SG (2) SG10201507846YA (es)
TW (1) TWI595838B (es)
WO (1) WO2011123693A1 (es)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
CN102170797B (zh) 2008-07-31 2014-02-19 西诺米克斯公司 包含甜味增强剂的组合物和它们的制备方法
EP2323997B1 (en) 2008-07-31 2017-09-06 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
US9000054B2 (en) 2010-08-12 2015-04-07 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MY179876A (en) * 2011-08-12 2020-11-18 Firmenich Incorporated Sweet flavor modifier
EP2793622B1 (de) 2011-12-21 2019-02-27 Merck Patent GmbH Verwendung von cyclohexanolderivaten als antimikrobielle wirkstoffe
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
EP3593648B1 (en) * 2012-08-06 2021-07-14 Firmenich Incorporated Sweet flavor modifier
GB201222241D0 (en) * 2012-12-11 2013-01-23 Morris George J Control of ice formation
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
CN103497151B (zh) * 2013-10-30 2015-07-15 山东铂源药业有限公司 一种4-氨基-6-甲基烟酸的合成方法
US11339128B2 (en) 2014-11-07 2022-05-24 Firmenich Incorporated Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
JP6949838B2 (ja) 2015-10-29 2021-10-13 フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ 高甘味度甘味料
US20190234926A1 (en) * 2016-07-06 2019-08-01 Mccormick & Company, Incorporated Method of predicting flavor performance
RS61004B2 (sr) 2016-09-21 2025-05-30 Celanese Int Corp Kompozicije acesulfam-kalijuma i postupci za njihovu proizvodnju
DK3317260T4 (da) 2016-09-21 2025-08-18 Celanese Int Corp Acesulfam-kalium-sammensætninger og fremgangsmåder til fremstilling heraf
HUE055805T2 (hu) 2016-09-21 2021-12-28 Celanese Int Corp Aceszulfám-kálium kompozíciók és eljárások ezek elõállítására
PT3319949T (pt) 2016-09-21 2020-10-12 Celanese Int Corp Composições de acessulfame de potássio e processos para produzir o mesmo
JP7285786B2 (ja) 2017-05-03 2023-06-02 フィルメニッヒ インコーポレイテッド 高強度の甘味料の製造方法
CN112703193A (zh) 2018-08-07 2021-04-23 弗门尼舍公司 5-取代的4-氨基-1H-苯并[c][1,2,6]噻二嗪2,2-二氧化物及其制剂和用途
CN120365272A (zh) 2018-10-05 2025-07-25 安娜普尔纳生物股份有限公司 用于治疗与apj受体活性有关的疾病的化合物和组合物
US12286661B2 (en) 2018-11-07 2025-04-29 Firmenich Incorporated Methods for making high intensity sweeteners
JP2022512931A (ja) 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
WO2020161939A1 (ja) * 2019-02-06 2020-08-13 株式会社Ｍｉｚｋａｎ Ｈｏｌｄｉｎｇｓ 甘い風味が増強された乾燥植物粉末および飲食品
JP7572357B2 (ja) 2019-03-28 2024-10-23 フイルメニツヒ ソシエテ アノニム フレーバーシステム
US12227539B2 (en) 2019-04-04 2025-02-18 Firmenich Sa Mogroside compounds and uses thereof
US20220167642A1 (en) 2019-06-28 2022-06-02 Firmenich Sa Fat blends, emulsions thereof, and related uses
JP2022547292A (ja) 2019-09-05 2022-11-11 フイルメニツヒ ソシエテ アノニム フラバノン誘導体及び甘味増強剤としてのフラバノン誘導体の使用
WO2021094268A1 (en) 2019-11-11 2021-05-20 Firmenich Sa Gingerol compounds and their use as flavor modifiers
BR112022009553A2 (pt) 2019-12-13 2022-08-02 Firmenich Incorporated Composições modificadoras de sabor e usos das mesmas
WO2021118864A1 (en) 2019-12-13 2021-06-17 Firmenich Incorporated Taste modifying compositions and uses thereof
EP4044827A1 (en) 2019-12-18 2022-08-24 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2021126569A1 (en) 2019-12-18 2021-06-24 Firmenich Incorporated Taste modifying compositions and uses thereof
EP4048086A1 (en) 2020-03-05 2022-08-31 Firmenich SA 11-oxo-cucurbitanes and their use as flavor modifiers
CN115279206A (zh) 2020-03-31 2022-11-01 弗门尼舍有限公司 风味剂组合物
EP4055006A1 (en) 2020-04-17 2022-09-14 Firmenich SA Amino acid derivatives and their use as flavor modifiers
CN115279414A (zh) 2020-05-22 2022-11-01 弗门尼舍有限公司 用于减少咸味的组合物及其用途
JP7770328B2 (ja) 2020-06-03 2025-11-14 フイルメニツヒ ソシエテ アノニム 雑味を減らす組成物およびその使用
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
EP4171266A1 (en) 2020-06-24 2023-05-03 Firmenich SA Sweetening compositions and uses thereof
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022006457A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
CN115551598A (zh) 2020-07-14 2022-12-30 弗门尼舍有限公司 口腔护理产品中的不希望的味道调性的减少
CN116322366A (zh) 2020-07-24 2023-06-23 弗门尼舍公司 通过跨膜区结合进行的美味增强
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
JP2023541748A (ja) 2020-09-22 2023-10-04 フイルメニツヒ ソシエテ アノニム サリチル酸メチル不含のウィンターグリーンフレーバー組成物
CN114901081B (zh) 2020-10-13 2023-03-24 弗门尼舍有限公司 丙二酰基甜菊醇糖苷及其可食用用途
US20230345986A1 (en) 2020-10-27 2023-11-02 Firmenich Sa Conjugated diynes and their use as flavor modifiers
US20240036041A1 (en) 2020-11-24 2024-02-01 Firmenich Incorporated Kokumi taste enhancement and related screening methods
EP4175490A1 (en) 2020-11-29 2023-05-10 Firmenich SA Compositions that reduce peroxide off taste and uses thereof
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
EP4213636A1 (en) 2020-12-23 2023-07-26 Firmenich SA Uses of fat blends and emulsions thereof
US20240058238A1 (en) 2021-01-13 2024-02-22 Firmenich Incorporated Compositions that enhance the cooling effect
CN116963609A (zh) 2021-01-15 2023-10-27 弗门尼舍公司 包含罗汉果苷的甜味剂组合物及其用途
JP2024503100A (ja) 2021-01-15 2024-01-24 フィルメニッヒ インコーポレイテッド シアメノシドｉを含む甘味料組成物およびその使用
WO2022155667A1 (en) 2021-01-15 2022-07-21 Firmenich Incorporated Sweetener compositions comprising mogrosides and uses thereof
WO2022171569A1 (en) 2021-02-10 2022-08-18 Firmenich Sa Fiber blends, sweetened fiber blends, and their comestible use
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
WO2022189156A1 (en) 2021-03-09 2022-09-15 Firmenich Sa Hydroxy- and methoxy-substituted flavonoids and their use
WO2022189155A1 (en) 2021-03-09 2022-09-15 Firmenich Sa Hydroxy- and methoxy-substituted flavones and their use
EP4277474A1 (en) 2021-04-06 2023-11-22 Firmenich SA Use of gingerdiol compounds to enhance flavor
JP2024517691A (ja) 2021-04-26 2024-04-23 フィルメニッヒ インコーポレイテッド アミド化合物および風味修飾剤としてのその使用
WO2022231918A1 (en) 2021-04-26 2022-11-03 Firmenich Incorporated Amide compounds and their use as flavor modifiers
WO2022238249A2 (en) 2021-05-11 2022-11-17 Firmenich Sa Process of making gingerol compounds and their use as flavor modifiers
WO2022248405A1 (en) 2021-05-24 2022-12-01 Firmenich Sa Flavored fiber blends and their comestible use
US20240238183A1 (en) 2021-05-28 2024-07-18 Firmenich Incorporated Compositions that enhance the cooling effect
JP2024522442A (ja) 2021-06-02 2024-06-21 フイルメニツヒ ソシエテ アノニム 脱アセチル化の方法、組成物、およびその使用
JP2024524266A (ja) 2021-06-23 2024-07-05 フイルメニツヒ ソシエテ アノニム ラクターゼを含むフレーバー修飾組成物
WO2023278394A1 (en) 2021-06-28 2023-01-05 Firmenich Incorporated Polycationic salts of phenolic compounds and uses thereof
WO2023274808A1 (en) 2021-06-29 2023-01-05 Firmenich Sa Licorice compounds and their use as flavor modifiers
CN117580464A (zh) 2021-06-29 2024-02-20 弗门尼舍公司 罗汉果苷化合物及其食用用途
EP4362689A1 (en) 2021-09-27 2024-05-08 Firmenich SA Flavor compositions containing iron compounds and their use
WO2023049308A1 (en) 2021-09-27 2023-03-30 Firmenich Incorporated Use of vanillyl ethers to modify flavor of distilled spirits
JP2024539838A (ja) 2021-11-01 2024-10-31 フイルメニツヒ ソシエテ アノニム 栄養素および味調節剤を含む組成物
WO2023091315A2 (en) 2021-11-16 2023-05-25 Firmenich Incorporated Amide compounds and their use as flavor modifiers
WO2023107904A1 (en) 2021-12-07 2023-06-15 Firmenich Incorporated Reduction of bitter taste of plant proteins and related assays and screening methods
WO2023118002A1 (en) 2021-12-20 2023-06-29 Firmenich Sa Encapsulated metal compounds and comestible uses thereof
EP4415542A1 (en) 2021-12-23 2024-08-21 Firmenich SA Antimicrobial composition having encapsulated colorant
JP2025508354A (ja) 2022-03-04 2025-03-26 フイルメニツヒ ソシエテ アノニム ポリメトキシル化フラボノイドの精製方法およびそれから得られる組成物
US20250280861A1 (en) 2022-03-07 2025-09-11 Firmenich Incorporated Sweetener compositions
CN118973993A (zh) 2022-03-10 2024-11-15 弗门尼舍有限公司 甜味剂组合物
WO2023172394A1 (en) 2022-03-11 2023-09-14 Firmenich Incorporated Flavanone compounds and their use as flavor modifiers
CN118843399A (zh) 2022-03-11 2024-10-25 弗门尼舍公司 酰胺化合物及其作为风味修饰剂的用途
JP2025509672A (ja) 2022-03-17 2025-04-11 インサイト・コーポレイション Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物
US20250194649A1 (en) 2022-03-25 2025-06-19 Firmenich Sa Fatty acid amides and their use as flavor modifiers
WO2023186792A1 (en) 2022-03-28 2023-10-05 Firmenich Sa Non-animal protein compositions and uses thereof
US20250204564A1 (en) 2022-04-06 2025-06-26 Firmenich Incorporated Taste modifying compositions and uses thereof
US20250331542A1 (en) 2022-04-11 2025-10-30 Firmenich Sa Sweetener compositions
JP2025517321A (ja) 2022-05-16 2025-06-05 フィルメニッヒ インコーポレイテッド 飽和脂肪酸および味を改変するための飽和脂肪酸の使用
EP4492989A1 (en) 2022-05-16 2025-01-22 Firmenich Incorporated Unsaturated fatty acids and their use to modify taste
US20250344736A1 (en) 2022-06-03 2025-11-13 Firmenich Sa Fat reduction in non-animal protein compositions
CN119325346A (zh) 2022-06-14 2025-01-17 弗门尼舍有限公司 蛋白质的聚电解质复合物及其用途
EP4507522A1 (en) 2022-06-24 2025-02-19 Firmenich SA Taste modifying compositions and uses thereof
JP2025520966A (ja) 2022-07-07 2025-07-03 フィルメニッヒ インコーポレイテッド 冷却効果を増強する組成物
EP4514142A1 (en) 2022-08-22 2025-03-05 Firmenich SA Gel compositions and their use in seafood analogue products
EP4577059A1 (en) 2022-10-26 2025-07-02 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2024089025A1 (en) 2022-10-26 2024-05-02 Firmenich Sa Extrusion methods and flavored products formed thereby
EP4580420A1 (en) 2022-11-01 2025-07-09 Firmenich SA Low-calorie composition for flavor modification
WO2024137186A1 (en) 2022-12-23 2024-06-27 Firmenich Incorporated Beta-cyclodextrin and its use to modify flavor
WO2024149754A1 (en) 2023-01-09 2024-07-18 Firmenich Sa Use of plant fibers to improve flavor of fermented products
WO2024170640A1 (en) 2023-02-15 2024-08-22 Firmenich Sa Thermoresponsive gel composition and uses thereof
CN120752224A (zh) 2023-02-25 2025-10-03 弗门尼舍公司 黄烷酮化合物及其作为风味修饰剂的用途
CN120916646A (zh) 2023-03-23 2025-11-07 弗门尼舍公司 香兰基醚修饰风味的用途
WO2024200171A1 (en) 2023-03-24 2024-10-03 Firmenich Sa Microparticles containing algal proteins and uses thereof
CN120981169A (zh) 2023-03-29 2025-11-18 弗门尼舍公司 脂肪酸用于修饰风味的用途
WO2024208837A1 (en) 2023-04-04 2024-10-10 Firmenich Sa Polysaccharide compositions and their comestible use
WO2024227789A1 (en) 2023-05-03 2024-11-07 Firmenich Sa Encapsulated phenolic compounds and their comestible use
WO2024251755A1 (en) 2023-06-09 2024-12-12 Dsm-Firmenich Ag Compositions for reducing off notes and uses thereof
EP4480319A1 (en) 2023-06-22 2024-12-25 DSM-Firmenich AG Granola cluster
WO2025067974A1 (en) 2023-09-26 2025-04-03 Firmenich Sa Vegan cheese compositions and methods of making the same
WO2025073683A1 (en) 2023-10-04 2025-04-10 Firmenich Sa Flavanone compounds and their use as flavor modifiers
WO2025125286A1 (en) 2023-12-13 2025-06-19 Firmenich Sa Biopolymer compositions and their use in foamed compositions
WO2025132821A1 (en) 2023-12-19 2025-06-26 Firmenich Sa Comestible products having high fiber and low sugar
WO2025132803A1 (en) 2023-12-20 2025-06-26 Firmenich Sa 3-hydroxybenzoic acid and its use as a flavor modifier
WO2025191050A1 (en) 2024-03-15 2025-09-18 Firmenich Sa Lipid particles and their comestible use
WO2025221883A1 (en) 2024-04-17 2025-10-23 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2025230968A1 (en) 2024-04-30 2025-11-06 Firmenich Incorporated Ketone compounds for enhancing alcohol perception

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2030899A1 (de) * 1970-06-18 1971-12-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen Chinolincarbonsäurederivate
FR2101004B2 (es) * 1970-08-05 1974-02-01 Bellon Labor Sa Roger
JPS5833843B2 (ja) * 1974-10-24 1983-07-22 武田薬品工業株式会社 スイサンヨウ ヤクザイ
JPS52142098A (en) 1976-05-20 1977-11-26 Sumitomo Chem Co Ltd 1-fluoroalkyl-491h)-oxo-3-quinolinecarboxylic acid derivatives
DE3111155A1 (de) * 1981-03-21 1982-09-30 Troponwerke GmbH & Co KG, 5000 Köln 5,6-dimethyl-pyrrolo (2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552883A (en) 1982-06-15 1985-11-12 Ici Americas Inc. Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
GB8600651D0 (en) * 1986-01-11 1986-02-19 Beecham Group Plc Compounds
US4952584A (en) 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
JPH0676401B2 (ja) * 1990-10-19 1994-09-28 エスエス製薬株式会社 キノリン誘導体及びこれを含有する医薬
GB9125485D0 (en) 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
GB9127252D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06199855A (ja) * 1992-12-31 1994-07-19 Nippon Nohyaku Co Ltd ピラゾロピリジン誘導体及びこれを含有する血小板凝集抑制剤
US5776942A (en) 1994-06-17 1998-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Bronchodilating pyrido 2,3-d!pyrimidine derivatives
JPH083046A (ja) * 1994-06-17 1996-01-09 Nippon Zoki Pharmaceut Co Ltd 気管支喘息治療剤
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AR016817A1 (es) * 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
AU779412B2 (en) * 1999-09-22 2005-01-20 Sanofi-Aventis Deutschland Gmbh 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
AU2002356868A1 (en) * 2001-10-30 2003-05-12 Institut National De La Recherche Scientifique Methods for the prevention or treatment of bacterial and fungal infections
EP1451156A4 (en) * 2001-11-27 2005-05-25 Merck & Co Inc 4-AMINOCHINOLINVERBINDUNGEN
JP2006506442A (ja) * 2002-07-09 2006-02-23 ポイント セラピューティクス， インコーポレイテッド ボロプロリン化合物併用療法
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
NZ619746A (en) 2003-08-06 2014-05-30 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
JP4859676B2 (ja) * 2004-02-11 2012-01-25 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害剤
US20070203133A1 (en) 2004-03-11 2007-08-30 Neurogen Corporation Substituted 5,12-diaza-benzoanthracene analogues
WO2005123686A1 (en) 2004-06-09 2005-12-29 Avanir Pharmaceuticals Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
PL2489659T3 (pl) * 2004-06-24 2018-06-29 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą atp
JP2006036762A (ja) * 2004-06-25 2006-02-09 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
GB0425572D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd 1,7-Naphthyridines
PL1828199T3 (pl) 2004-12-17 2009-10-30 Hoffmann La Roche Pochodne tieno-pirydyny jako alosteryczne wzmacniacze gaba-b
GB0505621D0 (en) * 2005-03-18 2005-04-27 Glaxo Group Ltd Novel compounds
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
BRPI0611521A2 (pt) * 2005-05-18 2010-09-14 Wyeth Corp inibidores de 4,6-diamino-[1,7]naftiridina-3-carbonitrila de quìnase tpl2 e métodos de fabricação e uso dos mesmos
JP2008542249A (ja) * 2005-05-24 2008-11-27 アストラゼネカ アクチボラグ 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体
AR055329A1 (es) 2005-06-15 2007-08-15 Senomyx Inc Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor
EA200870385A1 (ru) * 2006-03-29 2009-04-28 Фолдркс Фармасьютикалз, Инк. Ингибирование токсичности альфа-синуклеина
DE102006029446A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Neue 3-substituierte-Chinoline als Kinase-Inhibitoren
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
HUE025421T2 (en) * 2007-11-15 2016-02-29 Clanotech Ab Quinoline derivatives, pharmaceutical compositions containing them, and their use
DK2247196T3 (en) 2008-02-06 2015-02-16 Senomyx Inc Sweetener FORMATIONS AND PROCESSES FOR PREPARING THEM
EP2512242B8 (en) 2009-12-18 2015-12-09 GlaxoSmithKline Intellectual Property Limited Novel compounds
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
US9000054B2 (en) 2010-08-12 2015-04-07 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MY179876A (en) * 2011-08-12 2020-11-18 Firmenich Incorporated Sweet flavor modifier
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US20140272068A1 (en) 2013-03-14 2014-09-18 Indra Prakash Beverages containing rare sugars
JP6055730B2 (ja) 2013-07-17 2016-12-27 株式会社東海理化電機製作所 遠隔操作システム

Also Published As

Publication number Publication date
NZ603332A (en) 2014-11-28
EP2552207A1 (en) 2013-02-06
CN102933081A (zh) 2013-02-13
ES2753523T3 (es) 2020-04-13
US20150265711A1 (en) 2015-09-24
PH12012501846A1 (en) 2013-02-04
AU2011235069B2 (en) 2016-03-17
JP5988506B2 (ja) 2016-09-07
BR112012025167A2 (pt) 2015-09-08
US20160251372A1 (en) 2016-09-01
US20140128481A1 (en) 2014-05-08
MY175079A (en) 2020-06-04
SG10201507846YA (en) 2015-10-29
MX2012011386A (es) 2012-11-29
RU2605549C2 (ru) 2016-12-20
IL222219A0 (en) 2012-12-31
TW201141391A (en) 2011-12-01
US8592592B2 (en) 2013-11-26
AR081814A1 (es) 2012-10-24
WO2011123693A1 (en) 2011-10-06
US9049878B2 (en) 2015-06-09
JP2013525278A (ja) 2013-06-20
US20110245353A1 (en) 2011-10-06
CA2792068A1 (en) 2011-10-06
BR112012025167B1 (pt) 2024-01-09
KR20130012584A (ko) 2013-02-04
US9902737B2 (en) 2018-02-27
TWI595838B (zh) 2017-08-21
SG184156A1 (en) 2012-10-30
CL2012002477A1 (es) 2013-07-19
EP2552207B1 (en) 2019-08-21
HK1180900A1 (zh) 2013-11-01
PE20171345A1 (es) 2017-09-13
EP2552207A4 (en) 2016-04-06
CN102933081B (zh) 2016-04-13
KR101810265B1 (ko) 2017-12-18
RU2012146608A (ru) 2014-05-10
CO6630147A2 (es) 2013-03-01

Similar Documents

Publication Publication Date Title
PE20130211A1 (es) Modificador del sabor dulce
AR083873A1 (es) Derivados de acido amino-fenil-pentanoico sustituidos como inhibidores de nep
BR112014000471A2 (pt) processo para preparo de derivados de diamida de ácido antranílico substituídos com tetrazol por meio da reação de ácidos pirazóis com ésteres antranílicos
PE20141682A1 (es) Derivados de (4-fenilimidazol-2-il) etilamina utiles como moduladores de canal de sodio
PE20142452A1 (es) AMIDAS CICLICAS COMO INHIBIDORES DE MetAP-2
NZ631477A (en) Substituted pyrrolidine-2-carboxamides
MD20150052A2 (ro) Lactame aril şi heteroaril condensate
MY170922A (en) Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
PE20151335A1 (es) Composicion farmaceutica con biodisponibilidad mejorada
EA201690153A1 (ru) Замещенные бензофуранильные и бензоксазолильные соединения и их применения
MX361350B (es) Compuestos heterocíclicos fusionados como moduladores del canal de sodio.
PE20121500A1 (es) 2-amino-5,5-difluor-5,6-dihidro-4h-oxazinas como inhibidores de bace 1 y/o bace 2
MX378354B (es) Mejoramiento de autofagia o incremento de longevidad por administracion de urolitinas o precursores de las mismas.
EA201071329A1 (ru) Диамидные производные адамантана и их применение
MY178053A (en) Carboxylic acid compounds
PE20080359A1 (es) Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r
UA114611C2 (uk) Пестицидні композиції і способи, що їх стосуються
PE20130235A1 (es) Derivados de aminopirimidina como moduladores de la lrrk2
PH12014500842A1 (en) Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
PE20141529A1 (es) Derivados de biciclo [3,2,1] octilamida y sus usos
EA201270216A1 (ru) Фармацевтический состав
EA201591230A1 (ru) Композиция диклофенака
PE20181319A1 (es) Compuestos de isoindol
PE20142450A1 (es) Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de bace1
DOP2005000091A (es) (4-metoxi-7-morfolin-4-il-benzotiazol-2-il) amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico

Legal Events

Date Code Title Description
FG Grant, registration
AE Restoration of lapsed or forfeited application
FG Grant, registration