[go: up one dir, main page]

CL2012002477A1 - Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) - Google Patents

Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

Info

Publication number
CL2012002477A1
CL2012002477A1 CL2012002477A CL2012002477A CL2012002477A1 CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1 CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A CL2012002477 A CL 2012002477A CL 2012002477 A1 CL2012002477 A1 CL 2012002477A1
Authority
CL
Chile
Prior art keywords
formula
ingestible composition
compound
compounds
sweet taste
Prior art date
Application number
CL2012002477A
Other languages
English (en)
Inventor
Xiao Qing Tang
Donald S Karanewsky
Xiaodong Li
Feng Zhang
Qing Chen
Hong Zhang
Timothy Davis
Vincent Darmohusodo
Melissa Wong
Victor Selchau
Catherine Tachdjian
Guy Servant
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of CL2012002477A1 publication Critical patent/CL2012002477A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/205—Heterocyclic compounds
    • A23L27/2054—Heterocyclic compounds having nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)

Abstract

Compuestos derivados de quinolina; composición ingerible que comprende a dichos compuestos; método para mejorar el sabor dulce de una composición ingerible; composición ingerible; y formulación saborizante concentrada.
CL2012002477A 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i) CL2012002477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32052810P 2010-04-02 2010-04-02
US42234110P 2010-12-13 2010-12-13

Publications (1)

Publication Number Publication Date
CL2012002477A1 true CL2012002477A1 (es) 2013-07-19

Family

ID=44710373

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002477A CL2012002477A1 (es) 2010-04-02 2012-09-06 Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)

Country Status (22)

Country Link
US (4) US8592592B2 (es)
EP (1) EP2552207B1 (es)
JP (1) JP5988506B2 (es)
KR (1) KR101810265B1 (es)
CN (1) CN102933081B (es)
AR (1) AR081814A1 (es)
AU (1) AU2011235069B2 (es)
BR (1) BR112012025167B1 (es)
CA (1) CA2792068A1 (es)
CL (1) CL2012002477A1 (es)
CO (1) CO6630147A2 (es)
ES (1) ES2753523T3 (es)
IL (1) IL222219A0 (es)
MX (1) MX2012011386A (es)
MY (1) MY175079A (es)
NZ (1) NZ603332A (es)
PE (2) PE20130211A1 (es)
PH (1) PH12012501846A1 (es)
RU (1) RU2605549C2 (es)
SG (2) SG10201507846YA (es)
TW (1) TWI595838B (es)
WO (1) WO2011123693A1 (es)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8609173B2 (en) 2008-07-31 2013-12-17 Senomyx Inc. Compositions comprising sweetness enhancers and methods of making them
EP3085699B1 (en) 2008-07-31 2022-03-02 Firmenich Incorporated Processes for making sweet taste enhancers
RU2605549C2 (ru) 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
ES2607647T3 (es) 2011-08-12 2017-04-03 Senomyx, Inc. Modificador del sabor dulce
RU2642987C2 (ru) 2011-12-21 2018-01-29 Мерк Патент Гмбх Применение производных циклогексанола в качестве антимикробных активных соединений
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
KR20200028050A (ko) * 2012-08-06 2020-03-13 피르메니히 인코포레이티드 단맛 향미 개질제
GB201222241D0 (en) * 2012-12-11 2013-01-23 Morris George J Control of ice formation
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
CN103497151B (zh) * 2013-10-30 2015-07-15 山东铂源药业有限公司 一种4-氨基-6-甲基烟酸的合成方法
MX394005B (es) * 2014-11-07 2025-03-24 Firmenich Incorporated Acidos 4-amino-5- (ciclohexiloxi) quinolina-3-carboxilicos sustituidos como modificadores del sabor dulce.
NZ741741A (en) 2015-10-29 2019-08-30 Senomyx Inc High intensity sweeteners
US20190234926A1 (en) * 2016-07-06 2019-08-01 Mccormick & Company, Incorporated Method of predicting flavor performance
SI3322695T2 (sl) 2016-09-21 2025-08-29 Celanese International Corporation Sestavki kalijevega acesulfama in postopki za njihovo izdelavo
EP3319948B1 (en) 2016-09-21 2021-06-30 Celanese International Corporation Acesulfame potassium compositions and processes for producing same
JP6818896B2 (ja) 2016-09-21 2021-01-27 セラニーズ・インターナショナル・コーポレーション アセスルファムカリウム組成物及びその製造方法
HUE051396T2 (hu) 2016-09-21 2021-03-01 Celanese Int Corp Aceszulfám-kálium kompozíciók és az elõállításukra szolgáló eljárások
US11060124B2 (en) 2017-05-03 2021-07-13 Firmenich Incorporated Methods for making high intensity sweeteners
SG11202100846YA (en) 2018-08-07 2021-02-25 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof
HUE066335T2 (hu) 2018-10-05 2024-07-28 Annapurna Bio Inc Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére
JP2022512931A (ja) 2018-11-07 2022-02-07 フィルメニッヒ インコーポレイテッド 高甘味度甘味料の製造方法
CN113286523A (zh) 2018-11-07 2021-08-20 弗门尼舍公司 制备高强度甜味剂的方法
WO2020161939A1 (ja) * 2019-02-06 2020-08-13 株式会社Ｍｉｚｋａｎ Ｈｏｌｄｉｎｇｓ 甘い風味が増強された乾燥植物粉末および飲食品
JP7572357B2 (ja) 2019-03-28 2024-10-23 フイルメニツヒ ソシエテ アノニム フレーバーシステム
WO2020200916A1 (en) 2019-04-04 2020-10-08 Firmenich Sa Mogroside compounds and uses thereof
US20220167642A1 (en) 2019-06-28 2022-06-02 Firmenich Sa Fat blends, emulsions thereof, and related uses
US20220273012A1 (en) 2019-09-05 2022-09-01 Firmenich Sa Flavanone derivatives and their use as sweetness enhancers
US20220273011A1 (en) 2019-11-11 2022-09-01 Firmenich Sa Gingerol compounds and their use as flavor modifiers
WO2021118864A1 (en) 2019-12-13 2021-06-17 Firmenich Incorporated Taste modifying compositions and uses thereof
JP2023505951A (ja) 2019-12-13 2023-02-14 フィルメニッヒ インコーポレイテッド 味覚修飾組成物およびその使用
KR20220114529A (ko) 2019-12-18 2022-08-17 피르메니히 인코포레이티드 맛 개질 조성물 및 이의 용도
WO2021126569A1 (en) 2019-12-18 2021-06-24 Firmenich Incorporated Taste modifying compositions and uses thereof
EP4048086A1 (en) 2020-03-05 2022-08-31 Firmenich SA 11-oxo-cucurbitanes and their use as flavor modifiers
US20230148641A1 (en) 2020-03-31 2023-05-18 Firmenich Sa Flavor composition
CN114096515B (zh) 2020-04-17 2024-07-26 弗门尼舍有限公司 氨基酸衍生物及其作为风味改良剂的用途
CN115279414A (zh) 2020-05-22 2022-11-01 弗门尼舍有限公司 用于减少咸味的组合物及其用途
EP4096434A1 (en) 2020-06-03 2022-12-07 Firmenich SA Compositions for reducing off tastes and uses thereof
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
MX2022015148A (es) 2020-06-24 2023-01-11 Firmenich & Cie Composiciones edulcorantes y usos de las mismas.
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
AU2021300429A1 (en) 2020-07-02 2023-02-16 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
EP4110475A1 (en) 2020-07-14 2023-01-04 Firmenich SA Reduction of undesirable taste notes in oral care products
CN116322366A (zh) 2020-07-24 2023-06-23 弗门尼舍公司 通过跨膜区结合进行的美味增强
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2022063488A1 (en) 2020-09-22 2022-03-31 Firmenich Sa Wintergreen flavor compositions free of methyl salicylate
US20230329299A1 (en) 2020-10-13 2023-10-19 Firmenich Sa Malonyl steviol glycosides and their comestible use
US20230345986A1 (en) 2020-10-27 2023-11-02 Firmenich Sa Conjugated diynes and their use as flavor modifiers
EP4211469A1 (en) 2020-11-24 2023-07-19 Firmenich Incorporated Kokumi taste enhancement and related screening methods
CN115988967A (zh) 2020-11-29 2023-04-18 弗门尼舍有限公司 减少过氧化物异味的组合物及其用途
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
US20230397627A1 (en) 2020-12-23 2023-12-14 Firmenich Sa Uses of fat blends and emulsions thereof
US20240058238A1 (en) 2021-01-13 2024-02-22 Firmenich Incorporated Compositions that enhance the cooling effect
JP2024503101A (ja) 2021-01-15 2024-01-24 フィルメニッヒ インコーポレイテッド モグロシドを含む甘味料組成物およびその使用
JP2024503100A (ja) 2021-01-15 2024-01-24 フィルメニッヒ インコーポレイテッド シアメノシドｉを含む甘味料組成物およびその使用
US20240065302A1 (en) 2021-01-15 2024-02-29 Firmenich Incorporated Sweetener compositions comprising mogrosides and uses thereof
WO2022171569A1 (en) 2021-02-10 2022-08-18 Firmenich Sa Fiber blends, sweetened fiber blends, and their comestible use
TW202302589A (zh) 2021-02-25 2023-01-16 美商英塞特公司 作為ｊａｋ２ ｖ６１７ｆ抑制劑之螺環內醯胺
WO2022189156A1 (en) 2021-03-09 2022-09-15 Firmenich Sa Hydroxy- and methoxy-substituted flavonoids and their use
US20240114939A1 (en) 2021-03-09 2024-04-11 Firmenich Sa Hydroxy- and methoxy-substituted flavones and their use
WO2022214275A1 (en) 2021-04-06 2022-10-13 Firmenich Sa Use of gingerdiol compounds to enhance flavor
BR112023021909A2 (pt) 2021-04-26 2023-12-19 Firmenich Incorporated Compostos de amida e seu uso como modificadores de sabor
JP2024517691A (ja) 2021-04-26 2024-04-23 フィルメニッヒ インコーポレイテッド アミド化合物および風味修飾剤としてのその使用
EP4307919A2 (en) 2021-05-11 2024-01-24 Firmenich SA Process of making gingerol compounds and their use as flavor modifiers
WO2022248405A1 (en) 2021-05-24 2022-12-01 Firmenich Sa Flavored fiber blends and their comestible use
BR112023022601A2 (pt) 2021-05-28 2024-01-16 Firmenich Incorporated Composições que intensificam o efeito de refrescância
EP4301158A1 (en) 2021-06-02 2024-01-10 Firmenich SA Deacetylation process, compositions, and uses thereof
US20250040582A1 (en) 2021-06-23 2025-02-06 Firmenich Sa Flavor-modifying compositions containing lactase
WO2023278394A1 (en) 2021-06-28 2023-01-05 Firmenich Incorporated Polycationic salts of phenolic compounds and uses thereof
JP2024525466A (ja) 2021-06-29 2024-07-12 フィルメニッヒ インコーポレイテッド モグロシド化合物およびその食用利用
KR20240023515A (ko) 2021-06-29 2024-02-22 피르메니히 에스아 감초 화합물 및 향미 개질제로서 이의 용도
EP4384595A1 (en) 2021-09-27 2024-06-19 Firmenich Incorporated Use of vanillyl ethers to modify flavor of distilled spirits
WO2023046914A1 (en) 2021-09-27 2023-03-30 Firmenich Sa Flavor compositions containing iron compounds and their use
US20250127199A1 (en) 2021-11-01 2025-04-24 Firmenich Sa Composition comprising a nutrient and a taste modulator
US20250024871A1 (en) 2021-11-16 2025-01-23 Firmenich Incorporated Amide compounds and their use as flavor modifiers
EP4416503A1 (en) 2021-12-07 2024-08-21 Firmenich Incorporated Reduction of bitter taste of plant proteins and related assays and screening methods
WO2023118002A1 (en) 2021-12-20 2023-06-29 Firmenich Sa Encapsulated metal compounds and comestible uses thereof
CN118414086A (zh) 2021-12-23 2024-07-30 弗门尼舍有限公司 具有包封的着色剂的抗微生物组合物
WO2023165764A1 (en) 2022-03-04 2023-09-07 Firmenich Sa Purification process for polymethoxylated flavonoids and compositions obtained therefrom
US20250280861A1 (en) 2022-03-07 2025-09-11 Firmenich Incorporated Sweetener compositions
CN118973993A (zh) 2022-03-10 2024-11-15 弗门尼舍有限公司 甜味剂组合物
WO2023172394A1 (en) 2022-03-11 2023-09-14 Firmenich Incorporated Flavanone compounds and their use as flavor modifiers
CN118843399A (zh) 2022-03-11 2024-10-25 弗门尼舍公司 酰胺化合物及其作为风味修饰剂的用途
CN119173514A (zh) 2022-03-17 2024-12-20 因赛特公司 作为jak2 v617f抑制剂的三环脲化合物
US20250194649A1 (en) 2022-03-25 2025-06-19 Firmenich Sa Fatty acid amides and their use as flavor modifiers
CN119212569A (zh) 2022-03-28 2024-12-27 弗门尼舍有限公司 非动物蛋白组合物及其用途
EP4475686A1 (en) 2022-04-06 2024-12-18 Firmenich Incorporated Taste modifying compositions and uses thereof
JP2025510598A (ja) 2022-04-11 2025-04-15 フイルメニツヒ ソシエテ アノニム 甘味料組成物
CN119212571A (zh) 2022-05-16 2024-12-27 弗门尼舍公司 不饱和脂肪酸及其修饰味道的用途
EP4492988A1 (en) 2022-05-16 2025-01-22 Firmenich Incorporated Saturated fatty acids and their use to modify taste
US20250344736A1 (en) 2022-06-03 2025-11-13 Firmenich Sa Fat reduction in non-animal protein compositions
CN119325346A (zh) 2022-06-14 2025-01-17 弗门尼舍有限公司 蛋白质的聚电解质复合物及其用途
WO2023247332A1 (en) 2022-06-24 2023-12-28 Firmenich Sa Taste modifying compositions and uses thereof
WO2024011086A1 (en) 2022-07-07 2024-01-11 Firmenich Incorporated Compositions that enhance the cooling effect
EP4514142A1 (en) 2022-08-22 2025-03-05 Firmenich SA Gel compositions and their use in seafood analogue products
WO2024091457A1 (en) 2022-10-26 2024-05-02 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2024089025A1 (en) 2022-10-26 2024-05-02 Firmenich Sa Extrusion methods and flavored products formed thereby
WO2024094523A1 (en) 2022-11-01 2024-05-10 Firmenich Sa Low-calorie composition for flavor modification
WO2024137186A1 (en) 2022-12-23 2024-06-27 Firmenich Incorporated Beta-cyclodextrin and its use to modify flavor
EP4648621A1 (en) 2023-01-09 2025-11-19 Firmenich SA Use of plant fibers to improve flavor of fermented products
EP4665157A1 (en) 2023-02-15 2025-12-24 Firmenich SA Thermoresponsive gel composition and uses thereof
CN120752224A (zh) 2023-02-25 2025-10-03 弗门尼舍公司 黄烷酮化合物及其作为风味修饰剂的用途
WO2024196906A1 (en) 2023-03-23 2024-09-26 Firmenich Incorporated Use of vanillyl ethers to modify flavor
WO2024200171A1 (en) 2023-03-24 2024-10-03 Firmenich Sa Microparticles containing algal proteins and uses thereof
CN120981169A (zh) 2023-03-29 2025-11-18 弗门尼舍公司 脂肪酸用于修饰风味的用途
WO2024208837A1 (en) 2023-04-04 2024-10-10 Firmenich Sa Polysaccharide compositions and their comestible use
WO2024227789A1 (en) 2023-05-03 2024-11-07 Firmenich Sa Encapsulated phenolic compounds and their comestible use
WO2024251755A1 (en) 2023-06-09 2024-12-12 Dsm-Firmenich Ag Compositions for reducing off notes and uses thereof
EP4480319A1 (en) 2023-06-22 2024-12-25 DSM-Firmenich AG Granola cluster
WO2025067974A1 (en) 2023-09-26 2025-04-03 Firmenich Sa Vegan cheese compositions and methods of making the same
WO2025073683A1 (en) 2023-10-04 2025-04-10 Firmenich Sa Flavanone compounds and their use as flavor modifiers
WO2025125286A1 (en) 2023-12-13 2025-06-19 Firmenich Sa Biopolymer compositions and their use in foamed compositions
WO2025132821A1 (en) 2023-12-19 2025-06-26 Firmenich Sa Comestible products having high fiber and low sugar
WO2025132803A1 (en) 2023-12-20 2025-06-26 Firmenich Sa 3-hydroxybenzoic acid and its use as a flavor modifier
WO2025191050A1 (en) 2024-03-15 2025-09-18 Firmenich Sa Lipid particles and their comestible use
WO2025221883A1 (en) 2024-04-17 2025-10-23 Firmenich Incorporated Taste modifying compositions and uses thereof
WO2025230968A1 (en) 2024-04-30 2025-11-06 Firmenich Incorporated Ketone compounds for enhancing alcohol perception

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2030899A1 (de) * 1970-06-18 1971-12-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen Chinolincarbonsäurederivate
FR2101004B2 (es) * 1970-08-05 1974-02-01 Bellon Labor Sa Roger
JPS5833843B2 (ja) * 1974-10-24 1983-07-22 武田薬品工業株式会社 スイサンヨウ ヤクザイ
JPS52142098A (en) 1976-05-20 1977-11-26 Sumitomo Chem Co Ltd 1-fluoroalkyl-491h)-oxo-3-quinolinecarboxylic acid derivatives
DE3111155A1 (de) * 1981-03-21 1982-09-30 Troponwerke GmbH & Co KG, 5000 Köln 5,6-dimethyl-pyrrolo (2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4552883A (en) * 1982-06-15 1985-11-12 Ici Americas Inc. Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
US4952584A (en) 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
GB8600651D0 (en) 1986-01-11 1986-02-19 Beecham Group Plc Compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
JPH0676401B2 (ja) * 1990-10-19 1994-09-28 エスエス製薬株式会社 キノリン誘導体及びこれを含有する医薬
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
GB9125485D0 (en) 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
GB9127252D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06199855A (ja) * 1992-12-31 1994-07-19 Nippon Nohyaku Co Ltd ピラゾロピリジン誘導体及びこれを含有する血小板凝集抑制剤
JPH083046A (ja) * 1994-06-17 1996-01-09 Nippon Zoki Pharmaceut Co Ltd 気管支喘息治療剤
US5776942A (en) 1994-06-17 1998-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Bronchodilating pyrido 2,3-d!pyrimidine derivatives
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AR016817A1 (es) * 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
DE19738616A1 (de) * 1997-09-04 1999-03-11 Clariant Gmbh 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel
CZ2002992A3 (cs) * 1999-09-22 2002-06-12 Aventis Pharma Deutschland Gmbh Konjugáty 4-benzylaminochinolinů se ľlučovými kyselinami a jejich heteroanalogy, způsob jejich přípravy, farmaceutické prostředky je obsahující, a jejich pouľití
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US20050119302A1 (en) * 2001-10-30 2005-06-02 Rahme Laurence G. Methods for the prevention or treament of bacterial and fungal infections
WO2003045920A1 (en) 2001-11-27 2003-06-05 Merck & Co., Inc. 4-aminoquinoline compounds
AU2003248921A1 (en) * 2002-07-09 2004-01-23 Point Therapeutics, Inc. Boroproline compound combination therapy
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
US7476399B2 (en) 2003-08-06 2009-01-13 Senomyx Inc. Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
WO2005077050A2 (en) * 2004-02-11 2005-08-25 Smithkline Beecham Corporation Hiv integrase inhibitors
US20070203133A1 (en) 2004-03-11 2007-08-30 Neurogen Corporation Substituted 5,12-diaza-benzoanthracene analogues
RU2006145961A (ru) 2004-06-09 2008-07-20 Аванир Фармасьютикалс (Us) Гетероциклические производные для лечения гиперлипидемии и связанных заболеваний
ME02799B (me) * 2004-06-24 2018-01-20 Vertex Pharma Modulatori ATP-vezujućih kasetnih transportera
JP2006036762A (ja) * 2004-06-25 2006-02-09 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
US20060045953A1 (en) 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
GB0425572D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd 1,7-Naphthyridines
PL1828199T3 (pl) 2004-12-17 2009-10-30 Hoffmann La Roche Pochodne tieno-pirydyny jako alosteryczne wzmacniacze gaba-b
GB0505621D0 (en) * 2005-03-18 2005-04-27 Glaxo Group Ltd Novel compounds
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
AU2006247315A1 (en) * 2005-05-18 2006-11-23 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
EP1891078A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
AR055329A1 (es) 2005-06-15 2007-08-15 Senomyx Inc Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor
WO2007126841A2 (en) 2006-03-29 2007-11-08 Foldrx Pharmaceuticals, Inc. Inhibition of alpha-synuclein toxicity
DE102006029446A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Neue 3-substituierte-Chinoline als Kinase-Inhibitoren
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
EP2220047B1 (en) * 2007-11-15 2015-05-06 ClanoTech AB Quinoline derivatives, pharmaceutical compositions comprising them, and use thereof
CN101990404B (zh) 2008-02-06 2014-08-13 西诺米克斯公司 增甜剂组合物及其制备方法
EP2512242B8 (en) 2009-12-18 2015-12-09 GlaxoSmithKline Intellectual Property Limited Novel compounds
RU2605549C2 (ru) 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
ES2607647T3 (es) * 2011-08-12 2017-04-03 Senomyx, Inc. Modificador del sabor dulce
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US20140272068A1 (en) 2013-03-14 2014-09-18 Indra Prakash Beverages containing rare sugars
JP6055730B2 (ja) 2013-07-17 2016-12-27 株式会社東海理化電機製作所 遠隔操作システム

Also Published As

Publication number Publication date
SG10201507846YA (en) 2015-10-29
PE20130211A1 (es) 2013-03-22
CA2792068A1 (en) 2011-10-06
US9902737B2 (en) 2018-02-27
US20110245353A1 (en) 2011-10-06
AR081814A1 (es) 2012-10-24
PH12012501846A1 (en) 2013-02-04
ES2753523T3 (es) 2020-04-13
TWI595838B (zh) 2017-08-21
EP2552207A1 (en) 2013-02-06
KR20130012584A (ko) 2013-02-04
MX2012011386A (es) 2012-11-29
RU2605549C2 (ru) 2016-12-20
MY175079A (en) 2020-06-04
WO2011123693A1 (en) 2011-10-06
BR112012025167B1 (pt) 2024-01-09
CO6630147A2 (es) 2013-03-01
US20160251372A1 (en) 2016-09-01
PE20171345A1 (es) 2017-09-13
IL222219A0 (en) 2012-12-31
JP5988506B2 (ja) 2016-09-07
RU2012146608A (ru) 2014-05-10
US20140128481A1 (en) 2014-05-08
SG184156A1 (en) 2012-10-30
JP2013525278A (ja) 2013-06-20
US20150265711A1 (en) 2015-09-24
CN102933081A (zh) 2013-02-13
CN102933081B (zh) 2016-04-13
TW201141391A (en) 2011-12-01
KR101810265B1 (ko) 2017-12-18
AU2011235069B2 (en) 2016-03-17
HK1180900A1 (zh) 2013-11-01
EP2552207B1 (en) 2019-08-21
BR112012025167A2 (pt) 2015-09-08
NZ603332A (en) 2014-11-28
US9049878B2 (en) 2015-06-09
EP2552207A4 (en) 2016-04-06
US8592592B2 (en) 2013-11-26

Similar Documents

Publication Publication Date Title
CL2012002477A1 (es) Compuesto modificador del sabor formula (i), composicion ingerible que comprende el compuestos de la formula (i), metodo para mejorar el sabor dulce de una composicion ingerible combinando dicho producto con el compuesto de la formula (i)
JOP20210065A1 (ar) عملية لتحضير 5- فلورو-1h- بيرازولوبيريدينات مستبدلة
GB201216469D0 (en) Stabilisation of viral particles
MY176814A (en) Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis
BR112015014753A2 (pt) composições, utilização de uma composição, método para o combate dos fungos fitopatogênicos e semente
PH12015500900A1 (en) A stabilized pemetrexed formulation
WO2014195978A3 (en) PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
PH12014502567A1 (en) Piperidine derivatives for gpr119 agonist
EA201391488A1 (ru) Композиции со сниженной вязкостью
MY168212A (en) A new therapeutical composition containing apomorphine as active ingredient
BR112015015368A2 (pt) composições de absorventes de dejetos de animais revestidas debaixa densidade
GB201117233D0 (en) Stabilisation of polypeptides
PH12014500321A1 (en) Novel substituted cyclohexane compounds
CY1118514T1 (el) Μεθοδος για την παρασκευη πεμετρεξιδης και αλατος λυσινης αυτης
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
MX2013004878A (es) N-hetarilmetil pirazolilcarboxamidas.
EP4458153A3 (en) Pesticide composition and method
CY1116500T1 (el) Μεθοδος ενζυματικης συνθεσης toy (7s)-1-(3,4-διμεθοξυδικυκλο[4.2.0] οκτα-1,3,5-τριεν-7-υλ)-ν-μεθυλομεθαναμινης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων αυτης
PH12016500980A1 (en) Amide derivatives for gpr119 agonist
IN2013MU03308A (es)
WO2012150607A3 (en) Oral liquid composition comprising divalproex sodium and process for preparing thereof
WO2012104874A3 (en) Aqueous concentrated formulation of linezolid
MX338818B (es) Derivados de 5-alquenil-2-oxo-tetrahidrofurano como compuestos saborizantes.
WO2011104555A3 (en) Process for the preparation of sunitinib malate form i
IN2013CH04314A (es)